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Article ; Online: Risk Factors Influencing the Severity of Cognitive Decline in Elderly Taxi Drivers Over 65 Years of Age: Applying a Zero-Inflated Negative Binomial Regression Model.

Ok, Jong Sun / Kim, Hyeongsu / Kang, Kyonghwa / Myong, Jun-Pyo / Heo, Jae-Hyeok

2023 Volume 52, Issue 8, Page(s) 1773–1775

Language	English
Publishing date	2023-09-07
Publishing country	Iran
Document type	Journal Article
ISSN	2251-6093 ; 0304-4556
ISSN (online)	2251-6093
ISSN	0304-4556
DOI	10.18502/ijph.v52i8.13417
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Article: The Interplay between Autophagy and Aging.

Pyo, Jong-Ok / Yoo, Seung-Min / Jung, Yong-Keun

Diabetes & metabolism journal

2013 Volume 37, Issue 5, Page(s) 333–339

Abstract: Numerous studies have established a link between autophagy and aging; however, the relationship has not been clearly defined. Aging is a very complex process caused by the accumulation of various factors due to the gradual failure of cellular maintenance. ...

Abstract	Numerous studies have established a link between autophagy and aging; however, the relationship has not been clearly defined. Aging is a very complex process caused by the accumulation of various factors due to the gradual failure of cellular maintenance. Recent studies have shown that autophagy reduces the stress responses induced by starvation, reactive oxygen species, and the accumulation of intracellular proteins and organelles through cytoprotection, clearance of damaged mitochondria, and lysosomal degradation. Here, we summarize our current understanding of the relationship between autophagy and the aging process.
Language	English
Publishing date	2013-02-11
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2602402-0
ISSN	2233-6087 ; 2233-6079
ISSN (online)	2233-6087
ISSN	2233-6079
DOI	10.4093/dmj.2013.37.5.333
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Article ; Online: In Vivo Recovery of Bacteriophages and Their Effects on

Lee, Hyun-Gwan / Kim, Yoo-Bhin / Lee, Sang-Hyeok / Moon, Jun-Ok / Chae, Jong-Pyo / Kim, Yu-Jin / Lee, Kyung-Woo

Veterinary sciences

2022 Volume 9, Issue 3

Abstract: The objectives of this study were to recover bacteriophages (BPs) from the intestinal digesta of BP-fed broilers and to evaluate the antibacterial effects of encapsulated or powdered BPs in broiler chickens challenged ... ...

Abstract	The objectives of this study were to recover bacteriophages (BPs) from the intestinal digesta of BP-fed broilers and to evaluate the antibacterial effects of encapsulated or powdered BPs in broiler chickens challenged with
Language	English
Publishing date	2022-03-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2768971-2
ISSN	2306-7381 ; 2306-7381
ISSN (online)	2306-7381
ISSN	2306-7381
DOI	10.3390/vetsci9030119
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Article ; Online: Enzymatic synthesis and characterization of novel lipophilic inotodiol-oleic acid conjugates.

Nguyen, Phu Cuong / Nguyen, My Tuyen Thi / Ban, So-Young / Choi, Kyeong-Ok / Park, Ji-Hyun / Tran, Phuong Lan / Pyo, Jang-Won / Kim, Jaehan / Park, Jong-Tae

Food chemistry

2023 Volume 437, Issue Pt 1, Page(s) 137897

Abstract: In this study, we establish an efficient enzymatic approach for producing novel inotodiyl-oleates (IOs) from pure inotodiol and oleic acid to improve the properties of inotodiol. For the esterification between inotodiol and oleic acid, CALA and n-hexane ... ...

Abstract	In this study, we establish an efficient enzymatic approach for producing novel inotodiyl-oleates (IOs) from pure inotodiol and oleic acid to improve the properties of inotodiol. For the esterification between inotodiol and oleic acid, CALA and n-hexane were the optimal biocatalyst and solvents for forming IOs with 80.17% conversion yield. These IOs comprised two distinct monoesters, the C3 or C22 ester forms of inotodiol. Intriguingly, no diesters were detected. The IOs had a melting point of 53.48 °C, much lower than that of inotodiol (192.06 °C). The in vitro digestion rate of IOs (25-28%) was significantly (p < 0.05) lower than that of cholesteryl-oleate (60%). Additionally, IOs exhibited much lower in vivo absorption than inotodiol when orally administered using different formulations (p < 0.05). The results indicated that IOs were resistant to enzymatic digestion in the small intestine, which could be advantageous in targeting the large intestine for disease treatments.
MeSH term(s)	Oleic Acid ; Lanosterol ; Esterification ; Esters
Chemical Substances	Oleic Acid (2UMI9U37CP) ; inotodiol ; Lanosterol (1J05Z83K3M) ; Esters
Language	English
Publishing date	2023-10-29
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2023.137897
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Article ; Online: Isolation, characterization, and genomic analysis of the novel T4-like bacteriophage ΦCJ20.

Kim, Jaegon / Chae, Jong Pyo / Kim, Gyeong-Hwuii / Kim, Jae-Won / Lee, Na-Gyeong / Moon, Jun-Ok / Yoon, Sung-Sik

Food science and biotechnology

2021 Volume 30, Issue 5, Page(s) 735–744

Abstract: Pathogenic : Supplementary information: The online version contains supplementary material available at 10.1007/s10068-021-00906-y. ...

Abstract	Pathogenic Supplementary information: The online version contains supplementary material available at 10.1007/s10068-021-00906-y.
Language	English
Publishing date	2021-05-11
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2000008-X
ISSN	2092-6456 ; 1226-7708
ISSN (online)	2092-6456
ISSN	1226-7708
DOI	10.1007/s10068-021-00906-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A purified inactivated vaccine derived from Vero cell-adapted zika virus elicits protection in mice.

Oh, Hyun-Seok / Yoon, Jong Won / Lee, Sanghyun / Kim, Soo-Ok / Hong, Sun Pyo

Virology

2021 Volume 560, Page(s) 124–130

Abstract: The Zika virus (ZIKV) outbreak in 2015-2016 raised public health concerns and created a pressing need for vaccine development. However, no vaccine has been developed and most of the ones under development use a single serotype of ZIKV. In this study, we ... ...

Abstract	The Zika virus (ZIKV) outbreak in 2015-2016 raised public health concerns and created a pressing need for vaccine development. However, no vaccine has been developed and most of the ones under development use a single serotype of ZIKV. In this study, we established a Vero cell-adapted ZIKV strain (GMZ-002) and developed a purified inactivated virus (PIV) vaccine. GMZ-002 presented significantly increased productivity in Vero cells, and IFNAR1-blocked C57BL/6 mice administered two doses of the PIV were fully protected against lethal challenge. Vaccine efficacy was illustrated by the high level of serum neutralizing antibodies and strong innate immune response, along with an absence of detectable viremia in vaccinated mice. Furthermore, anti-sera neutralized both African and Asian genetic lineages of the virus in vitro. Our results suggest that GMZ-002 PIV elicited robust and persistent protective immunity, and therefore represents a promising vaccine candidate for ZIKV.
MeSH term(s)	Adaptation, Physiological ; Animals ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; Cell Line ; Chlorocebus aethiops ; Female ; Immunogenicity, Vaccine/immunology ; Mice ; Mice, Inbred C57BL ; Receptor, Interferon alpha-beta/genetics ; Vaccination ; Vaccine Efficacy ; Vaccines, Inactivated/immunology ; Vero Cells ; Viral Vaccines/immunology ; Zika Virus/immunology ; Zika Virus Infection/immunology ; Zika Virus Infection/prevention & control
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Ifnar1 protein, mouse ; Vaccines, Inactivated ; Viral Vaccines ; Receptor, Interferon alpha-beta (156986-95-7)
Language	English
Publishing date	2021-05-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	200425-2
ISSN	1096-0341 ; 0042-6822
ISSN (online)	1096-0341
ISSN	0042-6822
DOI	10.1016/j.virol.2021.05.003
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Article: In Vivo Recovery of Bacteriophages and Their Effects on Clostridium perfringens-Infected Broiler Chickens

Lee, Hyun-Gwan / Kim, Yoo-Bhin / Lee, Sang-Hyeok / Moon, Jun-Ok / Chae, Jong-Pyo / Kim, Yu-Jin / Lee, Kyung-Woo

Veterinary sciences. 2022 Mar. 07, v. 9, no. 3

2022

Abstract	The objectives of this study were to recover bacteriophages (BPs) from the intestinal digesta of BP-fed broilers and to evaluate the antibacterial effects of encapsulated or powdered BPs in broiler chickens challenged with Clostridium perfringens. Day-old broiler chicks (n = 320/experiment) were randomly assigned to 32 pens (n = 10 broilers/pen) and allocated to one of four dietary groups: (1) unchallenged group (NEG); (2) C. perfringens-challenged group (POS); (3) POS group fed a diet supplemented with powdered BPs; and (4) POS group fed a diet supplemented with encapsulated BPs. On days 21, 22, and 23 post-hatch, all chickens except NEG were orally inoculated twice a day with 2 mL C. perfringens (1.0 × 10⁸ cfu/mL). Varying BP levels were detected in gut digesta at all ages and were numerically or significantly higher in the encapsulated BP group than in the powdered BP group. Dietary powder or encapsulated BPs reversed the C. perfringens-mediated increase in crypt depth. In addition, villus height to crypt depth ratio was elevated in the NEG and BP-treated/challenged groups compared with that in the POS group. C. perfringens counts in the cecum were significantly lower in the BP-fed chickens than in the POS group. The encapsulated BP-supplemented diet-fed chickens had the highest serum IgA levels. Collectively, our results suggest that dietary BP remains viable in intestinal digesta upon ingestion and can inhibit cecal C. perfringens counts.
Keywords	Clostridium perfringens ; blood serum ; cecum ; diet ; digesta ; encapsulation ; ingestion ; villi
Language	English
Dates of publication	2022-0307
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2768971-2
ISSN	2306-7381
ISSN	2306-7381
DOI	10.3390/vetsci9030119
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: In Vivo Recovery of Bacteriophages and Their Effects on Clostridium perfringens -Infected Broiler Chickens

Hyun-Gwan Lee / Yoo-Bhin Kim / Sang-Hyeok Lee / Jun-Ok Moon / Jong-Pyo Chae / Yu-Jin Kim / Kyung-Woo Lee

Veterinary Sciences, Vol 9, Iss 119, p

2022 Volume 119

Abstract	The objectives of this study were to recover bacteriophages (BPs) from the intestinal digesta of BP-fed broilers and to evaluate the antibacterial effects of encapsulated or powdered BPs in broiler chickens challenged with Clostridium perfringens . Day-old broiler chicks ( n = 320/experiment) were randomly assigned to 32 pens ( n = 10 broilers/pen) and allocated to one of four dietary groups: (1) unchallenged group (NEG); (2) C. perfringens -challenged group (POS); (3) POS group fed a diet supplemented with powdered BPs; and (4) POS group fed a diet supplemented with encapsulated BPs. On days 21, 22, and 23 post-hatch, all chickens except NEG were orally inoculated twice a day with 2 mL C. perfringens (1.0 × 10 8 cfu/mL). Varying BP levels were detected in gut digesta at all ages and were numerically or significantly higher in the encapsulated BP group than in the powdered BP group. Dietary powder or encapsulated BPs reversed the C. perfringens -mediated increase in crypt depth. In addition, villus height to crypt depth ratio was elevated in the NEG and BP-treated/challenged groups compared with that in the POS group. C. perfringens counts in the cecum were significantly lower in the BP-fed chickens than in the POS group. The encapsulated BP-supplemented diet-fed chickens had the highest serum IgA levels. Collectively, our results suggest that dietary BP remains viable in intestinal digesta upon ingestion and can inhibit cecal C. perfringens counts.
Keywords	Clostridium perfringens ; bacteriophage ; broiler chicken ; gut health ; Veterinary medicine ; SF600-1100
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Overexpression of Atg5 in mice activates autophagy and extends lifespan.

Pyo, Jong-Ok / Yoo, Seung-Min / Ahn, Hye-Hyun / Nah, Jihoon / Hong, Se-Hoon / Kam, Tae-In / Jung, Sunmin / Jung, Yong-Keun

Nature communications

2013 Volume 4, Page(s) 2300

Abstract: Autophagy has been implicated in the ageing process, but whether autophagy activation extends lifespan in mammals is unknown. Here we show that ubiquitous overexpression of Atg5, a protein essential for autophagosome formation, extends median lifespan of ...

Abstract	Autophagy has been implicated in the ageing process, but whether autophagy activation extends lifespan in mammals is unknown. Here we show that ubiquitous overexpression of Atg5, a protein essential for autophagosome formation, extends median lifespan of mice by 17.2%. We demonstrate that moderate overexpression of Atg5 in mice enhances autophagy, and that Atg5 transgenic mice showed anti-ageing phenotypes, including leanness, increased insulin sensitivity and improved motor function. Furthermore, mouse embryonic fibroblasts cultured from Atg5 transgenic mice are more tolerant to oxidative damage and cell death induced by oxidative stress, and this tolerance was reversible by treatment with an autophagy inhibitor. Our observations suggest that the leanness and lifespan extension in Atg5 transgenic mice may be the result of increased autophagic activity.
MeSH term(s)	Aging/genetics ; Animals ; Autophagy/genetics ; Autophagy/physiology ; Autophagy-Related Protein 5 ; Body Mass Index ; Cells, Cultured ; Female ; Insulin Resistance/genetics ; Insulin Resistance/physiology ; Longevity/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microtubule-Associated Proteins/biosynthesis ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Mitochondria/metabolism ; Motor Activity/genetics ; Motor Activity/physiology ; Muscle Strength/genetics ; Muscle Strength/physiology ; Oxidative Stress/genetics ; Oxidative Stress/physiology ; Oxygen/metabolism ; Oxygen Consumption/genetics ; Oxygen Consumption/physiology ; Thinness/genetics
Chemical Substances	Atg5 protein, mouse ; Autophagy-Related Protein 5 ; Microtubule-Associated Proteins ; Oxygen (S88TT14065)
Language	English
Publishing date	2013-08-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/ncomms3300
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Article: Isolation, characterization, and genomic analysis of the novel T4-like bacteriophage ΦCJ20

Kim, Jaegon / Chae, Jong Pyo / Kim, Gyeong-Hwuii / Kim, Jae-Won / Lee, Na-Gyeong / Moon, Jun-Ok / Yoon, Sung-Sik

Food science and biotechnology. 2021 May, v. 30, no. 5

2021

Abstract: Pathogenic Escherichia coli infections have been consistently reported annually. The basic characteristics and genome of the newly isolated ΦCJ20 from swine feces was analyzed. To determine basic characteristics, dotting assays and double-layer agar ... ...

Abstract	Pathogenic Escherichia coli infections have been consistently reported annually. The basic characteristics and genome of the newly isolated ΦCJ20 from swine feces was analyzed. To determine basic characteristics, dotting assays and double-layer agar assays were conducted. Bacteriophage particles were analyzed via transmission electron microscopy. Sodium dodecyl sulfate–polyacrylamide gel electrophoresis was performed to determine the sizes of major structural proteins. The complete genome of the phage was analyzed. Bacteriophage particles were identified as Myoviridae, with a head measuring 110.57 ± 1.89 nm and a contractile tail measuring 107.97 ± 3.20 nm and were found to infect E. coli. Major structural proteins of ΦCJ20 showed two well-pronounced bands of approximately 53.6 and 70.9 kDa. The genome size of ΦCJ20 was 169,884 bp, and 118 of 307 open reading frames were annotated. This study provides a baseline for the development of E. coli infection treatment strategies.
Keywords	Escherichia coli ; Myoviridae ; agar ; bacteriophages ; biotechnology ; feces ; food science ; genome ; genomics ; head ; polyacrylamide gel electrophoresis ; swine ; transmission electron microscopy
Language	English
Dates of publication	2021-05
Size	p. 735-744.
Publishing place	Springer Singapore
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2000008-X
ISSN	1226-7708
ISSN	1226-7708
DOI	10.1007/s10068-021-00906-y
Database	NAL-Catalogue (AGRICOLA)

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