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Article ; Online: Chilblain lupus during treatment with golimumab for rheumatoid arthritis.

Urata, Yoichiro / Honda, Tetsuya / Kaku, Yo / Kabashima, Kenji

2019 Volume 46, Issue 9, Page(s) e314–e315

MeSH term(s)	Antibodies, Monoclonal/adverse effects ; Antirheumatic Agents/adverse effects ; Arthritis, Rheumatoid/drug therapy ; Chilblains/chemically induced ; Chilblains/diagnosis ; Chilblains/pathology ; Female ; Humans ; Lupus Erythematosus, Cutaneous/chemically induced ; Lupus Erythematosus, Cutaneous/diagnosis ; Lupus Erythematosus, Cutaneous/pathology ; Middle Aged ; Skin/pathology
Chemical Substances	Antibodies, Monoclonal ; Antirheumatic Agents ; golimumab (91X1KLU43E)
Language	English
Publishing date	2019-04-05
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	800103-0
ISSN	1346-8138 ; 0385-2407
ISSN (online)	1346-8138
ISSN	0385-2407
DOI	10.1111/1346-8138.14884
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Article ; Online: Acute generalized exanthematous pustulosis during apalutamide treatment in a patient with prostate cancer.

Honda, Tomoko / Tohi, Yoichiro / Kaku, Yo / Kimura, Nachino / Kato, Takuma / Haba, Reiji / Dainichi, Teruki / Sugimoto, Mikio

IJU case reports

2022 Volume 5, Issue 6, Page(s) 497–500

Abstract: Introduction: Acute generalized exanthematous pustulosis is a type of severe cutaneous drug adverse reaction. While apalutamide is known for its high incidence of cutaneous adverse events, it remains unknown whether acute generalized exanthematous ... ...

Abstract	Introduction: Acute generalized exanthematous pustulosis is a type of severe cutaneous drug adverse reaction. While apalutamide is known for its high incidence of cutaneous adverse events, it remains unknown whether acute generalized exanthematous pustulosis can develop during apalutamide treatment. Case presentation: A 72-year-old man with metastatic castration-sensitive prostate cancer developed small erythema on the face and trunk after 41 days of apalutamide treatment. Three days later, apalutamide was discontinued. However, 9 days after the discontinuation of apalutamide, the patient had a high fever with hemodynamic instability and showed diffuse erythema throughout the body with numerous small pustules. Skin biopsy revealed subcorneal and intraepidermal pustules admixed with many eosinophils, which led to the diagnosis of acute generalized exanthematous pustulosis. The skin rash improved in 14 days with systemic corticosteroid administration. Conclusion: We present the first case of a skin rash with clinical features of acute generalized exanthematous pustulosis during apalutamide treatment.
Language	English
Publishing date	2022-08-16
Publishing country	Australia
Document type	Case Reports
ISSN	2577-171X
ISSN (online)	2577-171X
DOI	10.1002/iju5.12525
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Article ; Online: The significance of CD163-expressing macrophages in asthma.

Tokunaga, Yoshihisa / Imaoka, Haruki / Kaku, Yoichiro / Kawayama, Tomotaka / Hoshino, Tomoaki

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

2019 Volume 123, Issue 3, Page(s) 263–270

Abstract: Background: CD163 is one of the scavenger receptors that are specifically expressed on macrophages and are well known to be upregulated by various inflammatory responses, including chronic obstructive pulmonary disease in airway diseases.: Objective: ...

Abstract	Background: CD163 is one of the scavenger receptors that are specifically expressed on macrophages and are well known to be upregulated by various inflammatory responses, including chronic obstructive pulmonary disease in airway diseases. Objective: To evaluate the CD163 expression in the lungs of patients with fatal asthma and investigated whether CD163 contributes to the pathogenesis in asthma. Methods: The CD163 expressions in the lungs of patients with fatal asthma (n = 9) and in those of nonasthma control subjects (n = 8) were tested by immunohistochemistry. In mouse models of asthma, airway hyperresponsiveness (AHR) and the numbers of airway inflammatory cells in the bronchoalveolar lavage fluid (BALF) were analyzed in the CD163-deficient mice and the control wild-type mice. Results: The numbers of CD163-positive macrophages in the lung tissues were significantly increased in the all 6 patients with fatal asthma than in the control subjects. In mouse models of asthma, AHR and the numbers of infiltrating leukocytes, such as eosinophils, lymphocytes, neutrophils, and macrophages, in the BALF were significantly decreased in the CD163-deficient mice when compared with control wild-type mice. The concentrations of interferon γ and interleukin 5 in the BALF were significantly decreased in the CD163-deficient mice when compared with those in the control wild-type mice. Conclusion: CD163 may play important roles in airway inflammation and AHR in asthma.
MeSH term(s)	Aged ; Animals ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/genetics ; Antigens, Differentiation, Myelomonocytic/metabolism ; Asthma/diagnosis ; Asthma/immunology ; Disease Models, Animal ; Female ; Humans ; Immunohistochemistry ; Leukocyte Count ; Lung/pathology ; Macrophages/immunology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Middle Aged ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism ; Respiratory Hypersensitivity/diagnosis ; Respiratory Hypersensitivity/immunology
Chemical Substances	Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; CD163 antigen ; Receptors, Cell Surface
Language	English
Publishing date	2019-05-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1228189-x
ISSN	1534-4436 ; 0003-4738 ; 1081-1206
ISSN (online)	1534-4436
ISSN	0003-4738 ; 1081-1206
DOI	10.1016/j.anai.2019.05.019
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Article ; Online: Apalutamide-associated skin rash in patients with prostate cancer: Histological evaluation by skin biopsy.

Tohi, Yoichiro / Kataoka, Koki / Miyai, Yumi / Kaku, Yo / Dainichi, Teruki / Haba, Reiji / Tsunemori, Hiroyuki / Sugimoto, Mikio

IJU case reports

2021 Volume 4, Issue 5, Page(s) 299–302

Abstract: Introduction: Apalutamide-associated skin rash is a more common adverse event in the Japanese population than in the global population. However, its mechanism remains elusive, and limited histopathological information hampers further understanding.: ... ...

Abstract	Introduction: Apalutamide-associated skin rash is a more common adverse event in the Japanese population than in the global population. However, its mechanism remains elusive, and limited histopathological information hampers further understanding. Case presentation: Case 1: a 71-year-old man with metastatic castration-sensitive prostate cancer developed a skin rash after 70 days of apalutamide treatment. Case 2: a 71-year-old man with non-metastatic castration-resistant prostate cancer developed a skin rash after 71 days of apalutamide treatment. In both cases, the skin rash presented as a slightly exudative erythema. The histology showed spongiosis of the epidermis and perivascular and interstitial infiltration of lymphocytes and eosinophils in the upper dermis without necrotic keratinocytes. Conclusion: Apalutamide-induced skin rashes can involve an eczematous reaction clinically and histologically.
Language	English
Publishing date	2021-06-27
Publishing country	Australia
Document type	Case Reports
ISSN	2577-171X
ISSN (online)	2577-171X
DOI	10.1002/iju5.12331
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Article ; Online: Technique for identifying keratinized gingival tissue and soft tissue morphology on 3-dimensional implant-planning software images.

Kaku, Toshio / Ogino, Yoichiro / Matsushita, Yasuyuki / Koyano, Kiyoshi

The Journal of prosthetic dentistry

2016 Volume 116, Issue 1, Page(s) 21–24

Abstract: Preoperative 3-dimensional (3D) planning using cone beam computed tomography (CBCT) and 3D implant-planning software is used routinely for implant placement. However, despite its importance in planning surgical technique (conventional or flapless surgery) ...

Abstract	Preoperative 3-dimensional (3D) planning using cone beam computed tomography (CBCT) and 3D implant-planning software is used routinely for implant placement. However, despite its importance in planning surgical technique (conventional or flapless surgery) and prognosis, the distribution of keratinized gingival tissues (KGT) and soft tissue morphology cannot be identified with CBCT or planning software images. This report introduces a technique for identifying the distribution of KGT and soft tissue morphology during preoperative 3D planning.
Language	English
Publishing date	2016-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	218157-5
ISSN	1097-6841 ; 0022-3913
ISSN (online)	1097-6841
ISSN	0022-3913
DOI	10.1016/j.prosdent.2015.09.031
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Article ; Online: Attenuated Airway Eosinophilic Inflammations in IL-38 Knockout Mouse Model.

Matsuoka, Masanobu / Kawayama, Tomotaka / Tominaga, Masaki / Kaieda, Shinjiro / Tokunaga, Yoshihisa / Kaku, Yoichiro / Imaoka, Haruki / Kinoshita, Takashi / Okamoto, Masaki / Akiba, Jun / Hoshino, Tomoaki

The Kurume medical journal

2019 Volume 65, Issue 2, Page(s) 37–46

Abstract: Background: The role of IL-38, a new member of the IL-1 family, in airway eosinophilic inflammatory conditions such as asthma is unclear. To investigate the role of IL-38 in airway eosinophilic inflammation, an IL-38-gene deficient (KO) murine asthma ... ...

Abstract	Background: The role of IL-38, a new member of the IL-1 family, in airway eosinophilic inflammatory conditions such as asthma is unclear. To investigate the role of IL-38 in airway eosinophilic inflammation, an IL-38-gene deficient (KO) murine asthma model was analyzed. Methods: The numbers of eosinophils and neutrophils, and levels of IL-5, IL-13 and IL-17A protein and mRNA in bronchoalveolar lavage fluid (BALF) and lung tissue were compared between wild-type (WT) and IL-38-KO mice after OVA sensitization and challenge. The effects of additional purified recombinant mouse (rm) IL-38 protein were investigated in the IL-38-KO murine asthma model. Results: The IL-38 and IL-5 mRNA in WT mice was significantly higher after OVA challenge than after saline challenge (p<0.05). The number of airway eosinophils in IL-38-KO mice was significantly lower than in WT mice after OVA challenge (p<0.01). BALF analysis confirmed the lower number of airway eosinophils in IL-38-KO mice and showed that this was significantly associated with lower IL-5 protein levels (r=0.92, p<0.0001). However, the additional rm IL-38 protein did not neutralize airway eosinophilia in IL-38-KO mice. Conclusion: IL-38 may enhance airway eosinophilic inflammation in asthma through IL-5 induction.
MeSH term(s)	Animals ; Asthma/genetics ; Asthma/metabolism ; Bronchoalveolar Lavage Fluid ; Crosses, Genetic ; Disease Models, Animal ; Enzyme-Linked Immunosorbent Assay ; Eosinophilia/genetics ; Eosinophilia/metabolism ; Female ; Inflammation/genetics ; Inflammation/metabolism ; Interleukin-1/genetics ; Interleukin-1/metabolism ; Interleukin-13/metabolism ; Interleukin-17/metabolism ; Interleukin-5/genetics ; Interleukin-5/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neutrophils/metabolism ; Ovalbumin ; RNA, Messenger/metabolism ; Recombinant Proteins/metabolism
Chemical Substances	Il17a protein, mouse ; Il1f10 protein, mouse ; Interleukin-1 ; Interleukin-13 ; Interleukin-17 ; Interleukin-5 ; RNA, Messenger ; Recombinant Proteins ; Ovalbumin (9006-59-1)
Language	English
Publishing date	2019-03-11
Publishing country	Japan
Document type	Journal Article
ZDB-ID	603905-4
ISSN	1881-2090 ; 0023-5679
ISSN (online)	1881-2090
ISSN	0023-5679
DOI	10.2739/kurumemedj.MS652009
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Article ; Online: Increased Serum Levels of Soluble IL-18 Receptor Complex in Patients with Allergic Asthma.

Imaoka, Haruki / Takenaka, Shin-Ichi / Kawayama, Tomotaka / Oda, Hanako / Kaku, Yoichiro / Matsuoka, Masanobu / Sakazaki, Yuki / O'Byrne, Paul M / Hoshino, Tomoaki

Allergology international : official journal of the Japanese Society of Allergology

2013 Volume 62, Issue 4, Page(s) 513–515

Language	English
Publishing date	2013
Publishing country	England
Document type	Letter
ZDB-ID	1336498-4
ISSN	1440-1592 ; 1323-8930
ISSN (online)	1440-1592
ISSN	1323-8930
DOI	10.2332/allergolint.13-LE-0548
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Article ; Online: IL-38: A new factor in rheumatoid arthritis.

Takenaka, Shin-Ichi / Kaieda, Shinjiro / Kawayama, Tomotaka / Matsuoka, Masanobu / Kaku, Yoichiro / Kinoshita, Takashi / Sakazaki, Yuki / Okamoto, Masaki / Tominaga, Masaki / Kanesaki, Katsuya / Chiba, Asako / Miyake, Sachiko / Ida, Hiroaki / Hoshino, Tomoaki

Biochemistry and biophysics reports

2015 Volume 4, Page(s) 386–391

Abstract: The newly characterized cytokine IL-38 (IL-1F10) belongs to the IL-1 family of cytokines. Previous work has demonstrated that IL-38 ... ...

Abstract	The newly characterized cytokine IL-38 (IL-1F10) belongs to the IL-1 family of cytokines. Previous work has demonstrated that IL-38 inhibited
Language	English
Publishing date	2015-10-31
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2831046-9
ISSN	2405-5808 ; 2405-5808
ISSN (online)	2405-5808
ISSN	2405-5808
DOI	10.1016/j.bbrep.2015.10.015
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Article ; Online: Increased serum levels of soluble IL-18 receptor complex in patients with allergic asthma.

Imaoka, Haruki / Takenaka, Shin-ichi / Kawayama, Tomotaka / Oda, Hanako / Kaku, Yoichiro / Matsuoka, Masanobu / Sakazaki, Yuki / O'Byrne, Paul M / Hoshino, Tomoaki

Allergology international : official journal of the Japanese Society of Allergology

2013 Volume 62, Issue 4, Page(s) 513–515

MeSH term(s)	Adult ; Aged ; Asthma/blood ; Female ; Humans ; Immunoglobulin E/blood ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Pulmonary Disease, Chronic Obstructive/blood ; Receptors, Interleukin-18/blood ; Receptors, Interleukin-18/genetics ; Respiratory Function Tests ; Sensitivity and Specificity ; Up-Regulation ; Young Adult
Chemical Substances	Receptors, Interleukin-18 ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2013-12
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1336498-4
ISSN	1440-1592 ; 1323-8930
ISSN (online)	1440-1592
ISSN	1323-8930
DOI	10.2332/allergolint.13-LE-0548
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Article ; Online: Ascorbic acid enhances radiation-induced apoptosis in an HL60 human leukemia cell line.

Shinozaki, Koji / Hosokawa, Yoichiro / Hazawa, Masakatsu / Kashiwakura, Ikuo / Okumura, Kazuhiko / Kaku, Tohru / Nakayama, Eiji

Journal of radiation research

2011 Volume 52, Issue 2, Page(s) 229–237

Abstract: This study was conducted to examine the utility of the combined use of ascorbic acid (AsA) and radiation in clinical applications. We investigated cell survival, DNA fragmentation, and caspase activation after X-ray irradiation and AsA treatment of human ...

Abstract	This study was conducted to examine the utility of the combined use of ascorbic acid (AsA) and radiation in clinical applications. We investigated cell survival, DNA fragmentation, and caspase activation after X-ray irradiation and AsA treatment of human leukemia HL60 cells. The number of living cells decreased after combined X-ray irradiation and AsA treatment (2 Gy + 5 mM) in comparison with that after X-ray irradiation (2 Gy) or AsA treatment (5 mM) alone. DNA fragmentation was more in the cells subjected to combined X-ray irradiation and AsA treatment than in those subjected to X-ray irradiation alone. Caspase-3, caspase-8, and caspase-9 were highly activated following combined X-ray irradiation and AsA treatment, but caspase-8 activity was not markedly increased after X-ray irradiation alone. Bax levels in the mitochondrial membrane fractions were increased after AsA treatment alone and after combined X-ray irradiation and AsA treatment. However, there was no apparent increase in the Bax levels after X-ray irradiation treatment alone. Thus, this study confirmed that supplementing X-ray irradiation with AsA treatment results in increased apoptosis in HL60 cells. With regard to the apoptosis-inducing factors, we hypothesized that Bax and caspase-8 were activated after combined X-ray irradiation and AsA treatment compared with either treatment alone.
MeSH term(s)	Apoptosis ; Ascorbic Acid/pharmacology ; Caspase 3/metabolism ; Caspase 8/metabolism ; Caspase 9/metabolism ; Cell Line, Tumor ; Cell Survival ; DNA Fragmentation ; HL-60 Cells ; Humans ; Leukemia/drug therapy ; Leukemia/pathology ; Leukemia/radiotherapy ; Mitochondria/metabolism ; Time Factors ; X-Rays ; bcl-2-Associated X Protein/metabolism
Chemical Substances	BAX protein, human ; bcl-2-Associated X Protein ; Caspase 3 (EC 3.4.22.-) ; Caspase 8 (EC 3.4.22.-) ; Caspase 9 (EC 3.4.22.-) ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2011-02-19
Publishing country	England
Document type	Journal Article
ZDB-ID	603983-2
ISSN	1349-9157 ; 0449-3060
ISSN (online)	1349-9157
ISSN	0449-3060
DOI	10.1269/jrr.10089
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