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  1. Article ; Online: Efferocytosis and Anthrax: Implications for Bacterial Sepsis?

    Mytych, Joshua S / Pan, Zijian / Farris, A Darise

    Journal of cellular immunology

    2021  Volume 3, Issue 3, Page(s) 133–139

    Language English
    Publishing date 2021-07-24
    Publishing country United States
    Document type Journal Article
    ISSN 2689-2812
    ISSN (online) 2689-2812
    DOI 10.33696/immunology.3.090
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  2. Article ; Online: Overlapping B cell pathways in severe COVID-19 and lupus.

    Farris, A Darise / Guthridge, Joel M

    Nature immunology

    2020  Volume 21, Issue 12, Page(s) 1478–1480

    MeSH term(s) B-Lymphocytes/immunology ; COVID-19 ; Humans ; Lymphocyte Activation ; Pandemics ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-020-00822-z
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    Zs.A 5294: Show issues Location:
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    Zs.MG 42: Show issues

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  4. Article: Peptidoglycan from

    Mytych, Joshua S / Pan, Zijian / Lopez-Davis, Charmaine / Redinger, Nancy / Lawrence, Christina / Ziegler, Jadith / Popescu, Narcis I / James, Judith A / Farris, A Darise

    bioRxiv : the preprint server for biology

    2023  

    Abstract: ... Bacillus ... ...

    Abstract Bacillus anthracis
    Language English
    Publishing date 2023-09-30
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.30.535001
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  5. Article ; Online: Anti-vimentin antibodies are associated with higher severity of Sjögren's disease.

    Bagavant, Harini / Araszkiewicz, Antonina M / Rasmussen, Astrid / Pezant, Nathan / Montgomery, Courtney / Scofield, Robert Hal / Farris, Darise / Lessard, Christopher J / Deshmukh, Umesh S

    Clinical immunology (Orlando, Fla.)

    2023  Volume 247, Page(s) 109243

    Abstract: Vimentin is a ubiquitously present Type III intermediate filament protein, often targeted by autoimmune responses in multiple rheumatic disorders. Although previous studies have reported anti-vimentin antibodies in Sjögren's disease (SjD) patients, the ... ...

    Abstract Vimentin is a ubiquitously present Type III intermediate filament protein, often targeted by autoimmune responses in multiple rheumatic disorders. Although previous studies have reported anti-vimentin antibodies in Sjögren's disease (SjD) patients, the clinical significance of such antibodies is unknown. To address this issue, the presence of anti-vimentin antibodies was determined in serum samples from a well-characterized cohort of primary SjD patients, non-SjD Sicca, and healthy controls. The occurrence of anti-vimentin antibodies and their association with different clinical features of the disease were evaluated. Anti-vimentin antibodies were detected in 24% of primary SjD patients, compared to 4% in non-SjD sicca patients and 3% in healthy controls. In primary SjD patients, higher levels of anti-vimentin antibodies were significantly associated with reduced saliva and tear flow and severe ocular surface damage indicators. The anti-vimentin antibody levels did not show significant associations with the presence or absence of other autoantibodies like ANA, RF, and anti-Ro/La. Our data suggest that the anti-vimentin antibody specificity arises in a subset of primary SjD patients and is associated with oral and ocular features of the disease. Anti-vimentin can potentially serve as a novel biomarker for evaluating the severity of salivary and lacrimal gland dysfunction in primary SjD.
    MeSH term(s) Humans ; Antibodies, Antinuclear ; Sjogren's Syndrome ; Autoantibodies ; Biomarkers ; Vimentin
    Chemical Substances Antibodies, Antinuclear ; Autoantibodies ; Biomarkers ; Vimentin
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2023.109243
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    Zs.A 880: Show issues Location:
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  6. Article ; Online: Peptidoglycan from Bacillus anthracis Inhibits Human Macrophage Efferocytosis in Part by Reducing Cell Surface Expression of MERTK and TIM-3.

    Mytych, Joshua S / Pan, Zijian / Lopez-Davis, Charmaine / Redinger, Nancy / Lawrence, Christina / Ziegler, Jadith / Popescu, Narcis I / James, Judith A / Farris, A Darise

    ImmunoHorizons

    2024  Volume 8, Issue 3, Page(s) 269–280

    Abstract: Bacillus anthracis peptidoglycan (PGN) is a major component of the bacterial cell wall and a key pathogen-associated molecular pattern contributing to anthrax pathology, including organ dysfunction and coagulopathy. Increases in apoptotic leukocytes are ... ...

    Abstract Bacillus anthracis peptidoglycan (PGN) is a major component of the bacterial cell wall and a key pathogen-associated molecular pattern contributing to anthrax pathology, including organ dysfunction and coagulopathy. Increases in apoptotic leukocytes are a late-stage feature of anthrax and sepsis, suggesting there is a defect in apoptotic clearance. In this study, we tested the hypothesis that B. anthracis PGN inhibits the capacity of human monocyte-derived macrophages (MΦ) to efferocytose apoptotic cells. Exposure of CD163+CD206+ MΦ to PGN for 24 h impaired efferocytosis in a manner dependent on human serum opsonins but independent of complement component C3. PGN treatment reduced cell surface expression of the proefferocytic signaling receptors MERTK, TYRO3, AXL, integrin αVβ5, CD36, and TIM-3, whereas TIM-1, αVβ3, CD300b, CD300f, STABILIN-1, and STABILIN-2 were unaffected. ADAM17 is a major membrane-bound protease implicated in mediating efferocytotic receptor cleavage. We found multiple ADAM17-mediated substrates increased in PGN-treated supernatant, suggesting involvement of membrane-bound proteases. ADAM17 inhibitors TAPI-0 and Marimastat prevented TNF release, indicating effective protease inhibition, and modestly increased cell-surface levels of MerTK and TIM-3 but only partially restored efferocytic capacity by PGN-treated MΦ. We conclude that human serum factors are required for optimal recognition of PGN by human MΦ and that B. anthracis PGN inhibits efferocytosis in part by reducing cell surface expression of MERTK and TIM-3.
    MeSH term(s) Humans ; c-Mer Tyrosine Kinase/metabolism ; Bacillus anthracis ; Peptidoglycan/pharmacology ; Peptidoglycan/metabolism ; Anthrax/metabolism ; Anthrax/pathology ; Efferocytosis ; Hepatitis A Virus Cellular Receptor 2/metabolism ; Macrophages/metabolism ; Cell Wall/metabolism ; Cell Wall/pathology
    Chemical Substances c-Mer Tyrosine Kinase (EC 2.7.10.1) ; Peptidoglycan ; Hepatitis A Virus Cellular Receptor 2 ; MERTK protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article
    ISSN 2573-7732
    ISSN (online) 2573-7732
    DOI 10.4049/immunohorizons.2300109
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  7. Article ; Online: TScan-II: A genome-scale platform for the de novo identification of CD4

    Dezfulian, Mohammad H / Kula, Tomasz / Pranzatelli, Thomas / Kamitaki, Nolan / Meng, Qingda / Khatri, Bhuwan / Perez, Paola / Xu, Qikai / Chang, Aiquan / Kohlgruber, Ayano C / Leng, Yumei / Jupudi, Ananth Aditya / Joachims, Michelle L / Chiorini, John A / Lessard, Christopher J / Darise Farris, A / Muthuswamy, Senthil K / Warner, Blake M / Elledge, Stephen J

    Cell

    2023  Volume 186, Issue 25, Page(s) 5569–5586.e21

    Abstract: ... ...

    Abstract CD4
    MeSH term(s) Humans ; Antigen-Presenting Cells ; CD4 Antigens/metabolism ; CD4-Positive T-Lymphocytes ; Epitopes, T-Lymphocyte ; HLA Antigens/metabolism ; Receptors, Antigen, T-Cell/metabolism ; Cell Line ; Genome, Human
    Chemical Substances CD4 Antigens ; Epitopes, T-Lymphocyte ; HLA Antigens ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2023.10.024
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    Zs.A 1167: Show issues Location:
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  8. Article ; Online: Autoantibodies identify primary Sjögren's syndrome in patients lacking serum IgG specific for Ro/SS-A and La/SS-B.

    Longobardi, Sherri / Lopez-Davis, Charmaine / Khatri, Bhuwan / Georgescu, Constantin / Pritchett-Frazee, Cherilyn / Lawrence, Christina / Rasmussen, Astrid / Radfar, Lida / Scofield, Robert Hal / Baer, Alan N / Robinson, Susan A / Darrah, Erika / Axtell, Robert C / Pardo, Gabriel / Wren, Jonathan D / Koelsch, Kristi A / Guthridge, Joel M / James, Judith A / Lessard, Christopher J /
    Farris, Amy Darise

    Annals of the rheumatic diseases

    2023  Volume 82, Issue 9, Page(s) 1181–1190

    Abstract: Objective: Identify autoantibodies in anti-Ro/SS-A negative primary Sjögren's syndrome (SS).: Methods: This is a proof-of-concept, case-control study of SS, healthy (HC) and other disease (OD) controls. A discovery dataset of plasma samples (n=30 SS, ...

    Abstract Objective: Identify autoantibodies in anti-Ro/SS-A negative primary Sjögren's syndrome (SS).
    Methods: This is a proof-of-concept, case-control study of SS, healthy (HC) and other disease (OD) controls. A discovery dataset of plasma samples (n=30 SS, n=15 HC) was tested on human proteome arrays containing 19 500 proteins. A validation dataset of plasma and stimulated parotid saliva from additional SS cases (n=46 anti-Ro
    Results: Ro
    Conclusion: We identified antigenic targets of the autoantibody response in SS that may be useful for identifying up to half of Ro seronegative SS cases.
    MeSH term(s) Humans ; Autoantibodies ; Sjogren's Syndrome ; Case-Control Studies ; Autoantigens ; ROC Curve ; Immunoglobulin G ; Antibodies, Antinuclear
    Chemical Substances Autoantibodies ; Autoantigens ; Immunoglobulin G ; Antibodies, Antinuclear
    Language English
    Publishing date 2023-05-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/ard-2022-223105
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    Uh III Zs.114: Show issues Location:
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  9. Article ; Online: Toll-like receptors in systemic lupus erythematosus: potential targets for therapeutic intervention.

    Horton, Christopher G / Farris, A Darise

    Current allergy and asthma reports

    2011  Volume 12, Issue 1, Page(s) 1–7

    Abstract: Toll-like receptors (TLRs) have attracted increased attention in recent years, not only for their role in sensing conserved microbial components, but also in the realm of autoimmunity. Although TLRs are most widely known for their capacity to detect ... ...

    Abstract Toll-like receptors (TLRs) have attracted increased attention in recent years, not only for their role in sensing conserved microbial components, but also in the realm of autoimmunity. Although TLRs are most widely known for their capacity to detect conserved motifs of infectious agents, mounting evidence indicates that these innate receptors also promote autoimmune conditions by causing uncontrolled autoinflammation as a result of chronic recognition of self. In response to the need for modern approaches to treatment of autoimmune diseases, several groups have begun investigating ways to target TLRs as new therapeutic options for autoimmune conditions. Here we discuss recent data describing advances in TLRs as therapeutic targets for treatment of autoimmune diseases, with a focus on systemic lupus erythematosus.
    MeSH term(s) Animals ; Autoimmunity/drug effects ; Autoimmunity/immunology ; DNA/metabolism ; Humans ; Immunosuppressive Agents/pharmacology ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/metabolism ; Nucleic Acids/metabolism ; Toll-Like Receptors/agonists ; Toll-Like Receptors/antagonists & inhibitors ; Toll-Like Receptors/immunology ; Toll-Like Receptors/metabolism
    Chemical Substances Immunosuppressive Agents ; Nucleic Acids ; Toll-Like Receptors ; DNA (9007-49-2)
    Language English
    Publishing date 2011-11-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057370-4
    ISSN 1534-6315 ; 1529-7322
    ISSN (online) 1534-6315
    ISSN 1529-7322
    DOI 10.1007/s11882-011-0234-3
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    Zs.A 5548: Show issues Location:
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  10. Article ; Online: Bacillus anthracis

    Pan, Zijian / Dumas, Eric K / Lawrence, Christina / Pate, Lance / Longobardi, Sherri / Wang, Xiaodong / James, Judith A / Kovats, Susan / Farris, A Darise

    International journal of molecular sciences

    2019  Volume 20, Issue 5

    Abstract: ... ...

    Abstract The
    MeSH term(s) Antigens, Bacterial/pharmacology ; Antigens, Surface/metabolism ; Bacillus anthracis/metabolism ; Bacterial Toxins/pharmacology ; Cell Polarity/drug effects ; Cells, Cultured ; Coculture Techniques ; Cyclic AMP/metabolism ; Dexamethasone/pharmacology ; Dose-Response Relationship, Drug ; Humans ; Interleukin-10/metabolism ; Interleukin-4/metabolism ; Macrophages/cytology ; Macrophages/drug effects ; Macrophages/metabolism ; Milk Proteins/metabolism ; Neutrophils/cytology ; Neutrophils/drug effects ; Neutrophils/metabolism ; Phagocytosis/drug effects ; Protein S/metabolism ; Receptors, Vitronectin/metabolism ; Signal Transduction/drug effects ; c-Mer Tyrosine Kinase/metabolism
    Chemical Substances Antigens, Bacterial ; Antigens, Surface ; Bacterial Toxins ; IL10 protein, human ; IL4 protein, human ; MFGE8 protein, human ; Milk Proteins ; Protein S ; Receptors, Vitronectin ; anthrax toxin ; integrin alphaVbeta5 ; Interleukin-10 (130068-27-8) ; Interleukin-4 (207137-56-2) ; Dexamethasone (7S5I7G3JQL) ; Cyclic AMP (E0399OZS9N) ; MERTK protein, human (EC 2.7.10.1) ; c-Mer Tyrosine Kinase (EC 2.7.10.1)
    Language English
    Publishing date 2019-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms20051167
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