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  1. Article ; Online: Design, synthesis, and biological activity of D-bishomo-1α,25-dihydroxyvitamin D

    Fabisiak, Adrian / Brzeminski, Pawel / Sicinski, Rafal R / Rochel, Natacha / Maj, Ewa / Filip-Psurska, Beata / Wietrzyk, Joanna / Plum, Lori A / DeLuca, Hector F

    European journal of medicinal chemistry

    2024  Volume 271, Page(s) 116403

    Abstract: The biologically active metabolite of vitamin ... ...

    Abstract The biologically active metabolite of vitamin D
    Language English
    Publishing date 2024-04-10
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2024.116403
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: History of the discovery of vitamin D and its active metabolites.

    Deluca, Hector F

    BoneKEy reports

    2014  Volume 3, Page(s) 479

    Abstract: Before the twentieth century, it was not possible to describe the essentials of a diet that could support life, growth and reproduction of higher animals. The discovery of vitamin A by McCollum and Davis in 1913 ushered in the era of accessory food ... ...

    Abstract Before the twentieth century, it was not possible to describe the essentials of a diet that could support life, growth and reproduction of higher animals. The discovery of vitamin A by McCollum and Davis in 1913 ushered in the era of accessory food substances culminating in the achievement of that goal. It included the discovery of vitamin D and its production in skin caused by ultraviolet light. This was followed by a description of its actions at the physiological level that resulted in a healthy skeleton and beyond. To carry out these functions, vitamin D is converted to a hormone that acts through a nuclear receptor. The findings leading to this concept and their importance to biology and medicine are presented.
    Language English
    Publishing date 2014-01-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2816308-4
    ISSN 2047-6396
    ISSN 2047-6396
    DOI 10.1038/bonekey.2013.213
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  3. Article ; Online: Vitamin D esters are the major form of vitamin D produced by UV irradiation in mice.

    Duchow, Elizabeth G / Sibilska-Kaminski, Izabela K / Plum, Lori A / DeLuca, Hector F

    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

    2022  Volume 21, Issue 8, Page(s) 1399–1404

    Abstract: The primary source of vitamin D3 for humans is that produced in skin by ultraviolet irradiation. Ultraviolet (UV) B (UVB, 280-310 nm) light causes the isomerization of 7-dehydrocholesterol (7-DHC) to pre-vitamin D3 that is thermally isomerized to vitamin ...

    Abstract The primary source of vitamin D3 for humans is that produced in skin by ultraviolet irradiation. Ultraviolet (UV) B (UVB, 280-310 nm) light causes the isomerization of 7-dehydrocholesterol (7-DHC) to pre-vitamin D3 that is thermally isomerized to vitamin D3. In addition to free vitamin D3, it has been previously reported that esterified vitamin D3 is also found in the skin of rats irradiated with UVB. We found that a large fraction of the vitamin D3 precursor, 7-dehydrocholesterol is in the esterified form. Following UVB irradiation, vitamin D3 esters represent the majority of tissue vitamin D3, comprising approximately 80% in mice. Examination of vitamin D3 ester transport from skin in DBP
    MeSH term(s) Animals ; Cholecalciferol ; Esters ; Humans ; Mice ; Rats ; Skin/radiation effects ; Ultraviolet Rays ; Vitamin D/metabolism
    Chemical Substances Esters ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41)
    Language English
    Publishing date 2022-04-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2072584-X
    ISSN 1474-9092 ; 1474-905X
    ISSN (online) 1474-9092
    ISSN 1474-905X
    DOI 10.1007/s43630-022-00230-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Vitamin D: Historical Overview.

    DeLuca, Hector F

    Vitamins and hormones

    2016  Volume 100, Page(s) 1–20

    Abstract: A history of vitamin D has been provided, dating from the earliest description of rickets, the disease resulting from vitamin D deficiency, to a current understanding of vitamin D metabolism and the mechanism of action of its hormonal form in regulating ... ...

    Abstract A history of vitamin D has been provided, dating from the earliest description of rickets, the disease resulting from vitamin D deficiency, to a current understanding of vitamin D metabolism and the mechanism of action of its hormonal form in regulating gene expression in target organs. Vitamin D is produced in skin by impact of 280-310 nm light on 7-dehydrocholesterol. The vitamin D is then converted in the liver to a circulating form, 25-hydroxyvitamin D that is converted largely, if not exclusively, in the kidney to the final hormone, 1α,25-dihydroxyvitamin D. This hormone functions through a nuclear receptor that regulates expression of key genes in target organs. Among its many resulting functions are increased intestinal calcium and phosphate absorption, bone calcium mobilization, and renal reabsorption of calcium. The resultant increase in serum calcium and phosphate supports bone mineralization, curing rickets, and osteomalacia. There are many other functions of vitamin D that remain to be described that contribute to its health supporting role.
    MeSH term(s) Animals ; Calcium/metabolism ; Humans ; Vitamin D/biosynthesis ; Vitamin D/metabolism ; Vitamin D Deficiency/metabolism
    Chemical Substances Vitamin D (1406-16-2) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 201161-x
    ISSN 2162-2620 ; 0083-6729
    ISSN (online) 2162-2620
    ISSN 0083-6729
    DOI 10.1016/bs.vh.2015.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The development of a bone- and parathyroid-specific analog of vitamin D: 2-methylene-19-Nor-(20S)-1α,25-dihydroxyvitamin D3.

    Deluca, Hector F

    BoneKEy reports

    2014  Volume 3, Page(s) 514

    Abstract: The goal of synthetic chemists in the vitamin D field has been to produce an analog(s) of 1α,25-dihydroxyvitamin D3 (1,25-(OH)2D3) that is selective for a specific function. The accumulation of structure/function information has led to the synthesis of ... ...

    Abstract The goal of synthetic chemists in the vitamin D field has been to produce an analog(s) of 1α,25-dihydroxyvitamin D3 (1,25-(OH)2D3) that is selective for a specific function. The accumulation of structure/function information has led to the synthesis of two analogs that are both selective and more potent than 1,25-(OH)2D3, that is, 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 (2MD) and 2α-methyl-19-nor-(20S)-1α,25-dihydroxyvitamin D3 (2AMD). In vivo, the efficacy of 2MD is approximately equal to that of 1,25-(OH)2D3 in intestinal calcium transport but is 30- to 100-fold more active in bone mobilization. In vitro, 2MD supports new bone synthesis at 10(-12) M, whereas 1,25-(OH)2D3 is active at 10(-8) M. Similarly, 2MD is two orders of magnitude more potent than 1,25-(OH)2D3 in stimulating osteoclastogenesis and osteoclastic bone resorption. 2MD also markedly increases bone mass and bone strength of ovariectomized female rats. In postmenopausal women, 2MD significantly increases markers of both bone formation and resorption but has minimal effect on bone mass. Thus, in patients who are undergoing primarily remodeling rather than modeling (rat), the increased resorption largely counteracts the increased bone formation. So far, 2MD has not been tested for reduction of fractures in this population. However, its selectivity includes the parathyroid gland. Thus in the 5/6-nephrectomy model of chronic renal failure, 2MD is much more potent than currently available vitamin D compounds used to suppress secondary hyperparathyroidism of renal failure without causing hypercalcemia. It is currently in phase 2B trials in patients on dialysis.
    Language English
    Publishing date 2014-03-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2816308-4
    ISSN 2047-6396
    ISSN 2047-6396
    DOI 10.1038/bonekey.2014.9
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  6. Book ; Conference proceedings: Osteoporosis

    Deluca, Hector F.

    physiological basis, assessment, and treatment ; proceedings of the Nineteenth Steenbock Symposium held June 5 through June 8, 1989, at the University of Wisconsin-Madison, U.S.A

    1990  

    Event/congress Harry Steenbock Symposium (19, 1989, MadisonWis.)
    Author's details ed. by Hector F. DeLuca
    Keywords Osteoporosis / congresses ; Osteoporose
    Subject Knochenrarefikation ; Osteoporosis
    Size XXIX, 346 S. : Ill., graph. Darst.
    Edition 1. print.
    Publisher Elsevier
    Publishing place New York u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT003637739
    ISBN 0-444-01526-4 ; 978-0-444-01526-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 6194 order for loan Magazin

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  7. Article ; Online: Antibody production in mice requires neither vitamin D, nor the vitamin D receptor.

    Plum, Lori A / Blaser, William / Peter, Logan / Prahl, Jean / Seeman, Jeremy / DeLuca, Hector F

    Frontiers in immunology

    2022  Volume 13, Page(s) 960405

    Abstract: The vitamin D receptor as well as its ligand have been localized to various immune tissues and cells. These observations have led researchers to hypothesize a role for vitamin D in the immune system. However, a specific role for vitamin D in immunity has ...

    Abstract The vitamin D receptor as well as its ligand have been localized to various immune tissues and cells. These observations have led researchers to hypothesize a role for vitamin D in the immune system. However, a specific role for vitamin D in immunity has yet to be clearly delineated. The work in this report was undertaken to determine if mounting an antibody response is altered in the face of vitamin D-deficiency or when the signaling pathway is eliminated by removal of the nuclear receptor. This investigation provides direct evidence vitamin D is not necessary for producing antibodies, a process paramount for optimal attack against many foreign organisms. The idea that vitamin D plays a significant role in immunity has been proposed repeatedly for many years. To address this important idea we have carried out studies in mice to determine if vitamin D plays a significant role in antibody production. Two animal models were utilized: mice depleted of vitamin D and mice devoid of the vitamin D receptor. Further, a possible role of hypocalcemia resulting from vitamin D deficiency in antibody production was determined. Neither the absence of vitamin D or the vitamin D receptor nor hypocalcemia affected the ability of mice to mount an antibody response to an antigen challenge. Thus, we found no evidence that vitamin D or normal serum calcium is required for this major form of immunity.
    MeSH term(s) Mice ; Animals ; Vitamin D ; Receptors, Calcitriol/metabolism ; Antibody Formation ; Hypocalcemia ; Vitamin D Deficiency ; Vitamins
    Chemical Substances Vitamin D (1406-16-2) ; Receptors, Calcitriol ; Vitamins
    Language English
    Publishing date 2022-10-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.960405
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  8. Article ; Online: Vitamin D receptor absence does not enhance intestinal tumorigenesis in ApcPirc/+rats.

    Irving, Amy A / Waters, Bayley J / Seeman, Jeremy R / Plum, Lori A / DeLuca, Hector F

    Biology open

    2022  Volume 11, Issue 7

    Abstract: Epidemiological observations have prompted some to posit that elevated circulating vitamin D is responsible for reduced colon cancer in individuals residing near the equator. We have previously demonstrated that vitamin D has no effect on colon cancer in ...

    Abstract Epidemiological observations have prompted some to posit that elevated circulating vitamin D is responsible for reduced colon cancer in individuals residing near the equator. We have previously demonstrated that vitamin D has no effect on colon cancer in two rodent models of intestinal tumorigenesis. We have now extended this line of inquiry to ask whether ablation of vitamin D receptor (VDR) affects tumorigenesis. A VDR null rat was developed using Cas9-CRISPR technology, which allowed us to investigate whether 1,25(OH)D3 signaling through its receptor plays a role in intestinal tumorigenesis. Loss of VDR expression alone did not induce tumorigenesis, even in animals exposed to the inflammatory agent dextran sodium sulfate. These VDR-/- rats were then crossed with ApcPirc/+ rats, which are predisposed to the development of intestinal neoplasms. In combination with the Pirc/+ mutation, VDR loss did not enhance tumor multiplicity, growth, or progression in the colon or small intestine. This study demonstrates that the vitamin D receptor does not impact tumor development, and strongly supports previous findings that vitamin D itself does not play a role in colon cancer development or progression. Alternative explanations are needed for the original latitude hypothesis, as well as observational data in humans. This article has an associated First Person interview with the first author of the paper.
    MeSH term(s) Animals ; Animals, Genetically Modified ; Carcinogenesis/genetics ; Cell Transformation, Neoplastic ; Colonic Neoplasms/genetics ; Colonic Neoplasms/metabolism ; Humans ; Rats ; Receptors, Calcitriol/genetics ; Receptors, Calcitriol/metabolism ; Vitamin D/metabolism
    Chemical Substances Receptors, Calcitriol ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2022-07-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2632264-X
    ISSN 2046-6390 ; 2046-6390
    ISSN (online) 2046-6390
    ISSN 2046-6390
    DOI 10.1242/bio.059290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Guest editor's introduction.

    Deluca, Hector F

    Archives of biochemistry and biophysics

    2012  Volume 523, Issue 1, Page(s) 1

    MeSH term(s) Molecular Biology ; Safety ; Vitamin D/adverse effects ; Vitamin D/metabolism
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2012-07-01
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 523-x
    ISSN 1096-0384 ; 0003-9861
    ISSN (online) 1096-0384
    ISSN 0003-9861
    DOI 10.1016/j.abb.2012.05.009
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  10. Article ; Online: Vitamin D binding protein greatly improves bioactivity but is not essential for orally administered vitamin D.

    Duchow, Elizabeth G / Duchow, Mark W / Plum, Lori A / DeLuca, Hector F

    Physiological reports

    2021  Volume 9, Issue 23, Page(s) e15138

    Abstract: ... Vitamin ... ...

    Abstract Vitamin D
    MeSH term(s) Animals ; Calcium/blood ; Cholecalciferol/pharmacology ; Mice ; Mice, Knockout ; Skin/metabolism ; Skin/radiation effects ; Ultraviolet Rays ; Vitamin D-Binding Protein/genetics ; Vitamin D-Binding Protein/metabolism
    Chemical Substances Vitamin D-Binding Protein ; Cholecalciferol (1C6V77QF41) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-12-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.15138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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