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Article ; Online: Overview of management of children with COVID-19.

Wati, Dyah Kanya / Manggala, Arya Krisna

Clinical and experimental pediatrics

2020 Volume 63, Issue 9, Page(s) 345–354

Abstract: The widespread and contagious coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has become a burden in the global health domain. The subsequent discovery of the virus features and pathogenesis, and prompt and ... ...

Abstract	The widespread and contagious coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has become a burden in the global health domain. The subsequent discovery of the virus features and pathogenesis, and prompt and adequate management are still lacking and remain inconclusive. Children usually present milder symptoms than adults, and management focuses on providing symptomatic and respiratory supports. Several treatment modalities, including the utilization of mechanical ventilation (MV), antivirals, immune-modulating drugs, or other agents, may present promising results in reducing the symptoms of COVID-19, particularly in severe cases. Although no randomized clinical trials have been published to date, it is interesting to explore potential modalities for treating COVID-19 in children, based on review articles, case reports, and recent guidelines.
Keywords	covid19
Language	English
Publishing date	2020-07-17
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2713-4148
ISSN (online)	2713-4148
DOI	10.3345/cep.2020.00913
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ferritin in pediatric critical illness: a scoping review.

Valerie, Ivy Cerelia / Prabandari, Anak Agung Sagung Mirah / Wati, Dyah Kanya

Clinical and experimental pediatrics

2022 Volume 66, Issue 3, Page(s) 98–109

Abstract: This scoping review aimed to elucidate and summarize the predictive role of serum ferritin in critical pediatric illness. The Preferred Reporting Items for Systematic reviews and Meta-Analyses methodology was employed to conduct a scoping review of 5 ... ...

Abstract	This scoping review aimed to elucidate and summarize the predictive role of serum ferritin in critical pediatric illness. The Preferred Reporting Items for Systematic reviews and Meta-Analyses methodology was employed to conduct a scoping review of 5 databases (MEDLINE, CENTRAL, ProQuest, ScienceDirect, and Epistemonikos) from the date of inception through January 24, 2022. Primary research studies involving subjects aged <18 years and serum ferritin levels were screened and reviewed independently following an a priori defined protocol. Of the 1,580 retrieved studies, 66 were analyzed. Summary statistics of serum ferritin levels for overall and condition-specific studies were reported in 30 (45.4%) and 47 studies (71.2%), respectively. The normal range was defined in 16 studies (24.2%), whereas the threshold was determined in 43 studies (65.1%). A value of <500 ng/mL was most often the upper limit of the normal range. Serum ferritin as a numerical variable (78.9%) was usually significantly higher (80.8%) in the predicted condition than in controls, while as a categorical variable with preset thresholds, ferritin was a significant predictor in 84.6% of studies. A total of 22 predictive thresholds predicted mortality (12 of 46 [26.1%]), morbidity (18 of 46 [39.1%]), and specific (16 of 46 [34.8%]) outcomes in 15 unique conditions. Increased precision in serum ferritin measures followed by close attention to the threshold modeling strategy and reporting can accelerate the translation from evidence to clinical practice.
Language	English
Publishing date	2022-09-16
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2713-4148
ISSN (online)	2713-4148
DOI	10.3345/cep.2022.00654
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Studi Pendahuluan Perbandingan Terapi Salin Hipertonik 3% dengan Manitol 20% Intravena terhadap Luaran Anak Sindrom Ensefalitis Akut

Dyah Kanya Wati / I Gusti Ngurah Made Suwarba / Anlidya Permatasari Gunawijaya

Sari Pediatri, Vol 25, Iss 4, Pp 209-

2023 Volume 14

Abstract: Latar belakang. Terapi osmotik merupakan pilihan terapi penting dalam sindrom ensefalitis akut. Manitol adalah salah satu jenis terapi osmotik yang telah banyak digunakan, namun penggunaanya dapat menyebabkan ketidaknormalan elektrolit, seperti ... ...

Abstract	Latar belakang. Terapi osmotik merupakan pilihan terapi penting dalam sindrom ensefalitis akut. Manitol adalah salah satu jenis terapi osmotik yang telah banyak digunakan, namun penggunaanya dapat menyebabkan ketidaknormalan elektrolit, seperti hiponatremia dan hipokloremia. Tujuan. Tujuan dari penelitian ini adalah membandingkan salin hipertonik dan manitol pada anak-anak dengan sindrom ensefalitis akut. Metode. Penelitian ini menggunakan desain studi klinis pendahuluan untuk mengevaluasi perbedaan dalam durasi penurunan kesadaran, mortalitas, kadar natrium serum, dan osmolaritas darah pada pasien sindrom ensefalitis akutyang diberikan salin hipertonik dan manitol. Pendekatan acak digunakan untuk mengelompokan setiap sampel. Analisis univariat dan bivariat dilakukan menggunakan perangkat lunak analisis statistik. Hasil. Sembilan pasien secara acak dikelompokan pada salin hipertonik, dan sembilan pasien dikelompokan pada manitol dari total 18 subjek dengan usia median 49,5 (5-194) bulan. Kelompok manitol memiliki kadar natrium awal signifikan lebih tinggi (p=0,009). Antara kedua kelompok perlakukan, tidak terdapat perbedaan dalam durasi penurunan kesadaran maupun mortalitas. Perubahan kadar natrium dan osmolaritas menunjukan perbedaan signifikan. Antara sebelum dan setelah perlakuan, penurunan natrium pada kelompok salin hipertonik lebih besar daripada kelompok manitol [median (rentang); -6 (-47 to -4) mmol/L vs 1 (-6 to 17) mmol/L], dan perubahan osmolaritas secara signifikan lebih tinggi [Mean SD; -32,6 ± 26,9 mOsm/kg vs 4,7 ± 13,5 mOsm/kg]. Kesimpulan. Salin hipertonik dapat dianggap efektif dan aman seperti manitol dalam pengobatan non-traumatik sindrom ensefalitis akut pada anak.
Keywords	salin ; hipertonik ; manitol ; Medicine ; R ; Pediatrics ; RJ1-570
Language	Indonesian
Publishing date	2023-12-01T00:00:00Z
Publisher	Badan Penerbit Ikatan Dokter Anak Indonesia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effectiveness and Safety of Short-term Regimen for Multidrug-resistant Tuberculosis Treatment: A Systematic Review of Cohort Studies.

Mahardani, Putu Nandika / Wati, Dyah Kanya / Siloam, Azriel / Savitri, Ni Putu Ayu / Manggala, Arya Krisna

Oman medical journal

2022 Volume 37, Issue 1, Page(s) e337

Abstract: This systematic review explores the effectiveness and safety of a short-term regimen (STR) in treating multidrug-resistant tuberculosis (MDR-TB). We use several cohort studies which were searched using standardized Preferred Reporting Items for ... ...

Abstract	This systematic review explores the effectiveness and safety of a short-term regimen (STR) in treating multidrug-resistant tuberculosis (MDR-TB). We use several cohort studies which were searched using standardized Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The keywords were used based on problem, intervention, comparison, and outcome consisted of MDR-TB and STR. Seven cohort studies were selected from 314 studies. The result showed that STR has better therapeutic efficacy and shorter duration than the 2011 World Health Organization regimen for MDR-TB with success rates above 50% in respective studies. The most effective regimen was kanamycin-high-dose isoniazid-clofazimine-ethambutol-prothionamide-pyrazinamide-gatifloxacin in the intensive phase for four months and clofazimine-ethambutol-pyrazinamide-gatifloxacin-prothionamide in the continuation phase for eight months. Gastrointestinal problems, ototoxicity, dysglycemia, and liver problems were the most reported side effects. STR provides good effectiveness in MDR-TB treatment in terms of treatment success rate and short therapy duration.
Language	English
Publishing date	2022-01-31
Publishing country	Oman
Document type	Journal Article ; Review
ZDB-ID	2571431-4
ISSN	2070-5204 ; 1999-768X
ISSN (online)	2070-5204
ISSN	1999-768X
DOI	10.5001/omj.2021.64
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Overview of management of children with COVID-19

Dyah Kanya Wati / Arya Krisna Manggala

Clinical and Experimental Pediatrics, Vol 63, Iss 9, Pp 345-

2020 Volume 354

Abstract	The widespread and contagious coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has become a burden in the global health domain. The subsequent discovery of the virus features and pathogenesis, and prompt and adequate management are still lacking and remain inconclusive. Children usually present milder symptoms than adults, and management focuses on providing symptomatic and respiratory supports. Several treatment modalities, including the utilization of mechanical ventilation (MV), antivirals, immune-modulating drugs, or other agents, may present promising results in reducing the symptoms of COVID-19, particularly in severe cases. Although no randomized clinical trials have been published to date, it is interesting to explore potential modalities for treating COVID-19 in children, based on review articles, case reports, and recent guidelines.
Keywords	child ; covid-19 ; treatment ; Pediatrics ; RJ1-570 ; covid19
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	The Korean Pediatric Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Overview of Management of Children with COVID-19

Wati, Dyah Kanya / Manggala, Arya Krisna

Abstract: The widespread and contagious coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has become a burden in the global health domain. The subsequent discovery of the virus features and pathogenesis, and prompt and ... ...

Abstract	The widespread and contagious coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has become a burden in the global health domain. The subsequent discovery of the virus features and pathogenesis, and prompt and adequate management are still lacking and remain inconclusive. Children usually present milder symptoms than adults, and management focuses on providing symptomatic and respiratory supports. Several treatment modalities, including the utilization of mechanical ventilation, antivirals, immune-modulating drugs, or other agents, may present promising results in reducing the symptoms of COVID-19, particularly in severe cases. Although no randomized clinical trials have been published to date, it is interesting to explore potential modalities for treating COVID-19 in children, based on review articles, case reports, and recent guidelines.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #656987
Database	COVID19

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Article ; Online: Effectiveness and Safety of Short-term Regimen for Multidrug-resistant Tuberculosis Treatment

Putu Nandika Mahardani / Dyah Kanya Wati / Azriel Siloam / Ni Putu Ayu Savitri / Arya Krisna Manggala

Oman Medical Journal, Vol 37, Iss 1, Pp e337-e

A Systematic Review of Cohort Studies

2022 Volume 337

Abstract	This systematic review explores the effectiveness and safety of a short-term regimen (STR) in treating multidrug-resistant tuberculosis (MDR-TB). We use several cohort studies which were searched using standardized Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The keywords were used based on problem, intervention, comparison, and outcome consisted of MDR-TB and STR. Seven cohort studies were selected from 314 studies. The result showed that STR has better therapeutic efficacy and shorter duration than the 2011 World Health Organization regimen for MDR-TB with success rates above 50% in respective studies. The most effective regimen was kanamycin-high-dose isoniazid-clofazimine-ethambutol-prothionamide-pyrazinamide-gatifloxacin in the intensive phase for four months and clofazimine-ethambutol-pyrazinamide-gatifloxacin-prothionamide in the continuation phase for eight months. Gastrointestinal problems, ototoxicity, dysglycemia, and liver problems were the most reported side effects. STR provides good effectiveness in MDR-TB treatment in terms of treatment success rate and short therapy duration.
Keywords	tuberculosis ; multidrug-resistant ; duration of therapy ; safety ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Oman Medical Specialty Board
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Korelasi antara Kadar Seng Serum dengan Kadar Interleukin-6 dan Skor PELOD-2 pada Sepsis

Defranky Theodorus / Dyah Kanya Wati / I Gusti Ngurah Sanjaya Putra / Ida Bagus Subanada / Eka Gunawijaya / Komang Ayu Witarini / Wayan Gustawan

Sari Pediatri, Vol 23, Iss 4, Pp 262-

2021 Volume 9

Abstract: Latar belakang. Sepsis merupakan penyebab utama morbiditas dan mortalitas pada anak dengan penyakit kritis yang dirawat di unit perawatan intensif anak (UPIA). Pada 24 jam sepsis, terjadi penurunan kadar seng serum dan secara bersamaan terjadi ... ...

Abstract	Latar belakang. Sepsis merupakan penyebab utama morbiditas dan mortalitas pada anak dengan penyakit kritis yang dirawat di unit perawatan intensif anak (UPIA). Pada 24 jam sepsis, terjadi penurunan kadar seng serum dan secara bersamaan terjadi peningkatan kadar interleukin-6 (IL-6) dan skor PELOD-2. Hasil sebaliknya terjadi pada 72 jam sepsis. Tujuan. Untuk membuktikan korelasi negatif antara kadar seng serum dengan IL-6 dan skor PELOD-2 pada sepsis. Metode. Penelitian dengan rancangan potong lintang dua kali pengukuran dari Januari - Desember 2019 di UPIA RSUP Sanglah Denpasar. Subjek penelitian adalah anak berusia 29 hari sampai 18 tahun dengan sepsis berdasarkan skor PELOD-2 > 7 menggunakan metode consecutive sampling. Uji korelasi Pearson untuk menilai korelasi bivariat dan uji multivariat menggunakan uji korelasi parsial. Hasil. Empatpuluh subjek memenuhi kriteria inklusi. Rerata kadar seng serum pada 24 dan 72 jam adalah 59,5 µg/dl versus 64,2 µg/dl. Median IL-6 pada 24 dan 72 jam adalah 8,6 pg/dL versus 4,4 pg/dL, rerata skor PELOD-2 24 dan 72 jam adalah 11,2 versus 11,0. Korelasi Pearson kadar seng serum dengan kadar IL-6 pada 24 dan 72 jam adalah r= -0,078, p= 0,632 versus r= -0,218, p= 0,178. Korelasi Pearson kadar seng serum dengan skor PELOD-2 pada 24 dan 72 jam adalah r= -0,513, p= 0,001 versus r= 0,242, p= 0,132. Analisis korelasi parsial kadar seng serum dengan PELOD-2 pada 24 jam adalah r= -0,493, p= 0,002. Kesimpulan. Terdapat korelasi negatif sedang bermakna pada 24 jam sepsis antara kadar seng serum dengan skor PELOD-2 setelah mengontrol variabel kendali.
Keywords	sepsis ; kadar seng serum ; interleukin-6 ; skor pelod-2 ; Medicine ; R ; Pediatrics ; RJ1-570
Language	Indonesian
Publishing date	2021-12-01T00:00:00Z
Publisher	Badan Penerbit Ikatan Dokter Anak Indonesia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Validitas Skala Nyeri Non Verbal Pain Scale RevisedSebagai Penilai Nyeri di Ruang Perawatan Intensif Anak

Dyah Kanya Wati / Antonius Pudjiadi / Abdul Latief

Sari Pediatri, Vol 14, Iss 1, Pp 8-

2016 Volume 13

Abstract: Latar belakang. Berdasarkan berbagai penelitian, diperlukan skala nyeri yang divalidasi untuk menilai nyeri di ruang perawatan intensif anak dari aspek respon otonom dan evaluasi bentuk intervensi tata laksana nyeri yang diberikan. Tujuan. Mengetahui ... ...

Abstract	Latar belakang. Berdasarkan berbagai penelitian, diperlukan skala nyeri yang divalidasi untuk menilai nyeri di ruang perawatan intensif anak dari aspek respon otonom dan evaluasi bentuk intervensi tata laksana nyeri yang diberikan. Tujuan. Mengetahui validitas alat pengukur skala nyeri non verbal pain scale (NVPS) yang dapat dipakai di ruang perawatan intensif anak. Metode. Subyek penelitian yang diberikan intervensi nyeri melalui berbagai prosedur pemeriksaan atau terapi, dinilai respon nyeri melalui perekaman video. Respon dinilai selama 2-10 menit sebelum, selama, dan setelah intervensi nyeri diberikan. Sebagai baku emas digunakan skala nyeri Wong Baker pain scale (WBPS) Hasil. Dari 38 sampel yang dinilai didapatkan sensitifitas NVPSR 85%, spesifisitas 66%, nilai prediksi positif 96%%, negatif prediksi negatif 50%. Nilai korelasi antara skala NVPSR dan WBPS adalah 0,95 (p<0,05). Kesimpulan. Non verbal pain scale revised(NVPSR) memiliki korelasi yang kuat dengan WBPS dalam menilai nyeri pada anak. Sensitifitas yang cukup tinggi sebagai alat skrening nyeri namun memiliki spesifitas yang sedang sebagai alat diagnostik nyeri pada anak.
Keywords	ruang perawatan intensif anak ; skala nyeri NVPSR ; validasi ; Medicine ; R ; Pediatrics ; RJ1-570
Language	Indonesian
Publishing date	2016-11-01T00:00:00Z
Publisher	Badan Penerbit Ikatan Dokter Anak Indonesia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pengaruh Menyusui, Glukosa 40% dan Memeluk Bayi terhadap Respon Nyeri pada Bayi Cukup Bulan (Suatu Uji Klinis)

Dyah Kanya Wati / Soetjiningsih Soetjiningsih / Retayasa Retayasa

Sari Pediatri, Vol 9, Iss 3, Pp 207-

2016 Volume 12

Abstract: Latar belakang. Berdasarkan berbagai penelitian acak, pemberian glukosa, menyusui dan stimulasi multisensoris merupakan penanganan yang dapat dipercaya manfaatnya sebagai bagian dari penanganan non farmakologis. Tujuan. Melihat respon nyeri pada bayi ... ...

Abstract	Latar belakang. Berdasarkan berbagai penelitian acak, pemberian glukosa, menyusui dan stimulasi multisensoris merupakan penanganan yang dapat dipercaya manfaatnya sebagai bagian dari penanganan non farmakologis. Tujuan. Melihat respon nyeri pada bayi cukup bulan yang diimunisasi intrakutan dalam kondisi disusui, mendapatkan glukosa 40% atau dipeluk oleh ibunya. Metode. Subjek penelitian dibagi menjadi tiga kelompok. Kelompok A untuk menyusui, kelompok B untuk glukosa 40% dan kelompok C untuk kelompok memeluk bayi. Pada saat penyuntikan, subjek direkam dengan kamera video dan hasil rekaman dinilai untuk mengetahui respon nyerinya berdasarkan skala DAN (Douleur Aigue Nouveau-ne). Hasil. Dari 116 subjek didapatkan rerata hasil penilaian skala DAN 6,13 (SD 1,17) untuk kelompok menyusui, 7,93 (SD 1,05) untuk kelompok bayi yang mendapatkan glukosa 40% dan 7,65 (SD 1,12) untuk kelompok memeluk bayi. Kesimpulan. Kelompok menyusui memiliki respon nyeri yang paling rendah secara bermakna. Menyusui memberikan hasil yang berbeda bermakna dalam memberikan respon nyeri dibandingkan pemberian glukosa 40% dan memeluk bayi pada bayi yang diimunisasi.
Keywords	glukosa ; nyeri ; neonatus ; menyusui ; memeluk bayi ; Medicine ; R ; Pediatrics ; RJ1-570
Language	Indonesian
Publishing date	2016-11-01T00:00:00Z
Publisher	Badan Penerbit Ikatan Dokter Anak Indonesia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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