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  1. Book: Autoimmunity

    Perl, Andras

    methods and protocols

    (Methods in molecular biology ; 900 ; Springer protocols)

    2013  

    Author's details ed. by Andras Perl
    Series title Methods in molecular biology ; 900
    Springer protocols
    Collection
    Keywords Autoimmunity / physiology ; Autoimmune Diseases / physiopathology ; T-Lymphocytes / immunology ; Models, Immunological
    Language English
    Size XIV, 431 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017721215
    ISBN 978-1-60761-719-8 ; 9781607617204 ; 1-60761-719-6 ; 160761720X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 1964 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Expanding scope of TEMRA in autoimmunity.

    Perl, Andras / Morel, Laurence

    EBioMedicine

    2023  Volume 90, Page(s) 104520

    MeSH term(s) Humans ; Autoimmunity ; CD8-Positive T-Lymphocytes
    Language English
    Publishing date 2023-03-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2023.104520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7090: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Immmunometabolism of systemic lupus erythematosus.

    Furment, Marlene Marte / Perl, Andras

    Clinical immunology (Orlando, Fla.)

    2024  Volume 261, Page(s) 109939

    Abstract: Systemic lupus erythematosus (SLE) is a potentially fatal chronic autoimmune disease which is underlain by complex dysfunction of the innate and adaptive immune systems. Although a series of well-defined genetic and environmental factors have been ... ...

    Abstract Systemic lupus erythematosus (SLE) is a potentially fatal chronic autoimmune disease which is underlain by complex dysfunction of the innate and adaptive immune systems. Although a series of well-defined genetic and environmental factors have been implicated in disease etiology, neither the development nor the persistence of SLE is well understood. Given that several disease susceptibility genes and environmental factors interact and influence inflammatory lineage specification through metabolism, the field of immunometabolism has become a forefront of cutting edge research. Along these lines, metabolic checkpoints of pathogenesis have been identified as targets of effective therapeutic interventions in mouse models and validated in clinical trials. Ongoing studies focus on mitochondrial oxidative stress, activation of the mechanistic target of rapamycin, calcium signaling, glucose utilization, tryptophan degradation, and metabolic cross-talk between gut microbiota and the host immune system.
    MeSH term(s) Animals ; Mice ; Lupus Erythematosus, Systemic ; Immune System
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2024.109939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 880: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book: Autoimmunity

    Perl, Andras

    methods and protocols

    (Methods in molecular medicine ; 102)

    2004  

    Author's details ed. by Andras Perl
    Series title Methods in molecular medicine ; 102
    Collection
    Keywords Autoimmunity / physiology ; Autoimmune Diseases / physiopathology ; T-Lymphocytes / immunology ; Models, Immunological
    Language English
    Size XIV, 431 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT014039883
    ISBN 1-58829-231-2 ; 978-1-58829-231-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 A 1994 order for loan Magazin

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  5. Article ; Online: Endosome Traffic Modulates Pro-Inflammatory Signal Transduction in CD4

    Park, Joy S / Perl, Andras

    International journal of molecular sciences

    2023  Volume 24, Issue 13

    Abstract: Endocytic recycling regulates the cell surface receptor composition of the plasma membrane. The surface expression levels of the T cell receptor (TCR), in concert with signal transducing co-receptors, regulate T cell responses, such as proliferation, ... ...

    Abstract Endocytic recycling regulates the cell surface receptor composition of the plasma membrane. The surface expression levels of the T cell receptor (TCR), in concert with signal transducing co-receptors, regulate T cell responses, such as proliferation, differentiation, and cytokine production. Altered TCR expression contributes to pro-inflammatory skewing, which is a hallmark of autoimmune diseases, such as systemic lupus erythematosus (SLE), defined by a reduced function of regulatory T cells (Tregs) and the expansion of CD4
    MeSH term(s) Humans ; Cytokines ; T-Lymphocytes, Helper-Inducer ; Lupus Erythematosus, Systemic/drug therapy ; Signal Transduction ; Receptors, Antigen, T-Cell/therapeutic use ; Endosomes/metabolism
    Chemical Substances Cytokines ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2023-06-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241310749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Editorial: Mitochondrial dysfunction in inflammation and autoimmunity.

    Staal, Jens / Blanco, Luz Pamela / Perl, Andras

    Frontiers in immunology

    2023  Volume 14, Page(s) 1304315

    MeSH term(s) Humans ; Autoimmunity ; Reactive Oxygen Species ; Inflammation ; Mitochondria
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2023-10-04
    Publishing country Switzerland
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1304315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Endosome Traffic Modulates Pro-Inflammatory Signal Transduction in CD4 + T Cells—Implications for the Pathogenesis of Systemic Lupus Erythematosus

    Joy S. Park / Andras Perl

    International Journal of Molecular Sciences, Vol 24, Iss 10749, p

    2023  Volume 10749

    Abstract: Endocytic recycling regulates the cell surface receptor composition of the plasma membrane. The surface expression levels of the T cell receptor (TCR), in concert with signal transducing co-receptors, regulate T cell responses, such as proliferation, ... ...

    Abstract Endocytic recycling regulates the cell surface receptor composition of the plasma membrane. The surface expression levels of the T cell receptor (TCR), in concert with signal transducing co-receptors, regulate T cell responses, such as proliferation, differentiation, and cytokine production. Altered TCR expression contributes to pro-inflammatory skewing, which is a hallmark of autoimmune diseases, such as systemic lupus erythematosus (SLE), defined by a reduced function of regulatory T cells (Tregs) and the expansion of CD4 + helper T (Th) cells. The ensuing secretion of inflammatory cytokines, such as interferon-γ and interleukin (IL)-4, IL-17, IL-21, and IL-23, trigger autoantibody production and tissue infiltration by cells of the adaptive and innate immune system that induce organ damage. Endocytic recycling influences immunological synapse formation by CD4 + T lymphocytes, signal transduction from crosslinked surface receptors through recruitment of adaptor molecules, intracellular traffic of organelles, and the generation of metabolites to support growth, cytokine production, and epigenetic control of DNA replication and gene expression in the cell nucleus. This review will delineate checkpoints of endosome traffic that can be targeted for therapeutic interventions in autoimmune and other disease conditions.
    Keywords CD4 + T cells ; endosome traffic ; lysosome ; metabolism ; glucose ; tryptophan ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 333 ; 570
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: Principles behind SLE treatment with

    Nasr, Sandy / Perl, Andras

    Immunometabolism (Cobham (Surrey, England))

    2022  Volume 4, Issue 4, Page(s) e00010

    Abstract: Systemic lupus erythematous (SLE) is a multisystem chronic autoimmune disease in which disrupted molecular pathways lead to multiple clinical manifestations. Currently approved treatments include hydroxychloroquine, some immunosuppressive medications, ... ...

    Abstract Systemic lupus erythematous (SLE) is a multisystem chronic autoimmune disease in which disrupted molecular pathways lead to multiple clinical manifestations. Currently approved treatments include hydroxychloroquine, some immunosuppressive medications, and some biologics. They all come with a range of side effects.
    Language English
    Publishing date 2022-10-25
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2633-0407
    ISSN (online) 2633-0407
    DOI 10.1097/IN9.0000000000000010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The mTOR pathway in the antiphospholipid syndrome.

    Ji, Lanlan / Zhang, Zhuoli / Perl, Andras

    Medical review (2021)

    2023  Volume 3, Issue 6, Page(s) 511–513

    Abstract: This perspective discussed the available evidence on the involvement of mTOR pathway in antiphospholipid syndrome (APS), from the aspects of endothelial cells, platelets, monocytes and anti-phospholipid antibodies (PLs), which may lead to future ... ...

    Abstract This perspective discussed the available evidence on the involvement of mTOR pathway in antiphospholipid syndrome (APS), from the aspects of endothelial cells, platelets, monocytes and anti-phospholipid antibodies (PLs), which may lead to future therapeutic applications of mTOR inhibition in APS.
    Language English
    Publishing date 2023-09-21
    Publishing country Germany
    Document type Journal Article
    ISSN 2749-9642
    ISSN (online) 2749-9642
    DOI 10.1515/mr-2023-0033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: mTOR-dependent autophagy contributes to end-organ resistance and serves as target for treatment in autoimmune disease.

    Perl, Andras

    EBioMedicine

    2018  Volume 36, Page(s) 12–13

    MeSH term(s) Animals ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/etiology ; Autoimmune Diseases/metabolism ; Autoimmune Diseases/therapy ; Autophagy ; Biomarkers ; Disease Susceptibility ; Humans ; Mice ; Oxidative Stress ; TOR Serine-Threonine Kinases/metabolism
    Chemical Substances Biomarkers ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1)
    Language English
    Publishing date 2018-09-24
    Publishing country Netherlands
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2018.09.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7090: Show issues Location:
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