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  1. Article ; Online: Expanding the Activation Continuum: From Patient to Provider Activation.

    Milani, Richard V / Grant, Arthur G

    The American journal of the medical sciences

    2021  Volume 361, Issue 6, Page(s) 812–813

    MeSH term(s) Clinical Decision-Making/methods ; Continuity of Patient Care/standards ; Continuity of Patient Care/trends ; Health Personnel/standards ; Health Personnel/trends ; Humans ; Patient Readmission/standards ; Patient Readmission/trends
    Language English
    Publishing date 2021-01-17
    Publishing country United States
    Document type Letter
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2021.01.010
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  2. Article: Assessment of resting myocardial blood flow in regions of known transmural scar to confirm accuracy and precision of 3D cardiac positron emission tomography.

    Bober, Robert M / Milani, Richard V / Kachur, Sergey M / Morin, Daniel P

    EJNMMI research

    2023  Volume 13, Issue 1, Page(s) 87

    Abstract: Background: Composite invasive and non-invasive data consistently demonstrate that resting myocardial blood flow (rMBF) in regions of known transmural myocardial scar (TMS) converge on a value of ~ 0.30 mL/min/g or lower. This value has been confirmed ... ...

    Abstract Background: Composite invasive and non-invasive data consistently demonstrate that resting myocardial blood flow (rMBF) in regions of known transmural myocardial scar (TMS) converge on a value of ~ 0.30 mL/min/g or lower. This value has been confirmed using the 3 most common myocardial perfusion agents (
    Results: Median rMBF (in mL/min/g) and COV in regions of TMS were 0.71 [IQR 0.52-1.02] and 0.16 with 4DM; 0.41 [0.34-0.54] and 0.10 with 4DM-FVD; 0.66 [0.51-0.85] and 0.11 with Cedars; 0.51 [0.43-0.61] and 0.08 with Emory-Votaw; 0.37 [0.30-0.42], 0.07 with Emory-Ottawa, and 0.26 [0.23-0.32], COV 0.07 with HeartSee.
    Conclusions: SWPs varied widely in low end accuracy based on measurement of rMBF in regions of known TMS. 3D PET using
    Trial registration: clinicaltrial.gov, NCT05286593, Registered December 28, 2021, https://clinicaltrials.gov/ct2/show/NCT05286593 .
    Language English
    Publishing date 2023-09-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2619892-7
    ISSN 2191-219X
    ISSN 2191-219X
    DOI 10.1186/s13550-023-01037-7
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  3. Article ; Online: Omega 3, Atrial Fibrillation, and Cardiovascular Outcomes.

    O'Keefe, Evan L / Lavie, Carl J / Elagizi, Andrew / Milani, Richard V / Laukkanen, Jari A

    Journal of the American College of Cardiology

    2023  Volume 82, Issue 21, Page(s) e201–e202

    MeSH term(s) Humans ; Atrial Fibrillation/epidemiology ; Fatty Acids, Omega-3/therapeutic use ; Heart ; Cardiovascular System
    Chemical Substances Fatty Acids, Omega-3
    Language English
    Publishing date 2023-11-14
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2023.08.059
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  4. Article ; Online: Secondary hypertension: evaluation and management.

    Tandan, Nitin / Lavie, Carl J / Stewart, Merrill H / Milani, Richard V / Ventura, Hector O

    Current opinion in cardiology

    2023  Volume 38, Issue 4, Page(s) 318–325

    Abstract: Purpose of review: Hypertension (HTN) that can be attributed to a particular source is known as secondary HTN (SH). Often, SH is difficult to control and thus referred to as resistant HTN, although the two terms are not mutually exclusive.: Recent ... ...

    Abstract Purpose of review: Hypertension (HTN) that can be attributed to a particular source is known as secondary HTN (SH). Often, SH is difficult to control and thus referred to as resistant HTN, although the two terms are not mutually exclusive.
    Recent findings: A common theme across several contributors to SH are coactivation of the sympathetic drive and hormonal changes, independent of hormonal axis activation. The key to effective management of SH is early recognition and treatment to avoid catastrophic cardiovascular disease effects and mortality.
    Summary: This review article provides a contemporary summary of the conditions associated with SH and briefly reviews diagnostics and management.
    MeSH term(s) Humans ; Hypertension/diagnosis ; Hypertension/therapy ; Cardiovascular Diseases
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 645186-x
    ISSN 1531-7080 ; 0268-4705
    ISSN (online) 1531-7080
    ISSN 0268-4705
    DOI 10.1097/HCO.0000000000001059
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  5. Article ; Online: New aspects in the management of hypertension in the digital era.

    Milani, Richard V / Lavie, Carl J / Ventura, Hector O

    Current opinion in cardiology

    2021  Volume 36, Issue 4, Page(s) 398–404

    Abstract: Purpose of review: Hypertension (HTN) is the most common chronic disease impacting over half the US adult population. Our current office-based model of care is failing in its ability to control blood pressure (BP) as only 44% of adult US hypertensives ... ...

    Abstract Purpose of review: Hypertension (HTN) is the most common chronic disease impacting over half the US adult population. Our current office-based model of care is failing in its ability to control blood pressure (BP) as only 44% of adult US hypertensives are achieving minimal levels of BP control (< 140/90 mmHg), leading to high rates of preventable cardiovascular events and death.
    Recent findings: Reengineering care delivery using a fully digital platform combined with a dedicated team-based approach to HTN management has demonstrated superior BP control rates, very high levels patient acceptance, and the ability to better diagnose and treat masked and white coat HTN.
    Summary: A digital medicine program in the clinical care setting can be an effective and convenient mechanism of delivering HTN management, outperforming traditional office-based care, and is well accepted by patients.
    MeSH term(s) Adult ; Blood Pressure ; Blood Pressure Monitoring, Ambulatory ; Delivery of Health Care ; Humans ; Hypertension/diagnosis ; Hypertension/epidemiology ; Hypertension/prevention & control ; White Coat Hypertension
    Language English
    Publishing date 2021-07-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645186-x
    ISSN 1531-7080 ; 0268-4705
    ISSN (online) 1531-7080
    ISSN 0268-4705
    DOI 10.1097/HCO.0000000000000870
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  6. Article ; Online: Update on Omega-3 Polyunsaturated Fatty Acids on Cardiovascular Health.

    Rodriguez, Daniel / Lavie, Carl J / Elagizi, Andrew / Milani, Richard V

    Nutrients

    2022  Volume 14, Issue 23

    Abstract: Twenty percent of deaths in the United States are secondary to cardiovascular diseases (CVD). In patients with hyperlipidemia and hypertriglyceridemia, studies have shown high atherosclerotic CVD (ASCVD) event rates despite the use of statins. Given the ... ...

    Abstract Twenty percent of deaths in the United States are secondary to cardiovascular diseases (CVD). In patients with hyperlipidemia and hypertriglyceridemia, studies have shown high atherosclerotic CVD (ASCVD) event rates despite the use of statins. Given the association of high triglyceride (TG) levels with elevated cholesterol and low levels of high-density lipoprotein cholesterol, the American Heart Association (AHA)/American College of Cardiology (ACC) cholesterol guidelines recommend using elevated TGs as a "risk-enhancing factor" for ASCVD and using omega 3 fatty acids (Ω3FAs) for patients with persistently elevated severe hypertriglyceridemia. Ω3FA, or fish oils (FOs), have been shown to reduce very high TG levels, hospitalizations, and CVD mortality in randomized controlled trials (RCTs). We have published the largest meta-analysis to date demonstrating significant effects on several CVD outcomes, especially fatal myocardial infarctions (MIs) and total MIs. Despite the most intensive research on Ω3FAs on CVD, their benefits have been demonstrated to cluster across multiple systems and pathologies, including autoimmune diseases, infectious diseases, chronic kidney disease, central nervous system diseases, and, most recently, the COVID-19 pandemic. A review and summary of the controversies surrounding Ω3FAs, some of the latest evidence-based findings, and the current and most updated recommendations on Ω3FAs are presented in this paper.
    Language English
    Publishing date 2022-12-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14235146
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  7. Article ; Online: Omega-3 Benefits Remain Strong Post-STRENGTH.

    Bernasconi, Aldo A / Lavie, Carl J / Milani, Richard V / Laukkanen, Jari A

    Mayo Clinic proceedings

    2021  Volume 96, Issue 5, Page(s) 1371–1372

    MeSH term(s) Cardiovascular Diseases/prevention & control ; Fatty Acids, Omega-3/therapeutic use ; Humans
    Chemical Substances Fatty Acids, Omega-3
    Language English
    Publishing date 2021-04-08
    Publishing country England
    Document type Letter ; Meta-Analysis
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2021.03.004
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  8. Article ; Online: In Reply-Impact of a High-Shrimp Diet on Cardiovascular Risk: An NHANES Analysis.

    Lavie, Carl J / Milani, Richard V / Laukkanen, Jari A / Bernasconi, Aldo A

    Mayo Clinic proceedings

    2021  Volume 96, Issue 2, Page(s) 508

    MeSH term(s) Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Diet ; Heart Disease Risk Factors ; Humans ; Nutrition Surveys ; Risk Factors
    Language English
    Publishing date 2021-01-22
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2020.10.028
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  9. Article ; Online: Assessment of resting myocardial blood flow in regions of known transmural scar to confirm accuracy and precision of 3D cardiac positron emission tomography

    Robert M. Bober / Richard V. Milani / Sergey M. Kachur / Daniel P. Morin

    EJNMMI Research, Vol 13, Iss 1, Pp 1-

    2023  Volume 16

    Abstract: Abstract Background Composite invasive and non-invasive data consistently demonstrate that resting myocardial blood flow (rMBF) in regions of known transmural myocardial scar (TMS) converge on a value of ~ 0.30 mL/min/g or lower. This value has been ... ...

    Abstract Abstract Background Composite invasive and non-invasive data consistently demonstrate that resting myocardial blood flow (rMBF) in regions of known transmural myocardial scar (TMS) converge on a value of ~ 0.30 mL/min/g or lower. This value has been confirmed using the 3 most common myocardial perfusion agents (13N, 15O-H2O and 82Rb) incorporating various kinetic models on older 2D positron emission tomography (PET) systems. Thus, rMBF in regions of TMS can serve as a reference “truth” to evaluate low-end accuracy of various PET systems and software packages (SWPs). Using 82Rb on a contemporary 3D-PET-CT system, we sought to determine whether currently available SWP can accurately and precisely measure rMBF in regions of known TMS. Results Median rMBF (in mL/min/g) and COV in regions of TMS were 0.71 [IQR 0.52–1.02] and 0.16 with 4DM; 0.41 [0.34–0.54] and 0.10 with 4DM-FVD; 0.66 [0.51–0.85] and 0.11 with Cedars; 0.51 [0.43–0.61] and 0.08 with Emory-Votaw; 0.37 [0.30–0.42], 0.07 with Emory-Ottawa, and 0.26 [0.23–0.32], COV 0.07 with HeartSee. Conclusions SWPs varied widely in low end accuracy based on measurement of rMBF in regions of known TMS. 3D PET using 82Rb and HeartSee software accurately (0.26 mL/min/g, consistent with established values) and precisely (COV = 0.07) quantified rMBF in regions of TMS. The Emory-Ottawa software yielded the next-best accuracy (0.37 mL/min/g), though rMBF was higher than established gold-standard values in ~ 5% of the resting scans. 4DM, 4DM-FDV, Cedars and Emory-Votaw SWP consistently resulted values higher than the established gold standard (0.71, 0.41, 0.66, 0.51 mL/min/g, respectively), with higher interscan variability (0.16, 0.11, 0.11, and 0.09, respectively). Trial registration: clinicaltrial.gov, NCT05286593, Registered December 28, 2021, https://clinicaltrials.gov/ct2/show/NCT05286593 .
    Keywords Positron emission tomography (PET) ; Myocardial scar ; Resting myocardial blood flow ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Subject code 610
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
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  10. Article ; Online: Updates on obesity and the obesity paradox in cardiovascular diseases.

    Tutor, Austin W / Lavie, Carl J / Kachur, Sergey / Milani, Richard V / Ventura, Hector O

    Progress in cardiovascular diseases

    2022  Volume 78, Page(s) 2–10

    Abstract: The prevalence of obesity has reached pandemic proportions worldwide and certainly in the United States. Obesity is a well-established independent risk factor for development of many cardiovascular diseases (CVD), including heart failure, coronary heart ... ...

    Abstract The prevalence of obesity has reached pandemic proportions worldwide and certainly in the United States. Obesity is a well-established independent risk factor for development of many cardiovascular diseases (CVD), including heart failure, coronary heart disease, atrial fibrillation, and hypertension. Therefore, it is logical to expect obesity would have a strong correlation with CVD mortality. However, a substantial body of literature demonstrates a paradox with improved prognosis of overweight and obese patients with established CVD compared to lean patients with the identical CVD. Surprisingly, similar data has also shown that cardiovascular fitness, rather than weight loss alone, influences the relationship between obesity and mortality in those with established CVD. The impact of fitness, exercise, physical activity (PA), and weight loss and their relationship to the obesity paradox are all reviewed here.
    MeSH term(s) Humans ; United States ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Obesity Paradox ; Obesity/diagnosis ; Obesity/epidemiology ; Obesity/therapy ; Risk Factors ; Weight Loss ; Body Mass Index
    Language English
    Publishing date 2022-12-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 209312-1
    ISSN 1873-1740 ; 1532-8643 ; 0033-0620
    ISSN (online) 1873-1740 ; 1532-8643
    ISSN 0033-0620
    DOI 10.1016/j.pcad.2022.11.013
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