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Article: Potential protective effects of red grape seed extract in a rat model of malathion-induced neurotoxicity.

Saadh, Mohamed Jamal

2023 Volume 16, Issue 2, Page(s) 380–385

Abstract: Background and aim: Exposure to pesticide mixtures used in agricultural practice poses a grave risk to non-target animals. This study aimed to determine whether red grape seed extract (RGSE, which is 95% bioflavonoids and equal to 12,000 mg of fresh red ...

Abstract	Background and aim: Exposure to pesticide mixtures used in agricultural practice poses a grave risk to non-target animals. This study aimed to determine whether red grape seed extract (RGSE, which is 95% bioflavonoids and equal to 12,000 mg of fresh red grape seed, and 150 mg of vitamin C) alleviated the changes in brain-derived neurotrophic factor (BDNF) level, acetylcholinesterase activity, oxidative stress, and apoptosis induced by orally administered malathion in a rat model of malathion-induced neurotoxicity. Materials and methods: Thirty-two adult male Wistar albino rats were divided into four groups and exposed to malathion with or without 4 weeks of RGSE treatment, treated with RGSE alone, or left untreated as controls. The animals were euthanized 24 h after last treatment. Brain samples were collected to measure acetylcholinesterase, superoxide dismutase (SOD), and caspase 3 activity, total antioxidant capacity (TAC), and BDNF levels. Results: Malathion significantly reduced acetylcholinesterase and SOD activity and TAC and significantly increased caspase 3 activity. In comparison, acetylcholinesterase and SOC activity, BDNF level, and TAC were improved and caspase 3 activity was decreased in the malathion-RGSE group, indicating that RGSE corrected the alterations detected in these biochemical parameters. Conclusion: Oxidative stress and apoptosis in the brains of rats exposed to oral malathion were substantially controlled by RGSE treatment.
Language	English
Publishing date	2023-02-26
Publishing country	India
Document type	Journal Article
ZDB-ID	2456277-4
ISSN	2231-0916 ; 0972-8988
ISSN (online)	2231-0916
ISSN	0972-8988
DOI	10.14202/vetworld.2023.380-385
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Article ; Online: Potential protective effects of red grape seed extract in a rat model of malathion-induced neurotoxicity

Mohamed Jamal Saadh

Veterinary World, Vol 16, Iss 2, Pp 380-

2023 Volume 385

Abstract: Background and Aim: Exposure to pesticide mixtures used in agricultural practice poses a grave risk to non-target animals. This study aimed to determine whether red grape seed extract (RGSE, which is 95% bioflavonoids and equal to 12,000 mg of fresh red ... ...

Abstract	Background and Aim: Exposure to pesticide mixtures used in agricultural practice poses a grave risk to non-target animals. This study aimed to determine whether red grape seed extract (RGSE, which is 95% bioflavonoids and equal to 12,000 mg of fresh red grape seed, and 150 mg of vitamin C) alleviated the changes in brain-derived neurotrophic factor (BDNF) level, acetylcholinesterase activity, oxidative stress, and apoptosis induced by orally administered malathion in a rat model of malathion-induced neurotoxicity. Materials and Methods: Thirty-two adult male Wistar albino rats were divided into four groups and exposed to malathion with or without 4 weeks of RGSE treatment, treated with RGSE alone, or left untreated as controls. The animals were euthanized 24 h after last treatment. Brain samples were collected to measure acetylcholinesterase, superoxide dismutase (SOD), and caspase 3 activity, total antioxidant capacity (TAC), and BDNF levels. Results: Malathion significantly reduced acetylcholinesterase and SOD activity and TAC and significantly increased caspase 3 activity. In comparison, acetylcholinesterase and SOC activity, BDNF level, and TAC were improved and caspase 3 activity was decreased in the malathion-RGSE group, indicating that RGSE corrected the alterations detected in these biochemical parameters. Conclusion: Oxidative stress and apoptosis in the brains of rats exposed to oral malathion were substantially controlled by RGSE treatment.
Keywords	apoptosis ; malathion toxicity ; oxidative stress ; pesticide ; red grape seed extract ; Animal culture ; SF1-1100 ; Veterinary medicine ; SF600-1100
Subject code	630
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Veterinary World
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prevalence, antimicrobial susceptibility profile, and associated risk factors of uropathogenic

Mohamed, Fartun Yasin / Dahie, Hassan Abdullahi / Mohamoud, Jamal Hassan / Adam, Mohamed Hussein / Dirie, Hassan Mohamud

Frontiers in public health

2024 Volume 11, Page(s) 1203913

Abstract: Background: Uropathogenic : Methods: This cross-sectional study was conducted within a hospital setting between August 2022 and December 2022. Using consecutive convenient sampling, the research enrolled 220 pregnant women. The urine samples obtained ...

Abstract	Background: Uropathogenic Methods: This cross-sectional study was conducted within a hospital setting between August 2022 and December 2022. Using consecutive convenient sampling, the research enrolled 220 pregnant women. The urine samples obtained from these women were cultured on MacConkey and blood agar and incubated at 37°C overnight, followed by sub-culturing on Mueller Hinton media. Bacterial identification involved Gram staining and biochemical characterization (TSI, indole, citrate, methyl red, urea agar, and motility tests). Conversely, susceptibility tests were performed using the Kirby-Bauer disk diffusion method. A binary logistic regression model and analysis of odds ratios (ORs) were employed to evaluate the risk factors associated with Results: Out of the 220 urine samples examined, 42 (19%) exhibited a positive culture, indicating an Conclusion: The prevalence of
MeSH term(s)	Humans ; Infant ; Female ; Pregnancy ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Uropathogenic Escherichia coli ; Pregnant Women ; Cross-Sectional Studies ; Prevalence ; Somalia ; Agar/pharmacology ; Drug Resistance, Multiple, Bacterial ; Microbial Sensitivity Tests ; Urinary Tract Infections/epidemiology ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/microbiology ; Escherichia coli Infections/epidemiology ; Escherichia coli Infections/drug therapy ; Escherichia coli Infections/microbiology ; Hospitals ; Risk Factors
Chemical Substances	Anti-Bacterial Agents ; Agar (9002-18-0)
Language	English
Publishing date	2024-01-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1203913
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Article: The Molecular Landscape of Lung Metastasis in Primary Head and Neck Squamous Cell Carcinomas.

Thirumani, Logalakshmi / Helan, Mizpha / S, Vijayaraghavan / Jamal Mohamed, Umargani / Vimal, Sugumar / Madar, Inamul Hasan

Cureus

2024 Volume 16, Issue 4, Page(s) e57497

Abstract: Background Lung metastasis in head and neck cancer (HNC) patients is a critical concern, often indicating an advanced disease stage and a poor prognosis. This study explores the molecular complexities of such metastases, identifying specific genes and ... ...

Abstract	Background Lung metastasis in head and neck cancer (HNC) patients is a critical concern, often indicating an advanced disease stage and a poor prognosis. This study explores the molecular complexities of such metastases, identifying specific genes and pathways that may serve as valuable targets for diagnosis and treatment. The findings underscore the potential for significantly improved patient outcomes through targeted therapeutic strategies. Methodology In this research, we systematically collected raw gene expression data from head and neck squamous cell carcinoma (HNSCC) and lung squamous cell carcinoma (LSCC). By comparing tumorous and normal gene expression profiles from paired patient samples, we identified differentially expressed genes (DEGs). Network analysis helped visualize protein interactions and pinpoint crucial hub genes. Through validation and comparison across several datasets, we identified common DEGs. Additionally, we employed Kaplan-Meier analysis and log-rank testing to examine the relationship between gene expression patterns and patient survival. Result The study identified 145 overlapping DEGs in both HNSCC and LSCC, which are crucial for cancer progression and linked to lung metastasis, offering vital targets for personalized therapy by identifying key genes affecting disease development and patient survival. Pathway analyses linked these to lung metastasis, while protein-protein interaction network construction and hub gene identification highlighted genes crucial for development and patient survival, offering targets for personalized therapy. Conclusion Identifying key genes and pathways in lung metastasis from HNC, this study highlights potential targets for enhanced diagnosis and therapy. It underscores the crucial role of molecular insights in driving forward personalized treatment approaches and improving patient outcomes.
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.57497
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Article: Hypoglycemic and hypolipidemic activity of combined milk thistle and fenugreek seeds in alloxan-induced diabetic albino rats.

Saadh, Mohamed Jamal

Veterinary world

2020 Volume 13, Issue 8, Page(s) 1732–1736

Abstract: Background and aim: Despite the availability of antidiabetic drugs, they are not free from associated adverse side effects. This study aimed to evaluate the hypoglycemic and hypolipidemic effects of oral administration of seeds from two medicinal plants: ...

Abstract	Background and aim: Despite the availability of antidiabetic drugs, they are not free from associated adverse side effects. This study aimed to evaluate the hypoglycemic and hypolipidemic effects of oral administration of seeds from two medicinal plants: (1) Milk thistle and (2) fenugreek. Materials and methods: Plant seeds were washed in distilled water and ground with a coffee grinder. Alloxan was used to induce diabetes in 20 male albino rats. Diabetic rats were randomly divided into two groups: (1) Group 1 (n=10), diabetic rats fed with 0.5 g/kg milk thistle and 2 g/kg fenugreek seeds per day and (2) Group 2 (n=10), diabetic rats fed standard rodent food for 4 weeks. Results: Oral administration of milk thistle and fenugreek seeds for 2 weeks resulted in significant improvement in body weight, blood glucose, glycosylated hemoglobin (HbA1c), cholesterol, and triglyceride levels in alloxan-induced diabetic rats. After 4 weeks, this ameliorative effect was significantly elevated with respect to blood glucose (155.00±9.70 mg/dL vs. 427.50±5.70 mg/dL; p<0.001), HbA1c (5.5±0.19% vs. 13.65±1.77%; p<0.001), cholesterol (281.50±10.95 mg/dL vs. 334.30±6.80 mg/dL; p<0.001), triglyceride (239.60±6.87 mg/dL vs. 284.20±9.95 mg/dL; p<0.01), and body weight (265.30±8.10 g vs. 207.40±11.4 g; p<0.01) as compared with non-treated diabetic rats. Conclusion: Milk thistle and fenugreek seeds possess hypoglycemic and hypolipidemic properties and could be used as natural compounds that are suitable as parent compounds for the development of new antidiabetic drugs.
Language	English
Publishing date	2020-08-29
Publishing country	India
Document type	Journal Article
ZDB-ID	2456277-4
ISSN	2231-0916 ; 0972-8988
ISSN (online)	2231-0916
ISSN	0972-8988
DOI	10.14202/vetworld.2020.1732-1736
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Article: Bowel obstruction complicating an encapsulating peritoneal sclerosis: A case report.

Ola, Messaoud / Zahra, El Mansoury Fatima / Amine, Cherraqi / Mohamed, Abdellaoui / Jamal, Fenni / Rachida, Saouab

Radiology case reports

2023 Volume 19, Issue 3, Page(s) 1141–1143

Abstract: Encapsulating peritoneal sclerosis (EPS) is a rare pathological entity that can be classified into an idiopathic or secondary affection. Bowel obstruction is a frequent complication that has a characteristic radiological finding, with a cocoon appearance. ...

Abstract	Encapsulating peritoneal sclerosis (EPS) is a rare pathological entity that can be classified into an idiopathic or secondary affection. Bowel obstruction is a frequent complication that has a characteristic radiological finding, with a cocoon appearance. We present the case of a 40-year-old man who suffered an absolute constipation. He underwent a CT scan that was suggestive of encapsulating peritoneal sclerosis or abdominal cocoon responsible for small bowel obstruction.
Language	English
Publishing date	2023-12-30
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2023.11.084
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Article: Health-related risks of nursing practice at paediatric hospitals, Khartoum, Sudan.

Al-Buhairi, Jamal Othman Ahmed / Mohamed, Amal Abdelgadir Ali / Ahmed, Waled Am

Sudanese journal of paediatrics

2023 Volume 23, Issue 1, Page(s) 13–20

Abstract: In addition the nature of nurses working environment, duties and responsibilities, nurses are facing numerous health hazards while working at hospitals. This study aimed to identify the health-related risks of nursing practice at Ahmed Gasim Hospital and ...

Abstract	In addition the nature of nurses working environment, duties and responsibilities, nurses are facing numerous health hazards while working at hospitals. This study aimed to identify the health-related risks of nursing practice at Ahmed Gasim Hospital and Gafaar Ibnauf Children's Hospital, Khartoum State, Sudan. A descriptive cross-sectional study was conducted at two governmental paediatric hospitals in Khartoum, from August to December 2017, in which 74 nurses were selected by convenience sampling to participate. The data was collected by a validated questionnaire and analysed by Statistical Package for Social Sciences, version 25. About 65% of nurses reported that they had high level of awareness of health risks they were exposed to on their job while 75.7% indicated that the major factors contributing to health risks in the hospitals were working pressure and poor working environment. Low back pain was found to be the most common health-related risks (77%) that might result from the extreme pressure at work (75.7%). Gender and years of experience had statistically significant association with health hazards among nurses (0.042 and 0.047, respectively). The study concluded that the majority of nurses have high awareness of health-related risks. The reported problems were low back pain which was found to be the most common health-related risk that might result from the extreme pressure at work.
Language	English
Publishing date	2023-07-19
Publishing country	Sudan
Document type	Journal Article
ZDB-ID	3035197-2
ISSN	1858-8360 ; 0256-4408
ISSN (online)	1858-8360
ISSN	0256-4408
DOI	10.24911/SJP.106-1647513845
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Article ; Conference proceedings: Advancements in AI-Driven Systematic Review Methodologies: A Novel Approach Exemplified through Chronic Iliac Vein Obstruction Treatment Analysis

Azooz, Syfe / Mohamed, Ahmed Elzein / Alkoteesh, Jamal Aldeen / Goyal, Nimit

The Arab Journal of Interventional Radiology

2024 Volume 08, Issue S 01

Event/congress	PAIRS 2024 Annual Congress, World Trade Center, Dubai, UAE, 2024-02-10
Language	English
Publishing date	2024-02-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ISSN	2542-7083 ; 2542-7075
ISSN (online)	2542-7083
ISSN	2542-7075
DOI	10.1055/s-0044-1785829
Database	Thieme publisher's database

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Article ; Online: Botany, associated microbiota, traditional medicinal uses, and phytochemistry of Vachellia tortilis subsp. raddiana (Savi)

Mohamed Hnini / Kaoutar Taha / Jamal Aurag

Journal of Agriculture and Food Research, Vol 12, Iss , Pp 100566- (2023)

A systematic review

2023

Abstract: Vachellia tortilis subsp. raddiana is a well-adapted tree to the severe climatic conditions prevailing in arid and desert regions. Its adaptation is mainly related to a deep root system and small leaves, in addition to its interaction with different ... ...

Abstract	Vachellia tortilis subsp. raddiana is a well-adapted tree to the severe climatic conditions prevailing in arid and desert regions. Its adaptation is mainly related to a deep root system and small leaves, in addition to its interaction with different beneficial microorganisms, such as mycorrhizas, nitrogen-fixing rhizobia, phytobeneficial rhizobacteria, and endophytes. Given its adaptation, vachellia is considered a suitable pioneer plant to be used in rehabilitation, restoration, and reforestation programs in areas threatened by desertification. Moreover, it's a valuable source of diversified bioactive chemicals such as phenolic acids, flavones/flavonols, flavonoids, and isoflavones. Beyond the direct usage of raw plant extracts as potential drugs, the different parts of the tree (seeds, leaves, gum exudates, etc) are used traditionally to treat diseases such as allergy, inflammatory reactions, cough, gastric irritation, and diarrhea. They also have antibacterial, antifungal, anti-malarial, antiviral, anti-parasitic and anti-diabetic properties. This review highlights the need to update the current scientific knowledge concerning this tree and several research paths are proposed, such as (i) using genomic approaches for studying the diversity and putative functions of the tree associated-microbiota, (ii) systematic evaluation of potential microbial positive impacts on tree growth and adaptation in the current climate change context, (iii) investigating the effect of the microbial endophytes on the tree secondary metabolites diversity and biological activities, and (iv)updating the traditional knowledge on medical uses, by adopting normalized and approved in vivo tests and standardized pharmacological methods to study the efficacy and mechanisms of action of extracts and bioactive molecules, and their cytotoxicity.
Keywords	Vachellia tortilis subsp. raddiana ; Aridity tolerance ; Microbial interactions ; Traditional uses ; Ethnobotany ; Phytochemistry ; Agriculture (General) ; S1-972 ; Nutrition. Foods and food supply ; TX341-641
Subject code	571
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluating helmet-wearing of single-vehicle overspeeding motorcycle crashes: Insights from temporal instability in parsimonious pooled framework.

Wang, Chenzhu / Abdel-Aty, Mohamed / M Easa, Said / Chen, Fei / Cheng, Jianchuan / Jamal, Arshad

Traffic injury prevention

2024 Volume 25, Issue 4, Page(s) 623–630

Abstract: Objective: A lower helmet-wearing rate and overspeeding in Pakistan are critical risk behaviors of motorcyclists, causing severe injuries. To explore the differences in the determinants affecting the injury severities among helmeted and non-helmeted ... ...

Abstract	Objective: A lower helmet-wearing rate and overspeeding in Pakistan are critical risk behaviors of motorcyclists, causing severe injuries. To explore the differences in the determinants affecting the injury severities among helmeted and non-helmeted motorcyclists in motorcycle crashes caused by overspeeding behavior, single-vehicle motorcycle crash data in Rawalpindi city for 2017-2019 is collected. Considering three possible crash injury severity outcomes of motorcyclists: fatal injury, severe injury and minor injury, the rider, roadway, environmental, and temporal characteristics are estimated. Methods: To provide a mathematically simpler framework, the current study introduces parsimonious pooled random parameters logit models. Then, the standard pooled random parameters logit models without considering temporal effects are also simulated for comparison. By comparing the goodness of fit measure and estimation results, the parsimonious pooled random parameters logit model is suitable for capturing the temporal instability. Then, the non-transferability among helmeted and non-helmeted overspeeding motorcycle crashes is illustrated by likelihood ratio tests and out-of-sample prediction, and two types of models provide robust results. The marginal effects are also calculated. Results: Several variables, such as age, cloudy and weekday indicators illustrate temporal instability. Moreover, several variables are observed to only show significance in non-helmeted models, showing non-transferability across helmeted and non-helmeted models. Conclusions: More educational campaigns, regulation and enforcement, and management countermeasures should be organized for non-helmeted motorcyclists and overspeeding behavior. Such findings also provide research reference for the risk-compensating behavior and self-selected group issues under overspeeding riding considering the usage of helmets.
MeSH term(s)	Humans ; Head Protective Devices ; Motorcycles ; Accidents, Traffic ; Logistic Models ; Risk-Taking ; Wounds and Injuries
Language	English
Publishing date	2024-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2089818-6
ISSN	1538-957X ; 1538-9588
ISSN (online)	1538-957X
ISSN	1538-9588
DOI	10.1080/15389588.2024.2331644
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