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Article ; Online: mTORC1 controls murine postprandial hepatic glycogen synthesis via Ppp1r3b.

Uehara, Kahealani / Lee, Won Dong / Stefkovich, Megan / Biswas, Dipsikha / Santoleri, Dominic / Garcia Whitlock, Anna / Quinn, William / Coopersmith, Talia / Creasy, Kate Townsend / Rader, Daniel J / Sakamoto, Kei / Rabinowitz, Joshua D / Titchenell, Paul M

The Journal of clinical investigation

2024 Volume 134, Issue 7

Abstract: In response to a meal, insulin drives hepatic glycogen synthesis to help regulate systemic glucose homeostasis. The mechanistic target of rapamycin complex 1 (mTORC1) is a well-established insulin target and contributes to the postprandial control of ... ...

Abstract	In response to a meal, insulin drives hepatic glycogen synthesis to help regulate systemic glucose homeostasis. The mechanistic target of rapamycin complex 1 (mTORC1) is a well-established insulin target and contributes to the postprandial control of liver lipid metabolism, autophagy, and protein synthesis. However, its role in hepatic glucose metabolism is less understood. Here, we used metabolomics, isotope tracing, and mouse genetics to define a role for liver mTORC1 signaling in the control of postprandial glycolytic intermediates and glycogen deposition. We show that mTORC1 is required for glycogen synthase activity and glycogenesis. Mechanistically, hepatic mTORC1 activity promotes the feeding-dependent induction of Ppp1r3b, a gene encoding a phosphatase important for glycogen synthase activity whose polymorphisms are linked to human diabetes. Reexpression of Ppp1r3b in livers lacking mTORC1 signaling enhances glycogen synthase activity and restores postprandial glycogen content. mTORC1-dependent transcriptional control of Ppp1r3b is facilitated by FOXO1, a well characterized transcriptional regulator involved in the hepatic response to nutrient intake. Collectively, we identify a role for mTORC1 signaling in the transcriptional regulation of Ppp1r3b and the subsequent induction of postprandial hepatic glycogen synthesis.
MeSH term(s)	Animals ; Humans ; Mice ; Glycogen/genetics ; Glycogen/metabolism ; Glycogen Synthase/metabolism ; Insulin/metabolism ; Liver/metabolism ; Liver Glycogen/metabolism ; Mechanistic Target of Rapamycin Complex 1/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Protein Phosphatase 1/metabolism ; Postprandial Period
Chemical Substances	Glycogen (9005-79-2) ; Glycogen Synthase (EC 2.4.1.11) ; Insulin ; Liver Glycogen ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; Ppp1r3b protein, mouse (EC 3.1.3.16) ; Protein Phosphatase 1 (EC 3.1.3.16)
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI173782
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Article ; Online: A genome-first approach to variants in MLXIPL and their association with hepatic steatosis and plasma lipids.

Hehl, Leonida / Creasy, Kate T / Vitali, Cecilia / Scorletti, Eleonora / Seeling, Katharina S / Vell, Mara S / Rendel, Miriam D / Conlon, Donna / Vujkovic, Marijana / Zandvakili, Inuk / Trautwein, Christian / Schneider, Kai M / Rader, Daniel J / Schneider, Carolin V

Hepatology communications

2024 Volume 8, Issue 5

Abstract: Background: Common variants of the max-like protein X (MLX)-interacting protein-like (MLXIPL) gene, encoding the transcription factor carbohydrate-responsive element-binding protein, have been shown to be associated with plasma triglyceride levels. ... ...

Abstract	Background: Common variants of the max-like protein X (MLX)-interacting protein-like (MLXIPL) gene, encoding the transcription factor carbohydrate-responsive element-binding protein, have been shown to be associated with plasma triglyceride levels. However, the role of these variants in steatotic liver disease (SLD) is unclear. Methods: We used a genome-first approach to analyze a variety of metabolic phenotypes and clinical outcomes associated with a common missense variant in MLXIPL, Gln241His, in 2 large biobanks: the UK Biobank and the Penn Medicine Biobank. Results: Carriers of MLXIPL Gln241His were associated with significantly lower serum levels of triglycerides, apolipoprotein-B, gamma-glutamyl transferase, and alkaline phosphatase. Additionally, MLXIPL Gln241His carriers were associated with significantly higher serum levels of HDL cholesterol and alanine aminotransferase. Carriers homozygous for MLXIPL Gln241His showed a higher risk of SLD in 2 unrelated cohorts. Carriers of MLXIPL Gln241His were especially more likely to be diagnosed with SLD if they were female, obese, and/or also carried the PNPLA3 I148M variant. Furthermore, the heterozygous carriage of MLXIPL Gln241His was associated with significantly higher all-cause, liver-related, and cardiovascular mortality rates. Nuclear magnetic resonance metabolomics data indicated that carriage of MLXIPL Gln241His was significantly associated with lower serum levels of VLDL and increased serum levels of HDL cholesterol. Conclusions: Analyses of the MLXIPL Gln241His polymorphism showed a significant association with a higher risk of SLD diagnosis and elevated serum alanine aminotransferase as well as significantly lower serum triglycerides and apolipoprotein-B levels. MLXIPL might, therefore, be a potential pharmacological target for the treatment of SLD and hyperlipidemia, notably for patients at risk. More mechanistic studies are needed to better understand the role of MLXIPL Gln241His on lipid metabolism and steatosis development.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Acyltransferases ; Alanine Transaminase/blood ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics ; Cholesterol, HDL/blood ; Fatty Liver/genetics ; Fatty Liver/blood ; Genetic Predisposition to Disease ; Lipase/genetics ; Lipase/blood ; Lipids/blood ; Membrane Proteins/genetics ; Membrane Proteins/blood ; Mutation, Missense ; Phospholipases A2, Calcium-Independent ; Triglycerides/blood
Chemical Substances	Acyltransferases (EC 2.3.-) ; Alanine Transaminase (EC 2.6.1.2) ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ; Cholesterol, HDL ; Lipase (EC 3.1.1.3) ; Lipids ; Membrane Proteins ; MLXIPL protein, human ; Phospholipases A2, Calcium-Independent (EC 3.1.1.4) ; PNPLA3 protein, human (EC 3.1.1.3) ; Triglycerides
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ISSN	2471-254X
ISSN (online)	2471-254X
DOI	10.1097/HC9.0000000000000427
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Article ; Online: Acclimating Nursing Students After the Pandemic: "It's ASNAP!"

Saylor, Jennifer / Ruelens-Trinkaus, Donna / Graber, Jennifer S / Clark, Lindsey A / Jackson, Zachary / Creasy-Thomas, Joanne / Heilferty, Cathy

The Journal of nursing education

2023 Volume 62, Issue 9, Page(s) 516–518

Abstract: Background: This article describes the development of a comprehensive pilot program, "It's ASNAP!" (Acclimating Nursing Students After the Pandemic). The program incorporated the academic, social, and emotional well-being of undergraduate nursing ... ...

Abstract	Background: This article describes the development of a comprehensive pilot program, "It's ASNAP!" (Acclimating Nursing Students After the Pandemic). The program incorporated the academic, social, and emotional well-being of undergraduate nursing students returning to campus after the coronavirus disease 2019 (COVID-19) pandemic. Method: A purposeful sample of 488 students was recruited to participate via an anonymous survey on the academic, social, and emotional aspects of acclimating back to campus life. Results: A total of 121 undergraduate nursing students responded to the survey. The majority of students reported study groups (79%) and de-stressing events (86%) were the most helpful as they acclimated back to campus. Compared with the emotional and social areas of support, the academic area of support was of highest interest to the students. Conclusion: The "It's ASNAP!" program has been acculturated into the school of nursing to support students via study halls, tutoring, and social activities, as well as resilient threads and listening sessions during finals week.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Education, Nursing, Baccalaureate ; Pandemics ; Students, Nursing ; Emotions
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	410686-6
ISSN	1938-2421 ; 0148-4834
ISSN (online)	1938-2421
ISSN	0148-4834
DOI	10.3928/01484834-20230712-08
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Article ; Online: Elucidating Harm Reduction Principles in a Client-Centered Representative Payee Program.

Abua, Joseph / Hagert, Zack / Baumann, Sara / Batey, Scott / Creasy, Stephanie / Davis, Dana / Kay, Emma / Hawk, Mary

Community mental health journal

2023 Volume 60, Issue 2, Page(s) 366–375

Abstract: Harm Reduction seeks to mitigate harms associated with health behaviors without the expectation that these behaviors be extinguished completely. Client-Centered Representative Payee (CCRP) is an intervention that modifies the US Social Security ... ...

Abstract	Harm Reduction seeks to mitigate harms associated with health behaviors without the expectation that these behaviors be extinguished completely. Client-Centered Representative Payee (CCRP) is an intervention that modifies the US Social Security Administration's (SSA) Representative Payee policy by incorporating relational harm reduction. We used Human-Centered Design (HCD) methods to elucidate ways that harm reduction principles are present in and integral to CCRP and to create a blueprint for replication. Thirteen individuals familiar with CCRP brainstormed 88 statements, which were parsed, consolidated, and then independently assigned by a subgroup of participants to six principles of harm reduction. After refining the data, 29 statements aligning with harm reduction principles remained. Delineating harm reduction within CCRP, which can empower and establish trust with clients, may help other providers identify how to offer representative payee services that are respectful, compassionate, rooted in harm reduction, and ultimately improve client outcomes.
MeSH term(s)	Humans ; Harm Reduction ; Social Security
Language	English
Publishing date	2023-09-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	215855-3
ISSN	1573-2789 ; 0010-3853
ISSN (online)	1573-2789
ISSN	0010-3853
DOI	10.1007/s10597-023-01180-4
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Article ; Online: Preoperative CT and survival data for patients undergoing resection of colorectal liver metastases.

Simpson, Amber L / Peoples, Jacob / Creasy, John M / Fichtinger, Gabor / Gangai, Natalie / Keshavamurthy, Krishna N / Lasso, Andras / Shia, Jinru / D'Angelica, Michael I / Do, Richard K G

Scientific data

2024 Volume 11, Issue 1, Page(s) 172

Abstract: The liver is a common site for the development of metastases in colorectal cancer. Treatment selection for patients with colorectal liver metastases (CRLM) is difficult; although hepatic resection will cure a minority of CRLM patients, recurrence is ... ...

Abstract	The liver is a common site for the development of metastases in colorectal cancer. Treatment selection for patients with colorectal liver metastases (CRLM) is difficult; although hepatic resection will cure a minority of CRLM patients, recurrence is common. Reliable preoperative prediction of recurrence could therefore be a valuable tool for physicians in selecting the best candidates for hepatic resection in the treatment of CRLM. It has been hypothesized that evidence for recurrence could be found via quantitative image analysis on preoperative CT imaging of the future liver remnant before resection. To investigate this hypothesis, we have collected preoperative hepatic CT scans, clinicopathologic data, and recurrence/survival data, from a large, single-institution series of patients (n = 197) who underwent hepatic resection of CRLM. For each patient, we also created segmentations of the liver, vessels, tumors, and future liver remnant. The largest of its kind, this dataset is a resource that may aid in the development of quantitative imaging biomarkers and machine learning models for the prediction of post-resection hepatic recurrence of CRLM.
MeSH term(s)	Humans ; Colorectal Neoplasms/pathology ; Hepatectomy/adverse effects ; Liver Neoplasms/secondary ; Tomography, X-Ray Computed
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Dataset ; Journal Article
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-024-02981-2
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Article ; Online: Community-engaged Processes for Restarting Federally Funded Research in a Community-based Organization during the Coronavirus Disease 2019 Pandemic.

Kay, Emma Sophia / Creasy, Stephanie L / Bruce, Josh / Olaniyan, Abisola / Scheinert, Mary / Batey, D Scott / Hawk, Mary

Progress in community health partnerships : research, education, and action

2022 Volume 16, Issue 2S, Page(s) 99–107

Abstract: Background: Birmingham AIDS Outreach (BAO) is one of three study sites partnering with the University of Pittsburgh Graduate School of Public Health (Pitt Public Health) for a National Institutes of Health-funded randomized controlled trial on a ... ...

Abstract	Background: Birmingham AIDS Outreach (BAO) is one of three study sites partnering with the University of Pittsburgh Graduate School of Public Health (Pitt Public Health) for a National Institutes of Health-funded randomized controlled trial on a financial management intervention for people with HIV who are experiencing homelessness or housing instability. After the onset of the coronavirus disease 2019 (COVID-19) pandemic in March 2020, the study team used a community-engaged approach to adapt research protocols at this site. We sought to describe a community-engaged approach to restarting National Institutes of Health-funded research during the COVID-19 pandemic. Methods: Partners at Pitt Public Health and BAO developed a set of agency-wide COVID-19 policies and procedures for BAO organized around Rhodes' critical elements of community engagement. Conclusions: The challenges presented by COVID-19 in the research sector have provided an opportunity to reevaluate study activities and increase the extent to which research is conducted in a community-centered manner.
MeSH term(s)	COVID-19 ; Community Participation ; Community-Based Participatory Research ; Humans ; Pandemics ; Stakeholder Participation
Language	English
Publishing date	2022-08-15
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2275483-0
ISSN	1557-055X ; 1557-0541
ISSN (online)	1557-055X
ISSN	1557-0541
DOI	10.1353/cpr.2022.0044
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Article: Matrix and analysis metadata standards (MAMS) to facilitate harmonization and reproducibility of single-cell data.

Wang, Yichen / Sarfraz, Irzam / Teh, Wei Kheng / Sokolov, Artem / Herb, Brian R / Creasy, Heather H / Virshup, Isaac / Dries, Ruben / Degatano, Kylee / Mahurkar, Anup / Schnell, Daniel J / Madrigal, Pedro / Hilton, Jason / Gehlenborg, Nils / Tickle, Timothy / Campbell, Joshua D

bioRxiv : the preprint server for biology

2023

Abstract: A large number of genomic and imaging datasets are being produced by consortia that seek to characterize healthy and disease tissues at single-cell resolution. While much effort has been devoted to capturing information related to biospecimen information ...

Abstract	A large number of genomic and imaging datasets are being produced by consortia that seek to characterize healthy and disease tissues at single-cell resolution. While much effort has been devoted to capturing information related to biospecimen information and experimental procedures, the metadata standards that describe data matrices and the analysis workflows that produced them are relatively lacking. Detailed metadata schema related to data analysis are needed to facilitate sharing and interoperability across groups and to promote data provenance for reproducibility. To address this need, we developed the Matrix and Analysis Metadata Standards (MAMS) to serve as a resource for data coordinating centers and tool developers. We first curated several simple and complex "use cases" to characterize the types of feature-observation matrices (FOMs), annotations, and analysis metadata produced in different workflows. Based on these use cases, metadata fields were defined to describe the data contained within each matrix including those related to processing, modality, and subsets. Suggested terms were created for the majority of fields to aid in harmonization of metadata terms across groups. Additional provenance metadata fields were also defined to describe the software and workflows that produced each FOM. Finally, we developed a simple list-like schema that can be used to store MAMS information and implemented in multiple formats. Overall, MAMS can be used as a guide to harmonize analysis-related metadata which will ultimately facilitate integration of datasets across tools and consortia. MAMS specifications, use cases, and examples can be found at https://github.com/single-cell-mams/mams/.
Language	English
Publishing date	2023-03-07
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.03.06.531314
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Article ; Online: Observations of Mantle Seismic Anisotropy Using Array Techniques: Shear‐Wave Splitting of Beamformed SmKS Phases

Wolf, Jonathan / Frost, Daniel A. / Long, Maureen D. / Garnero, Edward / Aderoju, Adeolu O. / Creasy, Neala / Bozdağ, Ebru

Journal of Geophysical Research: Solid Earth. 2023 Jan., v. 128, no. 1 p.e2022JB025556-

2023

Abstract: Shear‐wave splitting measurements are commonly used to resolve seismic anisotropy in both the upper and lowermost mantle. Typically, such techniques are applied to SmKS phases that have reflected (m‐1) times off the underside of the core‐mantle boundary ... ...

Abstract	Shear‐wave splitting measurements are commonly used to resolve seismic anisotropy in both the upper and lowermost mantle. Typically, such techniques are applied to SmKS phases that have reflected (m‐1) times off the underside of the core‐mantle boundary before being recorded. Practical constraints for shear‐wave splitting studies include the limited number of suitable phases as well as the large fraction of available data discarded because of poor signal‐to‐noise ratios (SNRs) or large measurement uncertainties. Array techniques such as beamforming are commonly used in observational seismology to enhance SNRs, but have not been applied before to improve SmKS signal strength and coherency for shear wave splitting studies. Here, we investigate how a beamforming methodology, based on slowness and backazimuth vespagrams to determine the most coherent incoming wave direction, can improve shear‐wave splitting measurement confidence intervals. Through the analysis of real and synthetic seismograms, we show that (a) the splitting measurements obtained from the beamformed seismograms (beams) reflect an average of the single‐station splitting parameters that contribute to the beam; (b) the beams have (on average) more than twice as large SNRs than the single‐station seismograms that contribute to the beam; (c) the increased SNRs allow the reliable measurement of shear wave splitting parameters from beams down to average single‐station SNRs of 1.3. Beamforming may thus be helpful to more reliably measure splitting due to upper mantle anisotropy. Moreover, we show that beamforming holds potential to greatly improve detection of lowermost mantle anisotropy by demonstrating differential SKS–SKKS splitting analysis using beamformed USArray data.
Keywords	anisotropy ; geophysics ; research ; signal strength
Language	English
Dates of publication	2023-01
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ISSN	2169-9313
DOI	10.1029/2022JB025556
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A coding variant in the microsomal triglyceride transfer protein reduces both hepatic steatosis and plasma lipids.

Schneider, Carolin V / Hehl, Leonida / Creasy, Kate T / Vitali, Cecilia / Vell, Mara S / Vujkovic, Marijana / Park, Joseph / Scorletti, Eleonora / Seeling, Katharina S / Rendel, Miriam D / Conlon, Donna M / Huang, Helen / Zandvakili, Inuk / Valmiki, Swati / Schneider, Kai Markus / Hussain, M Mahmood / Rader, Daniel J

Alimentary pharmacology & therapeutics

2023 Volume 58, Issue 2, Page(s) 238–249

Abstract: Background: Genetic inactivation and pharmacologic inhibition of the microsomal triglyceride transfer protein (MTP; gene name MTTP) inhibits hepatic secretion of VLDL, thereby reducing serum lipids and apoB at the expense of increasing hepatic steatosis. ...

Abstract	Background: Genetic inactivation and pharmacologic inhibition of the microsomal triglyceride transfer protein (MTP; gene name MTTP) inhibits hepatic secretion of VLDL, thereby reducing serum lipids and apoB at the expense of increasing hepatic steatosis. Aim: To examine the effects of missense variants in MTTP on hepatic and circulating lipids. Methods: We analysed the association of MTTP missense variants with metabolic, hepatic and clinical phenotypes in the Penn Medicine Biobank (PMBB; n = 37,960) and the UKBiobank (UKB; n = 451,444). Results: We analysed 24 missense variants in MTTP in PMBB for association with biopsy-proven hepatic steatosis and found that an isoleucine 128 to threonine variant (I128T: rs3816873-A, frequency 26%) was associated with reduced steatosis (p < 0.001). PMBB subjects with imaging-proven steatosis also revealed significantly fewer carriers of MTTP I128T compared to controls. Analysis in UKB also showed that MTTP I128T was associated with reduced risk of hepatic steatosis. Unexpectedly, MTTP I128T was found to be associated with reduced plasma levels of LDL-cholesterol and apoB (all p < 0.001). Functional studies indicated that MTTP I128T is neither a classic loss nor gain of function allele. Conclusions: MTTP I128T is associated with reduced hepatic steatosis as well as reduced plasma lipids and apoB. This paradoxical profile is not consistent with a simple gain or loss of function in MTP activity and suggests a more complex effect on MTP function. Further investigation of MTTP I128T will provide insight into the structure-function of MTP and potentially new approaches to modulate MTP activity that could both reduce hepatic and circulating lipids.
MeSH term(s)	Humans ; Carrier Proteins/genetics ; Fatty Liver/genetics ; Apolipoproteins B/genetics ; Apolipoproteins B/metabolism
Chemical Substances	microsomal triglyceride transfer protein ; Carrier Proteins ; Apolipoproteins B
Language	English
Publishing date	2023-05-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.17566
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Article ; Online: Computerized Diagnosis of Liver Tumors From CT Scans Using a Deep Neural Network Approach.

Midya, Abhishek / Chakraborty, Jayasree / Srouji, Rami / Narayan, Raja R / Boerner, Thomas / Zheng, Jian / Pak, Linda M / Creasy, John M / Escobar, Luz A / Harrington, Kate A / Gonen, Mithat / D'Angelica, Michael I / Kingham, T Peter / Do, Richard K G / Jarnagin, William R / Simpson, Amber L

IEEE journal of biomedical and health informatics

2023 Volume 27, Issue 5, Page(s) 2456–2464

Abstract: The liver is a frequent site of benign and malignant, primary and metastatic tumors. Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most common primary liver cancers, and colorectal liver metastasis (CRLM) is the most ... ...

Abstract	The liver is a frequent site of benign and malignant, primary and metastatic tumors. Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most common primary liver cancers, and colorectal liver metastasis (CRLM) is the most common secondary liver cancer. Although the imaging characteristic of these tumors is central to optimal clinical management, it relies on imaging features that are often non-specific, overlap, and are subject to inter-observer variability. Thus, in this study, we aimed to categorize liver tumors automatically from CT scans using a deep learning approach that objectively extracts discriminating features not visible to the naked eye. Specifically, we used a modified Inception v3 network-based classification model to classify HCC, ICC, CRLM, and benign tumors from pretreatment portal venous phase computed tomography (CT) scans. Using a multi-institutional dataset of 814 patients, this method achieved an overall accuracy rate of 96%, with sensitivity rates of 96%, 94%, 99%, and 86% for HCC, ICC, CRLM, and benign tumors, respectively, using an independent dataset. These results demonstrate the feasibility of the proposed computer-assisted system as a novel non-invasive diagnostic tool to classify the most common liver tumors objectively.
MeSH term(s)	Humans ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology ; Carcinoma, Hepatocellular/diagnostic imaging ; Neural Networks, Computer ; Tomography, X-Ray Computed ; Cholangiocarcinoma/pathology ; Bile Ducts, Intrahepatic/pathology ; Bile Duct Neoplasms/pathology
Language	English
Publishing date	2023-05-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2695320-1
ISSN	2168-2208 ; 2168-2194
ISSN (online)	2168-2208
ISSN	2168-2194
DOI	10.1109/JBHI.2023.3248489
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