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Article ; Online: EBCOG position statement inequalities in antenatal care provision in Europe: In the wake of an EBCOG survey.

Khattak, Hajra / Messinis, Ioannis E / Mukhopadhyay, Sambit / Mahmood, Tahir

European journal of obstetrics, gynecology, and reproductive biology

2022 Volume 279, Page(s) 107–108

Abstract: Health inequalities adversely affect the health outcomes generally but more so for those who are socially deprived, immigrants of unknown status and low socioeconomic status. The inequitable access to care during pregnancy can lead to long term adverse ... ...

Abstract	Health inequalities adversely affect the health outcomes generally but more so for those who are socially deprived, immigrants of unknown status and low socioeconomic status. The inequitable access to care during pregnancy can lead to long term adverse inter-generational effects. Current economic crisis within Europe will have deepening effect on the health of the vulnerable families. The European Board and College of Obstetrics and Gynaecology calls for action by the European Union.
MeSH term(s)	Female ; Pregnancy ; Humans ; Prenatal Care ; Gynecology ; Obstetrics ; Europe ; European Union ; Socioeconomic Factors
Language	English
Publishing date	2022-10-15
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2022.10.011
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Article ; Online: Response to: Premature ovulation; is any risk small enough to take when avoidable?

Messinis, Ioannis E / Messini, Christina I / Anifandis, George / Daponte, Alexandros

Reproductive biomedicine online

2021 Volume 43, Issue 3, Page(s) 580

MeSH term(s)	Female ; Fertilization in Vitro ; Humans ; Ovulation
Language	English
Publishing date	2021-07-23
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	2113823-0
ISSN	1472-6491 ; 1472-6483
ISSN (online)	1472-6491
ISSN	1472-6483
DOI	10.1016/j.rbmo.2021.07.009
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Article ; Online: Exogenous progesterone for LH surge prevention is redundant in ovarian stimulation protocols.

Messinis, Ioannis E / Messini, Christina I / Anifandis, George / Daponte, Alexandros

Reproductive biomedicine online

2021 Volume 42, Issue 4, Page(s) 694–697

Abstract: ... in which the 'freeze-all' protocol has been selected from the outset (e.g. donors), but the need for this has not been ...

Abstract	During ovarian stimulation for IVF-embryo transfer treatment, a premature LH surge may lead to progesterone elevation that disrupts endometrial maturation and affects the probability of pregnancy following fresh embryo transfer. Preventing this LH surge and progesterone elevation using gonadotrophin-releasing hormone (GnRH) analogues is considered a standard practice. The same policy applies to cycles in which the 'freeze-all' protocol has been selected from the outset (e.g. donors), but the need for this has not been discussed. Moreover, in 'freeze-all' cycles, exogenous progesterone administration tends to replace GnRH antagonists, without reducing efficacy after embryo transfer in frozen-thawed cycles. Nevertheless, as exogenous progesterone is expected to have the same impact on the endometrium as endogenous progesterone, it is clear that, unlike in fresh cycles, in 'freeze-all' cycles an endogenous LH surge prevention does not seem necessary. Therefore, both GnRH antagonists and exogenous progesterone appear to be redundant in 'freeze-all' cycles, and in this context the indications for the use of GnRH analogues in ovarian stimulation protocols need to be revisited.
MeSH term(s)	Female ; Gonadotropin-Releasing Hormone/analogs & derivatives ; Gonadotropin-Releasing Hormone/antagonists & inhibitors ; Humans ; Luteinizing Hormone/blood ; Ovulation Induction/methods ; Progesterone/administration & dosage
Chemical Substances	Gonadotropin-Releasing Hormone (33515-09-2) ; Progesterone (4G7DS2Q64Y) ; Luteinizing Hormone (9002-67-9)
Language	English
Publishing date	2021-01-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2113823-0
ISSN	1472-6491 ; 1472-6483
ISSN (online)	1472-6491
ISSN	1472-6483
DOI	10.1016/j.rbmo.2021.01.017
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Article ; Online: Enhancing Internet of Medical Things security with artificial intelligence: A comprehensive review.

Messinis, Sotirios / Temenos, Nikos / Protonotarios, Nicholas E / Rallis, Ioannis / Kalogeras, Dimitrios / Doulamis, Nikolaos

Computers in biology and medicine

2024 Volume 170, Page(s) 108036

Abstract: Over the past five years, interest in the literature regarding the security of the Internet of Medical Things (IoMT) has increased. Due to the enhanced interconnectedness of IoMT devices, their susceptibility to cyber-attacks has proportionally escalated. ...

Abstract	Over the past five years, interest in the literature regarding the security of the Internet of Medical Things (IoMT) has increased. Due to the enhanced interconnectedness of IoMT devices, their susceptibility to cyber-attacks has proportionally escalated. Motivated by the promising potential of AI-related technologies to improve certain cybersecurity measures, we present a comprehensive review of this emerging field. In this review, we attempt to bridge the corresponding literature gap regarding modern cybersecurity technologies that deploy AI techniques to improve their performance and compensate for security and privacy vulnerabilities. In this direction, we have systematically gathered and classified the extensive research on this topic. Our findings highlight the fact that the integration of machine learning (ML) and deep learning (DL) techniques improves both the performance of cybersecurity measures and their speed, reliability, and effectiveness. This may be proven to be useful for improving the security and privacy of IoMT devices. Furthermore, by considering the numerous advantages of AI technologies as opposed to their core cybersecurity counterparts, including blockchain, anomaly detection, homomorphic encryption, differential privacy, federated learning, and so on, we provide a structured overview of the current scientific trends. We conclude with considerations for future research, emphasizing the promising potential of AI-driven cybersecurity in the IoMT landscape, especially in patient data protection and in data-driven healthcare.
MeSH term(s)	Humans ; Artificial Intelligence ; Reproducibility of Results ; Internet ; Machine Learning ; Computer Security
Language	English
Publishing date	2024-01-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2024.108036
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Article ; Online: EBCOG position statement: Inequality in fertility treatment in people of colour.

Messinis, Ioannis E / Messini, Christina I / Anifandis, Georgios M / Daponde, Alexandros / Mukhopadhyay, Sambit / Mahmood, Tahir

European journal of obstetrics, gynecology, and reproductive biology

2021 Volume 266, Page(s) 74–76

Abstract: Despite advances in promoting sexual and reproductive rights by the United Nations, WHO and UNFPA, inequities in the provision of health care for women exist and are influenced by the socioeconomic status and the ethnicity and the migrant status. Of late, ...

Abstract	Despite advances in promoting sexual and reproductive rights by the United Nations, WHO and UNFPA, inequities in the provision of health care for women exist and are influenced by the socioeconomic status and the ethnicity and the migrant status. Of late, Human Fertility and Embryology Authority (HFEA) of the United Kingdom has identified that inequities exists in quality, accessibility and outcomes of fertility services for people of colour in the UK. EBCOG calls upon the EU Commission to set up a monitoring system akin to HFEA to ensure that all citizens of Europe not only enjoy equitable access to fertility treatments but also the outcomes of interventions meet the highest standards of care.
MeSH term(s)	Female ; Fertility ; Humans ; Reproductive Rights ; Reproductive Techniques, Assisted ; Skin Pigmentation ; United Kingdom
Language	English
Publishing date	2021-09-21
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2021.09.021
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Article ; Online: COVID-19 and fertility: a virtual reality.

Anifandis, George / Messini, Christina I / Daponte, Alexandros / Messinis, Ioannis E

Reproductive biomedicine online

2020 Volume 41, Issue 2, Page(s) 157–159

Abstract: The COVID-19 pandemic is an extraordinary global situation, and all countries have adopted their own strategies to diminish and eliminate the spread of the virus. All measures are in line with the recommendations provided by the World Health Organization. ...

Abstract	The COVID-19 pandemic is an extraordinary global situation, and all countries have adopted their own strategies to diminish and eliminate the spread of the virus. All measures are in line with the recommendations provided by the World Health Organization. Scientific societies, such as the European Society for Human Reproduction and Embryology and American Society for Reproductive Medicine, have provided recommendations and guidance to overcome and flatten the growing curve of infection in patients who undergo IVF treatments. Although there is as yet no evidence that the virus causing COVID-19 might have negative effects on IVF outcomes, fertility treatments have been postponed in order to support healthcare systems by avoiding placing them under additional stress. The possibility of the virus affecting sperm function and egg performance cannot be excluded. In addition, an indirect effect of the virus on gametes and embryos during their manipulation cannot be ruled out. This commentary aims to provide some ideas on the possible effect of the virus on gametes and embryos, as well as how it could affect the normal functioning of the embryology laboratory.
MeSH term(s)	Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Embryo, Mammalian/virology ; Female ; Fertility ; Fertility Clinics/statistics & numerical data ; Fertilization in Vitro/methods ; Fertilization in Vitro/statistics & numerical data ; Humans ; Male ; Oocytes/virology ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pregnancy ; Reproductive Techniques, Assisted/statistics & numerical data ; SARS-CoV-2 ; Spermatozoa/virology ; Treatment Outcome
Keywords	covid19
Language	English
Publishing date	2020-05-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2113823-0
ISSN	1472-6491 ; 1472-6483
ISSN (online)	1472-6491
ISSN	1472-6483
DOI	10.1016/j.rbmo.2020.05.001
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Article: The Contribution of Functional Near-Infrared Spectroscopy (fNIRS) to the Study of Neurodegenerative Disorders: A Narrative Review.

Liampas, Ioannis / Danga, Freideriki / Kyriakoulopoulou, Panagiota / Siokas, Vasileios / Stamati, Polyxeni / Messinis, Lambros / Dardiotis, Efthimios / Nasios, Grigorios

Diagnostics (Basel, Switzerland)

2024 Volume 14, Issue 6

Abstract: Functional near-infrared spectroscopy (fNIRS) is an innovative neuroimaging method that offers several advantages over other commonly used modalities. This narrative review investigated the potential contribution of this method to the study of ... ...

Abstract	Functional near-infrared spectroscopy (fNIRS) is an innovative neuroimaging method that offers several advantages over other commonly used modalities. This narrative review investigated the potential contribution of this method to the study of neurodegenerative disorders. Thirty-four studies involving patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), frontotemporal dementia (FTD), Parkinson's disease (PD), or amyotrophic lateral sclerosis (ALS) and healthy controls were reviewed. Overall, it was revealed that the prefrontal cortex of individuals with MCI may engage compensatory mechanisms to support declining brain functions. A rightward shift was suggested to compensate for the loss of the left prefrontal capacity in the course of cognitive decline. In parallel, some studies reported the failure of compensatory mechanisms in MCI and early AD; this lack of appropriate hemodynamic responses may serve as an early biomarker of neurodegeneration. One article assessing FTD demonstrated a heterogeneous cortical activation pattern compared to AD, indicating that fNIRS may contribute to the challenging distinction of these conditions. Regarding PD, there was evidence that cognitive resources (especially executive function) were recruited to compensate for locomotor impairments. As for ALS, fNIRS data support the involvement of extra-motor networks in ALS, even in the absence of measurable cognitive impairment.
Language	English
Publishing date	2024-03-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics14060663
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Article: Ovarian Stimulation with FSH Alone versus FSH plus a GnRH Antagonist for Elective Freezing in an Oocyte Donor/Recipient Programme: A Protocol for a Pilot Multicenter Observational Study.

Messinis, Ioannis E / Messini, Christina I / Papanikolaou, Evangelos G / Makrakis, Evangelos / Loutradis, Dimitrios / Christoforidis, Nikolaos / Arkoulis, Theodosis / Anifandis, Georgios / Daponte, Alexandros / Siristatidis, Charalampos

Journal of clinical medicine

2023 Volume 12, Issue 7

Abstract: Preliminary data have shown that it is possible to attempt in vitro fertilization (IVF) treatment in fresh cycles without the use of a gonadotropin-releasing hormone (GnRH) antagonist or any other medication to prevent the luteinizing hormone (LH) surge ... ...

Abstract	Preliminary data have shown that it is possible to attempt in vitro fertilization (IVF) treatment in fresh cycles without the use of a gonadotropin-releasing hormone (GnRH) antagonist or any other medication to prevent the luteinizing hormone (LH) surge during ovarian stimulation. To date, there is no information on this topic in the context of a prospective controlled trial. However, as prevention of the LH surge is an established procedure in fresh cycles, the question is whether such a study can be performed in frozen cycles. We aim to perform a pilot study in order to compare the efficacy of a protocol using FSH alone with that of a protocol using follicle-stimulating hormone (FSH) plus a GnRH antagonist for controlled ovarian hyperstimulation (COH) in cycles of elective freezing in the context of a donor/recipient program. This is a seven-center, two-arm prospective pilot cohort study conducted at the respective Assisted Reproductive Units in Greece. The hypothesis to be tested is that an ovarian stimulation protocol that includes FSH alone without any LH surge prevention regimens is not inferior to a protocol including FSH plus a GnRH antagonist in terms of the clinical outcome in a donor/recipient model. The results of the present study are expected to show whether the addition of the GnRH antagonist is necessary in terms of the frequency of LH secretory peaks and progesterone elevations >1 ng/mL during the administration of the GnRH antagonist according to the adopted frequency of blood sampling in all Units.
Language	English
Publishing date	2023-04-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12072743
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Article ; Online: Evaluation of the Efficacy and Feasibility of a Telerehabilitation Program Using Language and Cognitive Exercises in Multi-Domain Amnestic Mild Cognitive Impairment.

Nousia, Anastasia / Pappa, Evangelia / Siokas, Vasileios / Liampas, Ioannis / Tsouris, Zisis / Messinis, Lambros / Patrikelis, Panayiotis / Manouilidou, Christina / Dardiotis, Efthimios / Nasios, Grigorios

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

2022 Volume 38, Issue 2, Page(s) 224–235

Abstract: ... e.g., psychotherapy or/and physiotherapy). Duration of the telerehabilitation intervention was 15 ...

Abstract	Objective: The aim of the present study was to investigate the efficacy and feasibility of a telerehabilitation program in multi-domain amnestic Mild Cognitive Impairment (md-aMCI). The study sample consisted of 30 patients with md-aMCI and aged 60-80 years. Methods: The participants were randomly divided into two groups. The Training Group (TG), which received cognitive training by using the RehaCom software as well as paper-pencil language training and the Control Group (CG) which received standard clinical care (e.g., psychotherapy or/and physiotherapy). Duration of the telerehabilitation intervention was 15 weeks (twice a week for 60 min/session). Results: Our results revealed that the neuropsychological performance of the TG group after the telerehabilitation intervention improved on a statistically significant level on the domains of delayed and working memory, confrontation naming, verbal fluency, and global cognition. Comparison between the TG and CG revealed a significant impact of the telerehabilitation program on the domains of memory (delay and working) and language (naming and verbal fluency) as well as global cognition performance. Conclusion: The findings of the study are promising in that the telerehabilitation intervention appears to be a useful method in improving or stabilizing cognitive decline in md-aMCI individuals and was a particularly effective alternative approach during the period of the pandemic lockdown. Specifically, the beneficial impact of the telerehabilitation intervention on episodic memory (which is one of the first domains to show impairment in md-aMCI patients) provides us with hope and evidence that these types of interventions may be applied with similar success using face-to-face interventions.
MeSH term(s)	Humans ; Telerehabilitation ; Feasibility Studies ; Neuropsychological Tests ; Cognitive Dysfunction/psychology ; Cognition ; Language
Language	English
Publishing date	2022-09-26
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	632972-x
ISSN	1873-5843 ; 0887-6177
ISSN (online)	1873-5843
ISSN	0887-6177
DOI	10.1093/arclin/acac078
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Article ; Online: COVID-19 and fertility

Anifandis, George / Messini, Christina I. / Daponte, Alexandros / Messinis, Ioannis E.

Reproductive BioMedicine Online

a virtual reality

2020 Volume 41, Issue 2, Page(s) 157–159

Keywords	Developmental Biology ; Reproductive Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	2113823-0
ISSN	1472-6491 ; 1472-6483
ISSN (online)	1472-6491
ISSN	1472-6483
DOI	10.1016/j.rbmo.2020.05.001
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