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  1. Article ; Online: Incidental [18F]PSMA-1007 Appendiceal Uptake Mimicking Nodal Disease.

    Nawwar, Ayah Adel / Searle, Julie / Lyburn, Iain Douglas

    Clinical nuclear medicine

    2023  Volume 47, Issue 2, Page(s) 166–167

    Abstract: Abstract: When interpreting an [18F]prostate specific membrane antigen (PSMA)-1007 PET/CT, it is important to understand the normal biodistribution of the tracer. A 73-year-old man with prostate cancer underwent [18F]PSMA-1007 PET/CT for biochemical ... ...

    Abstract Abstract: When interpreting an [18F]prostate specific membrane antigen (PSMA)-1007 PET/CT, it is important to understand the normal biodistribution of the tracer. A 73-year-old man with prostate cancer underwent [18F]PSMA-1007 PET/CT for biochemical recurrence. There was no abnormal uptake in the prostatectomy bed, but PSMA-avid pelvic nodal disease was found. Incidental intense focal uptake was also noted corresponding to the tip of the appendix, which was concluded to be physiological. This is an example of an uncommon site of physiological uptake of [18F]PSMA-1007 in the appendix.
    MeSH term(s) Aged ; Appendix ; Gallium Radioisotopes ; Humans ; Male ; Niacinamide/analogs & derivatives ; Oligopeptides ; Positron Emission Tomography Computed Tomography ; Prostatectomy ; Prostatic Neoplasms/surgery ; Tissue Distribution
    Chemical Substances Gallium Radioisotopes ; Oligopeptides ; PSMA-1007 ; Niacinamide (25X51I8RD4)
    Language English
    Publishing date 2023-09-18
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000003920
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1276: Show issues Location:
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  2. Article ; Online: Bilateral Avid Axillary Nodes on FDG PET/CT Due to Concurrent Booster COVID-19 Immunization and Seasonal Influenza Vaccination.

    Nawwar, Ayah Adel / Searle, Julie / Lyburn, Iain Douglas

    Clinical nuclear medicine

    2022  Volume 47, Issue 8, Page(s) 712–713

    Abstract: Abstract: In an attempt to protect the high-risk demographic and reduce burden on health care systems, concomitant administration of COVID-19 and influenza vaccines has been recommended by health bodies. The ComFluCOV trial indicates this is well ... ...

    Abstract Abstract: In an attempt to protect the high-risk demographic and reduce burden on health care systems, concomitant administration of COVID-19 and influenza vaccines has been recommended by health bodies. The ComFluCOV trial indicates this is well tolerated with no reduction in immune response to either vaccine. A 48-year-old woman with right oropharyngeal squamous cell carcinoma underwent postradiotherapy FDG PET/CT, which demonstrated complete metabolic response. Incidental avid bilateral axillary lymphadenopathy of benign configuration was noted and concluded to be reactive in response to recent Pfizer-BioNTech booster and influenza vaccination. This is expected to be seen more frequently over the coming months.
    MeSH term(s) COVID-19/prevention & control ; Female ; Fluorodeoxyglucose F18/metabolism ; Humans ; Influenza, Human/metabolism ; Influenza, Human/pathology ; Influenza, Human/prevention & control ; Lymph Nodes/pathology ; Middle Aged ; Positron Emission Tomography Computed Tomography ; Seasons ; Vaccination
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2022-04-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000004169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1276: Show issues Location:
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  3. Article ; Online: Systemic Immune Response Syndrome After COVID-19 Immunization-Initial and Follow-up 18F-FDG PET/CT Imaging Appearances.

    Nawwar, Ayah Adel / Searle, Julie / Hagan, Ian / Lyburn, Iain Douglas

    Clinical nuclear medicine

    2022  Volume 47, Issue 3, Page(s) e327–e328

    Abstract: Abstract: A 46-year-old woman with previous history of breast cancer had follow-up 18F-FDG PET/CT 5 days after COVID-19 vaccination. In addition to avid axillary nodes, a well-documented feature, the scan demonstrated diffuse splenic and marrow uptake. ... ...

    Abstract Abstract: A 46-year-old woman with previous history of breast cancer had follow-up 18F-FDG PET/CT 5 days after COVID-19 vaccination. In addition to avid axillary nodes, a well-documented feature, the scan demonstrated diffuse splenic and marrow uptake. Clinical history, laboratory, and scan findings were in keeping with SIRS (systemic inflammatory response). The patient recovered with supportive management. On follow-up, 18F-FDG PET/CT imaging 3 months later features had resolved. SIRS after vaccination may be observed on 18F-FDG PET/CT.
    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Female ; Fluorodeoxyglucose F18 ; Follow-Up Studies ; Humans ; Immunity ; Middle Aged ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; SARS-CoV-2 ; Vaccination
    Chemical Substances COVID-19 Vaccines ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2022-01-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000004032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Features of Systemic Immune Response From COVID-19 Vaccination on 18F-FDG PET/CT.

    Nawwar, Ayah Adel / Searle, Julie / Lyburn, Iain Douglas

    Clinical nuclear medicine

    2021  Volume 47, Issue 1, Page(s) e89–e90

    Abstract: Abstract: The rapid rollout of COVID-19 vaccination is accompanied by incidental findings on 18F-FDG PET/CT. Most cases describe reactive axillary lymphadenopathy. A 46-year-old woman with previous history of stage 3A breast cancer underwent follow-up ... ...

    Abstract Abstract: The rapid rollout of COVID-19 vaccination is accompanied by incidental findings on 18F-FDG PET/CT. Most cases describe reactive axillary lymphadenopathy. A 46-year-old woman with previous history of stage 3A breast cancer underwent follow-up 18F-FDG PET/CT, which demonstrated avid left axillary nodes and intense diffuse splenic uptake and moderate diffuse bone marrow uptake. She had been administered COVID-19 vaccination in the left deltoid 1 week earlier and required hospitalization for 24 hours due to fever. Symptoms settled with supportive treatment. One month after the PET/CT scan, she remained well. Sites of uptake were taken to relate to a systemic immune response.
    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Female ; Fluorodeoxyglucose F18 ; Humans ; Immunity ; Middle Aged ; Positron Emission Tomography Computed Tomography ; SARS-CoV-2 ; Vaccination
    Chemical Substances COVID-19 Vaccines ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2021-06-22
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000003859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: COVID-19 vaccination induced axillary nodal uptake on [18F]FDG PET/CT.

    Nawwar, Ayah Adel / Searle, Julie / Hagan, Ian / Lyburn, Iain Douglas

    European journal of nuclear medicine and molecular imaging

    2021  Volume 48, Issue 8, Page(s) 2655–2656

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Fluorodeoxyglucose F18 ; Humans ; Lymph Nodes ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Radiopharmaceuticals ; SARS-CoV-2 ; Vaccination
    Chemical Substances COVID-19 Vaccines ; Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2021-02-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-021-05274-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1227: Show issues Location:
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  6. Article ; Online: Oxford-AstraZeneca COVID-19 vaccination induced lymphadenopathy on [18F]Choline PET/CT-not only an FDG finding.

    Nawwar, Ayah Adel / Searle, Julie / Singh, Rajiv / Lyburn, Iain Douglas

    European journal of nuclear medicine and molecular imaging

    2021  Volume 48, Issue 8, Page(s) 2657–2658

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Choline ; Fluorodeoxyglucose F18 ; Humans ; Lymphadenopathy/chemically induced ; Lymphadenopathy/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; Radiopharmaceuticals ; SARS-CoV-2 ; Vaccination
    Chemical Substances COVID-19 Vaccines ; Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Choline (N91BDP6H0X)
    Language English
    Publishing date 2021-03-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-021-05279-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: [18F]FDG-PET/CT Demonstration of Young Adult Onset Stills Disease Mimicking Lymphoma.

    Nawwar, Ayah Adel / Searle, Julie / Hodby, Katherine / Chavda, Nikesh Dhiraj / Qamhia, Naim / Lyburn, Iain Douglas

    BJR case reports

    2022  Volume 8, Issue 3, Page(s) 20210195

    Abstract: Adult-onset Still's disease (AOSD) is an inflammatory disease of unknown aetiology, with no specific diagnostic tests. A 17-year-old female presented with fevers, night sweats and weight loss. Markedly FDG avid lymphadenopathy, and diffuse marrow and ... ...

    Abstract Adult-onset Still's disease (AOSD) is an inflammatory disease of unknown aetiology, with no specific diagnostic tests. A 17-year-old female presented with fevers, night sweats and weight loss. Markedly FDG avid lymphadenopathy, and diffuse marrow and splenic uptake were demonstrated on [18F]FDG-PET/CT, most suggestive of lymphoma. After extensive investigations, the working diagnosis of AOSD was made. Other conditions, such AOSD, in addition to lymphoproliferative disorders, should be considered in the differential diagnosis of widespread avid lymphadenopathy in a teenager/young adult.
    Language English
    Publishing date 2022-02-16
    Publishing country England
    Document type Case Reports
    ISSN 2055-7159
    ISSN (online) 2055-7159
    DOI 10.1259/bjrcr.20210195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: False-Positive Axillary Lymph Nodes on FDG PET/CT Resulting From COVID-19 Immunization.

    Nawwar, Ayah Adel / Searle, Julie / Hopkins, Richard / Lyburn, Iain Douglas

    Clinical nuclear medicine

    2021  Volume 46, Issue 12, Page(s) 1004–1005

    Abstract: Abstract: World-wide mass COVID-19 vaccination has been deployed starting with those most vulnerable, including the elderly and cancer patients. A 70-year-old man with right lung cancer underwent staging FDG PET/CT, which demonstrated an avid right lung ...

    Abstract Abstract: World-wide mass COVID-19 vaccination has been deployed starting with those most vulnerable, including the elderly and cancer patients. A 70-year-old man with right lung cancer underwent staging FDG PET/CT, which demonstrated an avid right lung mass with avid hilar and mediastinal nodes. Avid left axillary nodes of benign configuration were also noted. The patient had the Oxford-AstraZeneca COVID-19 vaccination in the left arm a week earlier. On reflection, the axillary nodes were concluded to be reactive related to this. This is a potential COVID-19 vaccination associated pitfall on PET/CT that should be considered when interpreting FDG PET/CT images.
    MeSH term(s) Aged ; COVID-19 ; COVID-19 Vaccines ; Fluorodeoxyglucose F18 ; Humans ; Lymph Nodes/diagnostic imaging ; Male ; Neoplasm Staging ; Positron Emission Tomography Computed Tomography ; SARS-CoV-2 ; Vaccination
    Chemical Substances COVID-19 Vaccines ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2021-04-19
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000003657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pembrolizumab-Induced Thyroiditis and Colitis-Presentation and Resolution on Serial FDG PET/CT.

    Nawwar, Ayah Adel / Searle, Julie / Lyburn, Iain Douglas

    Clinical nuclear medicine

    2020  Volume 46, Issue 2, Page(s) e121–e122

    Abstract: Abstract: A 58-year-old man with previous melanoma of the left leg underwent whole-body 18F-FDG PET/CT to stage metastatic disease prior to commencing pembrolizumab. Follow-up FDG PET/CT after 3 months of treatment showed partial metabolic response of ... ...

    Abstract Abstract: A 58-year-old man with previous melanoma of the left leg underwent whole-body 18F-FDG PET/CT to stage metastatic disease prior to commencing pembrolizumab. Follow-up FDG PET/CT after 3 months of treatment showed partial metabolic response of soft tissue and nodal metastases and diffuse increased thyroid and colonic uptake, suggestive of thyroiditis and colitis. Pembrolizumab was ceased, and a repeat FDG PET/CT scan showed regression of uptake in the thyroid gland and colon, in keeping with resolution of inflammatory change. Immune-related adverse events induced by Immune checkpoint inhibitors, such as pembrolizumab, should be recognized-cessation of treatment often leads to resolution.
    MeSH term(s) Antibodies, Monoclonal, Humanized/adverse effects ; Antibodies, Monoclonal, Humanized/therapeutic use ; Colitis/chemically induced ; Colitis/diagnostic imaging ; Fluorodeoxyglucose F18 ; Humans ; Male ; Melanoma/diagnostic imaging ; Melanoma/drug therapy ; Middle Aged ; Positron Emission Tomography Computed Tomography ; Thyroiditis/chemically induced ; Thyroiditis/diagnostic imaging
    Chemical Substances Antibodies, Monoclonal, Humanized ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; pembrolizumab (DPT0O3T46P)
    Language English
    Publishing date 2020-09-19
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000003306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Infection Control of COVID-19: Surgical Mask-Related Facial Cutaneous Artifact on FDG PET/CT.

    Nawwar, Ayah Adel / Searle, Julie / Green, Christopher / Lyburn, Iain Douglas

    Clinical nuclear medicine

    2020  Volume 46, Issue 4, Page(s) e221–e223

    Abstract: Abstract: In accordance with published international COVID-19 pandemic guidance (American College of Nuclear Medicine, British Nuclear Medicine Society, and European Association of Nuclear Medicine), the use of face masks has become an essential part of ...

    Abstract Abstract: In accordance with published international COVID-19 pandemic guidance (American College of Nuclear Medicine, British Nuclear Medicine Society, and European Association of Nuclear Medicine), the use of face masks has become an essential part of infection control for both patients and staff. A 56-year-old man with mantle cell lymphoma underwent staging FDG PET/CT, which demonstrated avid lymphadenopathy below the diaphragm and an unusual diffuse FDG uptake projected over the face, raising the suspicion of cutaneous lymphomatous involvement. On reflection of the clinical scenario and scanning conditions, cutaneous involvement was discounted; the pattern of uptake and lack of CT correlate were supportive of a cutaneous artifact related to the presence of the patient's mask.
    MeSH term(s) Artifacts ; COVID-19/prevention & control ; Fluorodeoxyglucose F18 ; Humans ; Infection Control ; Lymphoma/diagnostic imaging ; Male ; Masks ; Middle Aged ; Positron Emission Tomography Computed Tomography ; SARS-CoV-2 ; Skin Diseases/diagnostic imaging
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2020-11-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000003424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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