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Article ; Online: Genetic susceptibility to prostate cancer in Taiwan: A genome-wide association study.

Bau, Da-Tian / Tsai, Chia-Wen / Chang, Wen-Shin / Yang, Jai-Sing / Liu, Ting-Yuan / Lu, Hsing-Fang / Wang, Yu-Wen / Tsai, Fuu-Jen

Molecular carcinogenesis

2024 Volume 63, Issue 4, Page(s) 617–628

Abstract: We conducted the first genome-wide association study (GWAS) of prostate cancer (PCa) in Taiwan with 1844 cases and 80,709 controls. Thirteen independent single-nucleotide polymorphisms (SNPs) reached genome-wide significance (p < 5 × ... ...

Abstract	We conducted the first genome-wide association study (GWAS) of prostate cancer (PCa) in Taiwan with 1844 cases and 80,709 controls. Thirteen independent single-nucleotide polymorphisms (SNPs) reached genome-wide significance (p < 5 × 10
MeSH term(s)	Male ; Humans ; Genome-Wide Association Study ; Genotype ; RNA, Long Noncoding/genetics ; Taiwan/epidemiology ; Genetic Predisposition to Disease ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/genetics ; Genetic Risk Score ; Polymorphism, Single Nucleotide ; Microfilament Proteins
Chemical Substances	RNA, Long Noncoding ; CORO2B protein, human ; Microfilament Proteins
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1004029-8
ISSN	1098-2744 ; 0899-1987
ISSN (online)	1098-2744
ISSN	0899-1987
DOI	10.1002/mc.23676
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Article ; Online: Images Combined With Surgical Procedures and Pathological Identification to Distinguish a Reactive Histiocytosis With Organized Hematoma From a Malignant Peripheral Nerve Sheath Tumor.

Chang, Chun-Jen / Chen, Chun-Chung / Cho, DER-Yang / Bau, DA-Tian / Chen, Chao-Hsuan

In vivo (Athens, Greece)

2023 Volume 37, Issue 3, Page(s) 1365–1372

Abstract: Background/aim: Malignant peripheral nerve sheath tumors (MPNST) are rare soft tissue malignant tumors. To the best of our knowledge, there have been no previous reports of benign reactive histiocytosis with hematoma that mimics MPNST on medical images.! ...

Abstract	Background/aim: Malignant peripheral nerve sheath tumors (MPNST) are rare soft tissue malignant tumors. To the best of our knowledge, there have been no previous reports of benign reactive histiocytosis with hematoma that mimics MPNST on medical images. Case report: A 57-year-old female with past history of hypertension came to our clinic due to low back pain with radiculopathy which was diagnosed with a tumor arising from L2 neuroforamen with L2 pedical erosion. Initial tentative diagnosis on the images was MPNST. However, after surgical resection, the pathologic report revealed no evidence of malignancy but only an organized hematoma with reactive histiocytosis. Conclusion: Images cannot provide enough diagnostic evidence for distinguishing a reactive histiocytosis from MPNST. Proper surgical procedures and expert pathological identification can correct the mistaking of the ambiguous identification as MPNST. Images can only provide precise and personalized medication accompanied by proper surgical procedures and expert pathological identification.
MeSH term(s)	Female ; Humans ; Middle Aged ; Nerve Sheath Neoplasms/diagnosis ; Nerve Sheath Neoplasms/surgery ; Nerve Sheath Neoplasms/pathology ; Neurofibrosarcoma/complications ; Histiocytosis/complications
Language	English
Publishing date	2023-04-27
Publishing country	Greece
Document type	Case Reports ; Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.13218
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Article: Impacts of

Wang, Bo-Ren / Chang, Wen-Shin / Liao, Cheng-Hsi / Wang, Yun-Chi / Gu, Jian / Bau, Da-Tian / Tsai, Chia-Wen

Biomedicines

2023 Volume 11, Issue 5

Abstract: The aim of this study was to investigate the association between single-nucleotide polymorphisms (SNPs) ... ...

Abstract	The aim of this study was to investigate the association between single-nucleotide polymorphisms (SNPs) in
Language	English
Publishing date	2023-05-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11051396
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Article ; Online: Let-7g

Hung, Kuang-Chen / Tien, Ni / Bau, Da-Tian / Yao, Chun-Hsu / Chen, Chan-Hung / Yang, Jiun-Long / Lin, Meng-Liang / Chen, Shih-Shun

Cells

2023 Volume 12, Issue 18

Abstract: The aberrant activation of signaling pathways contributes to cancer cells with metabolic reprogramming. Thus, targeting signaling modulators is considered a potential therapeutic strategy for cancer. Subcellular fractionation, coimmunoprecipitation, ... ...

Abstract	The aberrant activation of signaling pathways contributes to cancer cells with metabolic reprogramming. Thus, targeting signaling modulators is considered a potential therapeutic strategy for cancer. Subcellular fractionation, coimmunoprecipitation, biochemical analysis, and gene manipulation experiments revealed that decreasing the interaction of kirsten rat sarcoma viral oncogene homolog (KRAS) with p110α in lipid rafts with the use of naringenin (NGN), a citrus flavonoid, causes lipid raft-associated phosphatidylinositol 3-kinase (PI3K)-GTP-ras-related C3 botulinum toxin substrate 1 (Rac1)-protein kinase B (Akt)-regulated metabolic dysfunction of glycolysis and mitochondrial oxidative phosphorylation (OXPHOS), leading to apoptosis in human nasopharyngeal carcinoma (NPC) cells. The use of
Language	English
Publishing date	2023-09-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12182313
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Article ; Online: Novel genetic variants in long non-coding RNA MEG3 are associated with the risk of asthma

Kuo-Liang Chiu / Wen-Shin Chang / Chia-Wen Tsai / Mei-Chin Mong / Te-Chun Hsia / Da-Tian Bau

PeerJ, Vol 11, p e

2023 Volume 14760

Abstract: Background Asthma is the most common chronic inflammatory airway disease worldwide. Asthma is a complex disease whose exact etiologic mechanisms remain elusive; however, it is increasingly evident that genetic factors play essential roles in the ... ...

Abstract	Background Asthma is the most common chronic inflammatory airway disease worldwide. Asthma is a complex disease whose exact etiologic mechanisms remain elusive; however, it is increasingly evident that genetic factors play essential roles in the development of asthma. The purpose of this study is to identify novel genetic susceptibility loci for asthma in Taiwanese. We selected a well-studied long non-coding RNA (lncRNA), MEG3, which is involved in multiple cellular functions and whose expression has been associated with asthma. We hypothesize that genetic variants in MEG3 may influence the risk of asthma. Methods We genotyped four single nucleotide polymorphisms (SNPs) in MEG3, rs7158663, rs3087918, rs11160608, and rs4081134, in 198 patients with asthma and 453 healthy controls and measured serum MEG3 expression level in a subset of controls. Results The variant AG and AA genotypes of MEG3 rs7158663 were significantly over-represented in the patients compared to the controls (P = 0.0024). In logistic regression analyses, compared with the wild-type GG genotype, the heterozygous variant genotype (AG) was associated with a 1.62-fold [95% confidence interval (CI) [1.18–2.32], P = 0.0093] increased risk and the homozygous variant genotype (AA) conferred a 2.68-fold (95% CI [1.52–4.83], P = 0.003) increased risk of asthma. The allelic test showed the A allele was associated with a 1.63-fold increased risk of asthma (95% CI [1.25–2.07], P = 0.0004). The AG plus AA genotypes were also associated with severe symptoms (P = 0.0148). Furthermore, the AG and AA genotype carriers had lower serum MEG3 expression level than the GG genotype carriers, consistent with the reported downregulation of MEG3 in asthma patients. Conclusion MEG3 SNP rs7158663 is a genetic susceptibility locus for asthma in Taiwanese. Individuals carrying the variant genotypes have lower serum MEG3 level and are at increased risks of asthma and severe symptoms.
Keywords	Asthma ; Genotype ; MEG3 ; Polymorphism ; Transcriptional expression ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
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Article ; Online: Novel genetic variants in long non-coding RNA MEG3 are associated with the risk of asthma.

Chiu, Kuo-Liang / Chang, Wen-Shin / Tsai, Chia-Wen / Mong, Mei-Chin / Hsia, Te-Chun / Bau, Da-Tian

PeerJ

2023 Volume 11, Page(s) e14760

Abstract: Background: Asthma is the most common chronic inflammatory airway disease worldwide. Asthma is a complex disease whose exact etiologic mechanisms remain elusive; however, it is increasingly evident that genetic factors play essential roles in the ... ...

Abstract	Background: Asthma is the most common chronic inflammatory airway disease worldwide. Asthma is a complex disease whose exact etiologic mechanisms remain elusive; however, it is increasingly evident that genetic factors play essential roles in the development of asthma. The purpose of this study is to identify novel genetic susceptibility loci for asthma in Taiwanese. We selected a well-studied long non-coding RNA (lncRNA), Methods: We genotyped four single nucleotide polymorphisms (SNPs) in Results: The variant AG and AA genotypes of Conclusion: MEG3
MeSH term(s)	Humans ; Asthma/genetics ; Genetic Predisposition to Disease ; Genotype ; Polymorphism, Single Nucleotide ; RNA, Long Noncoding/genetics
Chemical Substances	RNA, Long Noncoding ; MEG3 non-coding RNA, human
Language	English
Publishing date	2023-01-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.14760
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Article ; Online: A Genome-Wide Association Study Identified Novel Genetic Susceptibility Loci for Oral Cancer in Taiwan.

Bau, Da-Tian / Liu, Ting-Yuan / Tsai, Chia-Wen / Chang, Wen-Shin / Gu, Jian / Yang, Jai-Sing / Shih, Liang-Chun / Tsai, Fuu-Jen

International journal of molecular sciences

2023 Volume 24, Issue 3

Abstract: Taiwan has the highest incidence rate of oral cancer in the world. Although oral cancer is mostly an environmentally induced cancer, genetic factors also play an important role in its etiology. Genome-wide association studies (GWAS) have identified nine ... ...

Abstract	Taiwan has the highest incidence rate of oral cancer in the world. Although oral cancer is mostly an environmentally induced cancer, genetic factors also play an important role in its etiology. Genome-wide association studies (GWAS) have identified nine susceptibility regions for oral cancers in populations of European descent. In this study, we performed the first GWAS of oral cancer in Taiwan with 1529 cases and 44,572 controls. We confirmed two previously reported loci on the 6p21.33 (HLA-B) and 6p21.32 (HLA-DQ gene cluster) loci, highlighting the importance of the human leukocyte antigen and, hence, the immunologic mechanisms in oral carcinogenesis. The TERT-CLMPT1L locus on 5p15.33, the 4q23 ADH1B locus, and the LAMC3 locus on 9q34.12 were also consistent in the Taiwanese. We found two new independent loci on 6p21.32, rs401775 in SKIV2L gene and rs9267798 in TNXB gene. We also found two suggestive novel Taiwanese-specific loci near the TPRS1 gene on 8q23.3 and in the TMED3 gene on 15q25.1. This study identified both common and unique oral cancer susceptibility loci in the Taiwanese as compared to populations of European descent and shed significant light on the etiology of oral cancer in Taiwan.
MeSH term(s)	Humans ; Genome-Wide Association Study ; Genetic Predisposition to Disease ; Taiwan ; Mouth Neoplasms/genetics ; Genetic Loci ; Histocompatibility Antigens Class I ; Polymorphism, Single Nucleotide ; Case-Control Studies ; Laminin ; Vesicular Transport Proteins
Chemical Substances	Histocompatibility Antigens Class I ; LAMC3 protein, human ; Laminin ; TMED3 protein, human ; Vesicular Transport Proteins
Language	English
Publishing date	2023-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24032789
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Article ; Online: Incidence of Pulmonary and Respiratory Conditions in Gaucher Disease from 2000 to 2020: A Multi-institutional Cohort Study.

Huang, Yu-Nan / Huang, Jing-Yang / Liao, Wen-Ling / Chiang, Shang-Lun / Liu, Kai-Wen / Bau, DA-Tian / Wang, Chung-Hsing / Su, Pen-Hua

In vivo (Athens, Greece)

2023 Volume 37, Issue 5, Page(s) 2276–2283

Abstract: Background/aim: Gaucher disease (GD) is a rare lysosomal storage disorder that can involve the lungs and pulmonary vasculature. The long-term effects of GD on respiratory health remain unclear due to limited data on the natural history of this disease. ... ...

Abstract	Background/aim: Gaucher disease (GD) is a rare lysosomal storage disorder that can involve the lungs and pulmonary vasculature. The long-term effects of GD on respiratory health remain unclear due to limited data on the natural history of this disease. We analyzed electronic health records for 11,004 patients with GD over 10-20 years to determine the incidence of pulmonary hypertension (PH), lung disease, and other respiratory comorbidities and better understand disease course to guide management. Patients and methods: We conducted a retrospective cohort study using the TriNetX research database of 130 million international patients. The incidence of primary/secondary PH, pulmonary heart disease, interstitial/obstructive/restrictive lung disease, pulmonary hemorrhage, and pulmonary embolism was assessed in patients with GD from 2000-2020. Results: Incidence rates of all conditions assessed increased from 10 to 20 years of follow-up. Excess risk of PH, lung disease, and pulmonary hemorrhage was significantly higher in GD patients after 20 versus 10 years. Conclusion: Extended follow-up in GD is associated with substantially higher risks of PH, lung disease and other respiratory comorbidities, highlighting the need for close monitoring and early intervention to mitigate long-term pulmonary decline. Improved understanding of mechanisms driving respiratory deterioration can support the development of novel treatments to optimize outcomes in this population at high risk of pulmonary morbidity and mortality.
MeSH term(s)	Humans ; Gaucher Disease/complications ; Gaucher Disease/epidemiology ; Incidence ; Retrospective Studies ; Lung ; Lung Diseases/etiology ; Lung Diseases/complications ; Cohort Studies ; Hemorrhage/epidemiology ; Hemorrhage/etiology
Language	English
Publishing date	2023-08-29
Publishing country	Greece
Document type	Multicenter Study ; Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.13330
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Article ; Online: The Long-term Lung and Respiratory Outcomes of Acid Sphingomyelinase Deficiency: A 10- and 20-year Follow-up Study.

Huang, Yu-Nan / Chiang, Shang-Lun / Huang, Jing-Yang / Lu, Wen-Li / Bau, DA-Tian / Su, Pen-Hua / Wang, Chung-Hsing

In vivo (Athens, Greece)

2023 Volume 38, Issue 1, Page(s) 437–444

Abstract: Background/aim: Acid sphingomyelinase deficiency (ASMD) is a rare lysosomal storage disorder characterized by sphingomyelin accumulation causing progressive lung disease, respiratory failure, and death.: Patients and methods: This retrospective ... ...

Abstract	Background/aim: Acid sphingomyelinase deficiency (ASMD) is a rare lysosomal storage disorder characterized by sphingomyelin accumulation causing progressive lung disease, respiratory failure, and death. Patients and methods: This retrospective observational study used the TriNetX database of electronic health records for 15,108 patients with ASMD from 2000-2020. After exclusions, 8,980 individuals were followed for 10 or 20 years. Outcomes included incidence and prevalence of respiratory disorders. Associations of age, sex and race were assessed. Results: Nearly all respiratory outcomes increased significantly over 20 versus 10 years. Other respiratory disorders, specified respiratory disorders and secondary pulmonary hypertension exhibited the greatest increases, reflecting progressive lung damage in ASMD. While outcomes were poor overall, older age, male sex, and racial minority status associated with greater risks, indicating differences in disease progression or care. Conclusion: This study confirms the progressive nature of ASMD and need for close monitoring and treatment of pulmonary complications to reduce long-term morbidity and mortality. Genetic testing enabling diagnosis even for milder, adult-onset forms is critical to optimize outcomes.
MeSH term(s)	Adult ; Humans ; Male ; Follow-Up Studies ; Sphingomyelin Phosphodiesterase/genetics ; Niemann-Pick Disease, Type A/diagnosis ; Niemann-Pick Disease, Type A/genetics ; Niemann-Pick Diseases ; Lung
Chemical Substances	Sphingomyelin Phosphodiesterase (EC 3.1.4.12)
Language	English
Publishing date	2023-12-24
Publishing country	Greece
Document type	Observational Study ; Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.13457
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Article ; Online: Elucidation of scandenolone as anti-cancer activity through impairment of the metabolic and signaling vulnerabilities in prostate cancer.

Basavaraj, Praveenkumar / Hsieh, Po-Fan / Jiang, Wen-Ping / Bau, Da-Tian / Huang, Guan-Jhong / Huang, Wen-Chin

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 164, Page(s) 114948

Abstract: Prostate cancer (PCa) is the most prevalent men's cancer in America and Western countries. No effective therapies are currently available for PCa aggressiveness, including castration-resistant progression (CRPC). This study aims at evaluation of the ... ...

Abstract	Prostate cancer (PCa) is the most prevalent men's cancer in America and Western countries. No effective therapies are currently available for PCa aggressiveness, including castration-resistant progression (CRPC). This study aims at evaluation of the prospective efficacy and the molecular mechanism of scandenolone (SCA), a natural isoflavone, in PCa progression. SCA suppressed cell viability and progression and induced apoptosis in PCa cells. SCA inhibited the expression of lipogenesis and cholesterogenesis related key genes. Through inhibition of these metabolic genes, SCA decreased the levels of fatty acids, lipid droplets and cholesterols in PCa cells. Moreover, SCA enhanced the expression of antioxidant factors, including Nrf2, HO-1, catalase and SOD-1, and reduced the ROS levels in PCa cells. Substantially, SCA displayed the potential efficacy on CRPC tumors. This paper offers a new insight into the underlying molecular basis of SCA in PCa cells. By coordinated impairment of the metabolic and signaling vulnerabilities, including lipogenesis, cholesterogenesis, ROS and the AR/PSA axis, SCA could be applied as a novel and promising remedy to cure malignant PCa.
MeSH term(s)	Male ; Humans ; Prostatic Neoplasms, Castration-Resistant/pathology ; Receptors, Androgen/metabolism ; Reactive Oxygen Species/metabolism ; Prospective Studies ; Apoptosis ; Cell Line, Tumor
Chemical Substances	Receptors, Androgen ; Reactive Oxygen Species
Language	English
Publishing date	2023-05-29
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114948
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