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  1. Article: Editorial: Nicotine and its derivatives in disorders of cognition: a challenging new topic of study.

    Gjedde, Albert

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1252705

    Language English
    Publishing date 2023-07-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1252705
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Metabolic and Vascular Imaging Biomarkers for Brain Aging and Alzheimer's Disease

    Lin, Ai-Ling / Gjedde, Albert / Hyder, Fahmeed

    2020  

    Keywords Science: general issues ; Neurosciences ; brain aging ; Alzheimer's disease ; metabolic neuroimaging biomarkers ; vascular neuroimaging biomarkers
    Size 1 electronic resource (242 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230791
    ISBN 9782889639052 ; 2889639053
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book: Physiological imaging of the brain with PET

    Gjedde, Albert

    2001  

    Author's details ed. by Albert Gjedde
    Language English
    Size XXII, 413 S. : Ill., graph. Darst.
    Publisher Academic Press
    Publishing place San Diego u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT012866366
    ISBN 0-12-285751-8 ; 978-0-12-285751-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2000 A 4907 order for loan Magazin

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  4. Article: Four decades of mapping and quantifying neuroreceptors at work

    Gjedde, Albert / Wong, Dean F

    Frontiers in neuroscience

    2022  Volume 16, Page(s) 943512

    Abstract: Decryption of brain images is the basis for the necessary translation of the findings from imaging to information required to meet the demands of clinical intervention. Tools of brain imaging, therefore, must satisfy the conditions dictated by the needs ... ...

    Abstract Decryption of brain images is the basis for the necessary translation of the findings from imaging to information required to meet the demands of clinical intervention. Tools of brain imaging, therefore, must satisfy the conditions dictated by the needs for interpretation in terms of diagnosis and prognosis. In addition, the applications must serve as fundamental research tools that enable the understanding of new therapeutic drugs, including compounds as diverse as antipsychotics, antidepressants, anxiolytics, and drugs serving the relief of symptoms from neurochemical disorders as unrelated as multiple sclerosis, stroke, and dementia. Here we review and explain the kinetics of methods that enable researchers to describe the brain's work and functions. We focus on methods invented by neurokineticists and expanded upon by practitioners during decades of experimental work and on the methods that are particularly useful to predict possible future approaches to the treatment of neurochemical disorders. We provide an overall description of the basic elements of kinetics and the underlying quantification methods, as well as the mathematics of modeling the recorded brain dynamics embedded in the images we obtain
    Language English
    Publishing date 2022-09-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2022.943512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: EEG Frequency Correlates with α

    Kemp, Adam F / Kinnerup, Martin / Johnsen, Birger / Jakobsen, Steen / Nahimi, Adjmal / Gjedde, Albert

    Biomolecules

    2024  Volume 14, Issue 2

    Abstract: Introduction: Increased theta and delta power and decreased alpha and beta power, measured with quantitative electroencephalography (EEG), have been demonstrated to have utility for predicting the development of dementia in patients with Parkinson's ... ...

    Abstract Introduction: Increased theta and delta power and decreased alpha and beta power, measured with quantitative electroencephalography (EEG), have been demonstrated to have utility for predicting the development of dementia in patients with Parkinson's disease (PD). Noradrenaline modulates cortical activity and optimizes cognitive processes. We claim that the loss of noradrenaline may explain cognitive impairment and the pathological slowing of EEG waves. Here, we test the relationship between the number of noradrenergic α
    Methods: We included nineteen patients with PD and thirteen healthy control (HC) subjects in the study. We used positron emission tomography (PET) with [
    Results: PD patients had higher power in the theta and delta bands compared to the HC volunteers. Patients' theta band power was inversely correlated with α
    Conclusions: The findings support the claim that the loss or dysfunction of noradrenergic neurotransmission may relate to the parallel processes of cognitive decline and EEG slowing.
    MeSH term(s) Humans ; Parkinson Disease ; Electroencephalography/methods ; Cognitive Dysfunction ; Norepinephrine ; Receptors, Adrenergic
    Chemical Substances Norepinephrine (X4W3ENH1CV) ; Receptors, Adrenergic
    Language English
    Publishing date 2024-02-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14020209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Transforming Neurology and Psychiatry: Organ-specific PET Instrumentation and Clinical Applications.

    Taha, Ahmed / Alassi, Amer / Gjedde, Albert / Wong, Dean F

    PET clinics

    2023  Volume 19, Issue 1, Page(s) 95–103

    Abstract: PET technology has immense potential for furthering understanding of the brain and associated disorders, including advancements in high-resolution tomographs and hybrid imaging modalities. Novel radiotracers targeting specific neurotransmitter systems ... ...

    Abstract PET technology has immense potential for furthering understanding of the brain and associated disorders, including advancements in high-resolution tomographs and hybrid imaging modalities. Novel radiotracers targeting specific neurotransmitter systems and molecular markers provide opportunities to unveil intricate mechanisms underlying neurologic and psychiatric conditions. As PET imaging techniques and analysis methods continue to be refined, the field is poised to make significant contributions to personalized medicine for more targeted and effective interventions. PET instrumentation has advanced the fields of neurology and psychiatry, providing insights into pathophysiology and development of effective treatments.
    MeSH term(s) Humans ; Positron-Emission Tomography/methods ; Neurology ; Brain/diagnostic imaging ; Tomography, X-Ray Computed ; Psychiatry
    Language English
    Publishing date 2023-10-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2764575-7
    ISSN 1879-9809 ; 1556-8598
    ISSN (online) 1879-9809
    ISSN 1556-8598
    DOI 10.1016/j.cpet.2023.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Einzelsignatur: Show issues

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  7. Article ; Online: Relationship between manual dexterity and left-right asymmetry of anatomical and functional properties of corticofugal tracts revealed by T2-weighted brain images.

    Oka, Noriyuki / Sakoh, Masaharu / Hirayama, Misato / Niiyama, Mayu / Gjedde, Albert

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 2738

    Abstract: The corticofugal tracts (CFT) are key agents of upper limb motor function. Although the tracts form high-intensity regions relative to surrounding tissue in T2-weighted magnetic resonance images (T2WI), the precise relations of signal intensities of the ... ...

    Abstract The corticofugal tracts (CFT) are key agents of upper limb motor function. Although the tracts form high-intensity regions relative to surrounding tissue in T2-weighted magnetic resonance images (T2WI), the precise relations of signal intensities of the left and right CFT regions to hand function are unknown. Here, we tested the hypothesis that the different signal intensities between the left and right CFT signify clinically important differences of hand motor function. Eleven right-handed and eleven left-handed healthy volunteers participated in the study. Based on horizontal T2WI estimates, we confirmed the relationship between the signal intensity ratios of the peak values of each CFT in the posterior limbs of the internal capsules (right CFT vs. left CFT). The ratios included the asymmetry indices of the hand motor functions, including grip and pinch strength, as well as the target test (TT) that expressed the speed and accuracy of hitting a target ([right-hand score - left-hand score]/[right-hand score + left-hand score]), using simple linear regression. The signal intensity ratios of each CFT structure maintained significant linear relations with the asymmetry index of the speed (R
    MeSH term(s) Humans ; Hand/diagnostic imaging ; Brain ; Hand Strength ; Pinch Strength ; Functional Laterality
    Language English
    Publishing date 2023-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-29557-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Dynamic multi-pinhole collimated brain SPECT of Parkinson's disease by [

    Fredensborg, Filip L H / Thilsing-Hansen, Kasper / Simonsen, Jane A / Grupe, Peter / Farahani, Ziba A / Andersen, Christian W / Gjedde, Albert / Hvidsten, Svend

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 6624

    Abstract: We investigated the feasibility of using a dopamine transporter (DaT) tracer ligand ([ ...

    Abstract We investigated the feasibility of using a dopamine transporter (DaT) tracer ligand ([
    MeSH term(s) Humans ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/metabolism ; Feasibility Studies ; Tropanes/metabolism ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Tomography, Emission-Computed, Single-Photon/methods ; Putamen/metabolism ; Brain/diagnostic imaging ; Brain/metabolism
    Chemical Substances 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane (155797-99-2) ; Tropanes ; Dopamine Plasma Membrane Transport Proteins
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-57152-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Effects of transdermal nicotine delivery on cognitive outcomes: A meta-analysis.

    Majdi, Alireza / Sadigh-Eteghad, Saeed / Gjedde, Albert

    Acta neurologica Scandinavica

    2021  Volume 144, Issue 2, Page(s) 179–191

    Abstract: Objective: By the association of nicotinic acetylcholine receptors in the brain, nicotine in the therapeutic window lowers neuronal damage and raises protective factors. These data, however, are contradicted by other findings. Here, we assessed the ... ...

    Abstract Objective: By the association of nicotinic acetylcholine receptors in the brain, nicotine in the therapeutic window lowers neuronal damage and raises protective factors. These data, however, are contradicted by other findings. Here, we assessed the effects of transdermal nicotine administration on cognitive functions in healthy non-smoker adults by systematic review and meta-analysis of clinical trials.
    Methods: We included reports of clinical trials comparing the effects of nicotine patches with placebo in healthy non-smoking adults. The main outcome was the impact of nicotine patches on overall cognitive function with a focus on attention and memory. Standard meta-analytic and statistical methods measured the effect of transdermal nicotine compared with placebo patches.
    Results: We included 31 publications involving 978 subjects. Nicotine patches boosted cognitive function in healthy adults (0.233 SMD, 95%CI, 0.111-0.355, p < .001). Overall heterogeneity of the studies was found to be modest (ϰ
    Conclusion: The meta-analysis showed that transdermal nicotine had statistically significant positive effects on attention, and non-significant effects on memory, in healthy non-smoking adults. The results encourage further studies of the therapeutic potential of nicotine patches in disorders of cognition.
    MeSH term(s) Administration, Cutaneous ; Adult ; Brain/drug effects ; Cognition/drug effects ; Humans ; Male ; Nicotine/administration & dosage ; Smoking Cessation/methods ; Young Adult
    Chemical Substances Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2021-04-26
    Publishing country Denmark
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 90-5
    ISSN 1600-0404 ; 0001-6314
    ISSN (online) 1600-0404
    ISSN 0001-6314
    DOI 10.1111/ane.13436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui I Zs.142: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: In Ischemic Heart Disease, Reduced Sensitivity to Pressure at the Sternum Accompanies Lower Mortality after Five Years: Evidence from a Randomized Controlled Trial.

    Ballegaard, Søren / Faber, Jens / Selmer, Christian / Gyntelberg, Finn / Kreiner, Svend / Karpatschof, Benny / Klausen, Tobias Wirenfeldt / Hjalmarson, Åke / Gjedde, Albert

    Journal of clinical medicine

    2023  Volume 12, Issue 24

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-12-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12247585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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