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Article: The Stability of Social and Behavioral Rhythms and Unexpected Low Rate of Relevant Depressive Symptoms in Old Adults during the COVID-19 Pandemic.

Sancassiani, Federica / Cossu, Giulia / Cantone, Elisa / Romano, Ferdinando / Perra, Alessandra / Urban, Antonio / Pinna, Samantha / Del Giacco, Stefano / Littera, Roberto / Firinu, Davide / Chessa, Luchino / Tramontano, Enzo / Nardi, Antonio Egidio / Carta, Mauro Giovanni

Journal of clinical medicine

2024 Volume 13, Issue 7

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2024-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13072005
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Article ; Online: Synthesis, Structure and (Photo)Catalytic Behavior of Ce-MOFs Containing Perfluoroalkylcarboxylate Linkers: Experimental and Theoretical Insights.

Morelli Venturi, Diletta / Sole Notari, Maria / Trovarelli, Letizia / Mosconi, Edoardo / Alothman, Asma A / Molokova, Anastasia / Ruser, Niklas / Meier, Christoph / Achenbach, Bastian / Lomachenko, Kirill A / Del Giacco, Tiziana / Costantino, Ferdinando / Stock, Norbert

Chemistry (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e202400433

Abstract: Cerium-based Metal-Organic frameworks (Ce-MOFs) are attracting increasing interest due to their similar structural features to zirconium MOFs. The redox behavior of Ce(III/IV) adds a range of properties to the compounds. Recently, perfluorinated linkers ... ...

Abstract	Cerium-based Metal-Organic frameworks (Ce-MOFs) are attracting increasing interest due to their similar structural features to zirconium MOFs. The redox behavior of Ce(III/IV) adds a range of properties to the compounds. Recently, perfluorinated linkers have been used in the synthesis of MOFs to introduce new characteristic into the structure. We report the synthesis and structural characterization of Ce(IV)-based MOFs constructed using two perfluorinated alkyl linkers. Their structure, based on hexanuclear Ce
Language	English
Publishing date	2024-04-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202400433
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Article ; Online: Impact of Exposure to Vaccination and Infection on Cellular and Antibody Response to SARS-CoV-2 in CVID Patients Through COVID-19 Pandemic.

Costanzo, Giulia Anna Maria Luigia / Deiana, Carla Maria / Sanna, Giuseppina / Perra, Andrea / Campagna, Marcello / Ledda, Andrea Giovanni / Coghe, Ferdinando / Palmas, Vanessa / Cappai, Riccardo / Manzin, Aldo / Chessa, Luchino / Del Giacco, Stefano / Firinu, Davide

Journal of clinical immunology

2023 Volume 44, Issue 1, Page(s) 12

Abstract: Purpose: The purpose of this study is to investigate the kinetics of response against SARS-CoV-2 elicited by vaccination and/or breakthrough infection (occurred after 3 doses of BNT162b2) in a cohort CVID patients.: Methods: We measured humoral and ... ...

Abstract	Purpose: The purpose of this study is to investigate the kinetics of response against SARS-CoV-2 elicited by vaccination and/or breakthrough infection (occurred after 3 doses of BNT162b2) in a cohort CVID patients. Methods: We measured humoral and cellular immunity using quantitative anti-spike antibody (anti-S-IgG) and neutralization assay and specific interferon-gamma release assay (IGRA) before and after the third or fourth dose of BNT162b2 and/or after COVID-19. Results: In CVID, 58.3% seroconverted after 2 doses that increased to 77.8% after 3 doses. Between the second and third dose, there was a decline in humoral compartment that led to titers below the cutoff of 1:10 (MNA90%) in CVID. This was paralleled by a significantly lower proportion (30%) and reduced magnitude of the residual cellular response among CVID. The third dose achieved a lower titer of anti-S and nAb against the Wuhan strain than HC and significantly decreased the rate of those showing solely a positive neutralizing activity and those with simultaneous negativity of IGRA and nAbs; the differences in IGRA were overall reduced with respect to HC. At further sampling after breakthrough SARS-COV-2 infection, mostly in the omicron era, or fourth dose, 6 months after the last event, the residual nAb titer to Wuhan strain was still significantly higher in HC, while there was no significant difference of nAbs to BA.1. The rate of IGRA responders was 65.5% in CVID and 90.5% in HC (p=0.04), while the magnitude of response was similar. None of CVID had double negativity to nAbs and IGRA at the last sampling. Conclusion: This data shows an increase of adaptive immunity in CVID after mRNA vaccination in parallel to boosters, accrual number of exposures and formation of hybrid immunity.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19/epidemiology ; BNT162 Vaccine ; Antibody Formation ; Pandemics ; Vaccination ; Antibodies ; Antibodies, Viral ; Antibodies, Neutralizing
Chemical Substances	BNT162 Vaccine ; Antibodies ; Antibodies, Viral ; Antibodies, Neutralizing
Language	English
Publishing date	2023-12-22
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	779361-3
ISSN	1573-2592 ; 0271-9142
ISSN (online)	1573-2592
ISSN	0271-9142
DOI	10.1007/s10875-023-01616-2
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Article: Seroprevalence of SARS-CoV-2 in unselected surgical patients: An update from an unicentric regional study.

Cappellacci, Federico / Anedda, Giacomo / Del Giacco, Stefano / Coghe, Ferdinando / Cappai, Riccardo / Canu, Gian Luigi / Erdas, Enrico / Calò, Pietro Giorgio / Medas, Fabio / Firinu, Davide

Annals of medicine and surgery (2012)

2021 Volume 66, Page(s) 102375

Language	English
Publishing date	2021-05-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2021.102375
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Article: Differences in lethality and diffusion of Covid-19 in countries using different kinds of vaccines.

Journal of public health research

2022 Volume 11, Issue 3, Page(s) 22799036221107062

Abstract: To verify if lethality and diffusivity of Covid-19 correlated with percentage of people vaccinated in different countries and whether results on these indicators were comparable under different types of vaccines. A linear regression analysis was ... ...

Abstract	To verify if lethality and diffusivity of Covid-19 correlated with percentage of people vaccinated in different countries and whether results on these indicators were comparable under different types of vaccines. A linear regression analysis was conducted between vaccines/inhabitant, new cases/inhabitants and ratio deaths/cases. A comparison between the three indicators was carried out in countries subdivided by kind of vaccine. The proportion of vaccinations/inhabitants correlates negatively with proportion of deaths × 100 cases (
Language	English
Publishing date	2022-09-10
Publishing country	United States
Document type	Journal Article
ISSN	2279-9028
ISSN	2279-9028
DOI	10.1177/22799036221107062
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Article ; Online: Rattler-induced aging dynamics in jammed granular systems.

Giacco, Ferdinando / de Arcangelis, Lucilla / Pica Ciamarra, Massimo / Lippiello, Eugenio

Soft matter

2017 Volume 13, Issue 48, Page(s) 9132–9137

Abstract: Granular materials jam when developing a network of contact forces able to resist the applied stresses. Through numerical simulations of the dynamics of the jamming process, we show that the jamming transition does not occur when the kinetic energy ... ...

Abstract	Granular materials jam when developing a network of contact forces able to resist the applied stresses. Through numerical simulations of the dynamics of the jamming process, we show that the jamming transition does not occur when the kinetic energy vanishes. Rather, as the system jams, the kinetic energy becomes dominated by rattler particles, which scatter within their cages. The relaxation of the kinetic energy in the jammed configuration exhibits a double power-law decay, which we interpret in terms of the interplay between backbone and rattler particles.
Language	English
Publishing date	2017-12-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2191476-X
ISSN	1744-6848 ; 1744-683X
ISSN (online)	1744-6848
ISSN	1744-683X
DOI	10.1039/c7sm01976a
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Article ; Online: Chronic spontaneous urticaria: a low-grade disseminated intravascular coagulation only partially reversed by Omalizumab.

Di Pino, Marina / Ruberto, Maria Filomena / Costanzo, Giulia / Firinu, Davide / Piras, Maria Sebastiana / Mura, Mario Nicola / Del Giacco, Stefano / Coghe, Ferdinando / Marongiu, Francesco / Barcellona, Doris

Clinical and experimental medicine

2022 Volume 23, Issue 2, Page(s) 495–502

Abstract: Chronic spontaneous urticaria (CSU) is a disorder characterized by wheals and/or angioedema. The coagulation cascade and inflammation pathways are closely linked together. The aim of our study was first to investigate the dynamics of clot formation in ... ...

Abstract	Chronic spontaneous urticaria (CSU) is a disorder characterized by wheals and/or angioedema. The coagulation cascade and inflammation pathways are closely linked together. The aim of our study was first to investigate the dynamics of clot formation in plasma (Clot Waveform Analysis, CWA) in a group of 47 patients with CSU along with other coagulative parameters dedicated to the study of hypercoagulability, such as D-Dimer, F 1 + 2 peptide, Fibrinogen, Platelet count and Mean Platelet Volume (MPV). Secondly, 23 out of 47 patients were treated with Omalizumab at four administration intervals from T0 to T4. A statistically significant increase in Activated Partial Thromboplastin (aPTT) ratio, D-Dimer, F1 + 2, Platelet count and MPV was found when compared with 53 healthy controls (HC). In contrast, the 2nd Derivative of aPTT showed lower values than those of the HC. No differences were found between 1st derivative of aPTT and Fibrinogen. D-Dimer only showed a significant difference between T0 and T3. An activation of both coagulation and fibrinolysis along with a weaker clot acceleration may be in agreement with a low-grade DIC. The accelerated turnover of platelets expressed by both an increase in platelet count and MPV further supports this pathway in CSU. Omalizumab does not affect the relationship between the immune and the hemostatic systems.
MeSH term(s)	Humans ; Omalizumab/therapeutic use ; Disseminated Intravascular Coagulation ; Urticaria/drug therapy ; Chronic Urticaria ; Fibrinogen
Chemical Substances	Omalizumab (2P471X1Z11) ; Fibrinogen (9001-32-5)
Language	English
Publishing date	2022-05-25
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2053018-3
ISSN	1591-9528 ; 1591-8890
ISSN (online)	1591-9528
ISSN	1591-8890
DOI	10.1007/s10238-022-00838-9
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Zs.A 5481: Show issues

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Article: Previous functional social and behavioral rhythms affect resilience to COVID-19-related stress among old adults.

Journal of public health research

2022 Volume 11, Issue 2

Abstract: Background: Functioning of Social Behavioral Rhythms (SBRs) may affect resilience toward stressful events across different age groups. However, the impact of SBRs on the coronavirus disease of 2019 (COVID-19) in elder people is yet to ascertain, ... ...

Abstract	Background: Functioning of Social Behavioral Rhythms (SBRs) may affect resilience toward stressful events across different age groups. However, the impact of SBRs on the coronavirus disease of 2019 (COVID-19) in elder people is yet to ascertain, representing the aim of the present report. Design and methods: Follow-up of a peer-reviewed randomized controlled trial on exercise on old adults (³65 years), concurrent to the onset of the pandemic-related lockdown. Post-RCT evaluations occurred after further 12 and 36 weeks since the beginning of the lockdown phase. People with Major Depressive Episode (MDE) at week-48 (follow-up endpoint) were deemed as cases, people without such condition were considered controls. MDE was ascertained using the Patient Health Questionnaire-9 (PHQ-9); SBRs functioning at week 12 onward, through the Brief Symptom Rating Scale (BSRS). Results: Seventy-nine individuals (53.2%, females) entered the RCT-follow-up phase. The frequency of MDE did not significantly change before versus during lockdown (OR 2.60, CI95%=0.87-9.13). People with BSRS>1 standard deviation of the whole sample score at week-12 had an inflated risk of DE during lockdown (OR=5.6, 95%CI: 1.5-21.4) compared to those with lower BSRS scores. Such odd hold after excluding individuals with MDD at week-12. The post-hoc analysis could be potentially affected by selection bias. Conclusions: Overall, older adults were resilient during the first phase of the pandemic when functioning of pre-lockdown was still preserved, in contrast to the subsequent evaluations when the impairment of daily rhythms was associated with impaired reliance.
Language	English
Publishing date	2022-03-16
Publishing country	Italy
Document type	Journal Article
ISSN	2279-9028
ISSN	2279-9028
DOI	10.4081/jphr.2022.2768
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Article ; Online: Associative memory of phase-coded spatiotemporal patterns in leaky Integrate and Fire networks.

Scarpetta, Silvia / Giacco, Ferdinando

Journal of computational neuroscience

2012 Volume 34, Issue 2, Page(s) 319–336

Abstract: We study the collective dynamics of a Leaky Integrate and Fire network in which precise relative phase relationship of spikes among neurons are stored, as attractors of the dynamics, and selectively replayed at different time scales. Using an STDP-based ... ...

Abstract	We study the collective dynamics of a Leaky Integrate and Fire network in which precise relative phase relationship of spikes among neurons are stored, as attractors of the dynamics, and selectively replayed at different time scales. Using an STDP-based learning process, we store in the connectivity several phase-coded spike patterns, and we find that, depending on the excitability of the network, different working regimes are possible, with transient or persistent replay activity induced by a brief signal. We introduce an order parameter to evaluate the similarity between stored and recalled phase-coded pattern, and measure the storage capacity. Modulation of spiking thresholds during replay changes the frequency of the collective oscillation or the number of spikes per cycle, keeping preserved the phases relationship. This allows a coding scheme in which phase, rate and frequency are dissociable. Robustness with respect to noise and heterogeneity of neurons parameters is studied, showing that, since dynamics is a retrieval process, neurons preserve stable precise phase relationship among units, keeping a unique frequency of oscillation, even in noisy conditions and with heterogeneity of internal parameters of the units.
MeSH term(s)	Action Potentials/physiology ; Animals ; Humans ; Learning/physiology ; Memory/physiology ; Models, Neurological ; Nerve Net/physiology ; Neural Pathways/physiology ; Neurons/physiology ; Noise ; Nonlinear Dynamics ; Time Factors
Language	English
Publishing date	2012-10-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1230659-9
ISSN	1573-6873 ; 0929-5313
ISSN (online)	1573-6873
ISSN	0929-5313
DOI	10.1007/s10827-012-0423-7
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Zs.A 4250: Show issues

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Article: Covid-19 vaccines work but other factors play a relevant role: a data analysis on spread and mortality in 24 countries.

Carta, Mauro Giovanni / Orrù, Germano / Cossu, Giulia / Velluzzi, Fernanda / Atzori, Laura / Aviles Gonzalez, Cesar Ivan / Romano, Ferdinando / Littera, Roberto / Chessa, Luchino / Firinu, Davide / Del Giacco, Stefano / Restivo, Angelo / Deidda, Simona / Scano, Alessandra / Onali, Simona / Kalcev, Goce / Coghe, Ferinando / Minerba, Luigi

Journal of public health research

2022 Volume 11, Issue 2

Abstract: Background: The aim was to outline a methodology to monitor the impact of vaccinations in different countries comparing at two different times within countries and between countries the frequency of new cases and Covid-19 related deaths and the ... ...

Abstract	Background: The aim was to outline a methodology to monitor the impact of vaccinations in different countries comparing at two different times within countries and between countries the frequency of new cases and Covid-19 related deaths and the percentage of vaccinations conducted. Design and methods: The 25 countries with the largest increase in SARS-CoV-2 cases on 8 August 2021 were evaluated. In each nation was calculated the proportion of Covid-19 deaths divided per new cases x 100 and the proportion of new cases per 1.000 inhabitants on 10 January 2021 (before vaccinations' distribution) and 8 August 2021 (when large percentage of the population had been vaccinated in many countries). Results: The study shows that in the countries with the highest number of cases as of 8 August 2021, the proportion of vaccinations carried out in the population correlates negatively with both the proportion between Covid-19 dead people x100 infected people and with the rate of new cases. However, the proportion of vaccinations does not correlate with the differences in the two same indicators considered in the weeks observed, thus additional factors seem to play an important role. Conclusions: This work indicates that mass vaccination is associated with a lower spread of the pandemic and, to greater extent, with a lowering of mortality in infected people.
Language	English
Publishing date	2022-03-24
Publishing country	Italy
Document type	Journal Article
ISSN	2279-9028
ISSN	2279-9028
DOI	10.4081/jphr.2022.2665
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