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Book ; Online: Zeit in Gesetzen erfasst - G. W. F. Hegels Theorie der Kodifikation

Müller, Michael W.

(Recht und Philosophie ; 10)

2021

Series title	Recht und Philosophie ; 10
Keywords	Jurisprudence & philosophy of law ; Philosophy: logic ; Georg Wilhelm Friedrich Hegel ; Kodifikation ; Rechtsphilosophie
Language	0\|d
Size	1 electronic resource (99 pages)
Publisher	Duncker and Humblot
Publishing place	Berlin
Document type	Book ; Online
Note	German ; Open Access
HBZ-ID	HT021610166
ISBN	978-3-428-58487-1 ; 3-428-58487-2
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: G-quadruplex ligands as potent regulators of lysosomes.

Ferret, Lucille / Alvarez-Valadez, Karla / Rivière, Jennifer / Muller, Alexandra / Bohálová, Natalia / Yu, Luo / Guittat, Lionel / Brázda, Vaclav / Kroemer, Guido / Mergny, Jean-Louis / Djavaheri-Mergny, Mojgan

Autophagy

2023 Volume 19, Issue 7, Page(s) 1901–1915

Abstract: Guanine-quadruplex structures (G4) are unusual nucleic acid conformations formed by guanine-rich DNA and RNA sequences and known to control gene expression mechanisms, from transcription to protein synthesis. So far, a number of molecules that recognize ... ...

Abstract	Guanine-quadruplex structures (G4) are unusual nucleic acid conformations formed by guanine-rich DNA and RNA sequences and known to control gene expression mechanisms, from transcription to protein synthesis. So far, a number of molecules that recognize G4 have been developed for potential therapeutic applications in human pathologies, including cancer and infectious diseases. These molecules are called G4 ligands. When the biological effects of G4 ligands are studied, the analysis is often limited to nucleic acid targets. However, recent evidence indicates that G4 ligands may target other cellular components and compartments such as lysosomes and mitochondria. Here, we summarize our current knowledge of the regulation of lysosome by G4 ligands, underlying their potential functional impact on lysosome biology and autophagic flux, as well as on the transcriptional regulation of lysosomal genes. We outline the consequences of these effects on cell fate decisions and we systematically analyzed G4-prone sequences within the promoter of 435 lysosome-related genes. Finally, we propose some hypotheses about the mechanisms involved in the regulation of lysosomes by G4 ligands.
MeSH term(s)	Humans ; Ligands ; Autophagy ; G-Quadruplexes ; DNA/metabolism ; Guanine
Chemical Substances	Ligands ; DNA (9007-49-2) ; Guanine (5Z93L87A1R)
Language	English
Publishing date	2023-02-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.1080/15548627.2023.2170071
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Article ; Online: Proinflammatory chemokine CXCL14 activates MAS-related G protein-coupled receptor MRGPRX2 and its putative mouse ortholog MRGPRB2.

Al Hamwi, Ghazl / Namasivayam, Vigneshwaran / Büschbell, Beatriz / Gedschold, Robin / Golz, Stefan / Müller, Christa E

Communications biology

2024 Volume 7, Issue 1, Page(s) 52

Abstract: ... CXCL14, whose target is still unknown. Screening of CXCL14 in a panel of human G protein-coupled ... induces robust activation of MRGPRX2 and its putative mouse ortholog MRGPRB2 in G protein-dependent and β ...

Abstract	Patients with idiopathic pulmonary fibrosis show a strongly upregulated expression of chemokine CXCL14, whose target is still unknown. Screening of CXCL14 in a panel of human G protein-coupled receptors (GPCRs) revealed its potent and selective activation of the orphan MAS-related GPCR X2 (MRGPRX2). This receptor is expressed on mast cells and - like CXCL14 - upregulated in bronchial inflammation. CXCL14 induces robust activation of MRGPRX2 and its putative mouse ortholog MRGPRB2 in G protein-dependent and β-arrestin recruitment assays that is blocked by a selective MRGPRX2/B2 antagonist. Truncation combined with mutagenesis and computational studies identified the pharmacophoric sequence of CXCL14 and its presumed interaction with the receptor. Intriguingly, C-terminal domain sequences of CXCL14 consisting of 4 to 11 amino acids display similar or increased potency and efficacy compared to the full CXCL14 sequence (77 amino acids). These results provide a rational basis for the future development of potential idiopathic pulmonary fibrosis therapies.
MeSH term(s)	Animals ; Humans ; Mice ; Amino Acids ; Biological Assay ; Chemokines ; Chemokines, CXC ; Idiopathic Pulmonary Fibrosis/genetics ; Nerve Tissue Proteins/genetics ; Receptors, G-Protein-Coupled/genetics ; Receptors, Neuropeptide
Chemical Substances	Amino Acids ; Chemokines ; Chemokines, CXC ; CXCL14 protein, human ; CXCL14 protein, mouse ; MRGPRX2 protein, human ; Nerve Tissue Proteins ; Receptors, G-Protein-Coupled ; Receptors, Neuropeptide ; Mrgprb2 protein, mouse
Language	English
Publishing date	2024-01-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-023-05739-5
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Article ; Online: The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.

Alexander, Stephen P H / Christopoulos, Arthur / Davenport, Anthony P / Kelly, Eamonn / Mathie, Alistair A / Peters, John A / Veale, Emma L / Armstrong, Jane F / Faccenda, Elena / Harding, Simon D / Davies, Jamie A / Abbracchio, Maria Pia / Abraham, George / Agoulnik, Alexander / Alexander, Wayne / Al-Hosaini, Khaled / Bäck, Magnus / Baker, Jillian G / Barnes, Nicholas M /

Bathgate, Ross / Beaulieu, Jean-Martin / Beck-Sickinger, Annette G / Behrens, Maik / Bernstein, Kenneth E / Bettler, Bernhard / Birdsall, Nigel J M / Blaho, Victoria / Boulay, Francois / Bousquet, Corinne / Bräuner-Osborne, Hans / Burnstock, Geoffrey / Caló, Girolamo / Castaño, Justo P / Catt, Kevin J / Ceruti, Stefania / Chazot, Paul / Chiang, Nan / Chini, Bice / Chun, Jerold / Cianciulli, Antonia / Civelli, Olivier / Clapp, Lucie H / Couture, Réjean / Cox, Helen M / Csaba, Zsolt / Dahlgren, Claes / Dent, Gordon / Douglas, Steven D / Dournaud, Pascal / Eguchi, Satoru / Escher, Emanuel / Filardo, Edward J / Fong, Tung / Fumagalli, Marta / Gainetdinov, Raul R / Garelja, Michael L / de Gasparo, Marc / Gerard, Craig / Gershengorn, Marvin / Gobeil, Fernand / Goodfriend, Theodore L / Goudet, Cyril / Grätz, Lukas / Gregory, Karen J / Gundlach, Andrew L / Hamann, Jörg / Hanson, Julien / Hauger, Richard L / Hay, Debbie L / Heinemann, Akos / Herr, Deron / Hollenberg, Morley D / Holliday, Nicholas D / Horiuchi, Mastgugu / Hoyer, Daniel / Hunyady, László / Husain, Ahsan / IJzerman, Adriaan P / Inagami, Tadashi / Jacobson, Kenneth A / Jensen, Robert T / Jockers, Ralf / Jonnalagadda, Deepa / Karnik, Sadashiva / Kaupmann, Klemens / Kemp, Jacqueline / Kennedy, Charles / Kihara, Yasuyuki / Kitazawa, Takio / Kozielewicz, Pawel / Kreienkamp, Hans-Jürgen / Kukkonen, Jyrki P / Langenhan, Tobias / Larhammar, Dan / Leach, Katie / Lecca, Davide / Lee, John D / Leeman, Susan E / Leprince, Jérôme / Li, Xaria X / Lolait, Stephen J / Lupp, Amelie / Macrae, Robyn / Maguire, Janet / Malfacini, Davide / Mazella, Jean / McArdle, Craig A / Melmed, Shlomo / Michel, Martin C / Miller, Laurence J / Mitolo, Vincenzo / Mouillac, Bernard / Müller, Christa E / Murphy, Philip M / Nahon, Jean-Louis / Ngo, Tony / Norel, Xavier / Nyimanu, Duuamene / O'Carroll, Anne-Marie / Offermanns, Stefan / Panaro, Maria Antonietta / Parmentier, Marc / Pertwee, Roger G / Pin, Jean-Philippe / Prossnitz, Eric R / Quinn, Mark / Ramachandran, Rithwik / Ray, Manisha / Reinscheid, Rainer K / Rondard, Philippe / Rovati, G Enrico / Ruzza, Chiara / Sanger, Gareth J / Schöneberg, Torsten / Schulte, Gunnar / Schulz, Stefan / Segaloff, Deborah L / Serhan, Charles N / Singh, Khuraijam Dhanachandra / Smith, Craig M / Stoddart, Leigh A / Sugimoto, Yukihiko / Summers, Roger / Tan, Valerie P / Thal, David / Thomas, Walter Wally / Timmermans, Pieter B M W M / Tirupula, Kalyan / Toll, Lawrence / Tulipano, Giovanni / Unal, Hamiyet / Unger, Thomas / Valant, Celine / Vanderheyden, Patrick / Vaudry, David / Vaudry, Hubert / Vilardaga, Jean-Pierre / Walker, Christopher S / Wang, Ji Ming / Ward, Donald T / Wester, Hans-Jürgen / Willars, Gary B / Williams, Tom Lloyd / Woodruff, Trent M / Yao, Chengcan / Ye, Richard D

British journal of pharmacology

2023 Volume 180 Suppl 2, Page(s) S23–S144

Abstract: ... of this section can be found at http://onlinelibrary.wiley.com/doi/bph.16177. G protein-coupled receptors are one ...

Abstract	The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.16177. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
MeSH term(s)	Humans ; Databases, Pharmaceutical ; Receptors, G-Protein-Coupled ; Ligands ; Ion Channels/chemistry ; Receptors, Cytoplasmic and Nuclear
Chemical Substances	Receptors, G-Protein-Coupled ; Ligands ; Ion Channels ; Receptors, Cytoplasmic and Nuclear
Language	English
Publishing date	2023-12-18
Publishing country	England
Document type	Journal Article
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/bph.16177
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Article ; Online: Patient-Reported Outcomes in OlympiA: A Phase III, Randomized, Placebo-Controlled Trial of Adjuvant Olaparib in g

Ganz, Patricia A / Bandos, Hanna / Španić, Tanja / Friedman, Sue / Müller, Volkmar / Kuemmel, Sherko / Delaloge, Suzette / Brain, Etienne / Toi, Masakazu / Yamauchi, Hideko / de Dueñas, Eduardo-M / Armstrong, Anne / Im, Seock-Ah / Song, Chuan-Gui / Zheng, Hong / Sarosiek, Tomasz / Sharma, Priyanka / Geng, Cuizhi / Fu, Peifen /

Rhiem, Kerstin / Frauchiger-Heuer, Heike / Wimberger, Pauline / t'Kint de Roodenbeke, Daphné / Liao, Ning / Goodwin, Annabel / Chakiba-Brugère, Camille / Friedlander, Michael / Lee, Keun Seok / Giacchetti, Sylvie / Takano, Toshimi / Henao-Carrasco, Fernando / Virani, Shamsuddin / Valdes-Albini, Frances / Domchek, Susan M / Bane, Charles / McCarron, Edward C / Mita, Monica / Rossi, Giovanna / Rastogi, Priya / Fielding, Anitra / Gelber, Richard D / Scheepers, Elsemieke D / Cameron, David / Garber, Judy / Geyer, Charles E / Tutt, Andrew N J

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2024 Volume 42, Issue 11, Page(s) 1288–1300

Abstract: Purpose: The OlympiA randomized phase III trial compared 1 year of olaparib (OL) or placebo (PL) as adjuvant therapy in patients with germline : Methods: Data were collected before random assignment, and at 6, 12, 18, and 24 months. The primary end ... ...

Abstract	Purpose: The OlympiA randomized phase III trial compared 1 year of olaparib (OL) or placebo (PL) as adjuvant therapy in patients with germline Methods: Data were collected before random assignment, and at 6, 12, 18, and 24 months. The primary end point was fatigue, measured with the Functional Assessment of Chronic Illness Therapy-Fatigue scale. Secondary end points, assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Core 30 item, included nausea and vomiting (NV), diarrhea, and multiple functional domains. Scores were compared between treatment groups using mixed model for repeated measures. Two-sided Results: One thousand five hundred and thirty-eight patients (NACT: 746, ACT: 792) contributed to the analysis. Fatigue severity was statistically significantly greater for OL versus PL, but not clinically meaningfully different by prespecified criteria (≥3 points) at 6 months (diff OL Conclusion: Treatment-emergent symptoms from OL were limited, generally resolving after treatment ended. OL- and PL-treated patients had similar functional scores, slowly improving during the 24 months after (N)ACT and there was no clinically meaningful persistence of fatigue severity in OL-treated patients.
MeSH term(s)	Female ; Humans ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Fatigue/chemically induced ; Mutation ; Nausea ; Patient Reported Outcome Measures ; Phthalazines ; Piperazines ; Quality of Life ; Receptor, ErbB-2 ; Vomiting
Chemical Substances	BRCA1 Protein ; BRCA1 protein, human ; BRCA2 Protein ; BRCA2 protein, human ; ERBB2 protein, human (EC 2.7.10.1) ; olaparib (WOH1JD9AR8) ; Phthalazines ; Piperazines ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Randomized Controlled Trial ; Clinical Trial, Phase III ; Journal Article
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.23.01214
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Article ; Online: When natural antibodies become pathogenic: autoantibodies targeted against G protein-coupled receptors in the pathogenesis of systemic sclerosis.

Akbarzadeh, Reza / Müller, Antje / Humrich, Jens Y / Riemekasten, Gabriela

Frontiers in immunology

2023 Volume 14, Page(s) 1213804

Abstract: ... present in the sera of patients suffering from SSc, functionally active Abs against G protein-coupled ...

Abstract	Systemic sclerosis (SSc) is a chronic, multisystem connective tissue, and autoimmune disease with the highest case-specific mortality and complications among rheumatic diseases. It is characterized by complex and variable features such as autoimmunity and inflammation, vasculopathy, and fibrosis, which pose challenges in understanding the pathogenesis of the disease. Among the large variety of autoantibodies (Abs) present in the sera of patients suffering from SSc, functionally active Abs against G protein-coupled receptors (GPCRs), the most abundant integral membrane proteins, have drawn much attention over the last decades. These Abs play an essential role in regulating the immune system, and their functions are dysregulated in diverse pathological conditions. Emerging evidence indicates that functional Abs targeting GPCRs, such as angiotensin II type 1 receptor (AT1R) and the endothelin-1 type A receptor (ETAR), are altered in SSc. These Abs are part of a network with several GPCR Abs, such as those directed to the chemokine receptors or coagulative thrombin receptors. In this review, we summarize the effects of Abs against GPCRs in SSc pathologies. Extending the knowledge on pathophysiological roles of Abs against GPCRs could provide insights into a better understanding of GPCR contribution to SSc pathogenesis and therefore help in developing potential therapeutic strategies that intervene with pathological functions of these receptors.
MeSH term(s)	Humans ; Autoantibodies ; Scleroderma, Systemic ; Autoimmunity ; Fibrosis ; Receptor, Endothelin A
Chemical Substances	Autoantibodies ; Receptor, Endothelin A
Language	English
Publishing date	2023-06-08
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1213804
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Article: Animals Experimentally Infected with SARS-CoV-2 Generate Functional Autoantibodies against G-Protein-Coupled Receptors.

Wallukat, Gerd / Wernike, Kerstin / Bachamanda Somesh, Dipthi / Mettenleiter, Thomas C / Müller, Johannes

Biomedicines

2023 Volume 11, Issue 10

Abstract: ... including cardiovascular complications. Functional autoantibodies targeting G-protein-coupled receptors have ... activity of functional autoantibodies targeting G-protein-coupled receptors after SARS-CoV-2 infection of selected ... tested positive for functional autoantibodies against G-protein-coupled receptors. These functional ...

Abstract	(1) Background: SARS-CoV-2 infection has been linked to diverse clinical manifestations in humans, including cardiovascular complications. Functional autoantibodies targeting G-protein-coupled receptors have emerged as potential contributors to these effects. This study sought to investigate the production and activity of functional autoantibodies targeting G-protein-coupled receptors after SARS-CoV-2 infection of selected animal species. (2) Methods: The presence of functional autoantibodies such as 2-adrenoceptor, angiotensin II AT1 receptor, muscarinic M2 receptor, and angiotensin 1-7 MAS receptor was assessed in cattle and ferrets experimentally infected with SARS-CoV-2. Bioassays were conducted to evaluate the positive or negative chronotropic responses induced by these autoantibodies. Further experiments identified the extracellular domains to which the functional autoantibodies bind, and receptor antagonists were employed to block the induced responses. (3) Results: Only two out of six cattle that were inoculated with SARS-CoV-2 displayed viral replication and tested positive for functional autoantibodies against G-protein-coupled receptors. These functional autoantibodies specifically recognized β2-adrenoceptor, angiotensin II AT1 receptor, muscarinic M2 receptor, and angiotensin 1-7 MAS receptor and induced distinct positive and negative chronotropic effects in the bioassay. Infected ferrets generated functional autoantibodies against β2-adrenoceptor and muscarinic M2 receptor and presented bioactivity similar to that in cattle. (4) Conclusions: This study uncovers functional autoantibodies targeting G-protein-coupled receptors in cattle and ferrets post-SARS-CoV-2 infection, with implications for cardiovascular function.
Language	English
Publishing date	2023-09-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11102668
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Book ; Thesis: Die Rolle des Angiogenic factor with G-patch and forkhead-associated domains 1 (AGGF-1) in Endothelzellen und glatten Gefäßmuskelzellen im Rahmen der Angiogenese

Müller, Simone

2018

Author's details	vorgelegt von Simone Müller
Language	English
Size	164 Seiten, Illustrationen, Diagramme, 30 cm
Publishing place	Heidelberg
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Ruprecht-Karls-Universität Heidelberg, 2018
HBZ-ID	HT019826164
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Discovery of Potent Agonists for the Predominant Variant of the Orphan MAS-Related G Protein-Coupled Receptor X4 (MRGPRX4).

Marx, Daniel / Alnouri, Mohamed Wessam / Clemens, Sophie / Gedschold, Robin / Riedel, Yvonne / Al Hamwi, Ghazl / Pillaiyar, Thanigaimalai / Hockemeyer, Jörg / Namasivayam, Vigneshwaran / Müller, Christa E

Journal of medicinal chemistry

2023 Volume 66, Issue 23, Page(s) 15674–15698

Abstract: The MAS-related G ...

Abstract	The MAS-related G
MeSH term(s)	Humans ; Receptors, G-Protein-Coupled/metabolism ; Xanthines ; Pruritus
Chemical Substances	Receptors, G-Protein-Coupled ; Xanthines
Language	English
Publishing date	2023-11-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.3c01013
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Article ; Online: Autoantibodies targeting G protein-coupled receptors: An evolving history in autoimmunity. Report of the 4th international symposium.

Cabral-Marques, Otávio / Moll, Guido / Catar, Rusan / Preuß, Beate / Bankamp, Lukas / Pecher, Ann-Christin / Henes, Joerg / Klein, Reinhild / Kamalanathan, A S / Akbarzadeh, Reza / van Oostveen, Wieke / Hohberger, Bettina / Endres, Matthias / Koolmoes, Bryan / Levarht, Nivine / Postma, Rudmer / van Duinen, Vincent / van Zonneveld, Anton Jan / de Vries-Bouwstra, Jeska /

Fehres, Cynthia / Tran, Florian / do Vale, Fernando Yuri Nery / da Silva Souza, Kamilla Batista / Filgueiras, Igor Salerno / Schimke, Lena F / Baiocchi, Gabriela Crispim / de Miranda, Gustavo Cabral / da Fonseca, Dennyson Leandro Mathias / Freire, Paula Paccielli / Hackel, Alexander M / Grasshoff, Hanna / Stähle, Anja / Müller, Antje / Dechend, Ralf / Yu, Xinhua / Petersen, Frank / Sotzny, Franziska / Sakmar, Thomas P / Ochs, Hans D / Schulze-Forster, Kai / Heidecke, Harald / Scheibenbogen, Carmen / Shoenfeld, Yehuda / Riemekasten, Gabriela

Autoimmunity reviews

2023 Volume 22, Issue 5, Page(s) 103310

Abstract: G protein-coupled receptors (GPCR) are involved in various physiological and ... e.g., systemic sclerosis and systemic lupus erythematosus). Beyond their association with disease ...

Abstract	G protein-coupled receptors (GPCR) are involved in various physiological and pathophysiological processes. Functional autoantibodies targeting GPCRs have been associated with multiple disease manifestations in this context. Here we summarize and discuss the relevant findings and concepts presented in the biennial International Meeting on autoantibodies targeting GPCRs (the 4th Symposium), held in Lübeck, Germany, 15-16 September 2022. The symposium focused on the current knowledge of these autoantibodies' role in various diseases, such as cardiovascular, renal, infectious (COVID-19), and autoimmune diseases (e.g., systemic sclerosis and systemic lupus erythematosus). Beyond their association with disease phenotypes, intense research related to the mechanistic action of these autoantibodies on immune regulation and pathogenesis has been developed, underscoring the role of autoantibodies targeting GPCRs on disease outcomes and etiopathogenesis. The observation repeatedly highlighted that autoantibodies targeting GPCRs could also be present in healthy individuals, suggesting that anti-GPCR autoantibodies play a physiologic role in modeling the course of diseases. Since numerous therapies targeting GPCRs have been developed, including small molecules and monoclonal antibodies designed for treating cancer, infections, metabolic disorders, or inflammatory conditions, anti-GPCR autoantibodies themselves can serve as therapeutic targets to reduce patients' morbidity and mortality, representing a new area for the development of novel therapeutic interventions.
MeSH term(s)	Humans ; Autoantibodies ; Autoimmunity ; COVID-19 ; Autoimmune Diseases ; Receptors, G-Protein-Coupled/metabolism
Chemical Substances	Autoantibodies ; Receptors, G-Protein-Coupled
Language	English
Publishing date	2023-03-10
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2144145-5
ISSN	1873-0183 ; 1568-9972
ISSN (online)	1873-0183
ISSN	1568-9972
DOI	10.1016/j.autrev.2023.103310
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