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Article: Renal Function at Discharge Among Kidney Recipients Experiencing Delayed Graft Function and Its Associations With Long-term Outcomes.

Kurian, Sunil M / Stewart, Darren E / Toll, Alice / Checchi, Kyle / Case, Jamie / Marsh, Christopher L

Transplantation direct

2022 Volume 8, Issue 12, Page(s) e1414

Abstract: Delayed graft function (DGF) after kidney transplantation is associated with higher rates of acute rejection and poor graft survival and outcomes. Current DGF definitions based on posttransplant need for dialysis are not standardized and there are no ... ...

Abstract	Delayed graft function (DGF) after kidney transplantation is associated with higher rates of acute rejection and poor graft survival and outcomes. Current DGF definitions based on posttransplant need for dialysis are not standardized and there are no objective methodologies for quantifying DGF severity. Methods: Using Organ Procurement and Transplantation Network data, we examined DGF, and used recipient serum creatinine at discharge as a correlate of renal function and DGF severity (mild: <2.5 mg/dL; severe: ≥2.5 mg/dL). The associations between donor and recipient factors and DGF severity were quantified using logistic regression. We also examined the associations between DGF severity and long-term recipient outcomes, adjusting for potential confounders. Results: A predictive model using donor and recipient factors had a reasonably good ability to discriminate mild (low creatinine) versus severe (high creatinine) DGF (c-statistic of 0.70). In Cox regression, DGF and creatinine at discharge were both independently associated with long-term outcomes, yet their effects differed depending on the outcome (graft function, death-censored graft function, recipient mortality). Our findings suggest that having DGF, but with relatively good renal function (creatinine <2.5) at discharge, may be less deleterious on graft and recipient survival compared with severe, prolonged DGF, which was associated with a decreased median graft survival of ~2.6 y compared with no DGF with low creatinine at discharge. Conclusions: Our novel DGF severity stratification identified unique factors associated with DGF severity, along with DGF's association with long-term graft and patient survival. The adverse cost and outcome implications of severe DGF warrant additional investigation to improve kidney transplantation practice.
Language	English
Publishing date	2022-11-17
Publishing country	United States
Document type	Journal Article
ISSN	2373-8731
ISSN	2373-8731
DOI	10.1097/TXD.0000000000001414
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Article ; Online: The Implementation of Pediatric Quarterly Mock Codes and its Impact on Resuscitation Skills Compliance.

Hutcheson, Jamie / Waggoner, Brittany / Gephart, Beth / Case, Leigh Anne / Pearcy, Ashley / Zehner, Stephanie

Journal of pediatric nursing

2020 Volume 55, Page(s) 266–269

MeSH term(s)	Cardiopulmonary Resuscitation ; Child ; Clinical Competence ; Humans ; Resuscitation
Language	English
Publishing date	2020-10-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	632731-x
ISSN	1532-8449 ; 0882-5963
ISSN (online)	1532-8449
ISSN	0882-5963
DOI	10.1016/j.pedn.2020.09.005
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Zs.B 2871: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Dominant negative effects by inactive Spa47 mutants inhibit T3SS function and Shigella virulence.

Burgess, Jamie L / Case, Heather B / Burgess, R Alan / Dickenson, Nicholas E

PloS one

2020 Volume 15, Issue 1, Page(s) e0228227

Abstract: Type three secretion systems (T3SS) are complex nano-machines that evolved to inject bacterial effector proteins directly into the cytoplasm of eukaryotic cells. Many high-priority human pathogens rely on one or more T3SSs to cause disease and evade host ...

Abstract	Type three secretion systems (T3SS) are complex nano-machines that evolved to inject bacterial effector proteins directly into the cytoplasm of eukaryotic cells. Many high-priority human pathogens rely on one or more T3SSs to cause disease and evade host immune responses, underscoring the need to better understand the mechanisms through which T3SSs function and their role(s) in supporting pathogen virulence. We recently identified the Shigella protein Spa47 as an oligomerization-activated T3SS ATPase that fuels the T3SS and supports overall Shigella virulence. Here, we provide both in vitro and in vivo characterization of Spa47 oligomerization and activation in the presence and absence of engineered ATPase-inactive Spa47 mutants. The findings describe mechanistic details of Spa47-catalyzed ATP hydrolysis and uncover critical distinctions between oligomerization mechanisms capable of supporting ATP hydrolysis in vitro and those that support T3SS function in vivo. Concentration-dependent ATPase kinetics and experiments combining wild-type and engineered ATPase inactive Spa47 mutants found that monomeric Spa47 species isolated from recombinant preparations exhibit low-level ATPase activity by forming short-lived oligomers with active site contributions from at least two protomers. In contrast, isolated Spa47 oligomers exhibit enhanced ATP hydrolysis rates that likely result from multiple preformed active sites within the oligomeric complex, as is predicted to occur within the context of the type three secretion system injectisome. High-resolution fluorescence microscopy, T3SS activity, and virulence phenotype analyses of Shigella strains co-expressing wild-type Spa47 and the ATPase inactive Spa47 mutants demonstrate that the N-terminus of Spa47, not ATPase activity, is responsible for incorporation into the injectisome where the mutant strains exhibit a dominant negative effect on T3SS function and Shigella virulence. Together, the findings presented here help to close a significant gap in our understanding of how T3SS ATPases are activated and define restraints with respect to how ATP hydrolysis is ultimately coupled to T3SS function in vivo.
MeSH term(s)	Adenosine Triphosphatases/chemistry ; Adenosine Triphosphatases/genetics ; Adenosine Triphosphatases/metabolism ; Adenosine Triphosphate/metabolism ; Hydrolysis ; Microscopy, Fluorescence ; Mutagenesis ; Protein Multimerization ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/chemistry ; Recombinant Proteins/isolation & purification ; Serogroup ; Shigella/pathogenicity ; Type III Secretion Systems/genetics ; Virulence/genetics
Chemical Substances	Recombinant Proteins ; Type III Secretion Systems ; Adenosine Triphosphate (8L70Q75FXE) ; Adenosine Triphosphatases (EC 3.6.1.-) ; Spa47 protein, Shigella flexneri (EC 3.6.1.-)
Language	English
Publishing date	2020-01-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0228227
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Article ; Online: Has the increased participation in the national campaign 'Dry January' been associated with cutting down alcohol consumption in England?

Case, Philippa / Angus, Colin / De Vocht, Frank / Holmes, John / Michie, Susan / Brown, Jamie

Drug and alcohol dependence

2021 Volume 227, Page(s) 108938

Abstract: Aims: Dry January is a national multimedia campaign in the UK that encourages people to abstain from drinking alcohol during the month of January. The population-level campaign makes extensive use of email and social media to support participants and ... ...

Abstract	Aims: Dry January is a national multimedia campaign in the UK that encourages people to abstain from drinking alcohol during the month of January. The population-level campaign makes extensive use of email and social media to support participants and has reported a substantial increase in participation since 2015. This study aimed to assess whether the increase in participation in Dry January between 2015 and 2018 was associated with reduced alcohol consumption in England. Design: Repeat cross-sectional design. Setting: England, March 2014 to January 2018. Participants: A total of 37,142 respondents to the Alcohol Toolkit Study, a monthly in-home survey of alcohol consumption among representative cross-sectional samples of people aged 16+ years in England. Measures: Outcomes included i) percentage of adults reporting drinking monthly or less frequently in the last 6 months and ii) mean weekly alcohol consumption among drinkers derived from the Alcohol Use Disorders Identification Test questions on typical frequency and quantity in the last 6 months. Analyses: For each outcome, regression models were fitted for month: January (2015 and 2018) vs March-December (2014 and 2017) and for year: 2014/15 vs 2017/18. Interaction terms were included in the models to examine whether the difference between January and the preceding months on each outcome measure depended upon the year (2014/15 vs 2017/18). For non-significant interactions, Bayes factors were calculated to assess the relative strength of evidence for large effects (OR = 1.80 on monthly drinking and β=-1.0 on mean consumption) compared with the null. Results: Differences between January and other months were similar in 2014/15 and 2017/18 for adults reporting drinking monthly or less frequently and the mean consumption among drinkers (OR = 0.91, 95 %CI 0.79-1.05, BF = 0.05; β = 0.55, 95 %CI=-0.14 to 1.25, BF = 0.13 respectively). Conclusions: The increase in participation in Dry January between 2015 and 2018 was not associated with large corresponding changes in people drinking monthly or less frequently over the last 6 months, or in mean weekly consumption among drinkers.
MeSH term(s)	Adult ; Alcohol Drinking/epidemiology ; Alcoholism ; Bayes Theorem ; Cross-Sectional Studies ; England/epidemiology ; Humans
Language	English
Publishing date	2021-07-30
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	519918-9
ISSN	1879-0046 ; 0376-8716
ISSN (online)	1879-0046
ISSN	0376-8716
DOI	10.1016/j.drugalcdep.2021.108938
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Article ; Online: Congenital cataract and spherophakia leading to starvation in a free-ranging muskox neonate from the Northwest Territories, Canada.

Case, Julia E / Pederzolli, Rae-Leigh A / Clark, Edward G / Fenton, Heather / Kutz, Susan J / Grahn, Bruce H / Rothenburger, Jamie L

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

2021 Volume 34, Issue 1, Page(s) 160–163

Abstract: A muskox neonate ( ...

Abstract	A muskox neonate (
MeSH term(s)	Animals ; Canada ; Cataract/veterinary ; Northwest Territories ; Ruminants ; Starvation/veterinary
Language	English
Publishing date	2021-11-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	287603-6
ISSN	1943-4936 ; 1040-6387
ISSN (online)	1943-4936
ISSN	1040-6387
DOI	10.1177/10406387211057470
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Article: Congenital cataract and spherophakia leading to starvation in a free-ranging muskox neonate from the Northwest Territories, Canada

Case, Julia E. / Pederzolli, Rae-Leigh A. / Clark, Edward G. / Fenton, Heather / Kutz, Susan J. / Grahn, Bruce H. / Rothenburger, Jamie L.

Journal of veterinary diagnostic investigation. 2022 Jan., v. 34, no. 1

2022

Abstract: A muskox neonate (Ovibos moschatus) that died of starvation was diagnosed with congenital lenticular anomalies that included spherophakia and hypermature cataract associated with probable lens-induced lymphocytic uveitis and neutrophilic keratitis. ... ...

Abstract	A muskox neonate (Ovibos moschatus) that died of starvation was diagnosed with congenital lenticular anomalies that included spherophakia and hypermature cataract associated with probable lens-induced lymphocytic uveitis and neutrophilic keratitis. Impaired sight as a result of cataract and associated inflammation likely contributed to abandonment and starvation, although maternal death cannot be excluded definitively. Ocular lesions, such as congenital cataracts and spherophakia in neonates, may be important factors affecting survival in free-ranging animals.
Keywords	Ovibos moschatus ; cataract ; death ; inflammation ; keratitis ; neonates ; starvation
Language	English
Dates of publication	2022-01
Size	p. 160-163.
Publishing place	SAGE Publications
Document type	Article
ZDB-ID	287603-6
ISSN	1943-4936 ; 1040-6387
ISSN (online)	1943-4936
ISSN	1040-6387
DOI	10.1177/10406387211057470
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Mesophotic benthic communities associated with a submerged palaeoshoreline in Western Australia.

Wakeford, Mary / Puotinen, Marji / Nicholas, William / Colquhoun, Jamie / Vaughan, Brigit I / Whalan, Steve / Parnum, Iain / Radford, Ben / Case, Mark / Galaiduk, Ronen / Miller, Karen J

PloS one

2023 Volume 18, Issue 8, Page(s) e0289805

Abstract: Key ecological features (KEFs) are elements of Australia's Commonwealth marine environment considered to be important for biodiversity or ecosystem function, yet many KEFs are poorly researched, which can impede effective decision-making about future ... ...

Abstract	Key ecological features (KEFs) are elements of Australia's Commonwealth marine environment considered to be important for biodiversity or ecosystem function, yet many KEFs are poorly researched, which can impede effective decision-making about future development and conservation. This study investigates a KEF positioned over the Last Glacial Maximum (LGM) shoreline on the northwest shelf of Australia (known as the 'Ancient Coastline at ~125m depth contour'; AC125). Seafloor bathymetry, sedimentology and benthic habitats were characterised within five study areas using multibeam sonar, sediment samples and towed video imagery. Direct evidence for the existence of a palaeoshoreline formed during the LGM was not found, however candidate areas to find palaeoshoreline material at or just below the modern seabed were discovered. Approximately 98% of the seabed surveyed was comprised of unconsolidated soft sediment habitat (mud/sand/silt) supporting negligible epibenthic biota. The prevalence of soft sediment suggests that post-glacial sediments have infilled parts of the palaeoshoreline, with cross-shelf, probably tidal currents in the northern section of the study area responsible for some of the sediment mobilisation and southern study areas more influenced by oceanic conditions. Within study areas, total biotic cover ranged from 0.02% to 1.07%. Of the biota encountered, most comprised filter feeder organisms (including gorgonians, sponges, and whip corals) whose distribution was associated with pockets of consolidated hard substrate. Benthic community composition varied with both study area and position in relation to the predicted AC125. In general, consolidated substrate was proportionally higher in water shallower than the AC125 compared to on the AC125 or deeper than the AC125. Spatially continuous maps of predicted benthic habitat classes (pre-determined benthic communities) in each study area were developed to characterise biodiversity. Spatial modelling corroborated depth and large-scale structural complexity of the seafloor as surrogates for predicting likely habitat class. This study provides an important assessment of the AC125 and shows that if a distinct coastline exists in the areas we surveyed, it is now largely buried and as such does not provide a unique hard substrate habitat. However, much work remains to fully locate and map the ancient coastline within the vast region of the AC125 and additional surveys in shallow waters adjacent to the AC125 may identify whether some sections lie outside the currently defined KEF.
MeSH term(s)	Animals ; Ecosystem ; Western Australia ; Biodiversity ; Anthozoa ; Biota
Language	English
Publishing date	2023-08-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0289805
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Article ; Online: Mitigation of radiation exposure during surgical hepatectomy after yttrium-90 radioembolization.

Decoteau, Mary A / Steuterman, Steven / Kurian, Sunil M / Case, Jamie / Lewis, Paul R / Fisher, Jonathan S / Schaffer, Randolph L / Marsh, Christopher L

Journal of radiological protection : official journal of the Society for Radiological Protection

2021 Volume 41, Issue 3

Abstract: Yttrium-90 (Y-90) radioembolization for the treatment of hepatocellular carcinoma can present safety challenges when transplanting recently treated Y-90 patients. To reduce surgeons' contact with radioactive tissue and remain within occupational dose ... ...

Abstract	Yttrium-90 (Y-90) radioembolization for the treatment of hepatocellular carcinoma can present safety challenges when transplanting recently treated Y-90 patients. To reduce surgeons' contact with radioactive tissue and remain within occupational dose limits, current guidelines recommend delaying transplants at least 14 days, if possible. We wanted to determine the level of radiation exposure to the transplant surgeon when explanting an irradiated liver before the recommended decay period. An
MeSH term(s)	Hepatectomy ; Humans ; Occupational Exposure/analysis ; Radiation Dosage ; Radiation Exposure ; Yttrium Radioisotopes/therapeutic use
Chemical Substances	Yttrium Radioisotopes ; Yttrium-90 (1K8M7UR6O1)
Language	English
Publishing date	2021-08-19
Publishing country	England
Document type	Journal Article
ZDB-ID	639411-5
ISSN	1361-6498 ; 0952-4746
ISSN (online)	1361-6498
ISSN	0952-4746
DOI	10.1088/1361-6498/ac09c0
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Article ; Online: Coupled intra- and interdomain dynamics support domain cross-talk in Pin1.

Zhang, Meiling / Frederick, Thomas E / VanPelt, Jamie / Case, David A / Peng, Jeffrey W

The Journal of biological chemistry

2020 Volume 295, Issue 49, Page(s) 16585–16603

Abstract: The functional mechanisms of multidomain proteins often exploit interdomain interactions, or "cross-talk." An example is human Pin1, an essential mitotic regulator consisting of a Trp-Trp (WW) domain flexibly tethered to a peptidyl-prolyl isomerase ( ... ...

Abstract	The functional mechanisms of multidomain proteins often exploit interdomain interactions, or "cross-talk." An example is human Pin1, an essential mitotic regulator consisting of a Trp-Trp (WW) domain flexibly tethered to a peptidyl-prolyl isomerase (PPIase) domain, resulting in interdomain interactions important for Pin1 function. Substrate binding to the WW domain alters its transient contacts with the PPIase domain via means that are only partially understood. Accordingly, we have investigated Pin1 interdomain interactions using NMR paramagnetic relaxation enhancement (PRE) and molecular dynamics (MD) simulations. The PREs show that apo-Pin1 samples interdomain contacts beyond the range suggested by previous structural studies. They further show that substrate binding to the WW domain simultaneously alters interdomain separation and the internal conformation of the WW domain. A 4.5-μs all-atom MD simulation of apo-Pin1 suggests that the fluctuations of interdomain distances are correlated with fluctuations of WW domain interresidue contacts involved in substrate binding. Thus, the interdomain/WW domain conformations sampled by apo-Pin1 may already include a range of conformations appropriate for binding Pin1's numerous substrates. The proposed coupling between intra-/interdomain conformational fluctuations is a consequence of the dynamic modular architecture of Pin1. Such modular architecture is common among cell-cycle proteins; thus, the WW-PPIase domain cross-talk mechanisms of Pin1 may be relevant for their mechanisms as well.
MeSH term(s)	Apoproteins/chemistry ; Apoproteins/metabolism ; Binding Sites ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Dynamics Simulation ; Mutagenesis ; NIMA-Interacting Peptidylprolyl Isomerase/chemistry ; NIMA-Interacting Peptidylprolyl Isomerase/genetics ; NIMA-Interacting Peptidylprolyl Isomerase/metabolism ; Nitrogen Oxides/chemistry ; Protein Binding ; Protein Structure, Tertiary ; Spin Labels ; Substrate Specificity ; WW Domains
Chemical Substances	Apoproteins ; NIMA-Interacting Peptidylprolyl Isomerase ; Nitrogen Oxides ; Spin Labels ; PIN1 protein, human (EC 5.2.1.8) ; nitroxyl (GFQ4MMS07W)
Language	English
Publishing date	2020-09-22
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.RA120.015849
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Article: UNOS/OPTN Data-guided Assessment of Focal Segmental Glomerulosclerosis After Kidney Transplantation and Evaluation of Immunosuppressive Protocols in a Steroid-free Center.

Kurian, Sunil M / Spierling Bagsic, Samantha R / Case, Jamie / Barrick, Bethany L / Schaffer, Randolph / Rice, James C / Marsh, Christopher L

Transplantation direct

2021 Volume 7, Issue 9, Page(s) e738

Abstract: Background: Focal segmental glomerulosclerosis (FSGS) is a common recurrent glomerulopathy associated with graft loss and patient survival after kidney transplantation (KT). However, its natural history, clinical predictors, and treatment response are ... ...

Abstract	Background: Focal segmental glomerulosclerosis (FSGS) is a common recurrent glomerulopathy associated with graft loss and patient survival after kidney transplantation (KT). However, its natural history, clinical predictors, and treatment response are still poorly understood. Steroid withdrawal regimens in KT have been associated with improvements in cardiovascular risk and patient outcomes. The Scripps Center for Organ Transplantation (SCOT) uses a rapid low-dose steroid withdrawal immunosuppression (IS) protocol for KT maintenance. Methods: We assessed the impact of our protocol on FSGS disease recurrence over a 10-y period to reassess our steroid and IS protocols and to evaluate if our patient outcomes diverge from published data. We compared 4 groups: steroids always, steroid free, steroid switch on, and steroid weaned off. We used IS and induction-matched retrospective data from United Network for Organ Sharing (UNOS) to investigate patient and graft survival for FSGS at SCOT. Results: Our analysis results differ from earlier studies showing that FSGS was associated with a higher risk of graft loss, perhaps because of selection of a UNOS data set filtered to match the SCOT IS protocol for making direct comparisons. Overall outcomes of graft failure and recipient death did not differ between SCOT patients and steroid-free transplant patient data from the UNOS data for FSGS. SCOT recurrence rate for FSGS was 7.5%, which was lower than in most published single-center studies. Conclusions: Based on our results, we believe that it is safe to continue the steroid avoidance protocols at SCOT and the steroid-free protocol may not be detrimental when the adverse effects and toxicities associated with steroid use are considered.
Language	English
Publishing date	2021-08-05
Publishing country	United States
Document type	Journal Article
ISSN	2373-8731
ISSN	2373-8731
DOI	10.1097/TXD.0000000000001196
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