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Article ; Online: Optimized Extraction, Identification and Anti-Biofilm Action of Wu Wei Zi (

Zhang, Zongyi / Zhao, Yanan / Cai, Jing / Wang, Tong / Song, Yujie / Lu, Jingyi / Du, Hairuo / Wang, Wenfang / Zhao, Yan / Guo, Lei

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 5

Abstract: The pathogenicity of ... ...

Abstract	The pathogenicity of foodborne
MeSH term(s)	Vibrio parahaemolyticus/genetics ; Schisandra ; Biofilms
Chemical Substances	schizandrol B (58546-54-6) ; schizandrer A (82042-38-4) ; schizandrin C (C8754W6B3G)
Language	English
Publishing date	2023-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28052268
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Article ; Online: Revealing the improvement of diabetes by Si Wei Jiang Huang Tang San through ERK/HIF1α signaling pathway via network pharmacology.

Xu, Tianshu / He, Ping / namWangdu, So / Xu, Chunyang / Hou, Biyu / Ma, Peng / Wang, Zijing / Zhang, Li / Du, Guanhua / Ring, Tse / Ji, Tengfei / Qiang, Guifen

Journal of ethnopharmacology

2023 Volume 319, Issue Pt 2, Page(s) 117254

Abstract: Ethnopharmacological relevance: Si Wei Jiang Huang Tang San (SWJHTS) is ...

Abstract	Ethnopharmacological relevance: Si Wei Jiang Huang Tang San (SWJHTS) is a traditional Tibetan medicine prescription for the treatment of urethritis, frequent urination, and urgency, composed of four traditional Chinese medicines: Curcumae longae rhizoma, Berberidis cortex, Tribuli fructus, and Phyllanthi fructus. However, whether SWJHTS exhibits hypoglycemic efficacy and its specific mechanism remain unclear. Aim of the study: In this study, we aimed to investigate the anti-diabetic effects of SWJHTS and elucidate the underlying mechanism. Materials and methods: HPLC-MS method was used to identify the key components of four kinds of traditional Chinese medicine (Curcumae longae rhizoma, Berberidis cortex., Tribuli fructus, and Phyllanthi fructus) which composed SWJHTS and determine their structure. Normal mice and 145 mg/kg STZ-induced type 1 diabetic mice were treated with three doses of SWJTHS by oral gavage. Body weight, 24h food and water intake, fasting blood glucose, glucose tolerance and other indicators were measured to evaluate the hypoglycemic effect of SWJHTS. OMIM, Genecards and other databases were used to collect targets of diabetes, and HPLC-MS results and TCMSP database information were used to collect drug component targets. Bioinformatics methods such as pathway enrichment analysis and molecular docking were used to predict the key targets of SWJHTS. The gene and protein expressions of HIF1α and ERK signaling pathways in HepG2 cells treated with SWJHTS were detected by RT-PCR and Western blot. Results: A total of 181 components were identified, including curcumin, palmatine, and berberine, etc. The in vivo studies showed that SWJHTS could significantly lower fasting blood glucose levels and improve the symptoms of polydipsia, polyphagia, and polyuria in diabetic mice. Furthermore, we identified HIF1α as the potential key target of SWJHTS against diabetes utilizing network pharmacology approach and in silico molecular docking. Subsequently, we experimentally confirmed that SWJHTS could suppress the high glucose-induced upregulation of HIF1α expression, which mediated the glucose consumption in HepG2 cells. The ERK signaling pathway was further found to be activated by the SWJHTS as the upstream of HIF1α. Conclusions: SWJHTS can improve glucose metabolism by targeting the ERK/HIF1α signaling pathway; hence might be a prospective anti-diabetic drug for diabetic patients as traditional Tibetan medicine.
MeSH term(s)	Humans ; Animals ; Mice ; Blood Glucose ; Diabetes Mellitus, Experimental/drug therapy ; Molecular Docking Simulation ; Network Pharmacology ; Signal Transduction ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use
Chemical Substances	Tribulus extract (4X4HLN92OT) ; Blood Glucose ; Hypoglycemic Agents ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-09-29
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117254
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Article ; Online: Wei-Tong-Xin ameliorates functional dyspepsia via inactivating TLR4/MyD88 by regulating gut microbial structure and metabolites.

Zhang, Xiaoying / Liu, Wenjuan / Zhang, Shuanglin / Wang, Jinyu / Yang, Xihan / Wang, Ruixuan / Yan, Tingxu / Wu, Bo / Du, Yiyang / Jia, Ying

Phytomedicine : international journal of phytotherapy and phytopharmacology

2022 Volume 102, Page(s) 154180

Abstract: Background: Wei-Tong-Xin (WTX) is a traditional Chinese medicine (TCM) that has been screened and ...

Abstract	Background: Wei-Tong-Xin (WTX) is a traditional Chinese medicine (TCM) that has been screened and improved in accordance with the famous ancient Chinese formula "Wan Ying Yuan". It has been shown to be clinically effective in treating gastric dysmotility, but its underlying molecular mechanism remains unclear. Purpose: This study primarily dealt with the effects and mechanisms of WTX on functional dyspepsia (FD) induced by chemotherapeutic drug cisplatin (CIS). Methods: Firstly, the UPLC fingerprint and multi-component determination of WTX were established. In vivo, gastrointestinal motility of mice was detected by charcoal propulsion test. Besides, H&E, western blot and qRT-PCR were performed to evaluate the occurrence of gastric antral inflammation. ROS-DHE staining was used to detect ROS levels. Further, the gut microbiota were subjected to sequencing by 16S rRNA, and the levels of bacterial metabolites short-chain fatty acids (SCFAs) and lipopolysaccharide (LPS) were detected by GC-MS and Limulus kits, respectively. The levels of GLP-1 in gastric antrum were assessed by ELISA kits. Finally, siRNA-FFAR2 experiment was performed in Raw 264.7 cells. Results: 23 common peaks were obtained from the UPLC fingerprint, and the content of 10 target components was determined. WTX increased the relative abundance of Firmicutes and decreased the number of Verrucomicrobia, accompanied by changes in the levels of SCFAs and LPS. By mediating the expression changes of free fatty acid receptor 2 (FFAR2) and toll-like receptor 4 (TLR4), WTX inhibited the phosphorylation of nuclear factor-κB (NF-κB), JNK and P38, decreased the levels of IL-1β, inducible nitric oxide synthase (iNOS) and ROS, increased the expressions of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), IL-4 and arginase-1 (Arg-1). Decreased expressions of glucagon-like peptide 1 (GLP-1) induced by WTX promoted gastric motility in FD mice. In vitro, siRNA-FFAR2 of Raw 264.7 cells eliminated the effects of WTX on TLR4 signaling pathway. Conclusions: In this study, the chemical profile of WTX was first reported. Based on remodeling the gut microbiota structure and adjusting the levels of metabolites (SCFAs and LPS), WTX inactivated the TLR4/MyD88 signaling pathway to inhibit the occurrence of gastric antral inflammation, which reversed the inhibitory effect of GLP-1 on gastric motility, and improved CIS-induced FD symptoms.
MeSH term(s)	Animals ; Dyspepsia/drug therapy ; Dyspepsia/metabolism ; Dyspepsia/microbiology ; Gastrointestinal Microbiome ; Glucagon-Like Peptide 1 ; Inflammation/drug therapy ; Lipopolysaccharides/pharmacology ; Mice ; Myeloid Differentiation Factor 88/metabolism ; NF-kappa B/metabolism ; RNA, Ribosomal, 16S ; RNA, Small Interfering ; Reactive Oxygen Species/metabolism ; Toll-Like Receptor 4/metabolism
Chemical Substances	Lipopolysaccharides ; Myd88 protein, mouse ; Myeloid Differentiation Factor 88 ; NF-kappa B ; RNA, Ribosomal, 16S ; RNA, Small Interfering ; Reactive Oxygen Species ; Tlr4 protein, mouse ; Toll-Like Receptor 4 ; Glucagon-Like Peptide 1 (89750-14-1)
Language	English
Publishing date	2022-05-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2022.154180
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Article: Arginine Biosynthesis Pathway Found to Play a Key Role in the Neuroprotective Effect of Liu-Wei-Luo-Bi (LWLB) Granules in Diabetic db/db Mice with Peripheral Neuropathy Using an Untargeted Metabolomics Strategy.

Liu, Qiong / Chen, Yafei / Wang, Bo / Chen, Yinying / Li, Bing / Guan, Shuang / Du, Kehe / Liu, Xiaoyang / Yu, Yanan / Liu, Jun / Wang, Zhong

Diabetes, metabolic syndrome and obesity : targets and therapy

2023 Volume 16, Page(s) 4065–4080

Abstract: Aim: Liu-Wei-Luo-Bi (LWLB) granules was a Chinese compound prescription for treating diabetic ...

Abstract	Aim: Liu-Wei-Luo-Bi (LWLB) granules was a Chinese compound prescription for treating diabetic peripheral neuropathy (DPN). The aim of this study was to investigate the effect of LWLB granules on diabetic mice with peripheral neuropathy and to elucidate the potential mechanism based on an untargeted metabolomics approach. Methods: One hundred forty db/db mice were randomly divided into seven groups: the Control group, DPN group, Mudan (MD) granules group, Epalrestat (Epa) group, and the LWLB low, medium, or high dose (LW-l, LW-m, or LW-h) group. After 12 weeks of treatment, body weight, blood glucose, mechanical pain threshold, motor conduction velocity (MCV), sensory conduction velocity (SCV), and Pathological Organization of the Sciatic and Caudal Nerves in mice were measured. Serum samples were collected for untargeted metabolomics analysis using liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) and multivariate statistics. Disease-related pathways were screened out with function enrichment analyses of candidate biomarkers. Results: LWLB granules can improve the peripheral neuropathy of type 2 diabetic mice with peripheral nerve conduction disorders, mainly through significantly improving the nerve conduction velocity (P < 0.05) and lowering the mechanical pain threshold (P < 0.05). A total of 43 metabolites were identified as potential biomarkers related to the therapeutic effect of LWLB granules. Fifty, 4, and 26; 23, 4, and 22; and 24, 1, and 16 biomarkers were discovered in the LW-l, LW-m, and LW-h groups at the 4th, 6th, and 12th weeks, respectively. Five, three, seven, five, and four metabolic pathways were found in MD, Epa, LW-l, LW-m, and LW-h groups, respectively. The arginine biosynthesis pathway is the overlapping pathway in LW-l, LW-m, and LW-h groups. Conclusion: LWLB granules have an obvious neuroprotective effect on diabetic peripheral neuropathy, and the metabolism mechanism of LWLB is mainly related to the arginine biosynthesis pathway on diabetic db/db mice with peripheral neuropathy.
Language	English
Publishing date	2023-12-11
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S423388
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Article ; Online: Characterization of the mitochondrial genome of Arge bella Wei & Du sp. nov. (Hymenoptera

Shiyu Du / Gengyun Niu / Tommi Nyman / Meicai Wei

PeerJ, Vol 6, p e

Argidae)

2018 Volume 6131

Abstract: We describe Arge bella Wei & Du sp. nov., a large and beautiful species of Argidae from south China ...

Abstract	We describe Arge bella Wei & Du sp. nov., a large and beautiful species of Argidae from south China, and report its mitochondrial genome based on high-throughput sequencing data. We present the gene order, nucleotide composition of protein-coding genes (PCGs), and the secondary structures of RNA genes. The nearly complete mitochondrial genome of A. bella has a length of 15,576 bp and a typical set of 37 genes (22 tRNAs, 13 PCGs, and 2 rRNAs). Three tRNAs are rearranged in the A. bella mitochondrial genome as compared to the ancestral type in insects: trnM and trnQ are shuffled, while trnW is translocated from the trnW-trnC-trnY cluster to a location downstream of trnI. All PCGs are initiated by ATN codons, and terminated with TAA, TA or T as stop codons. All tRNAs have a typical cloverleaf secondary structure, except for trnS1. H821 of rrnS and H976 of rrnL are redundant. A phylogenetic analysis based on mitochondrial genome sequences of A. bella, 21 other symphytan species, two apocritan representatives, and four outgroup taxa supports the placement of Argidae as sister to the Pergidae within the symphytan superfamily Tenthredinoidea.
Keywords	Arge bella ; Secondary structure ; Mitochondrial genome ; New species ; Taxonomy ; Cladistic analysis ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	590
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Efficacy and safety of Jia Wei Bushen Yiqi formulas as an adjunct therapy to systemic glucocorticoids on acute exacerbation of COPD

Qing Kong / Shuming Mo / Wenqian Wang / Zihui Tang / Ying Wei / Yijie Du / Baojun Liu / Lingwen Kong / Yubao Lv / Jingcheng Dong

Trials, Vol 21, Iss 1, Pp 1-

study protocol for a randomized, double-blinded, multi-center, placebo-controlled clinical trial

2020 Volume 16

Abstract: ... the efficacy and safety of Jia Wei Bushen Yiqi (JWBY) formulas in patients who suffer from COPD exacerbations ...

Abstract	Abstract Background Systemic glucocorticoids are effective for the management of chronic obstructive pulmonary disease (COPD) exacerbation but have serious adverse effects. Traditional Chinese medicine (TCM) can bring additional benefits to these patients but has few adverse effects. The present study aims to evaluate the efficacy and safety of Jia Wei Bushen Yiqi (JWBY) formulas in patients who suffer from COPD exacerbations and to investigate whether the short-term (5-days) systemic glucocorticoid therapy is non-inferior to the long-term (9-day) regime. Methods In this multi-center, randomized, double-blinded trial, eligible inpatients with COPD exacerbation are randomly assigned to four groups (A, B, C, and D). Group A will receive placebo plus 5-day prednisone, group B will receive placebo plus 9-day prednisone, group C will receive JWBY formulas plus 5-day prednisone, and group D will receive JWBY formulas plus 9-day prednisone. The primary outcomes are the time interval to the patient’s next exacerbation during a 180-day following up and the COPD assessment test (CAT) during treatment. Secondary outcomes include lung function, TCM syndrome assessment, laboratory tests, and safety. The changes of the hypothalamic pituitary adrenaline axis (HPA axis) and inflammatory cytokine will be measured as well. Discussion By demonstrating the advantages of utilizing TCM and an appropriate duration of systemic glucocorticoids, this effectiveness comparison trial will provide new references to physicians on how to improve the management of COPD exacerbation. The results of HPA axis and inflammation cytokine measurements will shed light on the molecular mechanisms and entail further mechanism studies. Trial registration www.chictr.org.cn ChiCTR1900023364. Registered on 24 May 2019.
Keywords	Randomized clinical trial ; Design and method ; Acute exacerbation of COPD ; Traditional Chinese medicine ; Systemic glucocorticoids duration ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Efficacy and safety of Jia Wei Bushen Yiqi formulas as an adjunct therapy to systemic glucocorticoids on acute exacerbation of COPD: study protocol for a randomized, double-blinded, multi-center, placebo-controlled clinical trial.

Kong, Qing / Mo, Shuming / Wang, Wenqian / Tang, Zihui / Wei, Ying / Du, Yijie / Liu, Baojun / Kong, Lingwen / Lv, Yubao / Dong, Jingcheng

Trials

2020 Volume 21, Issue 1, Page(s) 760

Abstract: ... the efficacy and safety of Jia Wei Bushen Yiqi (JWBY) formulas in patients who suffer from COPD exacerbations ...

Abstract	Background: Systemic glucocorticoids are effective for the management of chronic obstructive pulmonary disease (COPD) exacerbation but have serious adverse effects. Traditional Chinese medicine (TCM) can bring additional benefits to these patients but has few adverse effects. The present study aims to evaluate the efficacy and safety of Jia Wei Bushen Yiqi (JWBY) formulas in patients who suffer from COPD exacerbations and to investigate whether the short-term (5-days) systemic glucocorticoid therapy is non-inferior to the long-term (9-day) regime. Methods: In this multi-center, randomized, double-blinded trial, eligible inpatients with COPD exacerbation are randomly assigned to four groups (A, B, C, and D). Group A will receive placebo plus 5-day prednisone, group B will receive placebo plus 9-day prednisone, group C will receive JWBY formulas plus 5-day prednisone, and group D will receive JWBY formulas plus 9-day prednisone. The primary outcomes are the time interval to the patient's next exacerbation during a 180-day following up and the COPD assessment test (CAT) during treatment. Secondary outcomes include lung function, TCM syndrome assessment, laboratory tests, and safety. The changes of the hypothalamic pituitary adrenaline axis (HPA axis) and inflammatory cytokine will be measured as well. Discussion: By demonstrating the advantages of utilizing TCM and an appropriate duration of systemic glucocorticoids, this effectiveness comparison trial will provide new references to physicians on how to improve the management of COPD exacerbation. The results of HPA axis and inflammation cytokine measurements will shed light on the molecular mechanisms and entail further mechanism studies. Trial registration: www.chictr.org.cn ChiCTR1900023364. Registered on 24 May 2019.
MeSH term(s)	Double-Blind Method ; Glucocorticoids/adverse effects ; Humans ; Hypothalamo-Hypophyseal System ; Medicine, Chinese Traditional ; Multicenter Studies as Topic ; Pituitary-Adrenal System ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Randomized Controlled Trials as Topic ; Treatment Outcome
Chemical Substances	Glucocorticoids
Keywords	covid19
Language	English
Publishing date	2020-09-03
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1468-6708
ISSN (online)	1745-6215 ; 1468-6694
ISSN	1468-6708
DOI	10.1186/s13063-020-04669-5
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Article: Wei-Tong-Xin ameliorates functional dyspepsia via inactivating TLR4/MyD88 by regulating gut microbial structure and metabolites

Zhang, Xiaoying / Liu, Wenjuan / Zhang, Shuanglin / Wang, Jinyu / Yang, Xihan / Wang, Ruixuan / Yan, Tingxu / Wu, Bo / Du, Yiyang / Jia, Ying

Phytomedicine. 2022 July 20, v. 102

2022

Abstract: Wei-Tong-Xin (WTX) is a traditional Chinese medicine (TCM) that has been screened and improved ...

Abstract	Wei-Tong-Xin (WTX) is a traditional Chinese medicine (TCM) that has been screened and improved in accordance with the famous ancient Chinese formula "Wan Ying Yuan". It has been shown to be clinically effective in treating gastric dysmotility, but its underlying molecular mechanism remains unclear. This study primarily dealt with the effects and mechanisms of WTX on functional dyspepsia (FD) induced by chemotherapeutic drug cisplatin (CIS). Firstly, the UPLC fingerprint and multi-component determination of WTX were established. In vivo, gastrointestinal motility of mice was detected by charcoal propulsion test. Besides, H&E, western blot and qRT-PCR were performed to evaluate the occurrence of gastric antral inflammation. ROS-DHE staining was used to detect ROS levels. Further, the gut microbiota were subjected to sequencing by 16S rRNA, and the levels of bacterial metabolites short-chain fatty acids (SCFAs) and lipopolysaccharide (LPS) were detected by GC-MS and Limulus kits, respectively. The levels of GLP-1 in gastric antrum were assessed by ELISA kits. Finally, siRNA-FFAR2 experiment was performed in Raw 264.7 cells. 23 common peaks were obtained from the UPLC fingerprint, and the content of 10 target components was determined. WTX increased the relative abundance of Firmicutes and decreased the number of Verrucomicrobia, accompanied by changes in the levels of SCFAs and LPS. By mediating the expression changes of free fatty acid receptor 2 (FFAR2) and toll-like receptor 4 (TLR4), WTX inhibited the phosphorylation of nuclear factor-κB (NF-κB), JNK and P38, decreased the levels of IL-1β, inducible nitric oxide synthase (iNOS) and ROS, increased the expressions of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), IL-4 and arginase-1 (Arg-1). Decreased expressions of glucagon-like peptide 1 (GLP-1) induced by WTX promoted gastric motility in FD mice. In vitro, siRNA-FFAR2 of Raw 264.7 cells eliminated the effects of WTX on TLR4 signaling pathway. In this study, the chemical profile of WTX was first reported. Based on remodeling the gut microbiota structure and adjusting the levels of metabolites (SCFAs and LPS), WTX inactivated the TLR4/MyD88 signaling pathway to inhibit the occurrence of gastric antral inflammation, which reversed the inhibitory effect of GLP-1 on gastric motility, and improved CIS-induced FD symptoms.
Keywords	Firmicutes ; Limulus ; Oriental traditional medicine ; Toll-like receptor 4 ; Verrucomicrobia ; Western blotting ; charcoal ; cisplatin ; drug therapy ; free fatty acids ; gastrointestinal motility ; glucagon-like peptide 1 ; heme oxygenase (biliverdin-producing) ; indigestion ; inducible nitric oxide synthase ; inflammation ; interleukin-4 ; intestinal microorganisms ; lipopolysaccharides ; phosphorylation
Language	English
Dates of publication	2022-0720
Publishing place	Elsevier GmbH
Document type	Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2022.154180
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Active Ingredients and Anti-Arthritic Mechanisms of Ba-Wei-Long-Zuan Granule Revealed by

Fan, Gang / Li, Qi / Li, Hai-Jiao / Zhang, Yun-Sen / Xu, Xin-Mei / Fang, Gang / Ge, Yi-Man / Du, Lei-Lei

Chemistry & biodiversity

2020 Volume 17, Issue 6, Page(s) e2000122

Abstract: Ba-Wei-Long-Zuan granule (BWLZ) is a traditional herbal preparation. It has been widely used ...

Abstract	Ba-Wei-Long-Zuan granule (BWLZ) is a traditional herbal preparation. It has been widely used for the treatment of rheumatoid arthritis (RA). However, its active ingredients and mechanisms of action are still unclear. The present study aims to reveal the active compounds and anti-arthritic mechanisms of BWLZ against collagen-induced arthritis (CIA) by using
MeSH term(s)	Animals ; Antirheumatic Agents/chemistry ; Antirheumatic Agents/metabolism ; Antirheumatic Agents/pharmacology ; Arthritis, Experimental/chemically induced ; Arthritis, Experimental/drug therapy ; Binding Sites ; Biomarkers/blood ; Biomarkers/metabolism ; Cytochrome P-450 CYP1A2/chemistry ; Cytochrome P-450 CYP1A2/metabolism ; Discriminant Analysis ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/metabolism ; Drugs, Chinese Herbal/therapeutic use ; Hesperidin/chemistry ; Hesperidin/metabolism ; Hesperidin/therapeutic use ; Isoquinolines/chemistry ; Isoquinolines/metabolism ; Isoquinolines/therapeutic use ; Magnetic Resonance Spectroscopy ; Male ; Medicine, Chinese Traditional ; Metabolomics ; Molecular Docking Simulation ; Principal Component Analysis ; Protein Structure, Tertiary ; Rats ; Rats, Wistar
Chemical Substances	Antirheumatic Agents ; Biomarkers ; Drugs, Chinese Herbal ; Isoquinolines ; coclaurine (CW1576313Y) ; Hesperidin (E750O06Y6O) ; Cytochrome P-450 CYP1A2 (EC 1.14.14.1)
Language	English
Publishing date	2020-05-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202000122
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Article ; Online: Comprehensive chemical profiling of Jia-Wei-Qi-Fu-Yin and its network pharmacology-based analysis on Alzheimer's disease.

An, Hai-Ming / Huang, Da-Rong / Yang, Hua / Liu, Xin-Guang / Du, Jing / Li, Yi / Li, Chao-Ran / Pang, Han-Qing / Liu, Run-Zhou / Peng, Chao / Li, Ping / Gao, Wen

Journal of pharmaceutical and biomedical analysis

2020 Volume 189, Page(s) 113467

Abstract: Jia-Wei-Qi-Fu-Yin (JWQFY) is a newly developed anti-Alzheimer's disease (AD) prescription modified ...

Abstract	Jia-Wei-Qi-Fu-Yin (JWQFY) is a newly developed anti-Alzheimer's disease (AD) prescription modified from a classical traditional Chinese medicine formula, Qi-Fu-Yin (QFY). However, a systematic understanding of its chemical constituents and molecular mechanisms is still elusive. To address this problem, comprehensive chemical profiling followed by network pharmacology-based analysis of JWQFY was performed. Firstly, a total of 136 compounds were characterized by high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (HPLC-QTOF MS), 17 of them were specifically identified in JWQFY comparing with QFY. Seventy compounds were further quantified via a validated HPLC coupled with triple quadrupole tandem mass spectrometry (QQQ MS) method. Then the protein targets of the seventy compounds were gathered from public databases for network construction. As a result, fifty-seven compounds were filtered, which interacted with 655 targets. Thirty-four of them were mapped into the KEGG pathway of AD, indicating JWQFY might exert anti-AD effects by anti-inflammation, neuronal apoptosis intervening, Aβ production inhibition and phosphorylating tau protein moderating. Furthermore, in the compound-target-AD network, a list of hub compounds and hub targets was identified based on their topological features, including the degree, node betweenness and closeness. Four of the hub compounds were specifically originated from JWQFY, supporting the modification rationality of this formula. This study provided a scientific basis for understanding the bioactive compounds and the multi-target mechanism of JWQFY.
MeSH term(s)	Alzheimer Disease/drug therapy ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal ; Humans ; Tandem Mass Spectrometry
Chemical Substances	Drugs, Chinese Herbal ; qi-fu-yin
Language	English
Publishing date	2020-07-08
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2020.113467
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Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito