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Article ; Online: Hypertension at high altitude: the interplay between genetic and biochemical factors in the setting of oxidative stress.

Ashraf, Mohammad Z

Hypertension research : official journal of the Japanese Society of Hypertension

2016 Volume 39, Issue 4, Page(s) 199–200

MeSH term(s)	Altitude ; Blood Pressure/genetics ; Female ; Humans ; Hypertension/genetics ; Hypertension/physiopathology ; Male ; NADPH Oxidases/genetics ; Oxidative Stress/genetics
Chemical Substances	NADPH Oxidases (EC 1.6.3.-)
Language	English
Publishing date	2016-04
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1175297-x
ISSN	1348-4214 ; 0916-9636
ISSN (online)	1348-4214
ISSN	0916-9636
DOI	10.1038/hr.2015.140
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Zs.A 3898: Show issues

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Article: Sustained ethical analysis of global dilemmas and country-level decision making during and post the COVID-19 pandemic: A systematic review.

Sarfraz, Azza / Sarfraz, Zouina / Ashraf, Mohammad / Ashraf, Huma

Pakistan journal of medical sciences

2022 Volume 38, Issue 4Part-II, Page(s) 1056–1063

Abstract: The COVID-19 pandemic has highlighted the vulnerability of countries worldwide and their abilities to cope with the fast-paced demands of the research and medical community. A key to promoting ethical decision-making frameworks is by calibrating the ... ...

Abstract	The COVID-19 pandemic has highlighted the vulnerability of countries worldwide and their abilities to cope with the fast-paced demands of the research and medical community. A key to promoting ethical decision-making frameworks is by calibrating the sustainability at regional, national, and global levels to incorporate coordinated reforms. We performed a sustained ethical analysis and critically reviewed evidence addressing country-level responses to practices during the COVID-19 pandemic using PubMed (MEDLINE), Scopus, and CINAHL. The World Health Organization's ethical framework proposed for the entire population during the pandemic was applied to thematically delineate findings under equality, best outcomes (utility), prioritizing the worst off, and prioritizing those tasked with helping others. The findings demarcate ethical concerns about the validity of drug and vaccine trials in developing and developed countries, hints of unjust healthcare organizational policies, lack of equal allocation of pertinent resources, miscalculated allocation of resources to essential workers and stratified populations.
Language	English
Publishing date	2022-05-18
Publishing country	Pakistan
Document type	Journal Article ; Review
ZDB-ID	2032827-8
ISSN	1681-715X ; 1682-024X ; 1017-4699
ISSN (online)	1681-715X
ISSN	1682-024X ; 1017-4699
DOI	10.12669/pjms.38.4.4755
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Zs.A 3948: Show issues

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Article ; Online: Author Correction: Ultrasensitive and selective molecularly imprinted electrochemical oxaliplatin sensor based on a novel nitrogen-doped carbon nanotubes/Ag@cu MOF as a signal enhancer and reporter nanohybrid.

Mahnashi, Mater H / Mahmoud, Ashraf M / Alhazzani, Khalid / Alanazi, A Z / Alaseem, Ali Mohammed / Algahtani, Mohammad M / El-Wekil, Mohamed M

Mikrochimica acta

2023 Volume 190, Issue 6, Page(s) 227

Language	English
Publishing date	2023-05-18
Publishing country	Austria
Document type	Published Erratum
ZDB-ID	89-9
ISSN	1436-5073 ; 0026-3672
ISSN (online)	1436-5073
ISSN	0026-3672
DOI	10.1007/s00604-023-05810-2
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Article ; Online: Correction: Ultrasensitive and selective molecularly imprinted electrochemical oxaliplatin sensor based on a novel nitrogen-doped carbon nanotubes/Ag@cu MOF as a signal enhancer and reporter nanohybrid.

Mahnashi, Mater H / Mahmoud, Ashraf M / Alhazzani, Khalid / Alanazi, A Z / Alaseem, Ali Mohammed / Algahtani, Mohammad M / El-Wekil, Mohamed M

Mikrochimica acta

2023 Volume 190, Issue 4, Page(s) 156

Language	English
Publishing date	2023-03-25
Publishing country	Austria
Document type	Published Erratum
ZDB-ID	89-9
ISSN	1436-5073 ; 0026-3672
ISSN (online)	1436-5073
ISSN	0026-3672
DOI	10.1007/s00604-023-05730-1
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Article ; Online: Host-Viral Interactions Revealed among Shared Transcriptomics Signatures of ARDS and Thrombosis: A Clue into COVID-19 Pathogenesis.

Mishra, Aastha / Chanchal, Shankar / Ashraf, Mohammad Z

TH open : companion journal to thrombosis and haemostasis

2020 Volume 4, Issue 4, Page(s) e403–e412

Abstract: Severe novel corona virus disease 2019 (COVID-19) infection is associated with a considerable activation of coagulation pathways, endothelial damage, and subsequent thrombotic microvascular injuries. These consistent observations may have serious ... ...

Abstract	Severe novel corona virus disease 2019 (COVID-19) infection is associated with a considerable activation of coagulation pathways, endothelial damage, and subsequent thrombotic microvascular injuries. These consistent observations may have serious implications for the treatment and management of this highly pathogenic disease. As a consequence, the anticoagulant therapeutic strategies, such as low molecular weight heparin, have shown some encouraging results. Cytokine burst leading to sepsis which is one of the primary reasons for acute respiratory distress syndrome (ARDS) drive that could be worsened with the accumulation of coagulation factors in the lungs of COVID-19 patients. However, the obscurity of this syndrome remains a hurdle in making decisive treatment choices. Therefore, an attempt to characterize shared biological mechanisms between ARDS and thrombosis using comprehensive transcriptomics meta-analysis is made. We conducted an integrated gene expression meta-analysis of two independently publicly available datasets of ARDS and venous thromboembolism (VTE). Datasets GSE76293 and GSE19151 derived from National Centre for Biotechnology Information-Gene Expression Omnibus (NCBI-GEO) database were used for ARDS and VTE, respectively. Integrative meta-analysis of expression data (INMEX) tool preprocessed the datasets and effect size combination with random effect modeling was used for obtaining differentially expressed genes (DEGs). Network construction was done for hub genes and pathway enrichment analysis. Our meta-analysis identified a total of 1,878 significant DEGs among the datasets, which when subjected to enrichment analysis suggested inflammation-coagulation-hypoxemia convolutions in COVID-19 pathogenesis. The top hub genes of our study such as tumor protein 53 (TP53), lysine acetyltransferase 2B (KAT2B), DExH-box helicase 9 (DHX9), REL-associated protein (RELA), RING-box protein 1 (RBX1), and proteasome 20S subunit beta 2 (PSMB2) gave insights into the genes known to be participating in the host-virus interactions that could pave the way to understand the various strategies deployed by the virus to improve its replication and spreading.
Language	English
Publishing date	2020-12-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2901738-5
ISSN	2512-9465 ; 2567-3459
ISSN (online)	2512-9465
ISSN	2567-3459
DOI	10.1055/s-0040-1721706
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Article: Cordycepin- melittin nanoconjugate intensifies wound healing efficacy in diabetic rats.

Shaik, Rasheed A / Alotaibi, Mohammed F / Nasrullah, Mohammed Z / Alrabia, Mohammad W / Asfour, Hani Z / Abdel-Naim, Ashraf B

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

2023 Volume 31, Issue 5, Page(s) 736–745

Abstract: The current study was designed to develop a nanoconjugate of cordycepin-melittin (COR-MEL) and assess its healing property in wounded diabetic rats. The prepared nanoconjugate has a particle size of 253.5 ± 17.4 nm with a polydispersity index (PDI) of 0 ... ...

Abstract	The current study was designed to develop a nanoconjugate of cordycepin-melittin (COR-MEL) and assess its healing property in wounded diabetic rats. The prepared nanoconjugate has a particle size of 253.5 ± 17.4 nm with a polydispersity index (PDI) of 0.35 ± 0.04 and zeta potential of 17.2 ± 0.3 mV. To establish the wound healing property of the COR-MEL nanoconjugate, animal studies were pursued, where the animals with diabetes were exposed to excision and treated with COR hydrogel, MEL hydrogel, or COR-MEL nanoconjugate topically. The study demonstrated an accelerated wound contraction in COR-MEL nanoconjugate -treated diabetic rats, which was further validated by histological analysis. The nanoconjugate further exhibited antioxidant activities by inhibiting the accumulation of malondialdehyde (MDA) and exhaustion of superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzymatic activities. The nanoconjugate further demonstrated an enhanced anti-inflammatory activity by retarding the expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-α. Additionally, the nanoconjugate exhibits a strong expression of transforming growth factor (TGF)-β1, vascular endothelial growth factor (VEGF)-A, and platelet-derived growth factor (PDGFR)-β, indicating enrichment of proliferation. Likewise, nanoconjugate increased the concentration of hydroxyproline as well as the mRNA expression of collagen, type I, alpha 1 (Col 1A1). Thus, it is concluded that the nanoconjugate possesses a potent wound-healing activity in diabetic rats via antioxidant, anti-inflammatory, and pro-angiogenetic mechanisms.
Language	English
Publishing date	2023-03-27
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	1378024-4
ISSN	1319-0164
ISSN	1319-0164
DOI	10.1016/j.jsps.2023.03.014
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Zs.A 4758: Show issues

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Article ; Online: Cross-linking modifications of HDL apoproteins by oxidized phospholipids: structural characterization,

Gao, Detao / Ashraf, Mohammad Z / Zhang, Lifang / Kar, Niladri / Byzova, Tatiana V / Podrez, Eugene A

The Journal of biological chemistry

2020 Volume 295, Issue 7, Page(s) 1973–1984

Abstract: Apolipoprotein A-I (apoA-I) is cross-linked and dysfunctional in human atheroma. Although multiple mechanisms of apoA-I cross-linking have been ... ...

Abstract	Apolipoprotein A-I (apoA-I) is cross-linked and dysfunctional in human atheroma. Although multiple mechanisms of apoA-I cross-linking have been demonstrated
MeSH term(s)	Animals ; Aorta/metabolism ; Apolipoprotein A-I/genetics ; Chromatography, Liquid ; Humans ; Hydrogen Peroxide/metabolism ; Lipoproteins, HDL/genetics ; Lipoproteins, HDL3/genetics ; Macrophages/metabolism ; Mice ; Nitric Oxide/genetics ; Nitric Oxide/metabolism ; Oxidation-Reduction ; Oxidative Phosphorylation ; Phospholipids/genetics ; Phospholipids/metabolism ; Receptors, LDL/genetics ; Tandem Mass Spectrometry
Chemical Substances	Apolipoprotein A-I ; LDLR protein, human ; Lipoproteins, HDL ; Lipoproteins, HDL3 ; Phospholipids ; Receptors, LDL ; Nitric Oxide (31C4KY9ESH) ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2020-01-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.RA119.008445
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Uc I Zs.108: Show issues

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Article ; Online: Ferulic acid loaded pickering emulsions stabilized by resistant starch nanoparticles using ultrasonication: Characterization, in vitro release and nutraceutical potential.

Noor, Nairah / Gani, Adil / Jhan, Faiza / Ashraf Shah, Mohammad / Ul Ashraf, Zanoor

Ultrasonics sonochemistry

2022 Volume 84, Page(s) 105967

Abstract: The use of starch based nanoparticles have gained momentum in stabilizing pickering emulsions for it's numerous advantages. In present study resistant starch (RS) was isolated from lotus stem using enzymatic digestion and subjected to nanoprecipitation ... ...

Abstract	The use of starch based nanoparticles have gained momentum in stabilizing pickering emulsions for it's numerous advantages. In present study resistant starch (RS) was isolated from lotus stem using enzymatic digestion and subjected to nanoprecipitation and ultrasonication to yield resistant starch nanoparticles (RSN). RSN of varying concentrations (2%, 10% and 20%) were used to stabilize the flax seed-oil water mixture to form pickering emulsions. The emulsions were used to nanoencapsulate ferulic acid (FA) - a well known bioactive via ultrasonication. The emulsions were lyophilized to form FA loaded lyophilized pickering emulsion (FA-LPE). The FA-LPE (2%, 10 % and 20%) were characterized using dynamic light scattering (DLS), light microscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), atomic force microscopy (AFM) and attenuated total reflectance fourier transform infra-spectroscopy (ATR-FTIR). AFM showed FA-LPE as spherical droplets embedded in the matrix with maximum peak height of 8.47 nm and maximum pit height of 1.69 nm. SEM presented FA-LPE as an irregular and continuous surface having multiple folds and holes. The ATR-FTIR spectra of all the samples displayed peaks of C = C aromatic rings of FA at 1600 cm
MeSH term(s)	Coumaric Acids ; Dietary Supplements ; Emulsions/chemistry ; Nanoparticles/chemistry ; Particle Size ; Resistant Starch ; Starch/chemistry
Chemical Substances	Coumaric Acids ; Emulsions ; Resistant Starch ; Starch (9005-25-8) ; ferulic acid (AVM951ZWST)
Language	English
Publishing date	2022-03-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1208333-1
ISSN	1873-2828 ; 1350-4177
ISSN (online)	1873-2828
ISSN	1350-4177
DOI	10.1016/j.ultsonch.2022.105967
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Zs.A 4441: Show issues

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Article ; Online: Knowledge translation in health and wellness research focusing on immigrants in Canada.

Chowdhury, Nashit / Naidu, Jessica / Chowdhury, Mohammad Z I / Vaska, Marcus / Rumana, Nahid / Lasker, Mohammad Ali Ashraf / Turin, Tanvir C

Journal of primary health care

2021 Volume 13, Issue 2, Page(s) 139–156

Abstract: INTRODUCTION Knowledge translation (KT) is a relatively new concept referring to transfers of knowledge into practice in collaboration with multiple sectors that work for the health and wellness of society. Knowledge translation is crucial to identifying ...

Abstract	INTRODUCTION Knowledge translation (KT) is a relatively new concept referring to transfers of knowledge into practice in collaboration with multiple sectors that work for the health and wellness of society. Knowledge translation is crucial to identifying and addressing the health needs of immigrants. AIM To scope the evidence on KT research engaging immigrants in the host country regarding the health and wellness of immigrants. METHODS This study followed a scoping review approach suggested by Arksey O'Malley. We identified relevant studies from both academic and grey literature using structured criteria, charted the data from the selected studies, collated, summarised and report the results. RESULTS Analysis of the eligible studies found two types of KT research: integrated KT and end-of-grant KT. Meeting or discussion with community-level knowledge-users were common KT activities among immigrants, but they were involved in the entire research process only if they were hired as members of research teams. Most KT research among immigrants explored cancer screening and used a community-based participatory action research approach. Barriers and enablers usually came from researchers rather than from the community. There was little practice of evaluation and defined frameworks to conduct KT research among immigrants in Canada. CONCLUSION This study can help the researchers and other stakeholders of health and wellness of the immigrant population to identify appropriate KT research activities for immigrants and where KT research is required to facilitate the transfer of research knowledge into action.
MeSH term(s)	Community-Based Participatory Research ; Emigrants and Immigrants ; Humans ; Knowledge ; Research Design ; Translational Research, Biomedical
Language	English
Publishing date	2021-08-14
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2572943-3
ISSN	1172-6156 ; 1172-6156
ISSN (online)	1172-6156
ISSN	1172-6156
DOI	10.1071/HC20072
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Article: Splenic Artery Aneurysm Case Report.

Abhari, Pouya / Abhari, Sina / Jackson, Anwar / Moustafa, Ahmed S Z / Mercer, Leo / Ashraf, Mohammad

Case reports in obstetrics and gynecology

2019 Volume 2019, Page(s) 8347983

Abstract: Splenic artery aneurysm rupture is a rare complication of pregnancy with very high maternal and fetal mortality rate. In this paper, a case of splenic artery aneurysm rupture at 34 weeks of gestation with both maternal and fetal survival is presented. ...

Abstract	Splenic artery aneurysm rupture is a rare complication of pregnancy with very high maternal and fetal mortality rate. In this paper, a case of splenic artery aneurysm rupture at 34 weeks of gestation with both maternal and fetal survival is presented.
Language	English
Publishing date	2019-03-19
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627654-9
ISSN	2090-6692 ; 2090-6684
ISSN (online)	2090-6692
ISSN	2090-6684
DOI	10.1155/2019/8347983
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