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  1. Article ; Online: Desafíos y consideraciones ante la discontinuación de la producción de respiradores por parte de fabricantes líderes.

    González-Castro, A / Fajardo Campoverdi, A

    Journal of healthcare quality research

    2024  

    Title translation Challenges and considerations in discontinuation of respirator production by leading manufacturers.
    Language Spanish
    Publishing date 2024-04-04
    Publishing country Spain
    Document type Letter
    ISSN 2603-6479
    ISSN (online) 2603-6479
    DOI 10.1016/j.jhqr.2024.03.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Acute respiratory distress syndrome: a definition on the line.

    González-Castro, A / Cuenca Fito, E / Gonzalez, C

    Medicina intensiva

    2023  Volume 47, Issue 4, Page(s) 242

    MeSH term(s) Humans ; Respiratory Distress Syndrome/therapy ; Positive-Pressure Respiration
    Language English
    Publishing date 2023-01-03
    Publishing country Spain
    Document type Letter
    ISSN 2173-5727
    ISSN (online) 2173-5727
    DOI 10.1016/j.medine.2023.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: High frequency trauma: The new worl order?

    Fajardo-Campoverdi, Aurio / Ibarra-Estrada, Miguel / González-Castro, Alejandro / Cortés, Alejandra / Núñez-Silveira, Juan

    Medicina intensiva

    2024  

    Language English
    Publishing date 2024-04-08
    Publishing country Spain
    Document type Case Reports
    ISSN 2173-5727
    ISSN (online) 2173-5727
    DOI 10.1016/j.medine.2024.03.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Do we actively and early mobilize patients admitted to an intensive care unit during mechanical ventilation?

    González-Castro, A / Ferrero-Franco, R / Blanco-Uelga, C

    Enfermeria intensiva

    2023  Volume 35, Issue 1, Page(s) 73–74

    MeSH term(s) Humans ; Respiration, Artificial ; Intensive Care Units ; Hospitalization
    Language English
    Publishing date 2023-07-10
    Publishing country Spain
    Document type Letter
    ISSN 2529-9840
    ISSN (online) 2529-9840
    DOI 10.1016/j.enfie.2023.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The customization of mechanical ventilation: Yes, but… Keep calm.

    González-Castro, A / Modesto, V / Medina, A

    Medicina intensiva

    2022  Volume 46, Issue 12, Page(s) 724–725

    MeSH term(s) Respiration, Artificial
    Language English
    Publishing date 2022-11-11
    Publishing country Spain
    Document type Letter
    ISSN 2173-5727
    ISSN (online) 2173-5727
    DOI 10.1016/j.medine.2022.05.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: High-flow nasal cannulas in COVID-19 pneumonia.

    González-Castro, Alejandro / Fajardo Campoverde, Aurio / Roncalli, Angello

    Medicina clinica (English ed.)

    2022  Volume 159, Issue 8, Page(s) e53

    Language English
    Publishing date 2022-10-03
    Publishing country Spain
    Document type Journal Article
    ISSN 2387-0206
    ISSN (online) 2387-0206
    DOI 10.1016/j.medcle.2021.07.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Saline, balanced solutions and Thomas Bayes.

    González-Castro, Alejandro / Modesto I Alapont, Vicente / Ferrero-Franco, Raquel

    Medicina intensiva

    2023  Volume 47, Issue 5, Page(s) 301–302

    MeSH term(s) Bayes Theorem ; Saline Solution ; Fluid Therapy
    Chemical Substances Saline Solution
    Language English
    Publishing date 2023-03-10
    Publishing country Spain
    Document type Letter ; Comment
    ISSN 2173-5727
    ISSN (online) 2173-5727
    DOI 10.1016/j.medine.2023.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Adequacy of fluid therapy in critically-septic patients: evidence and discrepancies.

    Ferrero-Franco, Raquel / González-Castro, Alejandro / Blanco Huelga, Carmen

    Enfermeria clinica (English Edition)

    2023  Volume 33, Issue 4, Page(s) 311–312

    MeSH term(s) Humans ; Sepsis/therapy ; Fluid Therapy
    Language English
    Publishing date 2023-06-30
    Publishing country Spain
    Document type Letter
    ISSN 2445-1479
    ISSN (online) 2445-1479
    DOI 10.1016/j.enfcle.2023.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

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  9. Article ; Online: A multiscale model of the role of microenvironmental factors in cell segregation and heterogeneity in breast cancer development.

    Romero-Arias, J Roberto / González-Castro, Carlos A / Ramírez-Santiago, Guillermo

    PLoS computational biology

    2023  Volume 19, Issue 11, Page(s) e1011673

    Abstract: We analyzed a quantitative multiscale model that describes the epigenetic dynamics during the growth and evolution of an avascular tumor. A gene regulatory network (GRN) formed by a set of ten genes that are believed to play an important role in breast ... ...

    Abstract We analyzed a quantitative multiscale model that describes the epigenetic dynamics during the growth and evolution of an avascular tumor. A gene regulatory network (GRN) formed by a set of ten genes that are believed to play an important role in breast cancer development was kinetically coupled to the microenvironmental agents: glucose, estrogens, and oxygen. The dynamics of spontaneous mutations was described by a Yule-Furry master equation whose solution represents the probability that a given cell in the tissue undergoes a certain number of mutations at a given time. We assumed that the mutation rate is modified by a spatial gradient of nutrients. The tumor mass was simulated by means of cellular automata supplemented with a set of reaction diffusion equations that described the transport of microenvironmental agents. By analyzing the epigenetic state space described by the GRN dynamics, we found three attractors that were identified with cellular epigenetic states: normal, precancer and cancer. For two-dimensional (2D) and three-dimensional (3D) tumors we calculated the spatial distribution of the following quantities: (i) number of mutations, (ii) mutation of each gene and, (iii) phenotypes. Using estrogen as the principal microenvironmental agent that regulates cell proliferation process, we obtained tumor shapes for different values of estrogen consumption and supply rates. It was found that he majority of mutations occurred in cells that were located close to the 2D tumor perimeter or close to the 3D tumor surface. Also, it was found that the occurrence of different phenotypes in the tumor are controlled by estrogen concentration levels since they can change the individual cell threshold and gene expression levels. All results were consistently observed for 2D and 3D tumors.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cell Proliferation/genetics ; Diffusion ; Cell Separation ; Estrogens
    Chemical Substances Estrogens
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1011673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Valor predictivo de las escalas APACHEII y SOFA en la mortalidad de pacientes oncológicos en cuidados intensivos.

    Cuenca Fito, Elena / González-Castro, Alejandro / Gómez Acebo, Inés

    Medicina clinica

    2023  Volume 161, Issue 12, Page(s) 547–548

    Title translation Predictive value of the APACHEII and SOFA scales in the mortality of cancer patients in intensive care.
    Language Spanish
    Publishing date 2023-08-10
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2023.07.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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