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  1. Article ; Online: Unraveling the kinetochore nanostructure in Schizosaccharomyces pombe using multi-color SMLM imaging.

    Virant, David / Vojnovic, Ilijana / Winkelmeier, Jannik / Endesfelder, Marc / Turkowyd, Bartosz / Lando, David / Endesfelder, Ulrike

    The Journal of cell biology

    2023  Volume 222, Issue 4

    Abstract: The key to ensuring proper chromosome segregation during mitosis is the kinetochore (KT), a tightly regulated multiprotein complex that links the centromeric chromatin to the spindle microtubules and as such leads the segregation process. Understanding ... ...

    Abstract The key to ensuring proper chromosome segregation during mitosis is the kinetochore (KT), a tightly regulated multiprotein complex that links the centromeric chromatin to the spindle microtubules and as such leads the segregation process. Understanding its architecture, function, and regulation is therefore essential. However, due to its complexity and dynamics, only its individual subcomplexes could be studied in structural detail so far. In this study, we construct a nanometer-precise in situ map of the human-like regional KT of Schizosaccharomyces pombe using multi-color single-molecule localization microscopy. We measure each protein of interest (POI) in conjunction with two references, cnp1CENP-A at the centromere and sad1 at the spindle pole. This allows us to determine cell cycle and mitotic plane, and to visualize individual centromere regions separately. We determine protein distances within the complex using Bayesian inference, establish the stoichiometry of each POI and, consequently, build an in situ KT model with unprecedented precision, providing new insights into the architecture.
    MeSH term(s) Bayes Theorem ; Centromere/metabolism ; Chromosome Segregation ; Kinetochores/ultrastructure ; Mitosis ; Schizosaccharomyces/metabolism ; Schizosaccharomyces pombe Proteins/genetics ; Schizosaccharomyces pombe Proteins/metabolism ; Spindle Apparatus/metabolism
    Chemical Substances SAD1 protein, S pombe ; Schizosaccharomyces pombe Proteins
    Language English
    Publishing date 2023-01-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.202209096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A bullous variant of central serous chorioretinopathy treated with oral spironolactone.

    Isaac, David Leonardo Cruvinel / Lando, Leonardo / Silva, Hugo Mendes / Avila, Marcos P

    Arquivos brasileiros de oftalmologia

    2022  Volume 86, Issue 4, Page(s) 375–379

    Abstract: We report the case of a 39-year-old male patient who presented with visual loss in the right eye for 6 weeks. The best-corrected visual acuity was counting fingers in the right eye and 20/30 in the left eye. The fundus examination demonstrated a right ... ...

    Abstract We report the case of a 39-year-old male patient who presented with visual loss in the right eye for 6 weeks. The best-corrected visual acuity was counting fingers in the right eye and 20/30 in the left eye. The fundus examination demonstrated a right retinal detachment inferiorly extending to the fovea and a left macular serous detachment. After multimodal imaging study, the patient was diagnosed as having a bullous variant of central serous chorioretinopathy and treated with oral spironolactone associated with adjuvant laser photocoagulation. The retinal changes resolved after 6 months. The final visual acuity was 20/20 in both eyes.
    Language English
    Publishing date 2022-04-27
    Publishing country Brazil
    Document type Letter
    ZDB-ID 603915-7
    ISSN 1678-2925 ; 0004-2749
    ISSN (online) 1678-2925
    ISSN 0004-2749
    DOI 10.5935/0004-2749.20230033
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  3. Article ; Online: Optic Nerve Sheath Meningioma Presenting as a Slow-Growing Intraocular Mass.

    Lando, Leonardo / Munoz, David G / Dangboon, Wantanee / Krema, Hatem / Altomare, Filiberto

    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

    2022  Volume 44, Issue 1, Page(s) e101–e102

    MeSH term(s) Humans ; Meningioma/diagnostic imaging ; Meningioma/surgery ; Optic Nerve Neoplasms/diagnosis ; Optic Nerve Diseases ; Meningeal Neoplasms/diagnosis ; Meningeal Neoplasms/surgery ; Optic Nerve/diagnostic imaging
    Language English
    Publishing date 2022-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1189901-3
    ISSN 1536-5166 ; 1070-8022
    ISSN (online) 1536-5166
    ISSN 1070-8022
    DOI 10.1097/WNO.0000000000001703
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  4. Article ; Online: Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency.

    Lando, David / Ma, Xiaoyan / Cao, Yang / Jartseva, Aleksandra / Stevens, Tim J / Boucher, Wayne / Reynolds, Nicola / Montibus, Bertille / Hall, Dominic / Lackner, Andreas / Ragheb, Ramy / Leeb, Martin / Hendrich, Brian D / Laue, Ernest D

    Molecular cell

    2024  Volume 84, Issue 8, Page(s) 1406–1421.e8

    Abstract: Enhancers bind transcription factors, chromatin regulators, and non-coding transcripts to modulate the expression of target genes. Here, we report 3D genome structures of single mouse ES cells as they are induced to exit pluripotency and transition ... ...

    Abstract Enhancers bind transcription factors, chromatin regulators, and non-coding transcripts to modulate the expression of target genes. Here, we report 3D genome structures of single mouse ES cells as they are induced to exit pluripotency and transition through a formative stage prior to undergoing neuroectodermal differentiation. We find that there is a remarkable reorganization of 3D genome structure where inter-chromosomal intermingling increases dramatically in the formative state. This intermingling is associated with the formation of a large number of multiway hubs that bring together enhancers and promoters with similar chromatin states from typically 5-8 distant chromosomal sites that are often separated by many Mb from each other. In the formative state, genes important for pluripotency exit establish contacts with emerging enhancers within these multiway hubs, suggesting that the structural changes we have observed may play an important role in modulating transcription and establishing new cell identities.
    MeSH term(s) Mice ; Animals ; Mouse Embryonic Stem Cells/metabolism ; Regulatory Sequences, Nucleic Acid ; Embryonic Stem Cells/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Chromatin/genetics ; Chromatin/metabolism ; Enhancer Elements, Genetic
    Chemical Substances Transcription Factors ; Chromatin
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2024.02.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: PARACENTRAL ACUTE MIDDLE MACULOPATHY AFTER AORTIC ANEURYSM REPAIR.

    Lando, Leonardo / Isaac, David Leonardo C / Avila, Marcos P

    Retinal cases & brief reports

    2019  Volume 16, Issue 2, Page(s) 177–179

    Abstract: Purpose: We report a case of paracentral acute middle maculopathy secondary to cholesterol embolization syndrome after an endovascular aortic aneurism repair (EVAR).: Methods: Functional and anatomical damage was assessed by Snellen visual acuity, ... ...

    Abstract Purpose: We report a case of paracentral acute middle maculopathy secondary to cholesterol embolization syndrome after an endovascular aortic aneurism repair (EVAR).
    Methods: Functional and anatomical damage was assessed by Snellen visual acuity, fundoscopy, and optical coherence tomography.
    Results: A 67-year-old man presented with sudden vision loss in the right eye for one day with concomitant livedo reticularis in both feet. His medical history included an abdominal EVAR repair three days before the symptoms. The best-corrected visual acuity was 20/40 in the right eye and 20/20 in the left eye. Fundoscopy showed intraarteriolar cholesterol plaques (Hollenhorst) bilaterally, and a localized retinal whitening in the right eye. Optical coherence tomography at the lesion site revealed a hyperreflective band on the level of inner nuclear layer. The patient was referred for imaging and complete systemic evaluation. He was then closely followed up by a vascular team, without additional intervention. Retinal stigma partially regressed at six months with visual improvement.
    Conclusion: This case describes paracentral acute middle maculopathy as a rare ocular sign of cholesterol embolization in postoperative intraaortic operations. The diagnosis of this complication led to prompt clinical care with a multidisciplinary approach.
    MeSH term(s) Acute Disease ; Aged ; Aortic Aneurysm/surgery ; Humans ; Macular Degeneration/diagnostic imaging ; Macular Degeneration/etiology ; Male ; Retinal Diseases/diagnostic imaging ; Retinal Diseases/etiology ; Tomography, Optical Coherence
    Language English
    Publishing date 2019-09-12
    Publishing country United States
    Document type Case Reports
    ISSN 1937-1578
    ISSN (online) 1937-1578
    DOI 10.1097/ICB.0000000000000927
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  6. Article: Credit risk modeling

    Lando, David

    Handbook of financial time series , p. 787-798

    2009  , Page(s) 787–798

    Author's details David Lando
    Language English
    Publisher Springer
    Publishing place Berlin [u.a.]
    Document type Article
    Database ECONomics Information System

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  7. Article ; Online: Retinal ischemia following mandible tumor treatment with steroid injection.

    Lando, Leonardo / Silva, Hugo Mendes / Cardoso, Lincoln Lara / Isaac, David Leonardo Cruvinel / Teixeira, Kim-Ir-Sen Santos / Avila, Marcos

    Arquivos brasileiros de oftalmologia

    2021  Volume 83, Issue 6, Page(s) 543–546

    Abstract: Central giant cell granuloma is a rare osseous tumor affecting young patients with anatomical and functional compromise of the maxilla and mandible. Steroid injection therapy constitutes a less invasive treatment modality for disease control in selected ... ...

    Abstract Central giant cell granuloma is a rare osseous tumor affecting young patients with anatomical and functional compromise of the maxilla and mandible. Steroid injection therapy constitutes a less invasive treatment modality for disease control in selected cases. Retinal ischemia is a reported complication of multiple medical procedures, including dental interventions, and may lead to loss of vision with poor prognosis. We report a case of retinal arteriolar ischemic disease following central giant cell granuloma management with local injected corticosteroids.
    MeSH term(s) Adolescent ; Adrenal Cortex Hormones/adverse effects ; Bone Neoplasms/drug therapy ; Female ; Granuloma, Giant Cell/drug therapy ; Humans ; Ischemia/chemically induced ; Mandible
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2021-01-15
    Publishing country Brazil
    Document type Case Reports ; Letter
    ZDB-ID 603915-7
    ISSN 1678-2925 ; 0004-2749
    ISSN (online) 1678-2925
    ISSN 0004-2749
    DOI 10.5935/0004-2749.20200099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Calculation of 3D genome structures for comparison of chromosome conformation capture experiments with microscopy: An evaluation of single-cell Hi-C protocols.

    Lando, David / Stevens, Tim J / Basu, Srinjan / Laue, Ernest D

    Nucleus (Austin, Tex.)

    2018  Volume 9, Issue 1, Page(s) 190–201

    Abstract: Single-cell chromosome conformation capture approaches are revealing the extent of cell-to-cell variability in the organization and packaging of genomes. These single-cell methods, unlike their multi-cell counterparts, allow straightforward computation ... ...

    Abstract Single-cell chromosome conformation capture approaches are revealing the extent of cell-to-cell variability in the organization and packaging of genomes. These single-cell methods, unlike their multi-cell counterparts, allow straightforward computation of realistic chromosome conformations that may be compared and combined with other, independent, techniques to study 3D structure. Here we discuss how single-cell Hi-C and subsequent 3D genome structure determination allows comparison with data from microscopy. We then carry out a systematic evaluation of recently published single-cell Hi-C datasets to establish a computational approach for the evaluation of single-cell Hi-C protocols. We show that the calculation of genome structures provides a useful tool for assessing the quality of single-cell Hi-C data because it requires a self-consistent network of interactions, relating to the underlying 3D conformation, with few errors, as well as sufficient longer-range cis- and trans-chromosomal contacts.
    MeSH term(s) Chromosomes/genetics ; Humans ; Imaging, Three-Dimensional ; Models, Molecular ; Single-Cell Analysis
    Language English
    Publishing date 2018-02-07
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 2619626-8
    ISSN 1949-1042 ; 1949-1042
    ISSN (online) 1949-1042
    ISSN 1949-1042
    DOI 10.1080/19491034.2018.1438799
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  9. Article: Drug discovery in the HIF pathway: where do we go now?

    Lando, David

    Drug discovery today

    2004  Volume 9, Issue 18, Page(s) 782–783

    MeSH term(s) Basic Helix-Loop-Helix Transcription Factors ; Cerebrovascular Disorders/metabolism ; Heart Diseases/metabolism ; Humans ; Mixed Function Oxygenases/physiology ; Neoplasms/metabolism ; Oxygen/metabolism ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/physiology
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors ; Transcription Factors ; endothelial PAS domain-containing protein 1 ; Mixed Function Oxygenases (EC 1.-) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2004-09-15
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/S1359-6446(04)03210-6
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    Zs.A 4725: Show issues Location:
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  10. Book ; Online: Credit Risk Modeling

    Lando, David

    Theory and Applications

    (Princeton Series in Finance)

    2009  

    Abstract: ... in the modeling aspects of credit risk. David Lando considers the two broad approaches to credit risk analysis ...

    Series title Princeton Series in Finance
    Abstract Credit risk is today one of the most intensely studied topics in quantitative finance. This book provides an introduction and overview for readers who seek an up-to-date reference to the central problems of the field and to the tools currently used to analyze them. The book is aimed at researchers and students in finance, at quantitative analysts in banks and other financial institutions, and at regulators interested in the modeling aspects of credit risk. David Lando considers the two broad approaches to credit risk analysis: that based on classical option pricing models on the one hand
    Language English
    Size Online-Ressource (329 p)
    Publisher Princeton University Press
    Publishing place s.l
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9780691089294 ; 0691089299
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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