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Article ; Online: Differential implications of gut-related metabolites on outcomes between heart failure and myocardial infarction.

Israr, Muhammad Zubair / Salzano, Andrea / Sarmad, Sarir / Ng, Leong L / Suzuki, Toru

European journal of preventive cardiology

2023 Volume 31, Issue 3, Page(s) 368–372

MeSH term(s)	Humans ; Heart Failure/diagnosis ; Heart Failure/therapy ; Myocardial Infarction/diagnosis
Language	English
Publishing date	2023-09-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2626011-6
ISSN	2047-4881 ; 2047-4873
ISSN (online)	2047-4881
ISSN	2047-4873
DOI	10.1093/eurjpc/zwad305
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Zs.A 4686: Show issues

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Article ; Online: Higher handgrip strength is linked to higher salience ventral attention functional network segregation in older adults.

Chong, Joanna Su Xian / Chua, Kevin Yiqiang / Ng, Kwun Kei / Chong, Shin Wee / Leong, Ruth L F / Chee, Michael W L / Koh, Woon Puay / Zhou, Juan Helen

Communications biology

2024 Volume 7, Issue 1, Page(s) 214

Abstract: Converging evidence suggests that handgrip strength is linked to cognition in older adults, and this may be subserved by shared age-related changes in brain function and structure. However, the interplay among handgrip strength, brain functional ... ...

Abstract	Converging evidence suggests that handgrip strength is linked to cognition in older adults, and this may be subserved by shared age-related changes in brain function and structure. However, the interplay among handgrip strength, brain functional connectivity, and cognitive function remains poorly elucidated. Hence, our study sought to examine these relationships in 148 community-dwelling older adults. Specifically, we examined functional segregation, a measure of functional brain organization sensitive to ageing and cognitive decline, and its associations with handgrip strength and cognitive function. We showed that higher handgrip strength was related to better processing speed, attention, and global cognition. Further, higher handgrip strength was associated with higher segregation of the salience/ventral attention network, driven particularly by higher salience/ventral attention intra-network functional connectivity of the right anterior insula to the left posterior insula/frontal operculum and right midcingulate/medial parietal cortex. Importantly, these handgrip strength-related inter-individual differences in salience/ventral attention network functional connectivity were linked to cognitive function, as revealed by functional decoding and brain-cognition association analyses. Our findings thus highlight the importance of the salience/ventral attention network in handgrip strength and cognition, and suggest that inter-individual differences in salience/ventral attention network segregation and intra-network connectivity could underpin the handgrip strength-cognition relationship in older adults.
MeSH term(s)	Hand Strength ; Cognition ; Brain/diagnostic imaging ; Parietal Lobe
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-024-05862-x
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Article ; Online: Quantifying the HDL proteome by mass spectrometry: how many proteins truly associate with HDL? Reply.

Ng, Leong L / Voors, Adriaan A

European journal of heart failure

2018 Volume 20, Issue 6, Page(s) 1077–1078

MeSH term(s)	Heart Failure ; Humans ; Mass Spectrometry ; Proteome ; Proteomics
Chemical Substances	Proteome
Language	English
Publishing date	2018-03-02
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1483672-5
ISSN	1879-0844 ; 1388-9842
ISSN (online)	1879-0844
ISSN	1388-9842
DOI	10.1002/ejhf.1173
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Zs.A 5299: Show issues

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Article ; Online: Response to: Comment on 'simultaneous cardio-cerebral infarction: a meta-analysis'.

Ng, T P / Wong, C / Leong, E L E / Tan, B Y Q / Chan, M Y-Y / Yeo, L L L / Yeo, T-C / Wong, R C C / Leow, A S T / Ho, J S-Y / Sia, C-H

QJM : monthly journal of the Association of Physicians

2022 Volume 116, Issue 3, Page(s) 254

MeSH term(s)	Humans ; Cerebral Infarction/complications ; Heart
Language	English
Publishing date	2022-09-12
Publishing country	England
Document type	Meta-Analysis ; Journal Article ; Comment
ZDB-ID	1199985-8
ISSN	1460-2393 ; 0033-5622 ; 1460-2725
ISSN (online)	1460-2393
ISSN	0033-5622 ; 1460-2725
DOI	10.1093/qjmed/hcac200
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Ua VI Zs.131: Show issues

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Article ; Online: Effect of the use of earplugs and eye masks on the quality of sleep after major abdominal surgery: a randomised controlled trial.

Leong, R W / Davies, L J / Fook-Chong, S / Ng, S Y / Lee, Y L

Anaesthesia

2021 Volume 76, Issue 11, Page(s) 1482–1491

Abstract: Significant sleep disturbance can occur following major abdominal surgery. We aimed to evaluate the effectiveness of earplugs and eye masks in improving sleep quality and patient satisfaction, reducing nursing demands and in the incidence of delirium in ... ...

Abstract	Significant sleep disturbance can occur following major abdominal surgery. We aimed to evaluate the effectiveness of earplugs and eye masks in improving sleep quality and patient satisfaction, reducing nursing demands and in the incidence of delirium in patients after major abdominal surgery. We conducted a randomised controlled trial in 100 patients undergoing major abdominal surgery. We randomly allocated participants to sleep with or without earplugs and eye masks on postoperative days 1-3. The primary outcome measure was sleep quality as measured by the Richards-Campbell Sleep Questionnaire. Secondary outcomes were patient satisfaction, frequency of nursing demand and incidence of delirium measured by the Neelon and Champagne Confusion Scale. Median (IQR [range]) sleep scores were 64 (38-74 [0-100] and 60 (44-82 [18-100]) for the control and intervention groups, respectively (p = 0.310). Age and Pittsburgh Sleep Quality Index scores were found to be significant factors affecting sleep quality. There were no differences in patient satisfaction, reduction in frequency of nursing demands or incidence of delirium on postoperative days 1-3 after major abdominal surgery. The compliance rate in the intervention group was 60-65%. This study has demonstrated that the use of earplugs and eye masks did not contribute to improvements in sleep quality. Of note, sleep quality was moderate, with higher age and worse baseline sleep quality contributing to worse sleep scores. More studies are needed to investigate interventions to improve sleep quality after major abdominal surgery.
MeSH term(s)	Abdomen/surgery ; Adult ; Aged ; Aged, 80 and over ; Ear Protective Devices ; Eye Protective Devices ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Patient Satisfaction ; Postoperative Period ; Prospective Studies ; Single-Blind Method ; Sleep/physiology ; Surveys and Questionnaires
Language	English
Publishing date	2021-04-21
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	80033-8
ISSN	1365-2044 ; 0003-2409
ISSN (online)	1365-2044
ISSN	0003-2409
DOI	10.1111/anae.15468
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Zs.A 388: Show issues

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Article ; Online: Use of Nonhuman Sera as a Highly Cost-Effective Internal Standard for Quantitation of Multiple Human Proteins Using Species-Specific Tryptic Peptides: Applicability in Clinical LC-MS Analyses.

Williams, Geraldine / Couchman, Lewis / Taylor, David R / Sandhu, Jatinderpal K / Slingsby, Oliver C / Ng, Leong L / Moniz, Cajetan F / Jones, Donald J L / Maxwell, Colleen B

Journal of proteome research

2024

Abstract: Quantitation of proteins using liquid chromatography-tandem mass spectrometry (LC-MS/MS) is complex, with a multiplicity of options ranging from label-free techniques to chemically and metabolically labeling proteins. Increasingly, for clinically ... ...

Abstract	Quantitation of proteins using liquid chromatography-tandem mass spectrometry (LC-MS/MS) is complex, with a multiplicity of options ranging from label-free techniques to chemically and metabolically labeling proteins. Increasingly, for clinically relevant analyses, stable isotope-labeled (SIL) internal standards (ISs) represent the "gold standard" for quantitation due to their similar physiochemical properties to the analyte, wide availability, and ability to multiplex to several peptides. However, the purchase of SIL-ISs is a resource-intensive step in terms of cost and time, particularly for screening putative biomarker panels of hundreds of proteins. We demonstrate an alternative strategy utilizing nonhuman sera as the IS for quantitation of multiple human proteins. We demonstrate the effectiveness of this strategy using two high abundance clinically relevant analytes, vitamin D binding protein [Gc globulin] (DBP) and albumin (ALB). We extend this to three putative risk markers for cardiovascular disease: plasma protease C1 inhibitor (SERPING1), annexin A1 (ANXA1), and protein kinase, DNA-activated catalytic subunit (PRKDC). The results show highly specific, reproducible, and linear measurement of the proteins of interest with comparable precision and accuracy to the gold standard SIL-IS technique. This approach may not be applicable to every protein, but for many proteins it can offer a cost-effective solution to LC-MS/MS protein quantitation.
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021/acs.jproteome.3c00762
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Zs.A 6189: Show issues

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Article ; Online: The prevalence patterns and risk factor profiles of poor muscle health and its associated components in multiethnic older Asians: The PIONEER study.

Gupta, Preeti / Vu, Tai-Anh / Man, Ryan E K / Fenwick, Eva K / Tay, Laura / Yee Sien, Ng / Ng, David / Frederick, Koh Hong Xiang / Yong, Eu-Leong / Chew, Samuel T H / Lamoureux, Ecosse L

Journal of cachexia, sarcopenia and muscle

2024

Abstract: Background: We aim to determine the multiethnic patterns of the prevalence and associated factors of poor muscle health and its associated components in older Chinese, Malays, and Indian Asian adults.: Methods: We included 2199 participants (mean age ...

Abstract	Background: We aim to determine the multiethnic patterns of the prevalence and associated factors of poor muscle health and its associated components in older Chinese, Malays, and Indian Asian adults. Methods: We included 2199 participants (mean age ± SD: 72.9 ± 8.3 years; 54.3% female) from the baseline assessment of the Population Health and Eye Disease Profile in Elderly Singaporeans (PIONEER; 2017-2022) cohort study. Poor muscle health was defined as the presence of either low muscle mass (DEXA), or low muscle strength (handgrip strength), or low physical performance (gait speed). Its components include poor muscle function (low muscle strength and/or low physical performance without low muscle mass), pre-sarcopenia (low muscle mass only), and any sarcopenia (low muscle mass with low muscle strength and/or low physical performance). Sociodemographic, clinical, and lifestyle factors were assessed using biochemistry, clinical tests, and validated questionnaires. Regression models were utilized to evaluate the independent risk factors of poor muscle health and its components. Results: The national census-adjusted prevalence of poor muscle health (88%) was similar across the three ethnic groups. However, Chinese individuals had higher prevalence of pre-sarcopenia and any sarcopenia, and a lower prevalence of poor muscle function compared with Indians or Malays. We observed ethnic differences in modifiable risk factors (low physical activity, diabetes, osteoporosis, and obesity) of poor muscle health and its components. Although obesity was protective of pre-sarcopenia (RRR = 0.19, 95% CI: 0.11, 0.36) and any sarcopenia (RRR = 0.29, 95% CI: 0.18, 0.47) in the overall population and across ethnic groups, it was associated with 1.7 times (95% CI: 1.07, 2.67) the likelihood of poor muscle function in the entire population. Conclusions: Almost 90% of community dwelling Singaporean aged ≥60 years have poor muscle health across the three ethnic groups with ethnic disparities in modifiable risk factors, highlighting an urgent need for community-wide targeted interventions to promote muscle health.
Language	English
Publishing date	2024-04-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2586864-0
ISSN	2190-6009 ; 2190-5991
ISSN (online)	2190-6009
ISSN	2190-5991
DOI	10.1002/jcsm.13483
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Article ; Online: The Edge Effect in High-Throughput Proteomics: A Cautionary Tale.

Maxwell, Colleen B / Sandhu, Jatinderpal K / Cao, Thong H / McCann, Gerry P / Ng, Leong L / Jones, Donald J L

Journal of the American Society for Mass Spectrometry

2023 Volume 34, Issue 6, Page(s) 1065–1072

Abstract: In order for mass spectrometry to continue to grow as a platform for high-throughput clinical and translational research, careful consideration must be given to quality control by ensuring that the assay performs reproducibly and accurately and precisely. ...

Abstract	In order for mass spectrometry to continue to grow as a platform for high-throughput clinical and translational research, careful consideration must be given to quality control by ensuring that the assay performs reproducibly and accurately and precisely. In particular, the throughput required for large cohort clinical validation in biomarker discovery and diagnostic screening has driven the growth of multiplexed targeted liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) assays paired with sample preparation and analysis in multiwell plates. However, large scale MS-based proteomics studies are often plagued by batch effects: sources of technical variation in the data, which can arise from a diverse array of sources such as sample preparation batches, different reagent lots, or indeed MS signal drift. These batch effects can confound the detection of true signal differences, resulting in incorrect conclusions being drawn about significant biological effects or lack thereof. Here, we present an intraplate batch effect termed the edge effect arising from temperature gradients in multiwell plates, commonly reported in preclinical cell culture studies but not yet reported in a clinical proteomics setting. We present methods herein to ameliorate the phenomenon including proper assessment of heating techniques for multiwell plates and incorporation of surrogate standards, which can normalize for intraplate variation.
MeSH term(s)	Humans ; Chromatography, Liquid/methods ; Tandem Mass Spectrometry/methods ; Proteomics/methods ; Quality Control ; Reference Standards
Language	English
Publishing date	2023-05-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1073671-2
ISSN	1879-1123 ; 1044-0305
ISSN (online)	1879-1123
ISSN	1044-0305
DOI	10.1021/jasms.3c00035
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Zs.A 4618: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 241: Show issues

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Article: A prospective study of incidence and outcome of acute kidney injury among hospitalised patients in Malaysia (My-AKI).

Goh, C Y / Visvanathan, R / Leong, C T / Hooi, L S / Ch'ng, C C / Yee, S Y / Abd Manaf, K A / Mushahar, L / Goh, K W / Liew, Y F / Manocha, A B / Ong, L M

The Medical journal of Malaysia

2023 Volume 78, Issue 6, Page(s) 733–742

Abstract: Introduction: The incidence of acute kidney injury (AKI) among hospitalised patients has not been well studied in Malaysia.: Materials and methods: We conducted a prospective, multicentre study in seven hospitals in West Malaysia. All the adults ... ...

Abstract	Introduction: The incidence of acute kidney injury (AKI) among hospitalised patients has not been well studied in Malaysia. Materials and methods: We conducted a prospective, multicentre study in seven hospitals in West Malaysia. All the adults admitted in March 2017 fulfilling Kidney Disease Improving Global Outcomes (KDIGO) criteria for AKI were included. Results: Of the 34,204 patients screened, 2,457 developed AKI (7.18%), 13.1% of which occurred in intensive care unit (ICU). There were 60.2% males with a mean age of 57.8 (±17.5) years. The most common comorbidities were hypertension (55.0%), diabetes (46.6%), ischaemic heart disease (15.1%) and chronic kidney disease (12.0%). The commonest causes of AKI were sepsis (41.7%), pre-renal (24.2%) and cardiorenal syndrome (10.8%). Nephrotoxin exposure was reported in 31%. At diagnosis, the proportion of AKI stages 1, 2 and 3 were 79.1%, 9.7%, 11.2%, respectively. Referral to nephrologists was reported in 16.5%. Dialysis was required in 176 (7.2%) patients and 55.6% were performed in the ICU. Acidosis (46.2%), uraemia (31.6%) and electrolyte disturbance (11.1%) were the commonest indications. Continuous renal replacement therapy (CRRT) was required in 14%. The average length of hospital stay was 9.5 days. In-hospital mortality was 16.4%. Among survivors, full and partial renal recovery was seen in 74.7% and 16.4% respectively while 8.9% failed to recover. After a mean follow-up of 13.7 months, 593 (30.2%) of survivors died and 38 (1.9%) initiated chronic dialysis. Mortality was highest among those with malignancies (Hazard Ratio, HR 2.14), chronic liver disease (HR 2.13), neurological disease (HR 1.56) and cardiovascular disease (HR 1.17). Conclusion: AKI is common in hospitalised patients and is with associated high mortality during and after hospitalisation.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Middle Aged ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Incidence ; Kidney ; Malaysia/epidemiology ; Prospective Studies ; Retrospective Studies ; Risk Factors ; Aged
Language	English
Publishing date	2023-11-29
Publishing country	Malaysia
Document type	Multicenter Study ; Journal Article
ZDB-ID	604286-7
ISSN	0300-5283
ISSN	0300-5283
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Zs.A 1206: Show issues

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Article ; Online: Splitting sleep between the night and a daytime nap reduces homeostatic sleep pressure and enhances long-term memory.

Cousins, James N / Leong, Ruth L F / Jamaluddin, S Azrin / Ng, Alyssa S C / Ong, Ju Lynn / Chee, Michael W L

Scientific reports

2021 Volume 11, Issue 1, Page(s) 5275

Abstract: Daytime naps have been linked with enhanced memory encoding and consolidation. It remains unclear how a daily napping schedule impacts learning throughout the day, and whether these effects are the same for well-rested and sleep restricted individuals. ... ...

Abstract	Daytime naps have been linked with enhanced memory encoding and consolidation. It remains unclear how a daily napping schedule impacts learning throughout the day, and whether these effects are the same for well-rested and sleep restricted individuals. We compared memory in 112 adolescents who underwent two simulated school weeks containing 8 or 6.5 h sleep opportunities each day. Sleep episodes were nocturnal or split between nocturnal sleep and a 90-min afternoon nap, creating four experimental groups: 8 h-continuous, 8 h-split, 6.5 h-continuous and 6.5 h-split. Declarative memory was assessed with picture encoding and an educationally realistic factual knowledge task. Splitting sleep significantly enhanced afternoon picture encoding and factual knowledge under both 6.5 h and 8 h durations. Splitting sleep also significantly reduced slow-wave energy during nocturnal sleep, suggesting lower homeostatic sleep pressure during the day. There was no negative impact of the split sleep schedule on morning performance, despite a reduction in nocturnal sleep. These findings suggest that naps could be incorporated into a daily sleep schedule that provides sufficient sleep and benefits learning.
MeSH term(s)	Adolescent ; Cognition/physiology ; Female ; Homeostasis/physiology ; Humans ; Male ; Memory, Long-Term/physiology ; Polysomnography/methods ; Random Allocation ; Recognition, Psychology/physiology ; Sleep Quality ; Sleep, Slow-Wave/physiology ; Wakefulness/physiology ; Young Adult
Language	English
Publishing date	2021-03-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-84625-8
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