Article ; Online: B
Journal of magnetic resonance imaging : JMRI
2021 Volume 54, Issue 5, Page(s) 1529–1540
Abstract: Background: T1 mapping can potentially quantitatively assess the intrinsic properties of tumors. B ... Purpose: To assess the repeatability and reproducibility of B: Study type: Prospective reproducibility ... strength/sequence: A 3 T/B: Assessment: Intraobserver, interobserver, and test-retest reproducibility ...
Abstract | Background: T1 mapping can potentially quantitatively assess the intrinsic properties of tumors. B Purpose: To assess the repeatability and reproducibility of B Study type: Prospective reproducibility study. Population: Sixty lung cancer patients (22 with emphysema) with a total of 60 lesions (adenocarcinoma [n = 23], squamous cell carcinoma [n = 19], and small-cell lung cancer [SCLC] [n = 18]). Field strength/sequence: A 3 T/B Assessment: Intraobserver, interobserver, and test-retest reproducibility of minimum, maximum, mean, and SD of lung tumor T1 values were assessed. The correlation between mean T1 and apparent diffusion coefficient (ADC) and differences between different histological types of lung cancer were evaluated. Statistical tests: Intraclass correlation coefficients (ICCs), within-subject coefficients of variation (WCVs), Bland-Altman plots, Pearson's correlation coefficient (r), and analysis of variance (ANOVA). A P value <0.05 was considered to be statistically significant. Results: No significant differences were found in minimum, maximum, mean, and SD T1 values for repeated measurements (intraobserver and interobserver) and repeated examinations (P = 0.103-0.979). All parameters showed good intraobserver, interobserver and test-retest reproducibility (ICC, 0.780-0.978), except the maximum T1 value (ICC, 0.645-0.922). The mean T1 exhibited the best reproducibility and repeatability, with an average difference <6% for repeated measurements, <8% for repeated scans in lung cancer patients, and<10% for repeated scans in those with emphysema. The mean T1 correlated moderately with ADC (r = -0.580, -0.516, and -0.511 for observers A, B, and C). Both mean T1 and mean ADC were significantly different in SCLC patients compared with those in adenocarcinoma and squamous cell carcinoma patients. Data conclusion: The mean T1 from B Evidence level: 1 TECHNICAL EFFICACY: Stage 2. |
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MeSH term(s) | Biomarkers ; Diffusion Magnetic Resonance Imaging ; Humans ; Lung Neoplasms/diagnostic imaging ; Prospective Studies ; Reproducibility of Results |
Chemical Substances | Biomarkers |
Language | English |
Publishing date | 2021-07-22 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 1146614-5 |
ISSN | 1522-2586 ; 1053-1807 |
ISSN (online) | 1522-2586 |
ISSN | 1053-1807 |
DOI | 10.1002/jmri.27844 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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