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  1. Article ; Online: Quantitative study on the three-dimensional defense of Puzhuang Suo-Fort ancient wall and the moat.

    Shen, Shenge / Tan, Lifeng / Wang, Cheng / Zhao, Pengfei / Liu, Huanjie / Zhou, Jiayin / Wang, Yinggang / Yuan, Hong

    PloS one

    2023  Volume 18, Issue 3, Page(s) e0282537

    Abstract: ... of the ancient microscopic defense mechanism, using the ancient defense mechanism of Pu Zhuang Suo-Fort ...

    Abstract The spatial layout of the coastal forts defense system of the Ming Dynasty of China has been studied in a relatively comprehensive way. Nonetheless, ancient defense mechanisms have not been fully revealed. Previous studies have focused more on the macro and meso levels. Studies into its microscopic construction mechanism need to be enhanced. This research attempts to quantify and validate the rationality of the ancient microscopic defense mechanism, using the ancient defense mechanism of Pu Zhuang Suo-Fort in Zhejiang Province as an instance. This study concentrates on the distribution of firepower strength beyond the walls of coastal defense forts, as well as the effect of wall height on firepower defense capabilities. There is a specific firepower attenuation area near the walls due to the firing blind area in the coastal forts defense system. And the construction of the moat plays an additive role in its defensive capability. Meanwhile, the height of the fort wall will also affect the range of the firing blind zone under Yangmacheng. In theory, there is a reasonable height range of the wall and a proper position of the moat. This height range can meet both good economy and defensive capabilities. In turn, the position of the moats and the height of the walls can verify the rationality of the construction mechanism of the coastal forts' defense system.
    Language English
    Publishing date 2023-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0282537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Suo Quan Wan ameliorates bladder overactivity and regulates neurotransmission via regulating Myosin Va protein expression.

    Zhang, Yao / Zhang, Jiao / Hong, Ming / Huang, Jingyi / Xu, Siyuan / Wang, Rui / Zhou, Na / Huang, Ping / Tan, Bo / Cao, Hongying

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2022  Volume 104, Page(s) 154265

    Abstract: Background: Ancient prescriptions of Suo Quan Wan (SQW) have therapeutic effects on diabetic ...

    Abstract Background: Ancient prescriptions of Suo Quan Wan (SQW) have therapeutic effects on diabetic bladder dysfunction. However, the underlying mechanism remains unclear. Here, we hypothesized that SQW ameliorates bladder overactivity and regulates neurotransmission via regulating Myosin Va protein expression.
    Methods: After diabetic rats were induced by streptozotocin (65 mg/kg), the model of diabetic bladder dysfunction was established by detecting fasting blood glucose, urodynamic test, in vitro muscle strip experiments, and histological examination. One week after induction, SQW was given to observe the therapeutic effect. The expression levels of Myosin Va in control, Model, SQW L and SQW H groups were detected by RT-qPCR, RNAscope and immunofluorescence assay. The expression levels of ChAT, SP, nNOS and VIP proteins were observed by immunofluorescence assay. After knockdown and overexpression of Myosin Va, the expression changes of ChAT, SP, nNOS and VIP and the regulatory role of SQW were observed.
    Results: STZ-induced DM rats had significantly higher serum glucose levels and lower body weight. Compared with the diabetic rats, SQW treatment significantly improved urination function with decreased residual volume (RV), bladder compliance (BC), non-voiding contractions (NVCs), and increased voided efficiency (VE). In addition, contractile responses of muscle strips to electrical-field stimulation (EFS), carbachol (CCh), KCl were significantly lower in the SQW H and SQW L groups than those in the model group. RT-qPCR found that the expression of Myosin Va in the bladder tissue or bladder neurons in model group was significantly increased compared with the control group, and SQW treatment significantly decreased the levels of Myosin Va. In DM rats, ChAT and SP expression were significantly increased, while nNOS and VIP expression were significantly decreased, and SQW improved this phenomenon. Interestingly, SQW ameliorated the abnormal expression of ChAT, SP, nNOS and VIP caused by myosin Va knockdown, and Myosin Va overexpression results are consistent with these.
    Conclusions: SQW ameliorates overactive bladder and regulate neurotransmission via regulating Myosin Va mRNA and protein expression.
    MeSH term(s) Animals ; Diabetes Mellitus, Experimental/metabolism ; Muscle Contraction ; Myosins/metabolism ; Myosins/pharmacology ; Rats ; Streptozocin/pharmacology ; Synaptic Transmission ; Urinary Bladder ; Urodynamics
    Chemical Substances Streptozocin (5W494URQ81) ; Myosins (EC 3.6.4.1)
    Language English
    Publishing date 2022-06-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2022.154265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4115: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Quantitative study on the three-dimensional defense of Puzhuang Suo-Fort ancient wall and the moat.

    Shenge Shen / Lifeng Tan / Cheng Wang / Pengfei Zhao / Huanjie Liu / Jiayin Zhou / Yinggang Wang / Hong Yuan

    PLoS ONE, Vol 18, Iss 3, p e

    2023  Volume 0282537

    Abstract: ... of the ancient microscopic defense mechanism, using the ancient defense mechanism of Pu Zhuang Suo-Fort ...

    Abstract The spatial layout of the coastal forts defense system of the Ming Dynasty of China has been studied in a relatively comprehensive way. Nonetheless, ancient defense mechanisms have not been fully revealed. Previous studies have focused more on the macro and meso levels. Studies into its microscopic construction mechanism need to be enhanced. This research attempts to quantify and validate the rationality of the ancient microscopic defense mechanism, using the ancient defense mechanism of Pu Zhuang Suo-Fort in Zhejiang Province as an instance. This study concentrates on the distribution of firepower strength beyond the walls of coastal defense forts, as well as the effect of wall height on firepower defense capabilities. There is a specific firepower attenuation area near the walls due to the firing blind area in the coastal forts defense system. And the construction of the moat plays an additive role in its defensive capability. Meanwhile, the height of the fort wall will also affect the range of the firing blind zone under Yangmacheng. In theory, there is a reasonable height range of the wall and a proper position of the moat. This height range can meet both good economy and defensive capabilities. In turn, the position of the moats and the height of the walls can verify the rationality of the construction mechanism of the coastal forts' defense system.
    Keywords Medicine ; R ; Science ; Q
    Subject code 930
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Article: Suo Quan Wan ameliorates bladder overactivity and regulates neurotransmission via regulating Myosin Va protein expression

    Zhang, Yao / Zhang, Jiao / Hong, Ming / Huang, Jingyi / Xu, Siyuan / Wang, Rui / Zhou, Na / Huang, Ping / Tan, Bo / Cao, Hongying

    Phytomedicine. 2022 Sept., v. 104

    2022  

    Abstract: Ancient prescriptions of Suo Quan Wan (SQW) have therapeutic effects on diabetic bladder ...

    Abstract Ancient prescriptions of Suo Quan Wan (SQW) have therapeutic effects on diabetic bladder dysfunction. However, the underlying mechanism remains unclear. Here, we hypothesized that SQW ameliorates bladder overactivity and regulates neurotransmission via regulating Myosin Va protein expression. After diabetic rats were induced by streptozotocin (65 mg/kg), the model of diabetic bladder dysfunction was established by detecting fasting blood glucose, urodynamic test, in vitro muscle strip experiments, and histological examination. One week after induction, SQW was given to observe the therapeutic effect. The expression levels of Myosin Va in control, Model, SQW L and SQW H groups were detected by RT-qPCR, RNAscope and immunofluorescence assay. The expression levels of ChAT, SP, nNOS and VIP proteins were observed by immunofluorescence assay. After knockdown and overexpression of Myosin Va, the expression changes of ChAT, SP, nNOS and VIP and the regulatory role of SQW were observed. STZ-induced DM rats had significantly higher serum glucose levels and lower body weight. Compared with the diabetic rats, SQW treatment significantly improved urination function with decreased residual volume (RV), bladder compliance (BC), non-voiding contractions (NVCs), and increased voided efficiency (VE). In addition, contractile responses of muscle strips to electrical-field stimulation (EFS), carbachol (CCh), KCl were significantly lower in the SQW H and SQW L groups than those in the model group. RT-qPCR found that the expression of Myosin Va in the bladder tissue or bladder neurons in model group was significantly increased compared with the control group, and SQW treatment significantly decreased the levels of Myosin Va. In DM rats, ChAT and SP expression were significantly increased, while nNOS and VIP expression were significantly decreased, and SQW improved this phenomenon. Interestingly, SQW ameliorated the abnormal expression of ChAT, SP, nNOS and VIP caused by myosin Va knockdown, and Myosin Va overexpression results are consistent with these. SQW ameliorates overactive bladder and regulate neurotransmission via regulating Myosin Va mRNA and protein expression.
    Keywords bladder ; blood glucose ; body weight ; carbachol ; compliance ; fluorescent antibody technique ; histology ; muscles ; myosin ; protein synthesis ; streptozotocin ; synaptic transmission ; therapeutics ; urination
    Language English
    Dates of publication 2022-09
    Publishing place Elsevier GmbH
    Document type Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2022.154265
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4115: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Suo Quan Wan Protects Mouse From Early Diabetic Bladder Dysfunction by Mediating Motor Protein Myosin Va and Transporter Protein SLC17A9.

    Wang, Jing / Lian, Da-Wei / Yang, Xu-Feng / Xu, Yi-Fei / Chen, Fang-Jun / Lin, Wei-Jun / Wang, Rui / Tang, Li-Yao / Ren, Wen-Kang / Fu, Li-Jun / Huang, Ping / Cao, Hong-Ying

    Frontiers in pharmacology

    2019  Volume 10, Page(s) 552

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2019-05-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2019.00552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Ultra high performance liquid chromatography with tandem mass spectrometry for rapid separation and identification of main constituents in Chinese herbal formula Xuan Hu Suo San.

    Tang, Huaqi / Zhang, Xinyue / Luo, Shilin / Shang, Fei / Chen, Jianping / Wang, Jinghong / Duan, Xiaojie / Gao, Xiaoyan / Sun, Yikun

    Natural product research

    2017  Volume 31, Issue 14, Page(s) 1620–1624

    Abstract: Xuan Hu Suo San (XHSS) is a traditional Chinese medicine that has been extensively applied ...

    Abstract Xuan Hu Suo San (XHSS) is a traditional Chinese medicine that has been extensively applied in the treatment of osteoarthritis for many years, however, its chemical composition has not yet been elucidated. Thus, a rapid, efficient, and precise method based on ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was applied in both positive- and negative-ion modes to rapidly separate and identify the main chemical ingredients in XHSS for the first time. Finally, with the optimised separation and detection method, a total of 57 compounds were simultaneously separated within 13 min, among which 14 compounds were confirmed by comparing retention time and MS data with reference standards and others were tentatively identified by comparing with reference literatures. This rapid and sensitive approach is highly useful for the identification and characterisation of chemical constituents, and provides fundamental and extensive information supporting further metabolic and pharmacokinetic studies of XHSS.
    MeSH term(s) Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/chemistry ; Medicine, Chinese Traditional/methods ; Tandem Mass Spectrometry/methods
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2017-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2017.1285296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Zong mu lu, suo yin, nian biao

    Wang, Jingxian

    (Zhong guo mei shu quan ji : 中國美術全集 ; / Zhong guo mei shu quan ji bian ji wei yuan hui bian ; 1)

    2006  

    Author's details Wang jing xian
    Series title Zhong guo mei shu quan ji : 中國美術全集
    / Zhong guo mei shu quan ji bian ji wei yuan hui bian ; 1
    Language Chinese
    Size 402 S, Kart.
    Edition Di 2 ban
    Publisher Ren min mei shu chu ban she
    Publishing place Bei jing
    Document type Book
    ISBN 9787102005988 ; 7102005989
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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  8. Article: Ultra high performance liquid chromatography with tandem mass spectrometry for rapid separation and identification of main constituents in Chinese herbal formula Xuan Hu Suo San

    Tang, Huaqi / Xinyue Zhang / Shilin Luo / Fei Shang / Jianping Chen / Jinghong Wang / Xiaojie Duan / Xiaoyan Gao / Yikun Sun

    Natural product research. 2017 July 18, v. 31, no. 14

    2017  

    Abstract: Xuan Hu Suo San (XHSS) is a traditional Chinese medicine that has been extensively applied ...

    Abstract Xuan Hu Suo San (XHSS) is a traditional Chinese medicine that has been extensively applied in the treatment of osteoarthritis for many years, however, its chemical composition has not yet been elucidated. Thus, a rapid, efficient, and precise method based on ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was applied in both positive- and negative-ion modes to rapidly separate and identify the main chemical ingredients in XHSS for the first time. Finally, with the optimised separation and detection method, a total of 57 compounds were simultaneously separated within 13 min, among which 14 compounds were confirmed by comparing retention time and MS data with reference standards and others were tentatively identified by comparing with reference literatures. This rapid and sensitive approach is highly useful for the identification and characterisation of chemical constituents, and provides fundamental and extensive information supporting further metabolic and pharmacokinetic studies of XHSS.
    Keywords Oriental traditional medicine ; ingredients ; osteoarthritis ; pharmacokinetics ; reference standards ; tandem mass spectrometry ; ultra-performance liquid chromatography
    Language English
    Dates of publication 2017-0718
    Size p. 1620-1624.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2017.1285296
    Database NAL-Catalogue (AGRICOLA)

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  9. Book: Man xing wei suo xing wei yan Zhong xi yi jie he zhi liao

    Wang, Jiankang

    (Chang jian nan zhi bing Zhong xi yi jie he zhi liao cong shu)

    2009  

    Author's details zhu bian Wang Jiankang
    Series title Chang jian nan zhi bing Zhong xi yi jie he zhi liao cong shu
    MeSH term(s) Gastritis, Atrophic/therapy ; Chronic Disease/therapy ; Integrative Medicine
    Language Chinese
    Size 320 p. ;, 21 cm.
    Edition Di 1 ban.
    Publisher Ren min wei sheng chu ban she
    Publishing place Beijing
    Document type Book
    ISBN 9787117112697 ; 7117112697
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Book: Qing ren bie ming zi hao suo yin

    Wang, Deyi

    2001  

    Author's details Wang de yi bian zhu
    Language Chinese
    Size 975 p
    Edition Zai ban
    Publisher Wang de yi chu ban
    Publishing place Tai bei
    Document type Book
    ISBN 9577445411 ; 9789577445414
    Database Former special subject collection: coastal and deep sea fishing

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