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Article ; Online: Unilateral chronic angle-closure glaucoma in a pediatric patient with neurofibromatosis: a case report.

Jiang, Mingming / Zhang, Jing / Wan, Xiaomei / Ding, Yichao / Xie, Feijia

The Journal of international medical research

2023 Volume 51, Issue 5, Page(s) 3000605231173828

Abstract: Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disease that causes multi-system damage. It is rarely associated with angle-closure glaucoma, especially in pediatric patients. We herein report a case of unilateral chronic angle-closure ... ...

Abstract	Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disease that causes multi-system damage. It is rarely associated with angle-closure glaucoma, especially in pediatric patients. We herein report a case of unilateral chronic angle-closure glaucoma in a patient with NF1. A 5-year-old girl with a large subcutaneous soft mass and multiple scattered coffee-milk spots presented with low vision, increased intraocular pressure, and angle closure in her right eye. Lisch nodules were seen in both eyes. In her right eye, ectropion uveae was observed at the top and bottom margins of the pupil. Magnetic resonance imaging of the skull and orbit revealed no abnormalities. Finally, trabeculectomy was performed on the right eye, after which the right eye showed a stable intraocular pressure. NF1 combined with angle-closure glaucoma is rare and easily missed in the clinical setting. Early diagnosis and treatment may achieve good results.
MeSH term(s)	Humans ; Child ; Female ; Child, Preschool ; Glaucoma, Angle-Closure/complications ; Glaucoma, Angle-Closure/surgery ; Glaucoma, Angle-Closure/diagnosis ; Neurofibromatosis 1/complications ; Neurofibromatosis 1/diagnosis ; Intraocular Pressure
Language	English
Publishing date	2023-04-25
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605231173828
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Article ; Online: Conjunctival sac flora and drug susceptibility analysis in normal children in East China.

Jiang, Mingming / Zhang, Jing / Wan, Xiaomei / Ding, Yichao / Xie, Feijia

BMC ophthalmology

2023 Volume 23, Issue 1, Page(s) 248

Abstract: Purpose: To investigate the distribution characteristics of conjunctival sac flora and assess the susceptibility of commonly used topical antimicrobial agents in normal children under the age of 18 in East China.: Methods: In 2019, a study was ... ...

Abstract	Purpose: To investigate the distribution characteristics of conjunctival sac flora and assess the susceptibility of commonly used topical antimicrobial agents in normal children under the age of 18 in East China. Methods: In 2019, a study was conducted at Qingdao Eye Hospital of Shandong First Medical University to analyze the microorganism cultures of conjunctival sac in 1258 normal children (2516 eyes; average age, 6.21 ± 3.78 years) in East China. Exclusion criteria included children with ocular surface diseases and those who had used any topical antimicrobial agents recently. The microorganism species in the conjunctival sac were analyzed using the M-38A protocol (microdilution method; investigators read the minimum inhibitory concentration [MIC] values) by the Clinical and Laboratory Standards Institute to determine drug susceptibility. Results: The incidence of conjunctival sac microorganism in children was 32.87% (827/2516), a total of 541 cases (male 293, female 248). Children with conjunctival sac flora in a single eye were 255 and in both eyes were 286 (no statistical difference, P > 0.05). The concordance rate of children with binocular conjunctival sac flora was 32.16% (174/541; male 84, female 90). A total of 42 species of bacteria were detected. Children with Gram-positive cocci accounted for the highest proportion, 91.54% (757/827). The top three bacteria with the highest detection rates were Staphylococcus epidermidis (S. epidermidis; 52.12%), Streptococcus (12.09%), and Staphylococcus aureus (S. aureus; 10.76%). Streptococcus mitis (5.20%) accounted for the highest proportion of Streptococcus.S. epidermidis had the highest proportion in all age groups and was positively correlated with age (r = 0.89, P = 0.03). Before six years of age, the streptococcal proportion(mainly S. mitis) was greater than that of Staphylococcus aureus. The drug susceptibility analysis showed that S. epidermidis was most sensitive to gatifloxacin (98.61%), while it had the highest resistance rate to erythrocin (87.94%). S. aureus had the highest susceptibility to moxifloxacin (100%). Streptococcus was most sensitive to moxifloxacin (96.97%) and had the highest resistance rate to tobramycin (92.93%). Conclusions: Conjunctival sac flora in children was dominated by Gram-positive cocci, mainly S. epidermidis, S. aureus, and Streptococcus. S. epidermidis increased with age; the proportion of Streptococcus was higher than S. aureus among children aged 0-6 years. The typical conjunctiva sac flora was generally sensitive to quinolones, such as moxifloxacin and gatifloxacin; Streptococcus displayed high resistance to tobramycin antibiotics; and the female children had higher resistance to tobramycin than the male children.
MeSH term(s)	Humans ; Male ; Female ; Child ; Child, Preschool ; Gatifloxacin ; Moxifloxacin ; Staphylococcus aureus ; Lacrimal Apparatus ; Conjunctiva/microbiology ; Anti-Bacterial Agents/pharmacology ; Staphylococcus epidermidis ; Tobramycin ; Microbial Sensitivity Tests ; Streptococcus
Chemical Substances	Gatifloxacin (L4618BD7KJ) ; Moxifloxacin (U188XYD42P) ; Anti-Bacterial Agents ; Tobramycin (VZ8RRZ51VK)
Language	English
Publishing date	2023-06-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2050436-6
ISSN	1471-2415 ; 1471-2415
ISSN (online)	1471-2415
ISSN	1471-2415
DOI	10.1186/s12886-023-02995-1
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Article: Oxymatrine inhibits microglia activation via HSP60-TLR4 signaling.

Ding, Feijia / Li, Yunhong / Hou, Xiaolin / Zhang, Rui / Hu, Shuting / Wang, Yin

Biomedical reports

2016 Volume 5, Issue 5, Page(s) 623–628

Abstract: Oxymatrine (OMT) is an alkaloid extracted ... ...

Abstract	Oxymatrine (OMT) is an alkaloid extracted from
Language	English
Publishing date	2016-10-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2763624-0
ISSN	2049-9442 ; 2049-9434
ISSN (online)	2049-9442
ISSN	2049-9434
DOI	10.3892/br.2016.776
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Article ; Online: Dataset of tensile strength development of concrete with manufactured sand

Shunbo Zhao / Feijia Hu / Xinxin Ding / Mingshuang Zhao / Changyong Li / Songwei Pei

Data in Brief, Vol 11, Iss C, Pp 469-

2017 Volume 472

Abstract: This article presents 755 groups splitting tensile strength tests data of concrete with manufactured sand (MSC) in different curing age ranged from 1 day to 388 days related to the research article “Experimental study on tensile strength development of ... ...

Abstract	This article presents 755 groups splitting tensile strength tests data of concrete with manufactured sand (MSC) in different curing age ranged from 1 day to 388 days related to the research article “Experimental study on tensile strength development of concrete with manufactured sand” (Zhao et al., 2017) [1]. These data were used to evaluate the precision of the prediction formulas of tensile strength of MSC, and can be applied as dataset for further studies.
Keywords	Concrete with manufactured sand (MSC) ; Stone powder ; Water-cement ratio ; Splitting tensile strength ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Science (General) ; Q1-390
Language	English
Publishing date	2017-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Dataset of tensile strength development of concrete with manufactured sand.

Zhao, Shunbo / Hu, Feijia / Ding, Xinxin / Zhao, Mingshuang / Li, Changyong / Pei, Songwei

Data in brief

2017 Volume 11, Page(s) 469–472

Abstract: This article presents 755 groups splitting tensile strength tests data of concrete with manufactured sand (MSC) in different curing age ranged from 1 day to 388 days related to the research article "Experimental study on tensile strength development of ... ...

Abstract	This article presents 755 groups splitting tensile strength tests data of concrete with manufactured sand (MSC) in different curing age ranged from 1 day to 388 days related to the research article "Experimental study on tensile strength development of concrete with manufactured sand" (Zhao et al., 2017) [1]. These data were used to evaluate the precision of the prediction formulas of tensile strength of MSC, and can be applied as dataset for further studies.
Language	English
Publishing date	2017-02-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2017.02.043
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Article: Dataset of tensile strength development of concrete with manufactured sand

Zhao, Shunbo / Hu, Feijia / Ding, Xinxin / Zhao, Mingshuang / Li, Changyong / Pei, Songwei

Data in Brief. 2017 Apr., v. 11

2017

Abstract: This article presents 755 groups splitting tensile strength tests data of concrete with manufactured sand (MSC) in different curing age ranged from 1day to 388 days related to the research article “Experimental study on tensile strength development of ... ...

Abstract	This article presents 755 groups splitting tensile strength tests data of concrete with manufactured sand (MSC) in different curing age ranged from 1day to 388 days related to the research article “Experimental study on tensile strength development of concrete with manufactured sand” (Zhao et al., 2017) [1]. These data were used to evaluate the precision of the prediction formulas of tensile strength of MSC, and can be applied as dataset for further studies.
Keywords	concrete ; data collection ; prediction ; sand ; tensile strength
Language	English
Dates of publication	2017-04
Size	p. 469-472.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	2786545-9
ISSN	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2017.02.043
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Article ; Online: Microglia activation triggers oligodendrocyte precursor cells apoptosis via HSP60.

Li, Yunhong / Zhang, Rui / Hou, Xiaolin / Zhang, Yumei / Ding, Feijia / Li, Fan / Yao, Yao / Wang, Yin

Molecular medicine reports

2017 Volume 16, Issue 1, Page(s) 603–608

Abstract: Reactive microglia are present in lesions of myelin‑associated white matter disorders resulting in injuries to oligodendrocyte precursor cells (OPCs). Therefore, protection of OPCs from injury due to excessive activation of microglia is important in ... ...

Abstract	Reactive microglia are present in lesions of myelin‑associated white matter disorders resulting in injuries to oligodendrocyte precursor cells (OPCs). Therefore, protection of OPCs from injury due to excessive activation of microglia is important in treating these diseases. Heat shock protein 60 (HSP60) has been demonstrated to be released extracellularly in the failing heart upon stress or injury. However, the role of HSP60 in the central nervous system and whether it participates in the toxic effects of microglia on OPCs remains unclear. The present study used the co‑culture, cell death assays, binding assays, immunochemistry, western blot and ELISA. HSP60 was demonstrated to be released extracellularly by LPS‑activated microglia and to bind to OPCs, triggering OPC apoptosis. When pretreated with toll‑like receptor (TLR) 4 blocking antibody, the viability of OPCs increased, while the expression of nuclear factor κB (NFκB), caspase 3 and the release of proinflammatory cytokines triggered by HSP60 decreased. These results suggest that HSP60 released by microglia may mediate OPC apoptosis through binding to TLR4 on the surface of OPCs and subsequently activating the TLR4‑NFκB signaling pathway. HSP60 may, therefore, serve as a potential target for treatment of myelin‑associated neurodegenerative diseases that are accompanied by microglia activation.
Language	English
Publishing date	2017-07
Publishing country	Greece
Document type	Journal Article
ISSN	1791-3004
ISSN (online)	1791-3004
DOI	10.3892/mmr.2017.6673
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Article ; Online: Determining the neuroprotective effects of dextromethorphan in lipopolysaccharide‑stimulated BV2 microglia.

Cheng, Wenjing / Li, Yunhong / Hou, Xiaolin / Bai, Bin / Li, Fan / Ding, Feijia / Ma, Jiao / Zhang, Nan / Shen, Ying / Wang, Yin

Molecular medicine reports

2015 Volume 11, Issue 2, Page(s) 1132–1138

Abstract: Microglial activation has been recognized as being vital in the pathogenesis of several neurodegenerative disorders. Therefore, the identification of therapeutic drugs to prevent microglial activation and thus protect against inflammation‑mediated ... ...

Abstract	Microglial activation has been recognized as being vital in the pathogenesis of several neurodegenerative disorders. Therefore, the identification of therapeutic drugs to prevent microglial activation and thus protect against inflammation‑mediated neuronal injury, is required. In the present study, dextromethorphan (DM), a compound widely used in antitussive remedies that has been demonstrated to possess neuroprotective effects, was shown to reduce proinflammatory mediator production in lipopolysaccharide (LPS)‑stimulated BV2 mouse microglial cells. Western blot analysis revealed that DM markedly suppressed the activation of nuclear factor‑κB (NFκB), caspase‑3 signaling and the expression of another inflammation‑inducing factor, heat shock protein 60 (HSP60) and heat shock factor‑1, induced by LPS in BV2 cells. Results from ELISA assay demonstrated that DM reduced the release of HSP60, nitric oxide (NO), inducible NO synthase, tumor necrosis factor‑α, interleukin (IL)‑1β and IL‑6 induced by LPS in BV2 microglia. These results were confirmed by immunofluorescence, suggesting that DM may exert a neuroprotective and anti‑inflammatory effect by inhibiting microglial activation through the HSP60‑NFκB signaling pathway. Therefore, DM may offer substantial therapeutic benefits in the treatment of neurodegenerative diseases that are accompanied by microglial activation.
MeSH term(s)	Animals ; Cell Line ; Cell Survival/drug effects ; Chaperonin 60/analysis ; Dextromethorphan/pharmacology ; Enzyme-Linked Immunosorbent Assay ; Gene Expression/drug effects ; Interleukin-1beta/analysis ; Interleukin-6/analysis ; Lipopolysaccharides/toxicity ; Mice ; Microglia/cytology ; Microglia/drug effects ; Microglia/metabolism ; Mitochondrial Proteins/analysis ; NF-kappa B/metabolism ; Neuroprotective Agents/pharmacology ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Signal Transduction/drug effects ; Tumor Necrosis Factor-alpha/analysis
Chemical Substances	Chaperonin 60 ; Hspd1 protein, mouse ; Interleukin-1beta ; Interleukin-6 ; Lipopolysaccharides ; Mitochondrial Proteins ; NF-kappa B ; Neuroprotective Agents ; Tumor Necrosis Factor-alpha ; Nitric Oxide (31C4KY9ESH) ; Dextromethorphan (7355X3ROTS) ; Nitric Oxide Synthase Type II (EC 1.14.13.39)
Language	English
Publishing date	2015-02
Publishing country	Greece
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1791-3004
ISSN (online)	1791-3004
DOI	10.3892/mmr.2014.2794
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: HSP60 mediates the neuroprotective effects of curcumin by suppressing microglial activation.

Ding, Feijia / Li, Fan / Li, Yunhong / Hou, Xiaolin / Ma, Yi / Zhang, Nan / Ma, Jiao / Zhang, Rui / Lang, Bing / Wang, Hongyan / Wang, Yin

Experimental and therapeutic medicine

2016 Volume 12, Issue 2, Page(s) 823–828

Abstract: Curcumin has anti-inflammatory and antioxidant properties and has been widely used to treat or prevent neurodegenerative diseases. However, the mechanisms underlying the neuroprotective effects of curcumin are not well known. In the present study, the ... ...

Abstract	Curcumin has anti-inflammatory and antioxidant properties and has been widely used to treat or prevent neurodegenerative diseases. However, the mechanisms underlying the neuroprotective effects of curcumin are not well known. In the present study, the effect of curcumin on lipopolysaccharide (LPS)-stimulated BV2 mouse microglia cells was investigated using enzyme-linked immunosorbent assays of the culture medium and western blotting of cell lysates. The results showed that curcumin significantly inhibited the LPS-induced expression and release of heat shock protein 60 (HSP60) in the BV2 cells. The level of heat shock factor (HSF)-1 was upregulated in LPS-activated BV2 microglia, indicating that the increased expression of HSP60 was driven by HSF-1 activation. However, the increased HSF-1 level was downregulated by curcumin. Extracellular HSP60 is a ligand of Toll-like receptor 4 (TLR-4), and the level of the latter was increased in the LPS-activated BV2 microglia and inhibited by curcumin. The activation of TLR-4 is known to be associated with the activation of myeloid differentiation primary response 88 (MyD88) and nuclear factor (NF)-κB, with the subsequent production of proinflammatory and neurotoxic factors. In the present study, curcumin demonstrated marked suppression of the LPS-induced expression of MyD88, NF-κB, caspase-3, inducible nitric oxide synthase, tumor necrosis factor-α, interleukin (IL)-1β and IL-6 in the microglia. These results indicate that curcumin may exert its neuroprotective and anti-inflammatory effects by inhibiting microglial activation through the HSP60/TLR-4/MyD88/NF-κB signaling wpathway. Therefore, curcumin may be useful for the treatment of neurodegenerative diseases that are associated with microglial activation.
Language	English
Publishing date	2016-06-01
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2016.3413
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Article ; Online: HSP60 is involved in the neuroprotective effects of naloxone.

Cheng, Wenjing / Li, Yunhong / Hou, Xiaolin / Zhang, Nan / Ma, Jiao / Ding, Feijia / Li, Fan / Miao, Zhenhua / Zhang, Yanli / Qi, Qi / Li, Guanghua / Shen, Ying / Liu, Juan / Huang, Weidong / Wang, Yin

Molecular medicine reports

2014 Volume 10, Issue 4, Page(s) 2172–2176

Abstract: Heat shock protein (HSP)60 is primarily a mitochondrial protein. Previous experiments have found that changes in the location of intracellular HSP60 have been associated with apoptosis. Extracellular HSP60 mediates apoptosis via its ligand, Toll‑like ... ...

Abstract	Heat shock protein (HSP)60 is primarily a mitochondrial protein. Previous experiments have found that changes in the location of intracellular HSP60 have been associated with apoptosis. Extracellular HSP60 mediates apoptosis via its ligand, Toll‑like receptor (TLR)-4. TLR-4 is an important factor expressed on microglia, with a central role in generating neuroimmune responses in the pathogenesis of neurodegenerative disorders. Naloxone is a highly effective nonselective opioid receptor antagonist, and has been reported to be pharmacologically beneficial for the treatment of brain diseases through inhibiting microglia activation. However, the mechanisms underlying these beneficial effects of naloxone remain poorly understood. The present study aimed to investigate the role of HSP60 in the neuroprotective effects of naloxone on the production of proinflammatory mediators in lipopolysaccharide (LPS)-stimulated BV2 murine microglial cells and the possible signaling pathways involved. The results demonstrated that naloxone significantly inhibited the expression and release of HSP60 in BV2 cells. The expression levels of heat shock factor (HSF)-1 were upregulated in LPS‑activated BV2 cells, which indicated that the increased expression of HSP60 was driven by HSF-1 activation. However, increased HSF‑1 levels may be downregulated by naloxone. The levels of TLR‑4 were elevated in activated BV2 cells, and then inhibited by naloxone. Activation of TLR‑4 is characterized by activation of nuclear factor-κB (NF-κB) followed by the production of various proinflammatory and neurotoxic factors. Data from the present study demonstrated that naloxone reduced the expression levels of NF-κB and its upstream protein caspase‑3, and reduced the LPS-induced production of nitric oxide, inducible nitric oxide synthase, tumor necrosis factor α, interleukin-1β and interleukin-6 in BV2 microglia. In light of this data, it was concluded that naloxone may exert its neuroprotective and anti‑inflammatory effects by inhibiting microglia activation through a HSP60‑TLR‑4‑NF‑κB signaling pathway.
MeSH term(s)	Animals ; Caspase 3/metabolism ; Cell Line ; Cell Survival/drug effects ; Chaperonin 60/metabolism ; DNA-Binding Proteins/metabolism ; Gene Expression/drug effects ; Heat Shock Transcription Factors ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; Lipopolysaccharides/toxicity ; Mice ; NF-kappa B/metabolism ; Naloxone/pharmacology ; Neuroprotective Agents/pharmacology ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Signal Transduction/drug effects ; Toll-Like Receptor 4/metabolism ; Transcription Factors/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Chaperonin 60 ; DNA-Binding Proteins ; Heat Shock Transcription Factors ; Hsf1 protein, mouse ; Interleukin-1beta ; Interleukin-6 ; Lipopolysaccharides ; NF-kappa B ; Neuroprotective Agents ; Toll-Like Receptor 4 ; Transcription Factors ; Tumor Necrosis Factor-alpha ; Nitric Oxide (31C4KY9ESH) ; Naloxone (36B82AMQ7N) ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Caspase 3 (EC 3.4.22.-)
Language	English
Publishing date	2014-10
Publishing country	Greece
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1791-3004
ISSN (online)	1791-3004
DOI	10.3892/mmr.2014.2411
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