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Article ; Online: Artificial Intelligence and Decision-Making in Healthcare: A Thematic Analysis of a Systematic Review of Reviews.

Khosravi, Mohsen / Zare, Zahra / Mojtabaeian, Seyyed Morteza / Izadi, Reyhane

Health services research and managerial epidemiology

2024 Volume 11, Page(s) 23333928241234863

Abstract: Introduction: The use of artificial intelligence (AI), which can emulate human intelligence and enhance clinical results, has grown in healthcare decision-making due to the digitalization effects and the COVID-19 pandemic. The purpose of this study was ... ...

Abstract	Introduction: The use of artificial intelligence (AI), which can emulate human intelligence and enhance clinical results, has grown in healthcare decision-making due to the digitalization effects and the COVID-19 pandemic. The purpose of this study was to determine the scope of applications of AI tools in the decision-making process in healthcare service delivery networks. Materials and methods: This study used a qualitative method to conduct a systematic review of the existing reviews. Review articles published between 2000 and 2024 in English-language were searched in PubMed, Scopus, ProQuest, and Cochrane databases. The CASP (Critical Appraisal Skills Programme) Checklist for Systematic Reviews was used to evaluate the quality of the articles. Based on the eligibility criteria, the final articles were selected and the data extraction was done independently by 2 authors. Finally, the thematic analysis approach was used to analyze the data extracted from the selected articles. Results: Of the 14 219 identified records, 18 review articles were eligible and included in the analysis, which covered the findings of 669 other articles. The quality assessment score of all reviewed articles was high. And, the thematic analysis of the data identified 3 main themes including clinical decision-making, organizational decision-making, and shared decision-making; which originated from 8 subthemes. Conclusions: This study revealed that AI tools have been applied in various aspects of healthcare decision-making. The use of AI can improve the quality, efficiency, and effectiveness of healthcare services by providing accurate, timely, and personalized information to support decision-making. Further research is needed to explore the best practices and standards for implementing AI in healthcare decision-making.
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2805732-6
ISSN	2333-3928 ; 2333-3928
ISSN (online)	2333-3928
ISSN	2333-3928
DOI	10.1177/23333928241234863
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Article ; Online: The Effects of Mesenchymal Stem Cells Loaded with Oncolytic Coxsackievirus A21 on Mouse Models of Colorectal Cancer.

Karbalaee, Reza / Mehdizadeh, Saber / Ghaleh, Hadi Esmaeili Gouvarchin / Izadi, Morteza / Kondori, Bahman Jalali / Dorostkar, Ruhollah / Hosseini, Seyed Morteza

Current cancer drug targets

2024

Abstract: Background: Cancer is a major cause of death worldwide. Colorectal cancer is the second most common type. Additional treatments like chemotherapy and radiation therapy may be recommended. Developing new techniques is vital due to drug resistance and a ... ...

Abstract	Background: Cancer is a major cause of death worldwide. Colorectal cancer is the second most common type. Additional treatments like chemotherapy and radiation therapy may be recommended. Developing new techniques is vital due to drug resistance and a lack of targeted therapies. Objective: In this study, the effects of mesenchymal stem cells (MSCs) loaded with oncolytic Coxsackievirus A21 (CVA21) on a mouse model of CRC were investigated. Methods: The therapeutic potency of MSCs loaded with oncolytic CVA21 was evaluated in an experimental mouse model of colorectal cancer which received an injection CT26 cells per mouse subcutaneously. Splenocyte proliferation index, lactate dehydrogenase (LDH) assay, nitric oxide (NO) production assessment, and cytokine assay (IFN-γ, IL-4, IL-10, and TGF-β) in the splenocyte supernatant were all used to evaluate the impact of MSCs loaded with CVA21. Results: The results of this study showed that the treatment of a mouse model of colorectal cancer with MSCs loaded with oncolytic CVA21 could significantly suppress the tumor growth, which was accompanied by stimulation of splenocytes proliferation index, an increase of NO and LDH. Also, MSCs loaded with oncolytic CVA21 increased the secretion of IFN-γ and decreased the secretion of IL-4, IL-10, and TGF-β. Conclusion: The results of the current study suggest that MSCs loaded with oncolytic CVA21 therapy for the CRC mouse model may have some potential advantages. On the other hand, the results of the study showed that, in addition to activating the acquired immune system, the use of MSCs loaded with oncolytic CVA21 also stimulates the innate immune system by increasing levels of nitric oxide.
Language	English
Publishing date	2024-01-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2064824-8
ISSN	1873-5576 ; 1568-0096
ISSN (online)	1873-5576
ISSN	1568-0096
DOI	10.2174/0115680096273465231201115839
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Article: Anti-inflammatory Effect of Metronidazole in Hospitalized Patients with Pneumonia due to COVID-19.

Kazempour, Muhanna / Izadi, Hossein / Chouhdari, Arezoo / Rezaeifard, Morteza

Iranian journal of pharmaceutical research : IJPR

2021 Volume 20, Issue 3, Page(s) 532–540

Abstract: Metronidazole (MTZ) can decrease the levels of several cytokines. This research aimed at the investigation of the anti-inflammatory impact of MTZ in COVID-19. A randomized, single-blind clinical trial for comparing the anti-inflammatory effect of MTZ in ... ...

Abstract	Metronidazole (MTZ) can decrease the levels of several cytokines. This research aimed at the investigation of the anti-inflammatory impact of MTZ in COVID-19. A randomized, single-blind clinical trial for comparing the anti-inflammatory effect of MTZ in two eligible groups of adult patients with lower respiratory tract involvement due to Covid-19 treated with a standard national method with or without MTZ was performed. Inflammatory markers were measured as the primary outcome in two groups. Oxygen saturation, length of hospital stays, and mortality of patients were evaluated as secondary outcomes. Among 44 patients with lower respiratory tract due to Covid-19, 20(45.5%) were randomly allocated in group A with the current standard treatment plus the MTZ tablet for 7 days orally and 24 (54.5%) in group B with the current standard treatment. The mean of
Language	English
Publishing date	2021-10-31
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2578271-X
ISSN	1726-6890 ; 1735-0328 ; 1735-0328
ISSN (online)	1726-6890 ; 1735-0328
ISSN	1735-0328
DOI	10.22037/ijpr.2021.114567.14917
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Article ; Online: Estimating Patient Survival and Risk of End-Stage Kidney Disease in Patients With Autosomal Dominant Polycystic Kidney Disease in Iran.

Malakoutian, Tahereh / Izadi, Shahrokh / Honarpisheh, Parisa / Bagheri, Seyed Morteza / Saffarzadeh, Negin / Akbari, Hounaz

Iranian journal of kidney diseases

2023 Volume 17, Issue 3, Page(s) 141–149

Abstract: Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary kidney disease that can affect several organs. The clinical course of the disease varies among patients; some never become symptomatic, and others reach end-stage kidney ... ...

Abstract	Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary kidney disease that can affect several organs. The clinical course of the disease varies among patients; some never become symptomatic, and others reach end-stage kidney disease (ESKD) in the 5th decade of their life. Methods: This historical cohort study was conducted on ADPKD patients to investigate kidney and patient survival rates and related risk factors in Iran. Survival analysis and risk ratio calculation were performed using the Cox proportional hazards model, Kaplan- Meier method, and log-rank test. Results: Among the 145 participants, 67 developed ESKD, and 20 died before the end of the study period. Developing chronic kidney disease (CKD) at the age of ≤ 40, baseline serum creatinine level (SCr) of more than 1.5 mg/dL, and cardiovascular disease increased the risk of ESKD by 4, 1.8, and 2.4 times; respectively. Patient survival analysis revealed a fourfold increase in mortality if the glomerular filtration rate (GFR) declined more than 5 cc/min annually and if CKD was diagnosed at the age of ≤ 40. Vascular thrombotic events or ESKD in the course of disease increased the risk of death by approximately 6- and 7-fold, respectively. Kidney survival was 48% by the age of 60 and 28% by the age of 70. Patient survival was 86.05% at the age of 60 and 67.99% at the age of 70. Additionally, men had a significantly better renal function and survival than women. Conclusion: Elevated baseline SCr and cardiovascular disease can increase ESKD risk in ADPKD patients. A rapid decline in GFR, ESKD development, and vascular thrombotic events increase the risk of death, but early CKD can affect both. DOI: 10.52547/ijkd.7551.
MeSH term(s)	Male ; Humans ; Female ; Polycystic Kidney, Autosomal Dominant/complications ; Polycystic Kidney, Autosomal Dominant/diagnosis ; Cohort Studies ; Cardiovascular Diseases ; Iran/epidemiology ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/etiology ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/etiology ; Glomerular Filtration Rate ; Disease Progression
Language	English
Publishing date	2023-07-10
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2388271-2
ISSN	1735-8604 ; 1735-8582
ISSN (online)	1735-8604
ISSN	1735-8582
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Article ; Online: Advances in early diagnosis of cervical cancer based on biosensors.

Ghaleh, Hadi Esmaeili Gouvarchin / Shahriary, Alireza / Izadi, Morteza / Farzanehpour, Mahdieh

Biotechnology and bioengineering

2022 Volume 119, Issue 9, Page(s) 2305–2312

Abstract: Human papillomavirus (HPV) is a causative agent of cervical cancer among women worldwide. Serological and molecular tests are commonly used to detect and identify HPV, but all the detection methods for HPV have some limitations. Nowadays, considerable ... ...

Abstract	Human papillomavirus (HPV) is a causative agent of cervical cancer among women worldwide. Serological and molecular tests are commonly used to detect and identify HPV, but all the detection methods for HPV have some limitations. Nowadays, considerable advancements in nanosensors have enabled monitoring of hybridization procedures dynamically for HPV detection. Biosensors, as effective, quick, economical, and highly sensitive tools, can be used in the diagnosis of HPV as an alternative technique instead of other detection methods. Biosensor detection methods of HPV in use from 2000 to 2021 were investigated using several databases such as Google Scholar, Scopus, PubMed, and the Scientific Information Database. Furthermore, a manual search of the references of the retrieved articles was performed. On analyzing the most recently developed biosensors for HPV identification, we observed that three biosensor systems, electrochemical, optical, and piezoelectric systems, are the main transducers used in the development of HPV biosensors. The aim of this review is to examine recent research on biosensors for the detection of HPV and perform a comparison with other diagnostic methods. Considering the importance of rapid HPV detection in the control of infection and development of public health measures, improvement of biosensors as an economical and quick method can be very useful in the diagnosis of HPV.
MeSH term(s)	Biosensing Techniques/methods ; Early Detection of Cancer/methods ; Female ; Humans ; Papillomaviridae/genetics ; Papillomavirus Infections/diagnosis ; Uterine Cervical Neoplasms/diagnosis
Language	English
Publishing date	2022-06-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	280318-5
ISSN	1097-0290 ; 0006-3592
ISSN (online)	1097-0290
ISSN	0006-3592
DOI	10.1002/bit.28149
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Article ; Online: Exosomes from Adipose Tissue-derived Mesenchymal Stem Cells Induce Regulatory T Cells in COVID-19 Patients.

Motallebnezhad, Morteza / Hazrati, Ali / Esmaeili Gouvarchin Ghaleh, Hadi / Jonaidi-Jafari, Nematollah / Abbaspour-Aghdam, Sanaz / Malekpour, Kosar / Yousefi, Mehdi / Samadi Kafil, Hossein / Jadidi-Niaragh, Farhad / Roshangar, Leila / Valizadeh, Hamed / Izadi, Morteza / Ahmadi, Majid

Iranian journal of allergy, asthma, and immunology

2023 Volume 22, Issue 3, Page(s) 233–244

Abstract: An imbalance between regulatory T (Treg) and T-helper (Th)-17 cells has been implicated in the pathogenesis of coronavirus disease 2019 (COVID-19). Mesenchymal stem cells (MSCs) exert immunomodulatory properties through secreting exosomes. This study ... ...

Abstract	An imbalance between regulatory T (Treg) and T-helper (Th)-17 cells has been implicated in the pathogenesis of coronavirus disease 2019 (COVID-19). Mesenchymal stem cells (MSCs) exert immunomodulatory properties through secreting exosomes. This study aimed to assess the effect of MSC-derived exosomes (MSC-Exo) on the differentiation of peripheral blood mononuclear cells (PBMCs) into Tregs from patients with COVID-19. Exosomes were isolated from adipose tissue-derived MSCs. PBMCs were separated from the whole blood of COVID-19 patients (n=20). Treg frequency was assessed before and 48 hours after treatment of PBMCs with MSC-Exo using flow cytometry. Expression of FOXP3 and cytokine genes, and the concentration of cytokines associated with Tregs, were assessed before and after treatment with MSC-Exo. The frequency of CD4+CD25+CD127- Tregs was significantly higher after treating PBMCs with MSC-Exo (6.695±2.528) compared to before treatment (4.981±2.068). The expressions of transforming growth factor (TGF)-β1, interleukin (IL)-10, and FOXP3 were significantly upregulated in MSC-Exo-treated PBMCs. The concentration of IL-10 increased significantly after treatment (994.7±543.9 pg/mL) of PBMCs with MSC-Exo compared with before treatment (563.5±408.6 pg/mL). The concentration of TGF-β was significantly higher in the supernatant of PBMCs after treatment with MSC-Exo (477.0±391.1 pg/mL) than PBMCs before treatment (257.7±226.3 pg/mL). MSC-Exo has the potential to raise anti-inflammatory responses by induction of Tregs, potentiating its therapeutic effects in COVID-19.
MeSH term(s)	Humans ; Exosomes ; T-Lymphocytes, Regulatory ; Leukocytes, Mononuclear ; COVID-19 ; Mesenchymal Stem Cells/metabolism ; Forkhead Transcription Factors/metabolism
Chemical Substances	Forkhead Transcription Factors
Language	English
Publishing date	2023-06-16
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2488724-9
ISSN	1735-5249 ; 1735-1502
ISSN (online)	1735-5249
ISSN	1735-1502
DOI	10.18502/ijaai.v22i3.13051
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Article ; Online: Effect of ozonated water and chlorhexidine mouthwash on oral health in critically ill patients on mechanical ventilation: A double-blind randomised clinical trial.

Izadi, Morteza / Bagheri, Mahdi / Bahrami Far, Ali / Sureda, Antoni / Soodmand, Mostafa

Intensive & critical care nursing

2021 Volume 66, Page(s) 103083

MeSH term(s)	Anti-Infective Agents, Local/therapeutic use ; Chlorhexidine/therapeutic use ; Critical Illness ; Humans ; Mouthwashes/therapeutic use ; Oral Health ; Pneumonia, Ventilator-Associated ; Respiration, Artificial/adverse effects ; Water
Chemical Substances	Anti-Infective Agents, Local ; Mouthwashes ; Water (059QF0KO0R) ; Chlorhexidine (R4KO0DY52L)
Language	English
Publishing date	2021-05-26
Publishing country	Netherlands
Document type	Letter ; Randomized Controlled Trial
ZDB-ID	1105892-4
ISSN	1532-4036 ; 0964-3397
ISSN (online)	1532-4036
ISSN	0964-3397
DOI	10.1016/j.iccn.2021.103083
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Article ; Online: Exosomes from Adipose Tissue-derived Mesenchymal Stem Cells Induce Regulatory T Cells in COVID‐19 Patients

Morteza Motallebnezhad / Ali Hazrati / Hadi Esmaeili Gouvarchin Ghaleh / Nematollah Jonaidi-Jafari / Sanaz Abbaspour-Aghdam / Kosar Malekpour / Mehdi Yousefi / Hossein Samadi Kafil / Farhad Jadidi-Niaragh / Leila Roshangar / Hamed Valizadeh / Morteza Izadi / Majid Ahmadi

Iranian Journal of Allergy, Asthma and Immunology, Vol 22, Iss

2023 Volume 3

Abstract	An imbalance between regulatory T (Treg) and T-helper (Th)-17 cells has been implicated in the pathogenesis of coronavirus disease 2019 (COVID-19). Mesenchymal stem cells (MSCs) exert immunomodulatory properties through secreting exosomes. This study aimed to assess the effect of MSC-derived exosomes (MSC-Exo) on the differentiation of peripheral blood mononuclear cells (PBMCs) into Tregs from patients with COVID-19. Exosomes were isolated from adipose tissue–derived MSCs. PBMCs were separated from the whole blood of COVID-19 patients (n=20). Treg frequency was assessed before and 48 hours after treatment of PBMCs with MSC-Exo using flow cytometry. Expression of FOXP3 and cytokine genes, and the concentration of cytokines associated with Tregs, were assessed before and after treatment with MSC-Exo. The frequency of CD4+CD25+CD127- Tregs was significantly higher after treating PBMCs with MSC-Exo (6.695±2.528) compared to before treatment (4.981±2.068). The expressions of transforming growth factor (TGF)-β1, interleukin (IL)-10, and FOXP3 were significantly upregulated in MSC-Exo–treated PBMCs. The concentration of IL‐10 increased significantly after treatment (994.7±543.9 pg/mL) of PBMCs with MSC-Exo compared with before treatment (563.5±408.6 pg/mL). The concentration of TGF-β was significantly higher in the supernatant of PBMCs after treatment with MSC-Exo (477.0±391.1 pg/mL) than PBMCs before treatment (257.7±226.3 pg/mL). MSC-Exo has the potential to raise anti-inflammatory responses by induction of Tregs, potentiating its therapeutic effects in COVID-19.
Keywords	COVID-19 ; Exosomes ; Immunomodulation ; Mesenchymal stem cells ; Peripheral blood mononuclear cells ; Regulatory T cells ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
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Article: The Effect of The Conditioned Medium from Human Embryonic Stem Cells on Mouse Oocytes In Vitro Maturation.

Rezaee Ranjbar Sardari, Roshan / Dehghani Ashkezari, Mahmood / Seifati, Seyed Morteza / Izadi, Mahin / Golzadeh, Jalal / Mazaheri, Fahime / Adib, Maryam / Aflatoonian, Behrouz

Cell journal

2023 Volume 25, Issue 7, Page(s) 455–460

Abstract: Objective: Some reports have indicated that conditioned medium from growing mouse embryonic stem cells (ESCs) provides a supportive condition for small follicles growing, oocyte maturation, and following embryo growth. The aim of this study is assessing ...

Abstract	Objective: Some reports have indicated that conditioned medium from growing mouse embryonic stem cells (ESCs) provides a supportive condition for small follicles growing, oocyte maturation, and following embryo growth. The aim of this study is assessing in vitro maturation (IVM) and consequent Materials and methods: In this experimental study, 240 germinal vesicle (GV) oocytes were took from NMRI female mice, aged 4-6 weeks, 48 hours before injection of 5 IU pregnant mare serum gonadotropin (PMSG). 120 GV oocytes without cumulus cells were cultured in each of the groups. 120 GV were cultured in HESCM as test groups and also 120 GV cultured in human embryonic stem cells medium (HESM) as control groups. After evaluating the metaphase II (MII) oocyte maturation rate at 8, 16 and 24 hours, the MII oocytes subsequently were fertilized Results: Our data indicated there are significant differences between the maturation rates in HESCM and HESM (P=0.004), also the two-cell embryo development was significant between two culture media (P=0.00). Conclusion: Similar to some other studies, the secretome of the HESCM showed a significant impact on the IVM outcomes in mice.
Language	English
Publishing date	2023-07-25
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2647430-X
ISSN	2228-5814 ; 2228-5806
ISSN (online)	2228-5814
ISSN	2228-5806
DOI	10.22074/cellj.2023.1987024.1217
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Article: Correction: Efficacy of ozone therapy on visual evoked potentials in diabetic patients.

Izadi, Morteza / Javanbakht, Mohammad / Sarafzadeh, Ali / Einollahi, Behzad / Futuhi, Farzaneh / Vahedi, Zahra / Zhao, Shi / Jonaidi-Jafari, Nematollah / Hosseini, Mahboobeh Sadat / Nejad, Javad Hosseini / Naeimi, Effat / Saadat, Seyed Hassan / Ghaleh, Hadi Esmaeili Gouvarchin / Fazel, Mozhgan / Einollahi, Zahra / Cegolon, Luca

Diabetology & metabolic syndrome

2023 Volume 15, Issue 1, Page(s) 153

Language	English
Publishing date	2023-07-07
Publishing country	England
Document type	Published Erratum
ZDB-ID	2518786-7
ISSN	1758-5996
ISSN	1758-5996
DOI	10.1186/s13098-023-01127-5
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