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Book ; Conference proceedings: Atherogenesis and aging

Bates, Sandra R.

[papers based on the Workshop on Atherogenesis and Aging, held June 30, July 1 - 2, 1985 at Wake Forest Univ., Winston Salem, NC]

1987

Institution	National Heart, Lung, and Blood Institute
Event/congress	Workshop on Atherogenesis and Aging (1985, Winston-SalemNC)
Author's details	ed. by Sandra R. Bates ; Edwin C. Gangloff. [Sponsored by the National Heart, Lung, and Blood Inst. and the National Inst. on Aging]
Keywords	Aging / congresses ; Arteriosclerosis / etiology / congresses ; Altern ; Arteriosklerose
Subject	Arterienverkalkung ; Atherosklerose ; Arteriosclerosis ; Alterungsprozess ; Altwerden ; Seneszenz ; Alterung
Size	XV, 213 S. : Ill., graph. Darst.
Edition	1. [Dr.]
Publisher	Springer
Publishing place	New York u.a.
Publishing country	United States
Document type	Book ; Conference proceedings
Note	Literaturangaben
HBZ-ID	HT003045174
ISBN	3-540-96393-6 ; 0-387-96393-6 ; 978-3-540-96393-6 ; 978-0-387-96393-8
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Facilitators and Barriers to Interacting With Clinical Decision Support in the ICU: A Mixed-Methods Approach.

Wong, Adrian / Berenbrok, Lucas A / Snader, Lauren / Soh, Yu Hyeon / Kumar, Vishakha K / Javed, Muhammad Ali / Bates, David W / Sorce, Lauren R / Kane-Gill, Sandra L

Critical care explorations

2023 Volume 5, Issue 9, Page(s) e0967

Abstract: Objectives: Clinical decision support systems (CDSSs) are used in various aspects of healthcare to improve clinical decision-making, including in the ICU. However, there is growing evidence that CDSS are not used to their full potential, often resulting ...

Abstract	Objectives: Clinical decision support systems (CDSSs) are used in various aspects of healthcare to improve clinical decision-making, including in the ICU. However, there is growing evidence that CDSS are not used to their full potential, often resulting in alert fatigue which has been associated with patient harm. Clinicians in the ICU may be more vulnerable to desensitization of alerts than clinicians in less urgent parts of the hospital. We evaluated facilitators and barriers to appropriate CDSS interaction and provide methods to improve currently available CDSS in the ICU. Design: Sequential explanatory mixed-methods study design, using the BEhavior and Acceptance fRamework. Setting: International survey study. Patient/subjects: Clinicians (pharmacists, physicians) identified via survey, with recent experience with clinical decision support. Interventions: An initial survey was developed to evaluate clinician perspectives on their interactions with CDSS. A subsequent in-depth interview was developed to further evaluate clinician (pharmacist, physician) beliefs and behaviors about CDSS. These interviews were then qualitatively analyzed to determine themes of facilitators and barriers with CDSS interactions. Measurements and main results: A total of 48 respondents completed the initial survey (estimated response rate 15.5%). The majority believed that responding to CDSS alerts was part of their job (75%) but felt they experienced alert fatigue (56.5%). In the qualitative analysis, a total of five facilitators (patient safety, ease of response, specificity, prioritization, and feedback) and four barriers (excess quantity, work environment, difficulty in response, and irrelevance) were identified from the in-depth interviews. Conclusions: In this mixed-methods survey, we identified areas that institutions should focus on to improve appropriate clinician interactions with CDSS, specific to the ICU. Tailoring of CDSS to the ICU may lead to improvement in CDSS and subsequent improved patient safety outcomes.
Language	English
Publishing date	2023-08-25
Publishing country	United States
Document type	Journal Article
ISSN	2639-8028
ISSN (online)	2639-8028
DOI	10.1097/CCE.0000000000000967
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Article ; Online: P63 (CKAP4) as an SP-A receptor: implications for surfactant turnover.

Bates, Sandra R

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

2009 Volume 25, Issue 1, Page(s) 41–54

Abstract: Surfactant protein-A (SP-A) plays an important role in the clearance of surfactant from the lung alveolar space and in the regulation of surfactant secretion and uptake by type II pneumocytes in culture. Two pathways are important for the endocytosis of ... ...

Abstract	Surfactant protein-A (SP-A) plays an important role in the clearance of surfactant from the lung alveolar space and in the regulation of surfactant secretion and uptake by type II pneumocytes in culture. Two pathways are important for the endocytosis of surfactant by type II cells and the intact lung, a receptor-mediated clathrin-dependent pathway and a non-clathrin, actin-mediated pathway. The critical role of the clathrin/receptor-mediated pathway in normal mice is supported by the finding that SP-A gene-targeted mice use the actin-dependent pathway to maintain normal clearance of surfactant. Addition of SP-A to the surfactant of the SP-A null mice "rescued" the phenotype, further emphasizing the essential role of the SP-A/receptor-mediated process in surfactant turnover. This review presents an overview of the structure of SP-A and its function in surfactant turnover. The evidence that the interaction of SP-A with type II cells is a receptor-mediated process is presented. A newly identified receptor for SP-A, P63/CKAP4, is described in detail, with elucidation of the specific structural features of this 63 kDa, nonglycosylated, highly coiled, transmembrane protein. The compelling evidence that P63 functions as a receptor for SP-A on type II cells is summarized. Regulation of P63 receptor density on the surface of pneumocytes may be a novel approach for the regulation of surfactant homeostasis by the lung.
MeSH term(s)	Alveolar Epithelial Cells/cytology ; Alveolar Epithelial Cells/metabolism ; Animals ; Humans ; Membrane Proteins/metabolism ; Pulmonary Surfactant-Associated Protein A/analysis ; Pulmonary Surfactant-Associated Protein A/metabolism ; Pulmonary Surfactants/metabolism ; Receptors, Cell Surface/analysis ; Receptors, Cell Surface/metabolism
Chemical Substances	CKAP4 protein, human ; Membrane Proteins ; Pulmonary Surfactant-Associated Protein A ; Pulmonary Surfactants ; Receptors, Cell Surface ; surfactant protein A receptor
Language	English
Publishing date	2009-12-22
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1067572-3
ISSN	1421-9778 ; 1015-8987
ISSN (online)	1421-9778
ISSN	1015-8987
DOI	10.1159/000272062
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Article ; Online: Exploring the Contributions of Combined Model Regional Medical Education Campuses to the Physician Workforce.

Bates, Joanna / Grand'Maison, Paul / Banner, Sandra R / Lovato, Chris Y / Eva, Kevin W

Academic medicine : journal of the Association of American Medical Colleges

2020 Volume 96, Issue 3, Page(s) 409–415

Abstract: Purpose: Physician shortages and maldistribution, particularly within family medicine, have led many medical schools worldwide to create regional medical campuses (RMCs) for clerkship training. However, Canadian medical schools have developed a number ... ...

Abstract	Purpose: Physician shortages and maldistribution, particularly within family medicine, have led many medical schools worldwide to create regional medical campuses (RMCs) for clerkship training. However, Canadian medical schools have developed a number of RMCs in which all years of training (i.e., a combined model that includes both preclerkship and clinical training) are provided geographically separate from the main campus. This study addresses the question: Are combined model RMC graduates more likely to enter postgraduate training in family medicine and rural-focused programs relative to main campus graduates? Method: The authors used a quasi-experimental research design and analyzed 2006-2016 data from the Canadian Resident Matching Service (CaRMS). Graduating students (N = 26,525) from 16 Canadian medical schools who applied for the CaRMS match in their year of medical school graduation were eligible for inclusion. The proportions of graduates who matched to postgraduate training in (1) family medicine and (2) rural-focused programs were compared for combined model RMCs and main campuses. Results: Of RMC graduates, 48.4% matched to family medicine (95% confidence interval [CI] = 46.1-50.7) compared with 37.1% of main campus graduates (95% CI = 36.5-37.7; P < .001). Of RMC graduates, 23.9% matched to rural-focused training programs (95% CI = 21.8-25.9) compared with 10.4% of main campus graduates (95% CI = 10.0-10.8; P < .001). Subanalyses ruled out a variety of potentially confounding variables. Conclusions: Combined model RMCs, in which all years of training take place away from the medical school's main campus, are associated with greater proportions of medical students entering family medicine postgraduate training and rural-focused training programs. These findings should encourage policymakers, health services agencies, and medical schools to continue seeking complements to academic medical center-based medical education.
MeSH term(s)	Canada/epidemiology ; Career Choice ; Clinical Clerkship/methods ; Education, Medical/statistics & numerical data ; Education, Medical/trends ; Family Practice/education ; Family Practice/statistics & numerical data ; Humans ; Internship and Residency/statistics & numerical data ; Non-Randomized Controlled Trials as Topic/methods ; Outcome Assessment, Health Care ; Physicians/supply & distribution ; Regional Medical Programs/organization & administration ; Regional Medical Programs/trends ; Rural Health Services/supply & distribution ; Rural Population/statistics & numerical data ; Schools, Medical/statistics & numerical data ; Students, Medical/statistics & numerical data ; Workforce/trends
Language	English
Publishing date	2020-07-02
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	96192-9
ISSN	1938-808X ; 1040-2446
ISSN (online)	1938-808X
ISSN	1040-2446
DOI	10.1097/ACM.0000000000003560
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Article ; Online: Global Regulatory DNA Potentiation by SMARCA4 Propagates to Selective Gene Expression Programs via Domain-Level Remodeling.

Cell reports

2020 Volume 31, Issue 12, Page(s) 107788

Language	English
Publishing date	2020-06-21
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2020.107788
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Article ; Online: Best-worst scaling methodology to evaluate constructs of the Consolidated Framework for Implementation Research: application to the implementation of pharmacogenetic testing for antidepressant therapy.

Salloum, Ramzi G / Bishop, Jeffrey R / Elchynski, Amanda L / Smith, D Max / Rowe, Elizabeth / Blake, Kathryn V / Limdi, Nita A / Aquilante, Christina L / Bates, Jill / Beitelshees, Amber L / Cipriani, Amber / Duong, Benjamin Q / Empey, Philip E / Formea, Christine M / Hicks, J Kevin / Mroz, Pawel / Oslin, David / Pasternak, Amy L / Petry, Natasha /

Ramsey, Laura B / Schlichte, Allyson / Swain, Sandra M / Ward, Kristen M / Wiisanen, Kristin / Skaar, Todd C / Van Driest, Sara L / Cavallari, Larisa H / Tuteja, Sony

Implementation science communications

2022 Volume 3, Issue 1, Page(s) 52

Abstract: Background: Despite the increased demand for pharmacogenetic (PGx) testing to guide antidepressant use, little is known about how to implement testing in clinical practice. Best-worst scaling (BWS) is a stated preferences technique for determining the ... ...

Abstract	Background: Despite the increased demand for pharmacogenetic (PGx) testing to guide antidepressant use, little is known about how to implement testing in clinical practice. Best-worst scaling (BWS) is a stated preferences technique for determining the relative importance of alternative scenarios and is increasingly being used as a healthcare assessment tool, with potential applications in implementation research. We conducted a BWS experiment to evaluate the relative importance of implementation factors for PGx testing to guide antidepressant use. Methods: We surveyed 17 healthcare organizations that either had implemented or were in the process of implementing PGx testing for antidepressants. The survey included a BWS experiment to evaluate the relative importance of Consolidated Framework for Implementation Research (CFIR) constructs from the perspective of implementing sites. Results: Participating sites varied on their PGx testing platform and methods for returning recommendations to providers and patients, but they were consistent in ranking several CFIR constructs as most important for implementation: patient needs/resources, leadership engagement, intervention knowledge/beliefs, evidence strength and quality, and identification of champions. Conclusions: This study demonstrates the feasibility of using choice experiments to systematically evaluate the relative importance of implementation determinants from the perspective of implementing organizations. BWS findings can inform other organizations interested in implementing PGx testing for mental health. Further, this study demonstrates the application of BWS to PGx, the findings of which may be used by other organizations to inform implementation of PGx testing for mental health disorders.
Language	English
Publishing date	2022-05-14
Publishing country	England
Document type	Journal Article
ISSN	2662-2211
ISSN (online)	2662-2211
DOI	10.1186/s43058-022-00300-7
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Article ; Online: Towards richer knowledge partnerships between ecology and ethnoecology.

Molnár, Zsolt / Aumeeruddy-Thomas, Yildiz / Babai, Dániel / Díaz, Sandra / Garnett, Stephen T / Hill, Rosemary / Bates, Peter / Brondízio, Eduardo S / Cariño, Joji / Demeter, László / Fernández-Llamazares, Álvaro / Guèze, Maximilien / McElwee, Pamela / Öllerer, Kinga / Purvis, Andy / Reyes-García, Victoria / Samakov, Aibek / Singh, Ranjay K

Trends in ecology & evolution

2023 Volume 39, Issue 2, Page(s) 109–115

Abstract: Indigenous and traditional practices based on ethnoecological knowledge are fundamental to biodiversity stewardship and sustainable use. Knowledge partnerships between Indigenous Peoples, traditional local communities, and ecologists can produce richer ... ...

Abstract	Indigenous and traditional practices based on ethnoecological knowledge are fundamental to biodiversity stewardship and sustainable use. Knowledge partnerships between Indigenous Peoples, traditional local communities, and ecologists can produce richer and fairer understandings of nature. We identify key topical areas where such collaborations can positively transform science, policy, and practice.
MeSH term(s)	Ecology ; Knowledge ; Biodiversity
Language	English
Publishing date	2023-11-17
Publishing country	England
Document type	Journal Article
ZDB-ID	284965-3
ISSN	1872-8383 ; 0169-5347
ISSN (online)	1872-8383
ISSN	0169-5347
DOI	10.1016/j.tree.2023.10.010
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Article ; Online: Global Regulatory DNA Potentiation by SMARCA4 Propagates to Selective Gene Expression Programs via Domain-Level Remodeling.

Cell reports

2020 Volume 31, Issue 8, Page(s) 107676

Abstract: The human genome encodes millions of regulatory elements, of which only a small fraction are active within a given cell type. Little is known about the global impact of chromatin remodelers on regulatory DNA landscapes and how this translates to gene ... ...

Abstract	The human genome encodes millions of regulatory elements, of which only a small fraction are active within a given cell type. Little is known about the global impact of chromatin remodelers on regulatory DNA landscapes and how this translates to gene expression. We use precision genome engineering to reawaken homozygously inactivated SMARCA4, a central ATPase of the human SWI/SNF chromatin remodeling complex, in lung adenocarcinoma cells. Here, we combine DNase I hypersensitivity, histone modification, and transcriptional profiling to show that SMARCA4 dramatically increases both the number and magnitude of accessible chromatin sites genome-wide, chiefly by unmasking sites of low regulatory factor occupancy. By contrast, transcriptional changes are concentrated within well-demarcated remodeling domains wherein expression of specific genes is gated by both distal element activation and promoter chromatin configuration. Our results provide a perspective on how global chromatin remodeling activity is translated to gene expression via regulatory DNA.
MeSH term(s)	Chromatin Assembly and Disassembly/genetics ; DNA/genetics ; DNA Helicases/metabolism ; Gene Expression/genetics ; Humans ; Nuclear Proteins/metabolism ; Transcription Factors/metabolism
Chemical Substances	Nuclear Proteins ; Transcription Factors ; DNA (9007-49-2) ; SMARCA4 protein, human (EC 3.6.1.-) ; DNA Helicases (EC 3.6.4.-)
Language	English
Publishing date	2020-05-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2020.107676
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Article ; Online: Integrative genomic analysis in African American children with asthma finds three novel loci associated with lung function.

Goddard, Pagé C / Keys, Kevin L / Mak, Angel C Y / Lee, Eunice Y / Liu, Amy K / Samedy-Bates, Lesly-Anne / Risse-Adams, Oona / Contreras, María G / Elhawary, Jennifer R / Hu, Donglei / Huntsman, Scott / Oh, Sam S / Salazar, Sandra / Eng, Celeste / Himes, Blanca E / White, Marquitta J / Burchard, Esteban G

Genetic epidemiology

2020 Volume 45, Issue 2, Page(s) 190–208

Abstract: Bronchodilator (BD) drugs are commonly prescribed for treatment and management of obstructive lung function present with diseases such as asthma. Administration of BD medication can partially or fully restore lung function as measured by pulmonary ... ...

Abstract	Bronchodilator (BD) drugs are commonly prescribed for treatment and management of obstructive lung function present with diseases such as asthma. Administration of BD medication can partially or fully restore lung function as measured by pulmonary function tests. The genetics of baseline lung function measures taken before BD medication have been extensively studied, and the genetics of the BD response itself have received some attention. However, few studies have focused on the genetics of post-BD lung function. To address this gap, we analyzed lung function phenotypes in 1103 subjects from the Study of African Americans, Asthma, Genes, and Environment, a pediatric asthma case-control cohort, using an integrative genomic analysis approach that combined genotype, locus-specific genetic ancestry, and functional annotation information. We integrated genome-wide association study (GWAS) results with an admixture mapping scan of three pulmonary function tests (forced expiratory volume in 1 s [FEV
MeSH term(s)	African Americans/genetics ; Asthma/drug therapy ; Asthma/genetics ; Child ; Forced Expiratory Volume ; Genome-Wide Association Study ; Genomics ; Humans ; Leukocytes, Mononuclear ; Lung ; Polymorphism, Single Nucleotide
Language	English
Publishing date	2020-09-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	605785-8
ISSN	1098-2272 ; 0741-0395
ISSN (online)	1098-2272
ISSN	0741-0395
DOI	10.1002/gepi.22365
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Article ; Online: Best–worst scaling methodology to evaluate constructs of the Consolidated Framework for Implementation Research

Ramzi G. Salloum / Jeffrey R. Bishop / Amanda L. Elchynski / D. Max Smith / Elizabeth Rowe / Kathryn V. Blake / Nita A. Limdi / Christina L. Aquilante / Jill Bates / Amber L. Beitelshees / Amber Cipriani / Benjamin Q. Duong / Philip E. Empey / Christine M. Formea / J. Kevin Hicks / Pawel Mroz / David Oslin / Amy L. Pasternak / Natasha Petry /

Laura B. Ramsey / Allyson Schlichte / Sandra M. Swain / Kristen M. Ward / Kristin Wiisanen / Todd C. Skaar / Sara L. Van Driest / Larisa H. Cavallari / Sony Tuteja

Implementation Science Communications, Vol 3, Iss 1, Pp 1-

application to the implementation of pharmacogenetic testing for antidepressant therapy

2022 Volume 9

Abstract: Abstract Background Despite the increased demand for pharmacogenetic (PGx) testing to guide antidepressant use, little is known about how to implement testing in clinical practice. Best–worst scaling (BWS) is a stated preferences technique for ... ...

Abstract	Abstract Background Despite the increased demand for pharmacogenetic (PGx) testing to guide antidepressant use, little is known about how to implement testing in clinical practice. Best–worst scaling (BWS) is a stated preferences technique for determining the relative importance of alternative scenarios and is increasingly being used as a healthcare assessment tool, with potential applications in implementation research. We conducted a BWS experiment to evaluate the relative importance of implementation factors for PGx testing to guide antidepressant use. Methods We surveyed 17 healthcare organizations that either had implemented or were in the process of implementing PGx testing for antidepressants. The survey included a BWS experiment to evaluate the relative importance of Consolidated Framework for Implementation Research (CFIR) constructs from the perspective of implementing sites. Results Participating sites varied on their PGx testing platform and methods for returning recommendations to providers and patients, but they were consistent in ranking several CFIR constructs as most important for implementation: patient needs/resources, leadership engagement, intervention knowledge/beliefs, evidence strength and quality, and identification of champions. Conclusions This study demonstrates the feasibility of using choice experiments to systematically evaluate the relative importance of implementation determinants from the perspective of implementing organizations. BWS findings can inform other organizations interested in implementing PGx testing for mental health. Further, this study demonstrates the application of BWS to PGx, the findings of which may be used by other organizations to inform implementation of PGx testing for mental health disorders.
Keywords	Best–worst scaling ; Pharmacogenetic testing ; Consolidated Framework for Implementation Research ; Medicine (General) ; R5-920
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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