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Article ; Online: Valuing tonsillitis manifestations in schoolchildren in Rio de Janeiro.

Goldenzon, Rafaela Valentim / Lucas, Tiago Oliveira / Roiseman, Maria de Marilacc Lima / Rodrigues, Marta Cristine Félix / Fonseca, Adriana Rodrigues / Oliveira, Sheila Knupp Feitosa de / Goldenzon, Andréa Valentim

Einstein (Sao Paulo, Brazil)

2022 Volume 20, Page(s) eAO6342

Abstract: Objective: To evaluate the importance attributed to tonsillitis by guardians and their level of knowledge about the disease, correlating their management with their schooling and socioeconomic profiles.: Methods: A quantitative, descriptive and ... ...

Abstract	Objective: To evaluate the importance attributed to tonsillitis by guardians and their level of knowledge about the disease, correlating their management with their schooling and socioeconomic profiles. Methods: A quantitative, descriptive and observational cross-sectional study involving students aged 5 to 17 years from state-owned and private schools. A questionnaire was applied on management of tonsillitis and knowledge about rheumatic fever, addressing demographic and socioeconomic data. Results: A total of 323 students were included, predominantly females (61.3%), from state-owned schools (77.1%), with a mean age of 9.7±0.3 years. Among the guardians, 48.6% completed high school. Among the students 75.2% had at least one episode of odynophagia in the previous 12 months. Considering the previous 2 years, 89.8% reported this symptom. There was no collection of bacteriological specimens in 67.8%, and in 83% if taking into account only the last episode, despite the search for medical care in most cases (92.6%). The use of anti-inflammatory drugs was very frequent (43.0% "always" and 42.4% "sometimes"). Among the guardians, 81.7% denied being aware of the relation between rheumatic fever and inappropriate treatment of odynophagia; 85.8% said they wished they had received more information. Conclusion: Although it is quite common in schoolchildren, tonsillitis is neglected by many guardians and health professionals, and the ignorance of its relation with rheumatic fever is practically universal, which may contribute to its high prevalence.
MeSH term(s)	Adolescent ; Brazil/epidemiology ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Humans ; Male ; Schools ; Students ; Tonsillitis/epidemiology
Language	English
Publishing date	2022-03-14
Publishing country	Brazil
Document type	Journal Article ; Observational Study
ZDB-ID	2418293-X
ISSN	2317-6385 ; 2317-6385
ISSN (online)	2317-6385
ISSN	2317-6385
DOI	10.31744/einstein_journal/2022AO6342
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Article ; Online: Comparison among ACR1997, SLICC and the new EULAR/ACR classification criteria in childhood-onset systemic lupus erythematosus.

Rodrigues Fonseca, Adriana / Felix Rodrigues, Marta Cristine / Sztajnbok, Flavio Roberto / Gerardin Poirot Land, Marcelo / Knupp Feitosa de Oliveira, Sheila

Advances in rheumatology (London, England)

2019 Volume 59, Issue 1, Page(s) 20

Abstract: Background: To date there are no specific classification criteria for childhood-onset systemic lupus erythematosus (cSLE). This study aims to compare the performance among the American College of Rheumatology (ACR) 1997, the Systemic Lupus International ...

Abstract	Background: To date there are no specific classification criteria for childhood-onset systemic lupus erythematosus (cSLE). This study aims to compare the performance among the American College of Rheumatology (ACR) 1997, the Systemic Lupus International Collaborating Clinics criteria (SLICC) and the new European League Against Rheumatism (EULAR)/ACR criteria, in a cSLE cohort. Methods: We conducted a medical chart review study of cSLE cases and controls with defined rheumatic diseases, both ANA positive, to establish each ACR1997, SLICC and EULAR/ACR criterion fulfilled, at first visit and 1-year-follow-up. Results: Study population included 122 cSLE cases and 89 controls. At first visit, SLICC criteria had higher sensitivity than ACR 1997 (89.3% versus 70.5%, p < 0.001), but similar specificity (80.9% versus 83.2%, p = 0.791), however performance was not statistically different at 1-year-follow-up. SLICC better scored in specificity compared to EULAR/ACR score ≥ 10 at first visit (80.9% versus 67.4%, p = 0.008) and at 1-year (76.4% versus 58.4%, p = 0.001), although sensitivities were similar. EULAR/ACR criteria score ≥ 10 exhibited higher sensitivity than ACR 1997 (87.7% versus 70.5%, p < 0.001) at first visit, but comparable at 1-year, whereas specificity was lower at first visit (67.4% versus 83.2%, p = 0.004) and 1-year (58.4% versus 76.4%, p = 0.002). A EULAR/ACR score ≥ 13 against a score ≥ 10, resulted in higher specificity, positive predictive value, and cut-off point accuracy. Compared to SLICC, a EULAR/ACR score ≥ 13 resulted in lower sensitivity at first visit (76.2% versus 89.3%, p < 0.001) and 1-year (91% versus 97.5%, p = 0.008), but similar specificities at both assessments. When compared to ACR 1997, a EULAR/ACR total score ≥ 13, resulted in no differences in sensitivity and specificity at both observation periods. Conclusions: In this cSLE population, SLICC criteria better scored at first visit and 1-year-follow-up. The adoption of a EULAR/ACR total score ≥ 13 in this study, against the initially proposed ≥10 score, was most appropriate to classify cSLE. Further studies are necessary to address if SLICC criteria might allow fulfillment of cSLE classification earlier in disease course and may be more inclusive of cSLE subjects for clinical studies.
MeSH term(s)	Adolescent ; Age of Onset ; Antibodies, Antinuclear/analysis ; Case-Control Studies ; Child ; Child, Preschool ; Europe ; Female ; Humans ; Lupus Erythematosus, Systemic/classification ; Lupus Erythematosus, Systemic/diagnosis ; Male ; Rheumatology ; Sensitivity and Specificity ; United States
Chemical Substances	Antibodies, Antinuclear
Language	English
Publishing date	2019-05-15
Publishing country	England
Document type	Comparative Study ; Journal Article
ISSN	2523-3106
ISSN (online)	2523-3106
DOI	10.1186/s42358-019-0062-z
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Article ; Online: Consensus-based recommendations for the management of juvenile systemic sclerosis.

Foeldvari, Ivan / Culpo, Roberta / Sperotto, Francesca / Anton, Jordi / Avcin, Tadej / Baildam, Eileen / Boros, Christina / Chaitow, Jeffrey / Constantin, Tamas / Kasapcopur, Ozgur / Knupp Feitosa de Oliveira, Sheila / Pilkington, Clarissa / Toplak, Natasa / van Royen, Annet / Saad Magalhaes, Claudia / Vastert, Sebastiaan J / Wulffraat, Nico / Zulian, Francesco

Rheumatology (Oxford, England)

2021 Volume 60, Issue 4, Page(s) 1651–1658

Abstract: Juvenile systemic sclerosis (JSSc) is a rare disease of childhood and currently no international consensus exists with regard to its assessment and treatment. This SHARE (Single Hub and Access point for paediatric Rheumatology in Europe) initiative, ... ...

Abstract	Juvenile systemic sclerosis (JSSc) is a rare disease of childhood and currently no international consensus exists with regard to its assessment and treatment. This SHARE (Single Hub and Access point for paediatric Rheumatology in Europe) initiative, based on expert opinion informed by the best available evidence, provides recommendations for the assessment and treatment of patients with JSSc with a view to improving their outcome. Experts focused attention not only on the skin assessment but also on the early signs of internal organ involvement whose proper treatment can significantly affect the long-term outcome. A score for disease severity is proposed in order to perform a structured assessment of outcome over time but a validation in a wider patient population is recommended. Finally, a stepwise treatment approach is proposed in order to unify the standard of care throughout Europe with the aim to reduce morbidity and mortality in this disease.
MeSH term(s)	Child ; Consensus ; Evidence-Based Medicine ; Humans ; Scleroderma, Localized/diagnosis ; Scleroderma, Localized/drug therapy ; Scleroderma, Systemic/diagnosis ; Scleroderma, Systemic/drug therapy ; Severity of Illness Index
Language	English
Publishing date	2021-06-04
Publishing country	England
Document type	Journal Article ; Practice Guideline ; Research Support, Non-U.S. Gov't
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keaa584
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Article ; Online: Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infection (PANDAS): a Controversial Diagnosis.

de Oliveira, Sheila Knupp Feitosa / Pelajo, Christina Feitosa

Current infectious disease reports

2011 Volume 12, Issue 2, Page(s) 103–109

Abstract: Despite more than a decade of studying pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS), it is still not possible to confirm its existence and whether it is a poststreptococcal autoimmune disorder. Many ... ...

Abstract	Despite more than a decade of studying pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS), it is still not possible to confirm its existence and whether it is a poststreptococcal autoimmune disorder. Many controversies remain: the diagnostic criteria have not been validated, evidence of autoimmunity remains inconclusive, evidence of a genetic predisposition is weak, and streptococcal infections are common in childhood and could represent only a trigger of exacerbations of tics and obsessive-compulsive disorder. Patients who fit the PANDAS criteria appear to represent a subgroup of children with chronic tic disorder and/or obsessive-compulsive disorder who may experience symptom exacerbations after group A β-hemolytic streptococci infections; however, those infections are not the sole or even the most common antecedent of exacerbations. There is not enough evidence to support PANDAS as a unique clinical entity.
Language	English
Publishing date	2011-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2019948-X
ISSN	1534-3146 ; 1523-3847
ISSN (online)	1534-3146
ISSN	1523-3847
DOI	10.1007/s11908-010-0082-7
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Book: Reumatologia pediátrica

Oliveira, Sheila Knupp Feitosa de

2001

Author's details	[edited by] Sheila Knupp Feitosa de Oliveira, Eneida Correia Lima Azevedo
MeSH term(s)	Rheumatic Diseases ; Adolescent ; Child ; Collagen Diseases ; Musculoskeletal Diseases
Language	Portuguese
Size	683 p. :, ill.
Edition	2. ed.
Publisher	Revinter
Publishing place	Rio de Janeiro, RJ
Document type	Book
ISBN	9788573094695 ; 8573094699
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: PANDAS: a new disease?

de Oliveira, Sheila Knupp Feitosa

Jornal de pediatria

2007 Volume 83, Issue 3, Page(s) 201–208

Abstract: Objective: To establish the diagnostic criteria for PANDAS and to analyze the existing evidence regarding its etiopathogenesis, treatment and prophylaxis.: Sources: Review of the scientific literature through a MEDLINE search carried out between 1989 ...

Abstract	Objective: To establish the diagnostic criteria for PANDAS and to analyze the existing evidence regarding its etiopathogenesis, treatment and prophylaxis. Sources: Review of the scientific literature through a MEDLINE search carried out between 1989 and 2006. Summary of the findings: The diagnostic criteria for PANDAS were established nearly 10 years ago, but a lot of controversy still exists over the actual existence of this new pediatric disease. The name of this new disease, supposedly of poststreptococcal etiology, derives from an acronym that stands for pediatric autoimmune neuropsychiatric disease associated with streptococcal infection. Tics and obsessive-compulsive symptoms are the major clinical signs of the disease, which develop after streptococcal infections, probably through autoimmune mechanisms. Even though these neuropsychiatric symptoms are common in rheumatic chorea, whose etiology is also poststreptococcal, the classic choreiform movements and other symptoms of rheumatic fevers are absent in PANDAS. The use of antimicrobial and immunologic therapy has been investigated and considered feasible in some cases. Conclusions: Further research is still necessary in order to answer the question posed in the title of this article. In the meantime, the identification of tic disorders and obsessive-compulsive disorders in children should include the possibility of PANDAS, seeking to provide evidence of previous streptococcal infection.
MeSH term(s)	Abbreviations as Topic ; Autoimmune Diseases/drug therapy ; Autoimmune Diseases/microbiology ; Autoimmune Diseases/prevention & control ; Child ; Child, Preschool ; Female ; Humans ; Male ; Obsessive-Compulsive Disorder/drug therapy ; Obsessive-Compulsive Disorder/microbiology ; Obsessive-Compulsive Disorder/prevention & control ; Streptococcal Infections/drug therapy ; Streptococcal Infections/prevention & control ; Streptococcal Infections/psychology ; Tics/drug therapy ; Tics/microbiology ; Tics/prevention & control
Language	English
Publishing date	2007-05-04
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	731324-x
ISSN	1678-4782 ; 0021-7557
ISSN (online)	1678-4782
ISSN	0021-7557
DOI	10.2223/JPED.1615
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Article ; Online: PANDAS

Sheila Knupp Feitosa de Oliveira

Jornal de Pediatria, Vol 83, Iss 3, Pp 201-

uma nova doença? PANDAS: a new disease?

2007 Volume 208

Abstract: ... a etiopatogenia, tratamento e profilaxia de PANDAS. FONTES DOS DADOS: Revisão de literatura científica através do ... MEDLINE no período de 1989 a 2006. SÍNTESE DOS DADOS: Os critérios diagnósticos para PANDAS foram ... pediátrica. A escolha deste nome para uma nova doença, supostamente de origem pós-estreptocócica, baseia-se ...

Abstract	OBJETIVO: Apresentar as bases diagnósticas e analisar as evidências que têm sido apontadas para a etiopatogenia, tratamento e profilaxia de PANDAS. FONTES DOS DADOS: Revisão de literatura científica através do MEDLINE no período de 1989 a 2006. SÍNTESE DOS DADOS: Os critérios diagnósticos para PANDAS foram estabelecidos há quase 10 anos, mas ainda há muita controvérsia sobre a real existência desta nova doença pediátrica. A escolha deste nome para uma nova doença, supostamente de origem pós-estreptocócica, baseia-se no acrônimo de P (pediátrico, porque ocorre em crianças), A (auto-imune), N (neuropsiquiátrico), D (doença), A (associada) e S (Streptococcus). Os tiques e os sintomas obsessivo-compulsivos são as principais manifestações clínicas da doença e surgem após infecções estreptocócicas, provavelmente por mecanismos auto-imunes. Apesar de estes sintomas neuropsiquiátricos serem comuns na coréia reumática, também de etiologia pós-estreptocócica, em PANDAS faltam os movimentos clássicos da coréia e as outras manifestações de febre reumática. As possibilidades de terapia antimicrobiana e imunológica estão sendo pesquisadas e demonstram viabilidade de uso em alguns casos. CONCLUSÕES: Pesquisas ainda são necessárias para responder à pergunta-título. Enquanto isso não ocorre, a identificação de casos de tiques e transtorno obsessivo-compulsivo em crianças deve considerar a possibilidade de PANDAS, buscando a evidência de infecção estreptocócica precedendo os episódios. OBJECTIVE: To establish the diagnostic criteria for PANDAS and to analyze the existing evidence regarding its etiopathogenesis, treatment and prophylaxis. SOURCES: Review of the scientific literature through a MEDLINE search carried out between 1989 and 2006. SUMMARY OF THE FINDINGS: The diagnostic criteria for PANDAS were established nearly 10 years ago, but a lot of controversy still exists over the actual existence of this new pediatric disease. The name of this new disease, supposedly of poststreptococcal etiology, derives from an acronym that stands for pediatric autoimmune neuropsychiatric disease associated with streptococcal infection. Tics and obsessive-compulsive symptoms are the major clinical signs of the disease, which develop after streptococcal infections, probably through autoimmune mechanisms. Even though these neuropsychiatric symptoms are common in rheumatic chorea, whose etiology is also poststreptococcal, the classic choreiform movements and other symptoms of rheumatic fevers are absent in PANDAS. The use of antimicrobial and immunologic therapy has been investigated and considered feasible in some cases. CONCLUSIONS: Further research is still necessary in order to answer the question posed in the title of this article. In the meantime, the identification of tic disorders and obsessive-compulsive disorders in children should include the possibility of PANDAS, seeking to provide evidence of previous streptococcal infection.
Keywords	PANDAS ; estreptococos ; coréia ; febre reumática ; tiques ; transtorno obsessivo-compulsivo ; streptococci ; chorea ; rheumatic fever ; tics ; obsessive-compulsive disorder ; Pediatrics ; RJ1-570 ; Medicine ; R ; DOAJ:Pediatrics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2007-06-01T00:00:00Z
Publisher	Sociedade Brasileira de Pediatria
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: Reumatologia para pediatras

Oliveira, Sheila Knupp Feitosa de

2003

Author's details	Sheila Knupp Feitosa de Oliveira
MeSH term(s)	Rheumatic Diseases ; Musculoskeletal Diseases ; Connective Tissue Diseases ; Adolescent ; Child
Language	Portuguese
Size	372 p. :, ill. +
Publisher	Revinter
Publishing place	Rio de Janeiro, RJ
Document type	Book
Accompanying material	1 CD (2 3/8 in.)
ISBN	9788573097467 ; 8573097469
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Consensus-based recommendations for the management of juvenile localised scleroderma.

Zulian, Francesco / Culpo, Roberta / Sperotto, Francesca / Anton, Jordi / Avcin, Tadej / Baildam, Eileen M / Boros, Christina / Chaitow, Jeffrey / Constantin, Tamàs / Kasapcopur, Ozgur / Knupp Feitosa de Oliveira, Sheila / Pilkington, Clarissa A / Russo, Ricardo / Toplak, Natasa / van Royen, Annet / Saad Magalhães, Claudia / Vastert, Sebastiaan J / Wulffraat, Nico M / Foeldvari, Ivan

Annals of the rheumatic diseases

2019 Volume 78, Issue 8, Page(s) 1019–1024

Abstract: In 2012, a European initiative called Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) was launched to optimise and disseminate diagnostic and management regimens in Europe for children and young adults with rheumatic diseases. ... ...

Abstract	In 2012, a European initiative called Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) was launched to optimise and disseminate diagnostic and management regimens in Europe for children and young adults with rheumatic diseases. Juvenile localised scleroderma (JLS) is a rare disease within the group of paediatric rheumatic diseases (PRD) and can lead to significant morbidity. Evidence-based guidelines are sparse and management is mostly based on physicians' experience. This study aims to provide recommendations for assessment and treatment of JLS. Recommendations were developed by an evidence-informed consensus process using the European League Against Rheumatism standard operating procedures. A committee was formed, mainly from Europe, and consisted of 15 experienced paediatric rheumatologists and two young fellows. Recommendations derived from a validated systematic literature review were evaluated by an online survey and subsequently discussed at two consensus meetings using a nominal group technique. Recommendations were accepted if ≥80% agreement was reached. In total, 1 overarching principle, 10 recommendations on assessment and 6 recommendations on therapy were accepted with ≥80% agreement among experts. Topics covered include assessment of skin and extracutaneous involvement and suggested treatment pathways. The SHARE initiative aims to identify best practices for treatment of patients suffering from PRDs. Within this remit, recommendations for the assessment and treatment of JLS have been formulated by an evidence-informed consensus process to produce a standard of care for patients with JLS throughout Europe.
MeSH term(s)	Administration, Oral ; Adolescent ; Child ; Combined Modality Therapy ; Consensus ; Disease Management ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Drug Therapy, Combination ; Europe ; Evidence-Based Medicine ; Female ; Humans ; Male ; Methotrexate/administration & dosage ; Phototherapy/methods ; Practice Guidelines as Topic ; Prednisone/administration & dosage ; Prognosis ; Scleroderma, Localized/diagnosis ; Scleroderma, Localized/therapy ; Severity of Illness Index ; Treatment Outcome
Chemical Substances	Prednisone (VB0R961HZT) ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2019-03-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/annrheumdis-2018-214697
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Article ; Online: Edema hemorrágico agudo da infância

Christina Feitosa Pelajo / Sheila Knupp Feitosa de Oliveira

Revista Brasileira de Reumatologia, Vol 47, Iss 1, Pp 69-

uma variante da púrpura de Henoch-Schönlein? Acute hemorrhagic edema of infancy: a variant of Henoch-Schönlein purpura?

2007 Volume 71

Abstract: ... aproximadamente 100 casos descritos na literatura de língua inglesa. As lesões cutâneas características são ... púrpuras palpáveis, que se localizam em face, orelhas e extremidades, e lembram a figura de um medalhão. É ... uma vasculite de pequenos vasos, característica de crianças menores de dois anos de idade. Na maioria ...

Abstract	O edema hemorrágico agudo da infância (EHAI) é uma vasculite leucocitoclástica rara, com aproximadamente 100 casos descritos na literatura de língua inglesa. As lesões cutâneas características são púrpuras palpáveis, que se localizam em face, orelhas e extremidades, e lembram a figura de um medalhão. É uma vasculite de pequenos vasos, característica de crianças menores de dois anos de idade. Na maioria das vezes, tem curso autolimitado e benigno, apesar da aparência das lesões. Relatamos o caso de uma lactente, que iniciou edema de mãos e pés, lesões purpúricas na face e febre, e comparamos a outros já descritos, de acordo com a revisão da literatura acerca do assunto. A raridade da doença pode estar associada ao subdiagnóstico ou ao diagnóstico equivocado de púrpura de Henoch-Schönlein (PHS). EHAI é precedido na maioria dos casos por infecções, imunizações ou drogas. O envolvimento de mucosas e vísceras raramente ocorre. Nenhum tratamento é recomendado atualmente. O alerta para essa vasculite tem como objetivo auxiliar o diagnóstico, tornando-o mais precoce, e evitar tratamentos e preocupações desnecessárias. Acute Hemorrhagic Edema of Infancy (AHEI) is a rare leukocytoclastic vasculitis and there are around 100 cases described in the English language literature. The typical cutaneous lesion is a palpable purpura localized on the face, ears, and extremities and resembles a medallion. It is a vasculitis of small vessels, mainly seen in children less than 2 years of age. It is usually self-limited and benign, despite its appearance. We report a case of an infant who presented with swelling of hands and feet, purpuric lesions on face and fever, and compare with other previously described cases, accordingly to the literature review. The rarity may be associated with underdiagnosis or mistaken diagnosis of Henoch-Schönlein purpura. AHEI is preceded in the majority of cases by infections, immunizations or drugs. Mucosal and visceral involvement is seldom seen. No treatment is currently recommended. The alert for this vasculitis aims to help the diagnosis, making it earlier and preventing unnecessary concern and treatment.
Keywords	edema hemorrágico agudo da infância ; vasculite ; púrpura ; acute hemorrhagic edema of infancy ; vasculitis ; purpura ; Diseases of the musculoskeletal system ; RC925-935 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	Portuguese
Publishing date	2007-02-01T00:00:00Z
Publisher	Sociedade Brasileira de Reumatologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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