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  1. Article ; Online: PAP therapy increases the risk of transmission of COVID-19.

    Lance, Colleen G

    Cleveland Clinic journal of medicine

    2020  

    Abstract: Positive airway pressure (PAP) therapy is an open system that can generate contact, droplet, and airborne COVID-19 thereby increasing the risk of transmission of COVID-19 like other procedures such as tracheal intubation, noninvasive ventilation, and ... ...

    Abstract Positive airway pressure (PAP) therapy is an open system that can generate contact, droplet, and airborne COVID-19 thereby increasing the risk of transmission of COVID-19 like other procedures such as tracheal intubation, noninvasive ventilation, and cardiopulmonary resuscitation. Medically prudent recommendations have been established for home use of PAP therapy in asymptomatic patients and patients with suspected or confirmed COVID-19. Recommendations for sleep clinics and sleep laboratory activities are also discussed as well as the emergency use of PAP devices as a substitute for ventilation.
    Keywords covid19
    Language English
    Publishing date 2020-05-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.87a.ccc003
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  2. Article ; Online: Positive airway pressure: Making an impact on sleep apnea.

    Lance, Colleen G

    Cleveland Clinic journal of medicine

    2019  Volume 86, Issue 9 Suppl 1, Page(s) 26–33

    Abstract: Positive airway pressure (PAP) devices deliver a pressurized column of air to open the airway in patients with sleep apnea. For patients with moderate to severe sleep apnea, PAP therapy is the gold standard for treatment, with demonstrated improvements ... ...

    Abstract Positive airway pressure (PAP) devices deliver a pressurized column of air to open the airway in patients with sleep apnea. For patients with moderate to severe sleep apnea, PAP therapy is the gold standard for treatment, with demonstrated improvements in daytime sleepiness and cardiovascular measures that are superior to conservative treatments. For a variety of reasons, adherence to PAP therapy is a challenge for many patients, resulting in deficits in the frequency and duration of use. To improve use and compliance to therapy, several advanced features are available to enhance comfort, pressure, and humidification factors associated with PAP devices. Patient motivation strategies such as motivational interviews, desensitization protocols, and PAP "NAPs" are also being employed to improve adherence to therapy.
    MeSH term(s) Continuous Positive Airway Pressure/psychology ; Humans ; Motivation ; Patient Compliance/psychology ; Sleep Apnea Syndromes/psychology ; Sleep Apnea Syndromes/therapy
    Language English
    Publishing date 2019-09-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.86.s1.05
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  3. Article: PAP therapy increases the risk of transmission of COVID-19

    Lance, Colleen G

    Clevel. clin. j. med

    Abstract: Positive airway pressure (PAP) therapy is an open system that can generate contact, droplet, and airborne COVID-19 thereby increasing the risk of transmission of COVID-19 like other procedures such as tracheal intubation, noninvasive ventilation, and ... ...

    Abstract Positive airway pressure (PAP) therapy is an open system that can generate contact, droplet, and airborne COVID-19 thereby increasing the risk of transmission of COVID-19 like other procedures such as tracheal intubation, noninvasive ventilation, and cardiopulmonary resuscitation. Medically prudent recommendations have been established for home use of PAP therapy in asymptomatic patients and patients with suspected or confirmed COVID-19. Recommendations for sleep clinics and sleep laboratory activities are also discussed as well as the emergency use of PAP devices as a substitute for ventilation.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #186685
    Database COVID19

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  4. Article ; Online: Study protocol of a randomized controlled trial to assess the efficacy of the "PrEPare for Work" intervention to enhance PrEP uptake and optimize adherence for HIV prevention among male sex workers in the U.S.

    Biello, Katie B / Chan, Philip A / Ndoye, Colleen D / Nelson, Lance / Nelson, Elizabeth / Silva, Vanessa / Kwak, Eun / Napoleon, Siena / Cormack Orellana, Carolina / Richards, Olly G / Davis, Evan / Mimiaga, Matthew J

    BMC public health

    2024  Volume 24, Issue 1, Page(s) 424

    Abstract: Background: Male sex workers (MSWs), specifically cisgender men who exchange sex for money, goods, drugs, or other items of value with other cisgender men, are at high risk for HIV infection. Compared to men not engaged in sex work, MSWs are more likely ...

    Abstract Background: Male sex workers (MSWs), specifically cisgender men who exchange sex for money, goods, drugs, or other items of value with other cisgender men, are at high risk for HIV infection. Compared to men not engaged in sex work, MSWs are more likely to engage in frequent condomless sex with paying and non-paying sexual partners. While MSWs are often included as a subgroup of gay and bisexual men, data show that a large proportion identify as heterosexual; additionally, most MSWs do not identify as "sex workers." This places MSWs in a unique position where they may not engage with traditional HIV prevention programs, and when they do, they may not feel comfortable, leading to poor retention. Thus, HIV prevention interventions that address MSWs' unique life circumstances and provide support in exploring their sexual health options are needed.
    Methods: In this protocol paper, we describe the design and procedures for a National Institute of Health-funded, randomized controlled trial testing the efficacy of "PrEPare for Work,"- a theory-based, manualized PrEP uptake and adherence intervention for MSW - using a 2-stage randomization design. Stage 1: MSWs are equally randomized to receive either the "PrEPare for Work Stage 1 intervention" (strength-based case management and facilitated PrEP linkage) or Standard of Care (SOC) to evaluate successful PrEP uptake (prescription filled) within two months post-randomization. Stage 2: Those who initiate PrEP are then equally re-randomized to receive either the "PrEPare for Work Stage 2 intervention" (1-on-1 skills training, problem-solving, and motivational interviewing adherence counseling and personalized, daily text message reminders) or SOC to assess adherence (Tenofovir concentrations in hair) over 12 months of follow up. Planned analyses will examine intervention efficacy, specific conceptual mediators, and hypothesized moderators.
    Discussion: Based on our extensive preliminary research, multi-component, theory-informed interventions targeting this subpopulation of MSWs' unique life circumstances are urgently needed. In this study, we are evaluating whether "PrEPare for Work" can improve PrEP uptake and adherence among MSWs. If this intervention is efficacious, it would be readily disseminated to diverse community organizations that serve MSWs and possibly other community or clinic-based settings.
    Trial registration: ClinicalTrials.gov number NCT05736614, registered February 8, 2023.
    MeSH term(s) Male ; Humans ; HIV Infections/prevention & control ; HIV Infections/psychology ; Homosexuality, Male/psychology ; Sex Workers ; Sexual Behavior ; Counseling ; Pre-Exposure Prophylaxis/methods ; Anti-HIV Agents/therapeutic use ; Randomized Controlled Trials as Topic
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-024-17710-y
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  5. Article ; Online: A Primary Care Provider's Guide to Sexual Health for Individuals With Spinal Cord Injury.

    Hough, Sigmund / Cordes, Colleen Clemency / Goetz, Lance L / Kuemmel, Angela / Lieberman, Jesse A / Mona, Linda R / Tepper, Mitchell S / Varghese, Jithin G

    Topics in spinal cord injury rehabilitation

    2020  Volume 26, Issue 3, Page(s) 144–151

    Abstract: The collaboration with individuals regarding their sexual health is an important component of patient-centered health care. However, talking about sexual health in primary care settings is an area not fully addressed as a result of time limitations, ... ...

    Abstract The collaboration with individuals regarding their sexual health is an important component of patient-centered health care. However, talking about sexual health in primary care settings is an area not fully addressed as a result of time limitations, medical task prioritization, awareness or knowledge deficit, and discomfort with the topic of sexuality. A critical shift in professional focus from disease and medical illness to the promotion of health and wellness is a prerequisite to address sexual health in the primary care setting. This article provides guidance for practitioners in primary care settings who are caring for persons with spinal cord injury. Clinicians should seize the opportunity during the encounter to reframe the experience of disability as a social construct status, moving away from the narrow view of medical condition and "find it, fix it" to a broader understanding that provides increased access to care for sexual health and sexual pleasure.
    MeSH term(s) Humans ; Primary Health Care ; Sexual Dysfunction, Physiological/etiology ; Sexual Dysfunction, Physiological/therapy ; Sexual Health/education ; Spinal Cord Injuries/complications
    Language English
    Publishing date 2020-11-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1319299-1
    ISSN 1945-5763 ; 1082-0744
    ISSN (online) 1945-5763
    ISSN 1082-0744
    DOI 10.46292/sci2603-144
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    Zs.A 4430: Show issues Location:
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  6. Article ; Online: 1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis.

    Mayne, Christopher G / Spanier, Justin A / Relland, Lance M / Williams, Calvin B / Hayes, Colleen E

    European journal of immunology

    2011  Volume 41, Issue 3, Page(s) 822–832

    Abstract: Multiple sclerosis (MS) is an incurable autoimmune neurodegenerative disease. Environmental factors may be key to MS prevention and treatment. MS prevalence and severity decrease with increasing sunlight exposure and vitamin D(3) supplies, supporting our ...

    Abstract Multiple sclerosis (MS) is an incurable autoimmune neurodegenerative disease. Environmental factors may be key to MS prevention and treatment. MS prevalence and severity decrease with increasing sunlight exposure and vitamin D(3) supplies, supporting our hypothesis that the sunlight-dependent hormone, 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2) D(3) ), inhibits autoimmune T-cell responses in MS. Moreover, 1,25-(OH)(2) D(3) inhibits and reverses experimental autoimmune encephalomyelitis (EAE), an MS model. Here, we investigated whether 1,25-(OH)(2) D(3) inhibits EAE via the vitamin D receptor (VDR) in T lymphocytes. Using bone marrow chimeric mice with a disrupted VDR only in radio-sensitive hematopoietic cells or radio-resistant non-hematopoietic cells, we found that hematopoietic cell VDR function was necessary for 1,25-(OH)(2) D(3) to inhibit EAE. Furthermore, conditional targeting experiments showed that VDR function in T cells was necessary. Neither 1,25-(OH)(2) D(3) nor T-cell-specific VDR targeting influenced CD4(+) Foxp3(+) T-cell proportions in the periphery or the CNS in these studies. These data support a model wherein 1,25-(OH)(2) D(3) acts directly on pathogenic CD4(+) T cells to inhibit EAE.
    MeSH term(s) Animals ; Calcitriol/pharmacology ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/metabolism ; Encephalomyelitis, Autoimmune, Experimental/prevention & control ; Female ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/immunology ; Hematopoietic Stem Cells/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Receptors, Calcitriol/antagonists & inhibitors ; Receptors, Calcitriol/deficiency ; Receptors, Calcitriol/genetics ; Receptors, Calcitriol/metabolism ; T-Lymphocyte Subsets/drug effects ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
    Chemical Substances Receptors, Calcitriol ; Calcitriol (FXC9231JVH)
    Keywords covid19
    Language English
    Publishing date 2011-03
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.201040632
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    Zs.A 489: Show issues Location:
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  7. Article: 1,25-Dihydroxyvitamin D₃ acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis

    Mayne, Christopher G / Spanier, Justin A / Relland, Lance M / Williams, Calvin B / Hayes, Colleen E

    European journal of immunology. 2011 Mar., v. 41, no. 3

    2011  

    Abstract: Multiple sclerosis (MS) is an incurable autoimmune neurodegenerative disease. Environmental factors may be key to MS prevention and treatment. MS prevalence and severity decrease with increasing sunlight exposure and vitamin D₃ supplies, supporting our ... ...

    Abstract Multiple sclerosis (MS) is an incurable autoimmune neurodegenerative disease. Environmental factors may be key to MS prevention and treatment. MS prevalence and severity decrease with increasing sunlight exposure and vitamin D₃ supplies, supporting our hypothesis that the sunlight-dependent hormone, 1,25-dihydroxyvitamin D₃ (1,25-(OH)₂D₃), inhibits autoimmune T-cell responses in MS. Moreover, 1,25-(OH)₂D₃ inhibits and reverses experimental autoimmune encephalomyelitis (EAE), an MS model. Here, we investigated whether 1,25-(OH)₂D₃ inhibits EAE via the vitamin D receptor (VDR) in T lymphocytes. Using bone marrow chimeric mice with a disrupted VDR only in radio-sensitive hematopoietic cells or radio-resistant non-hematopoietic cells, we found that hematopoietic cell VDR function was necessary for 1,25-(OH)₂D₃ to inhibit EAE. Furthermore, conditional targeting experiments showed that VDR function in T cells was necessary. Neither 1,25-(OH)₂D₃ nor T-cell-specific VDR targeting influenced CD4⁺Foxp3⁺ T-cell proportions in the periphery or the CNS in these studies. These data support a model wherein 1,25-(OH)₂D₃ acts directly on pathogenic CD4⁺ T cells to inhibit EAE.
    Keywords covid19
    Language English
    Dates of publication 2011-03
    Size p. 822-832.
    Publishing place Wiley-VCH Verlag
    Document type Article
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.201040632
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  8. Article ; Online: Clinical care of two patients with Ebola virus disease in the United States.

    Lyon, G Marshall / Mehta, Aneesh K / Varkey, Jay B / Brantly, Kent / Plyler, Lance / McElroy, Anita K / Kraft, Colleen S / Towner, Jonathan S / Spiropoulou, Christina / Ströher, Ute / Uyeki, Timothy M / Ribner, Bruce S

    The New England journal of medicine

    2014  Volume 371, Issue 25, Page(s) 2402–2409

    Abstract: West Africa is currently experiencing the largest outbreak of Ebola virus disease (EVD) in history. Two patients with EVD were transferred from Liberia to our hospital in the United States for ongoing care. Malaria had also been diagnosed in one patient, ...

    Abstract West Africa is currently experiencing the largest outbreak of Ebola virus disease (EVD) in history. Two patients with EVD were transferred from Liberia to our hospital in the United States for ongoing care. Malaria had also been diagnosed in one patient, who was treated for it early in the course of EVD. The two patients had substantial intravascular volume depletion and marked electrolyte abnormalities. We undertook aggressive supportive measures of hydration (typically, 3 to 5 liters of intravenous fluids per day early in the course of care) and electrolyte correction. As the patients' condition improved clinically, there was a concomitant decline in the amount of virus detected in plasma.
    MeSH term(s) Adult ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Viral/therapeutic use ; Disease Outbreaks ; Drugs, Investigational/therapeutic use ; Ebolavirus/immunology ; Female ; Hemorrhagic Fever, Ebola/drug therapy ; Hemorrhagic Fever, Ebola/epidemiology ; Hemorrhagic Fever, Ebola/therapy ; Humans ; Liberia ; Male ; Middle Aged ; United States
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Viral ; Drugs, Investigational ; ZMapp
    Language English
    Publishing date 2014-12-18
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMoa1409838
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    Ua VI Zs.34: Show issues Location:
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  9. Article ; Online: Physical Activity and Sleep Measures Using a Fitness Tracking Device during Hematopoietic Cell Transplantation: A Pilot Study.

    Jurdi, Najla El / Nock, Nora / Fu, Pingfu / Cao, Shufen / Cotton, Joel M / Ali, Naveed / Ravi, Gayathri / Pinto, Raisa / Galloway, Erin / Kolke, Samantha / Cooper, Brenda / Tomlinson, Benjamin / Malek, Ehsan / Lance, Colleen / Kolk, Merle J / Ferrari, Nicole / Lee, Richard / de Lima, Marcos / Caimi, Paolo F /
    Metheny, Leland

    Transplantation and cellular therapy

    2021  Volume 27, Issue 6, Page(s) 502.e1–502.e6

    Abstract: Patients undergoing hematopoietic cell transplantation (HCT) experience decline in their physical activity during their transplant admission. There is limited experience with prospective monitoring of transplant recipients. We therefore measured physical ...

    Abstract Patients undergoing hematopoietic cell transplantation (HCT) experience decline in their physical activity during their transplant admission. There is limited experience with prospective monitoring of transplant recipients. We therefore measured physical activity and sleep patterns of subjects undergoing autologous and allogeneic HCT. Eighty-three patients were consented for this study. Sixty-three patients competed the study and had their physical activity prospectively assessed using the fitness-tracking device Fitbit HR. Outcomes included adherence, physical activity, readmission, hematopoietic engraftment, and 100-day survival. Sixty percent of patients (n = 37) underwent autologous HCT, and 40% (n = 26) underwent allogenic HCT. Both groups had a comparable number of steps at admission to the hospital. The number of daily steps during the study period was lower in the allogeneic group (2159 versus 3008, P = .07), as was the minimum number of steps recorded over the transplant admission (allogeneic HCT = 395 versus autologous HCT = 848, P = .01). Patients undergoing allogeneic HCT were less active on the day before discharge (1956 steps versus 3183 steps, P = .08). In multivariate analysis, physical activity was not associated with HCT-related outcomes. Patients undergoing HCT experience significant decline in their physical activity during their transplant admission that does not recover by the time of discharge. This effect can be objectively measured using fitness tracking devices.
    MeSH term(s) Exercise ; Hematopoietic Stem Cell Transplantation ; Humans ; Pilot Projects ; Prospective Studies ; Sleep ; Transplantation Conditioning ; Transplantation, Homologous
    Language English
    Publishing date 2021-02-19
    Document type Journal Article
    ZDB-ID 3062231-1
    ISSN 2666-6367
    ISSN (online) 2666-6367
    DOI 10.1016/j.jtct.2021.02.015
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  10. Article: External Stenting (Exostenting) to Correct Vascular Torsion and Angulation.

    Silva, Michael B / Shoaib, Muhammad / Miyara, Santiago J / Guevara, Sara / McCann-Molmenti, Alexia / Silva, H Colleen / Watt, Stacey / Zafeiropoulos, Stefanos / Hayashida, Kei / Takegawa, Ryosuke / Shinozaki, Koichiro / Choudhary, Rishabh C / Cho, Young Min / Kressel, Adam M / Alsalmay, Yaser M / Grande, Daniel A / Cicalese, Luca / Aranalde, Gabriel I / Covelli, Grace /
    Becker, Lance B / Shore-Lesserson, Linda / Molmenti, Ernesto P

    The International journal of angiology : official publication of the International College of Angiology, Inc

    2021  Volume 32, Issue 2, Page(s) 128–130

    Abstract: Organ transplantation can be associated with vascular torsions and angulations of both recipient and donor vessels. Such kinks and/or torsions of vessels can compromise the vascular integrity, obstruct inflow and/or outflow, and result in loss of the ... ...

    Abstract Organ transplantation can be associated with vascular torsions and angulations of both recipient and donor vessels. Such kinks and/or torsions of vessels can compromise the vascular integrity, obstruct inflow and/or outflow, and result in loss of the organ and/or body parts. On many occasions, mild angulations and torsions can be successfully addressed by repositioning the organ. In cases where the abnormal findings persist, maneuvers such as placing a fat pad to create a smoother curve, or even opening the peritoneum (in the case of kidney transplants) to allow for a better positioning of the organ, are associated with successful outcomes. When such torsions/angulations persist despite these approaches, further innovative tactics are required. In the current report, we propose a technique that involves longitudinally opening of a synthetic graft that is rigid enough to maintain its shape, such as a ringed polytetrafluoroethylene graft, and placing it as an external stent around the angulated/torsioned vessel. This maneuver will correct the underlying vascular compromise without having to perform any further invasive interventions, such as reimplanting the organ or resecting part of the involved vessel. Although primarily illustrated for application by describing an instance in which exostenting was applied during kidney transplantation, our approach could be applied to any vessel under many circumstances where angulations/twists are encountered. In this report, we describe the use of an external stent, also called exostenting, to correct a severe torsion/angulation of the external iliac artery in a kidney transplant recipient where all other measures were unsuccessful.
    Language English
    Publishing date 2021-05-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1144390-x
    ISSN 1061-1711
    ISSN 1061-1711
    DOI 10.1055/s-0041-1727132
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