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Article ; Online: Guaianolide Derivatives from the Invasive

Baldi, Sylvain / Bradesi, Pascale / Muselli, Alain

2022 Volume 27, Issue 21

Abstract: Ziniolide, xantholide B (11α-dihydroziniolide), and 11β-dihydroziniolide, three sesquiterpene lactones with 12,8-guaianolide skeletons, were identified as volatile metabolites from the roots ... ...

Abstract	Ziniolide, xantholide B (11α-dihydroziniolide), and 11β-dihydroziniolide, three sesquiterpene lactones with 12,8-guaianolide skeletons, were identified as volatile metabolites from the roots of
MeSH term(s)	Xanthium/chemistry ; Allelopathy ; Sesquiterpenes, Guaiane/pharmacology ; Oils, Volatile/pharmacology ; Oils, Volatile/chemistry ; Germination ; Seedlings ; Plant Extracts/pharmacology ; Plant Extracts/chemistry
Chemical Substances	ziniolide ; Sesquiterpenes, Guaiane ; Oils, Volatile ; Plant Extracts
Language	English
Publishing date	2022-10-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27217297
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Article ; Online: Mechanistic understanding of the effects of probiotics in the modulation of abdominal pain: one study at a time.

Bradesi, Sylvie

The Journal of physiology

2015 Volume 593, Issue 17, Page(s) 3769–3770

MeSH term(s)	Animals ; Bradycardia/therapy ; Jejunum/physiology ; Lactobacillus reuteri ; Male ; Probiotics ; Stomach Diseases/therapy ; TRPV Cation Channels/physiology
Chemical Substances	TRPV Cation Channels
Language	English
Publishing date	2015-09-01
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	3115-x
ISSN	1469-7793 ; 0022-3751
ISSN (online)	1469-7793
ISSN	0022-3751
DOI	10.1113/JP271121
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Article ; Online: Guaianolide Derivatives from the Invasive Xanthium spinosum L.

Sylvain Baldi / Pascale Bradesi / Alain Muselli

Molecules, Vol 27, Iss 7297, p

Evaluation of Their Allelopathic Potential

2022 Volume 7297

Abstract: ... species, the allelopathic effects of X. spinosum root’s volatile metabolites were assessed ...

Abstract	Ziniolide, xantholide B (11α-dihydroziniolide), and 11β-dihydroziniolide, three sesquiterpene lactones with 12,8-guaianolide skeletons, were identified as volatile metabolites from the roots of Xanthium spinosum L., an invasive plant harvested in Corsica. Essential oil, as well as hydrosol and hexane extracts, showed the presence of guaianolide analogues. The study highlights an analytical strategy involving column chromatography, GC-FID, GC-MS, NMR (1D and 2D), and the hemi-synthesis approach, to identify compounds with incomplete or even missing spectral data from the literature. Among them, we reported the 1 H- and 13 C-NMR data of 11β-dihydroziniolide, which was observed as a natural product for the first time. As secondary metabolites were frequently involved in the dynamic of the dispersion of weed species, the allelopathic effects of X. spinosum root’s volatile metabolites were assessed on seed germination and seedling growth (leek and radish). Essential oil, as well as hydrosol- and microwave-assisted extracts inhibited germination and seedling growth; root metabolite phytotoxicity was demonstrated. Nevertheless, the phytotoxicity of root metabolites was demonstrated with a more marked selectivity to the benefit of the monocotyledonous species compared to the dicotyledonous species. Ziniolide derivatives seem to be strongly involved in allelopathic interactions and could be the key to understanding the invasive mechanisms of weed.
Keywords	Xanthium spinosum ; essential oil ; volatile metabolites ; guaianolide ; allelopathy ; Organic chemistry ; QD241-441
Subject code	571
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Role of spinal cord glia in the central processing of peripheral pain perception.

Bradesi, S

Neurogastroenterology and motility

2010 Volume 22, Issue 5, Page(s) 499–511

Abstract: Background: The discovery that glial activation plays a critical role in the modulation of neuronal functions and affects the spinal processing of nociceptive signalling has brought new understanding on the mechanisms underlying central sensitization ... ...

Abstract	Background: The discovery that glial activation plays a critical role in the modulation of neuronal functions and affects the spinal processing of nociceptive signalling has brought new understanding on the mechanisms underlying central sensitization involved in chronic pain facilitation. Spinal glial activation is now considered an important component in the development and maintenance of allodynia and hyperalgesia in various models of chronic pain, including neuropathic pain and pain associated with peripheral inflammation. In addition, spinal glial activation is also involved in some forms of visceral hyperalgesia. Purpose: We discuss the signalling pathways engaged in central glial activation, including stress pathways, and the neuron-glia bidirectional relationships involved in the modulation of synaptic activity and pain facilitation. In this expanding field of research, the characterization of the mechanisms by which glia affect spinal neuro-transmission will increase our understanding of central pain facilitation, and has the potential for the development of new therapeutic agents for common chronic pain conditions.
MeSH term(s)	Afferent Pathways/physiopathology ; Animals ; Neuroglia/physiology ; Neurons/physiology ; Pain/physiopathology ; Signal Transduction/physiology ; Spinal Cord/physiopathology
Language	English
Publishing date	2010-03-16
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1186328-6
ISSN	1365-2982 ; 1350-1925
ISSN (online)	1365-2982
ISSN	1350-1925
DOI	10.1111/j.1365-2982.2010.01491.x
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Article ; Online: PAR4: a new role in the modulation of visceral nociception.

Bradesi, S

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

2009 Volume 21, Issue 11, Page(s) 1129–1132

Abstract: Protease-activated receptors (PARs) are a family of G-protein-coupled receptors with a widespread distribution that are involved in various physiological functions including inflammation and nociception. In a recent study in Neurogastroenterology and ... ...

Abstract	Protease-activated receptors (PARs) are a family of G-protein-coupled receptors with a widespread distribution that are involved in various physiological functions including inflammation and nociception. In a recent study in Neurogastroenterology and Motility, Augé et al. describe for the first time the presence of PAR4 on visceral primary afferent neurons and its role in modulating colonic nociceptive responses, colonic hypersensitivity and primary afferent responses to PAR2 and Transient Receptor Potential Vanilloid-4 (TRPV4). Using the model of visceromotor response (VMR) to colorectal distension (CRD), they show that a PAR4 agonist delivered into the colon lumen decreases basal visceral response to CRD and reduces the exacerbated VMR to CRD induced by treatment with PAR2 or TRPV4 agonists. In isolated sensory neurons, they show that a PAR4 agonist inhibits calcium mobilization induced by PAR2 or TRPV4 agonists. Finally, they describe increased pain behaviour evoked by luminal application of mustard oil in PAR4 deficient mice compared to wild type controls. The newly discovered role of PAR4 in modulating visceral pain adds to our growing understanding of the contribution of colonic proteases and PARs to the mechanisms involved in colonic hypersensitivity and their potential role as therapeutic targets for irritable bowel syndrome.
MeSH term(s)	Animals ; Colon/metabolism ; Humans ; Irritable Bowel Syndrome/metabolism ; Irritable Bowel Syndrome/pathology ; Mice ; Pain/metabolism ; Receptor, PAR-2/metabolism ; Receptors, Thrombin/metabolism ; TRPV Cation Channels/metabolism ; Visceral Afferents/metabolism
Chemical Substances	Receptor, PAR-2 ; Receptors, Thrombin ; TRPV Cation Channels ; Trpv4 protein, mouse ; protease-activated receptor 4 (JWE1M73YZN)
Language	English
Publishing date	2009-10-05
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	1186328-6
ISSN	1365-2982 ; 1350-1925
ISSN (online)	1365-2982
ISSN	1350-1925
DOI	10.1111/j.1365-2982.2009.01373.x
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Article: Chemical Composition of the Fruit Oils of Five Fortunella Species Grown in the Same Pedoclimatic Conditions in Corsica (France).

Sutour, Sylvain / Lurob, François / Bradesi, Pascale / Casanova, Joseph / Tomi, Félix

Natural product communications

2016 Volume 11, Issue 2, Page(s) 259–262

Abstract: Fruit oil from five species of kumquat (Fortunella japonica, F. margarita, F. crassifolia, F. obovata, and F. hindsii) grown in the same pedoclimatic conditions have been analyzed by a combination of chromatographic and spectroscopic techniques. The ... ...

Abstract	Fruit oil from five species of kumquat (Fortunella japonica, F. margarita, F. crassifolia, F. obovata, and F. hindsii) grown in the same pedoclimatic conditions have been analyzed by a combination of chromatographic and spectroscopic techniques. The compositions of the five fruit oils were strongly dominated by limonene (84.2-96.3%). Other components present with appreciable contents were myrcene (1.3-12.9%) and germacrene D (0.3-2.4%).
MeSH term(s)	Climate ; France ; Fruit/chemistry ; Plant Oils/chemistry ; Rutaceae/chemistry ; Rutaceae/classification ; Species Specificity
Chemical Substances	Plant Oils
Language	English
Publishing date	2016-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1934-578X
ISSN	1934-578X
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Article ; Online: Lionel Buéno, PhD, July 9, 1945-January 24, 2015.

Taché, Yvette / Million, Mulugeta / Bradesi, Sylvie / Larauche, Muriel / Theodorou, Vassilia

Gastroenterology

2015 Volume 148, Issue 5, Page(s) 863–864

MeSH term(s)	Biomedical Research/education ; Biomedical Research/history ; France ; Gastroenterology/education ; Gastroenterology/history ; History, 20th Century ; History, 21st Century ; Humans ; Mentors/history
Language	English
Publishing date	2015-05
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article ; Portraits
ZDB-ID	80112-4
ISSN	1528-0012 ; 0016-5085
ISSN (online)	1528-0012
ISSN	0016-5085
DOI	10.1053/j.gastro.2015.03.038
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Zs.MO 572: Show issues

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Article ; Online: An obesogenic refined low-fat diet disrupts attentional and behavioral control processes in a vigilance task in rats.

Blaisdell, Aaron P / Biedermann, Traci / Sosa, Eric / Abuchaei, Ava / Youssef, Neveen / Bradesi, Sylvie

Behavioural processes

2017 Volume 138, Page(s) 142–151

Abstract: Diets consisting of refined foods (REF) are associated with poor physical (e.g., obesity and diabetes) and mental (e.g., depression) health and impaired cognition. Few animal studies have explored the causal links between diet processing and health. ... ...

Abstract	Diets consisting of refined foods (REF) are associated with poor physical (e.g., obesity and diabetes) and mental (e.g., depression) health and impaired cognition. Few animal studies have explored the causal links between diet processing and health. Instead, most studies focus on the role of macronutrients, especially carbohydrate and fat concurrently with how processed are the ingredients. We previously showed that a REF low fat diet (LFD) caused greater adiposity and impaired motivation compared to an unrefined control (CON) diet consisting of similar macronutrient ratios (Blaisdell et al., 2014). Here we test the hypothesis that the same REF LFD adversely affects attentional processes and behavioral control relative to the CON diet. Rats with ad libitum access to the REF diet for two months gained greater adiposity than rats consuming the CON diet. Rats then completed training on a vigilance task involving pressing the correct lever signaled by a brief visual cue whose onset varied across trials. A REF diet reduced accuracy when there was a delay between the start of the trial and cue onset. Poorer accuracy was due to increased premature responses, reflecting impulsivity, and omissions, indicating an inability to sustain attention. These results corroborate the links between consumption of refined foods, obesity, and poor cognition in humans. We discuss the possible causal models that underlie this link.
MeSH term(s)	Adiposity ; Animals ; Attention ; Conditioning, Operant ; Diet, Fat-Restricted/adverse effects ; Male ; Rats
Language	English
Publishing date	2017-03-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	196999-7
ISSN	1872-8308 ; 0376-6357
ISSN (online)	1872-8308
ISSN	0376-6357
DOI	10.1016/j.beproc.2017.03.007
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Article ; Online: Experimental models of stress and pain: do they help to develop new therapies?

Bradesi, Sylvie / Mayer, Emeran A

Digestive diseases (Basel, Switzerland)

2009 Volume 27 Suppl 1, Page(s) 55–67

Abstract: The majority of functional gastrointestinal disorders are characterised by recurrent abdominal pain, with stress playing an important role in first onset and exacerbation of existing symptoms. These disorders are currently defined by symptom criteria, ... ...

Abstract	The majority of functional gastrointestinal disorders are characterised by recurrent abdominal pain, with stress playing an important role in first onset and exacerbation of existing symptoms. These disorders are currently defined by symptom criteria, while their pathophysiology remains controversial and incompletely understood. Modeling these disorders in humans and animals has been difficult. While some of the models have adequate face and construct validity, the predictive validity of most of the models has been disappointing, which has put into question the traditional modeling approach. Similar problems have been encountered in drug development for pain and psychiatric disorders. New approaches have been proposed in the form of reverse translation, which include better characterisation of biological intermediate phenotypes in human disease which can be modeled in humans and in animals. Continuation of the current approach focusing on complex clinical phenotypes is likely to be ineffective for the development of novel and effect treatments.
MeSH term(s)	Animals ; Disease Models, Animal ; Drug Discovery ; Gastrointestinal Transit/physiology ; Humans ; Irritable Bowel Syndrome/drug therapy ; Irritable Bowel Syndrome/physiopathology ; Pain Management ; Stress, Psychological/therapy
Language	English
Publishing date	2009
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	632798-9
ISSN	1421-9875 ; 0257-2753
ISSN (online)	1421-9875
ISSN	0257-2753
DOI	10.1159/000268122
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Article ; Online: The Glt1 glutamate receptor mediates the establishment and perpetuation of chronic visceral pain in an animal model of stress-induced bladder hyperalgesia.

Ackerman, A Lenore / Jellison, Forrest C / Lee, Una J / Bradesi, Sylvie / Rodríguez, Larissa V

American journal of physiology. Renal physiology

2016 Volume 310, Issue 7, Page(s) F628–F636

Abstract: Psychological stress exacerbates interstitial cystitis/bladder pain syndrome (IC/BPS), a lower urinary tract pain disorder characterized by increased urinary frequency and bladder pain. Glutamate (Glu) is the primary excitatory neurotransmitter ... ...

Abstract	Psychological stress exacerbates interstitial cystitis/bladder pain syndrome (IC/BPS), a lower urinary tract pain disorder characterized by increased urinary frequency and bladder pain. Glutamate (Glu) is the primary excitatory neurotransmitter modulating nociceptive networks. Glt1, an astrocytic transporter responsible for Glu clearance, is critical in pain signaling termination. We sought to examine the role of Glt1 in stress-induced bladder hyperalgesia and urinary frequency. In a model of stress-induced bladder hyperalgesia with high construct validity to human IC/BPS, female Wistar-Kyoto (WKY) rats were subjected to 10-day water avoidance stress (WAS). Referred hyperalgesia and tactile allodynia were assessed after WAS with von Frey filaments. After behavioral testing, we assessed Glt1 expression in the spinal cord by immunoblotting. We also examined the influence of dihydrokainate (DHK) and ceftriaxone (CTX), which downregulate and upregulate Glt1, respectively, on pain development. Rats exposed to WAS demonstrated increased voiding frequency, increased colonic motility, anxiety-like behaviors, and enhanced visceral hyperalgesia and tactile allodynia. This behavioral phenotype correlated with decreases in spinal Glt1 expression. Exogenous Glt1 downregulation by DHK resulted in hyperalgesia similar to that following WAS. Exogenous Glt1 upregulation via intraperitoneal CTX injection inhibited the development of and reversed preexisting pain and voiding dysfunction induced by WAS. Repeated psychological stress results in voiding dysfunction and hyperalgesia that correlate with altered central nervous system glutamate processing. Manipulation of Glu handling altered the allodynia developing after psychological stress, implicating Glu neurotransmission in the pathophysiology of bladder hyperalgesia in the WAS model of IC/BPS.
MeSH term(s)	Animals ; Behavior, Animal/drug effects ; Behavior, Animal/physiology ; Ceftriaxone/pharmacology ; Disease Models, Animal ; Excitatory Amino Acid Agonists/pharmacology ; Excitatory Amino Acid Antagonists/pharmacology ; Excitatory Amino Acid Transporter 2/metabolism ; Female ; Gastrointestinal Motility/drug effects ; Gastrointestinal Motility/physiology ; Hyperalgesia/metabolism ; Hyperalgesia/physiopathology ; Kainic Acid/analogs & derivatives ; Kainic Acid/pharmacology ; Rats ; Rats, Inbred WKY ; Spinal Cord/drug effects ; Spinal Cord/metabolism ; Stress, Physiological/physiology ; Urinary Bladder/physiopathology ; Visceral Pain/metabolism ; Visceral Pain/physiopathology
Chemical Substances	Excitatory Amino Acid Agonists ; Excitatory Amino Acid Antagonists ; Excitatory Amino Acid Transporter 2 ; Slc1a2 protein, rat ; dihydrokainic acid (52497-36-6) ; Ceftriaxone (75J73V1629) ; Kainic Acid (SIV03811UC)
Language	English
Publishing date	2016-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	603837-2
ISSN	1522-1466 ; 0363-6127
ISSN (online)	1522-1466
ISSN	0363-6127
DOI	10.1152/ajprenal.00297.2015
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