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Book ; Online ; E-Book: Digital technology, eating behaviors, and eating disorders

Šmahel, David / Machackova, Hana / Šmahelová, Martina / Čevelíček, Michal / Almenara, Carlos A. / Holubcikova, Jana

2018

Author's details	David Šmahel, Hana Macháčková, Martina Šmahelová, Michael Čevelíček, Carlos A. Almenara, Jana Holubčíková
Keywords	Psychology ; Eating disorders/Treatment ; Psychology, clinical ; Technology—Sociological aspects
Subject code	616.85/2606
Language	English
Size	1 Online-Ressource (xii, 199 Seiten), Illustrationen
Publisher	Springer
Publishing place	Cham
Publishing country	Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019848853
ISBN	978-3-319-93221-7 ; 9783319932200 ; 3-319-93221-7 ; 3319932209
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Aspartate β-hydroxylase Regulates Expression of

Kanwal, Madiha / Smahelova, Jana / Ciharova, Barbora / Johari, Shweta Dilip / Nunvar, Jaroslav / Olsen, Mark / Smahel, Michal

Journal of Cancer

2024 Volume 15, Issue 5, Page(s) 1138–1152

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-01-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.90422
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Article ; Online: Bioinformatics analysis of immune characteristics in tumors with alternative carcinogenesis pathways induced by human papillomaviruses.

Smahel, Michal / Nunvar, Jaroslav

Virology journal

2023 Volume 20, Issue 1, Page(s) 287

Abstract: Background: Human papillomaviruses (HPVs) induce a subset of head and neck squamous cell carcinomas (HNSCC) and anogenital cancers, particularly cervical cancer (CC). The major viral proteins that contribute to tumorigenesis are the E6 and E7 ... ...

Abstract	Background: Human papillomaviruses (HPVs) induce a subset of head and neck squamous cell carcinomas (HNSCC) and anogenital cancers, particularly cervical cancer (CC). The major viral proteins that contribute to tumorigenesis are the E6 and E7 oncoproteins, whose expression is usually enhanced after the integration of viral DNA into the host genome. Recently, an alternative tumorigenesis pathway has been suggested in approximately half of HNSCC and CC cases associated with HPV infection. This pathway is characterized by extrachromosomal HPV persistence and increased expression of the viral E2, E4, and E5 genes. The E6, E7, E5, and E2 proteins have been shown to modify the expression of numerous cellular immune-related genes. The antitumor immune response is a critical factor in the prognosis of HPV-driven cancers, and its characterization may contribute to the prediction and personalization of the increasingly used cancer immunotherapy. Methods: We analyzed the immune characteristics of HPV-dependent tumors and their association with carcinogenesis types. Transcriptomic HNSCC and CC datasets from The Cancer Genome Atlas were used for this analysis. Results: Clustering with immune-related genes resulted in two clusters of HPV16-positive squamous cell carcinomas in both tumor types: cluster 1 had higher activation of immune responses, including stimulation of the antigen processing and presentation pathway, which was associated with higher immune cell infiltration and better overall survival, and cluster 2 was characterized by keratinization. In CC, the distribution of tumor samples into clusters 1 and 2 did not depend on the level of E2/E5 expression, but in HNSCC, most E2/E5-high tumors were localized in cluster 1 and E2/E5-low tumors in cluster 2. Further analysis did not reveal any association between the E2/E5 levels and the expression of immune-related genes. Conclusions: Our results suggest that while the detection of immune responses associated with preserved expression of genes encoding components of antigen processing and presentation machinery in HPV-driven tumors may be markers of better prognosis and an important factor in therapy selection, the type of carcinogenesis does not seem to play a decisive role in the induction of antitumor immunity.
MeSH term(s)	Female ; Humans ; Human Papillomavirus Viruses ; Squamous Cell Carcinoma of Head and Neck/complications ; Papillomavirus Infections/complications ; Oncogene Proteins, Viral/genetics ; Oncogene Proteins, Viral/metabolism ; Papillomavirus E7 Proteins/genetics ; Carcinogenesis/genetics ; Uterine Cervical Neoplasms ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/complications
Chemical Substances	Oncogene Proteins, Viral ; Papillomavirus E7 Proteins
Language	English
Publishing date	2023-12-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2160640-7
ISSN	1743-422X ; 1743-422X
ISSN (online)	1743-422X
ISSN	1743-422X
DOI	10.1186/s12985-023-02241-6
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Article ; Online: PD-1/PD-L1 Blockade Therapy for Tumors with Downregulated MHC Class I Expression

Michal Šmahel

International Journal of Molecular Sciences, Vol 18, Iss 6, p

2017 Volume 1331

Abstract: The therapy of different advanced-stage malignancies with monoclonal antibodies blocking programmed cell death protein 1 (PD-1)/PD-1 ligand 1 (PD-L1) signaling has had an impressive long-lasting effect in a portion of patients, but in most cases, this ... ...

Abstract	The therapy of different advanced-stage malignancies with monoclonal antibodies blocking programmed cell death protein 1 (PD-1)/PD-1 ligand 1 (PD-L1) signaling has had an impressive long-lasting effect in a portion of patients, but in most cases, this therapy was not successful, or a secondary resistance developed. To enhance its efficacy in treated patients, predictive biomarkers are searched for and various combination treatments are intensively investigated. As the downregulation of major histocompatibility complex (MHC) class I molecules is one of the most frequent mechanisms of tumor escape from the host’s immunity, it should be considered in PD-1/PD-L1 checkpoint inhibition. The potential for the use of a PD-1/PD-L1 blockade in the treatment of tumors with aberrant MHC class I expression is discussed, and some strategies of combination therapy are suggested.
Keywords	PD-1 ; PD-L1 ; checkpoint blockade ; MHC class I ; tumor escape ; cancer immunotherapy ; biomarker ; interferon gamma ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	570
Language	English
Publishing date	2017-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: PD-1/PD-L1 Blockade Therapy for Tumors with Downregulated MHC Class I Expression.

Šmahel, Michal

International journal of molecular sciences

2017 Volume 18, Issue 6

Abstract	The therapy of different advanced-stage malignancies with monoclonal antibodies blocking programmed cell death protein 1 (PD-1)/PD-1 ligand 1 (PD-L1) signaling has had an impressive long-lasting effect in a portion of patients, but in most cases, this therapy was not successful, or a secondary resistance developed. To enhance its efficacy in treated patients, predictive biomarkers are searched for and various combination treatments are intensively investigated. As the downregulation of major histocompatibility complex (MHC) class I molecules is one of the most frequent mechanisms of tumor escape from the host's immunity, it should be considered in PD-1/PD-L1 checkpoint inhibition. The potential for the use of a PD-1/PD-L1 blockade in the treatment of tumors with aberrant MHC class I expression is discussed, and some strategies of combination therapy are suggested.
Language	English
Publishing date	2017-06-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms18061331
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Article ; Online: Chiral, Magnetic, and Photosensitive Liquid Crystalline Nanocomposites Based on Multifunctional Nanoparticles and Achiral Liquid Crystals.

Poryvai, Anna / Šmahel, Michal / Švecová, Marie / Nemati, Ahlam / Shadpour, Sasan / Ulbrich, Pavel / Ogolla, Timothy / Liu, Jiao / Novotná, Vladimíra / Veverka, Miroslav / Vejpravová, Jana / Hegmann, Torsten / Kohout, Michal

ACS nano

2022 Volume 16, Issue 8, Page(s) 11833–11841

Abstract: Nanoparticles serving as a multifunctional and multiaddressable dopant to modify the properties of liquid crystalline matrices are developed by combining cobalt ferrite nanocrystals with organic ligands featuring a robust photosensitive unit and a source ...

Abstract	Nanoparticles serving as a multifunctional and multiaddressable dopant to modify the properties of liquid crystalline matrices are developed by combining cobalt ferrite nanocrystals with organic ligands featuring a robust photosensitive unit and a source of chirality from the natural pool. These nanoparticles provide a stable nanocomposite when dispersed in achiral liquid crystals, giving rise to chiral supramolecular structures that can respond to UV-light illumination, and, at the same time, the formed nanocomposite possesses strong magnetic response. We report on a nanocomposite that shows three additional functionalities (chirality and responsiveness to UV light and magnetic field) upon the introduction of a single dopant into achiral liquid crystals.
Language	English
Publishing date	2022-07-22
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.1c10594
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Article: CD80 Expression on Tumor Cells Alters Tumor Microenvironment and Efficacy of Cancer Immunotherapy by CTLA-4 Blockade.

Vackova, Julie / Polakova, Ingrid / Johari, Shweta Dilip / Smahel, Michal

Cancers

2021 Volume 13, Issue 8

Abstract: Cluster of differentiation (CD) 80 is mainly expressed in immune cells but can also be found in several types of cancer cells. This molecule may either activate or inhibit immune reactions. Here, we determined the immunosuppressive role of CD80 in the ... ...

Abstract	Cluster of differentiation (CD) 80 is mainly expressed in immune cells but can also be found in several types of cancer cells. This molecule may either activate or inhibit immune reactions. Here, we determined the immunosuppressive role of CD80 in the tumor microenvironment by CRISPR/Cas9-mediated deactivation of the corresponding gene in the mouse oncogenic TC-1 cell line. The tumor cells with deactivated CD80 (TC-1/dCD80-1) were more immunogenic than parental cells and induced tumors that gained sensitivity to cytotoxic T-lymphocyte antigen 4 (CTLA-4) blockade, as compared with the TC-1 cells. In vivo depletion experiments showed that the deactivation of CD80 switched the pro-tumorigenic effect of macrophages observed in TC-1-induced tumors into an anti-tumorigenic effect in TC-1/dCD80-1 tumors and induced the pro-tumorigenic activity of CD4
Language	English
Publishing date	2021-04-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13081935
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Article ; Online: Abrogation of IFN-γ Signaling May not Worsen Sensitivity to PD-1/PD-L1 Blockade

Julie Vackova / Adrianna Piatakova / Ingrid Polakova / Michal Smahel

International Journal of Molecular Sciences, Vol 21, Iss 5, p

2020 Volume 1806

Abstract: Programmed cell death protein 1 (PD-1)/PD-1 ligand 1 (PD-L1) blockade is a promising therapy for various cancer types, but most patients are still resistant. Therefore, a larger number of predictive biomarkers is necessary. In this study, we assessed ... ...

Abstract	Programmed cell death protein 1 (PD-1)/PD-1 ligand 1 (PD-L1) blockade is a promising therapy for various cancer types, but most patients are still resistant. Therefore, a larger number of predictive biomarkers is necessary. In this study, we assessed whether a loss-of-function mutation of the interferon (IFN)-γ receptor 1 (IFNGR1) in tumor cells can interfere with anti-PD-L1 therapy. For this purpose, we used the mouse oncogenic TC-1 cell line expressing PD-L1 and major histocompatibility complex class I (MHC-I) molecules and its TC-1/A9 clone with reversibly downregulated PD-L1 and MHC-I expression. Using the CRISPR/Cas9 system, we generated cells with deactivated IFNGR1 (TC-1/dIfngr1 and TC-1/A9/dIfngr1). In tumors, IFNGR1 deactivation did not lead to PD-L1 or MHC-I reduction on tumor cells. From potential inducers, mainly IFN-α and IFN-β enhanced PD-L1 and MHC-I expression on TC-1/dIfngr1 and TC-1/A9/dIfngr1 cells in vitro. Neutralization of the IFN-α/IFN-β receptor confirmed the effect of these cytokines in vivo. Combined immunotherapy with PD-L1 blockade and DNA vaccination showed that IFNGR1 deactivation did not reduce tumor sensitivity to anti-PD-L1. Thus, the impairment of IFN-γ signaling may not be sufficient for PD-L1 and MHC-I reduction on tumor cells and resistance to PD-L1 blockade, and thus should not be used as a single predictive marker for anti-PD-1/PD-L1 cancer therapy.
Keywords	immune checkpoint therapy ; cancer ; pd-1/pd-l1 ; ifngr1 ; ifn-α ; ifn-β ; mhc class i ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	570 ; 610
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of inflammatory biomarkers and vitamins in hospitalized patients with SARS-CoV-2 infection and post-COVID syndrome.

Krčmová, Lenka Kujovská / Javorská, Lenka / Matoušová, Kateřina / Šmahel, Petr / Skála, Mikuláš / Kopecký, Michal / Suwanvecho, Chaweewan / Přívratská, Nikola / Turoňová, Dorota / Melichar, Bohuslav

Clinical chemistry and laboratory medicine

2024 Volume 62, Issue 6, Page(s) 1217–1227

Abstract: Objectives: Concentrations of neopterin, kynurenine and kynurenine/tryptophan ratios predict prognosis and the need for oxygen therapy in patients hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aims of the ... ...

Abstract	Objectives: Concentrations of neopterin, kynurenine and kynurenine/tryptophan ratios predict prognosis and the need for oxygen therapy in patients hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aims of the present study were to evaluate the changes of these biomarkers early in the course of infection, the association with the prior coronavirus disease (COVID-19) vaccination and therapeutic administration of Anti-SARS-CoV-2 monoclonal antibodies, investigation of other potential biomarkers including neuropilin, 8-hydroxy-2-deoxyguanosine and 8-hydroxyguanosine in patients hospitalized with SARS-CoV-2 infection and an assessment of these biomarkers and vitamins A, E and D in patients with post-COVID syndrome. Methods: Urine and blood samples were obtained on the 1st to the 4th day and 4th to 7th day from 108 patients hospitalized with COVID-19. Chromatography tandem mass spectrometry methods were used to analyse neopterin, kynurenine, tryptophan, liposoluble vitamins, and DNA damage biomarkers. Results: A statistically significant decrease of neopterin, kynurenine and kynurenine/tryptophan ratios was observed on after 4th to 7th day of hospitalization, and concentrations of these biomarkers were increased in patients with poor prognosis and subsequent post-COVID syndrome. The concentrations of remaining biomarker and vitamins were not associated with outcomes, although markedly decreased concentrations of vitamin A, E and D were noted. Conclusions: The concentrations of neopterin, kynurenine and kynurenine/tryptophan ratios decrease during the course of infection SARS-CoV-2 and are associated with the post-COVID syndrome. No other prognostic biomarkers were identified.
MeSH term(s)	Humans ; COVID-19/blood ; Biomarkers/blood ; Male ; Female ; Middle Aged ; Neopterin/blood ; Neopterin/urine ; Kynurenine/blood ; Aged ; SARS-CoV-2/isolation & purification ; Tryptophan/blood ; Vitamins/blood ; Hospitalization ; Adult ; Post-Acute COVID-19 Syndrome ; Vitamin A/blood ; Inflammation/blood ; Vitamin D/blood ; Vitamin E/blood
Chemical Substances	Biomarkers ; Neopterin (670-65-5) ; Kynurenine (343-65-7) ; Tryptophan (8DUH1N11BX) ; Vitamins ; Vitamin A (11103-57-4) ; Vitamin D (1406-16-2) ; Vitamin E (1406-18-4)
Language	English
Publishing date	2024-02-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2023-1297
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Article ; Online: Biolistic DNA vaccination against cervical cancer.

Smahel, Michal

Methods in molecular biology (Clifton, N.J.)

2013 Volume 940, Page(s) 339–355

Abstract: The development of cervical cancer is associated with infection by oncogenic human papillomaviruses (HPVs), of which type 16 (HPV16) is the most prevalent in HPV-induced malignant diseases. The viral oncoproteins E6 and E7 are convenient targets for anti- ...

Abstract	The development of cervical cancer is associated with infection by oncogenic human papillomaviruses (HPVs), of which type 16 (HPV16) is the most prevalent in HPV-induced malignant diseases. The viral oncoproteins E6 and E7 are convenient targets for anti-tumor immunization. To adapt the corresponding genes for DNA vaccination, their oncogenicity needs to be reduced and immunogenicity enhanced. The main modifications for achieving these aims include mutagenesis, rearrangement of gene parts, and fusion with supportive cellular or viral/bacterial genes or their functional parts. As HPVs are strictly human specific, an animal model of HPV infection does not exist. Therefore, immunization against HPV-induced tumors is most frequently tested in mouse models utilizing transplantable syngeneic tumor cells producing the HPV16 E6/E7 oncoproteins. In this chapter, one such cell line designated TC-1 is characterized and the effect of immunization with the modified E7 fusion gene against TC-1-induced subcutaneous tumors is described. As down-regulation of MHC class I molecules is one of the most important escape mechanisms of cervical carcinoma cells, the TC-1/A9 clone with reversibly reduced MHC class I expression has been developed and, herein, its response to DNA vaccination is also shown and compared with that of the TC-1 cells.
MeSH term(s)	Animals ; Biolistics/instrumentation ; Cancer Vaccines/administration & dosage ; Cancer Vaccines/chemistry ; Cancer Vaccines/genetics ; Cancer Vaccines/immunology ; Cell Line, Tumor ; Cell Proliferation ; Female ; Humans ; Mice ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/prevention & control ; Vaccination/instrumentation ; Vaccines, DNA/administration & dosage ; Vaccines, DNA/chemistry ; Vaccines, DNA/genetics ; Vaccines, DNA/immunology
Chemical Substances	Cancer Vaccines ; Vaccines, DNA
Language	English
Publishing date	2013
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-62703-110-3_25
Database	MEDical Literature Analysis and Retrieval System OnLINE

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