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Article ; Online: Precise Engineering of the Electrocatalytic Activity of FeN

Wu, Peng / Ma, Zengying / Xia, Xueqian / Song, Bowen / Zhong, Junwen / Yu, Yanghong / Huang, Yucheng

The journal of physical chemistry letters

2024 Volume 15, Issue 4, Page(s) 1121–1129

Abstract: Using first-principles calculations combined with a constant-potential implicit solvent model, we comprehensively studied the activity of oxygen electrode reactions catalyzed by electride-supported ... ...

Abstract	Using first-principles calculations combined with a constant-potential implicit solvent model, we comprehensively studied the activity of oxygen electrode reactions catalyzed by electride-supported FeN
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.3c03358
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Realizing multiferroics in α-Ga

Zhong, Junwen / Wu, Peng / Ma, Zengying / Xia, Xueqian / Song, Bowen / Yu, Yanghong / Wang, Sufan / Huang, Yucheng

Nanoscale

2024 Volume 16, Issue 8, Page(s) 4205–4211

Abstract: Using first-principles calculations, we report the realization of multiferroics in an intrinsic ferroelectric α- ... ...

Abstract	Using first-principles calculations, we report the realization of multiferroics in an intrinsic ferroelectric α-Ga
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d3nr06661d
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Article: Comparison of the efficacy of fish oil and probiotic supplementation on glucose and lipid metabolism in patients with type 2 diabetes: a systematic review and network meta-analysis.

Zhang, Mei / Yang, Fan / Feng, Qiu / Ou, Yanghong / Zhang, Jiaxing / Wan, Haiyan / Cao, Hongyi / Ning, Peng

Diabetology & metabolic syndrome

2024 Volume 16, Issue 1, Page(s) 25

Abstract: Background: Abnormalities in glucose and lipid metabolism contribute to the progression and exacerbation of type 2 diabetes mellitus (T2DM). Fish oil and probiotics are dietary supplements that have the potential to improve glucose and lipid metabolism. ...

Abstract	Background: Abnormalities in glucose and lipid metabolism contribute to the progression and exacerbation of type 2 diabetes mellitus (T2DM). Fish oil and probiotics are dietary supplements that have the potential to improve glucose and lipid metabolism. However, their efficacy remains unclear in T2DM patients. Methods: PubMed, Embase, and the Cochrane Library were retrieved to collect randomized controlled trials (RCTs) on the efficacy of fish oil or probiotic supplementation in T2DM patients from the database inception to December 13, 2023. Primary outcome indicators encompassed glycated hemoglobin (HbA1c), homeostatic model assessment for insulin resistance (HOMA-IR) and blood lipid profile (triglyceride (TG) and total cholesterol (TC). Secondary outcome indicators included inflammatory markers such as tumor necrosis factor -α (TNF-α) and adipocytokine (including leptin and adiponectin). The R software was used for statistical analysis, and GraphPad Prism was used for figure rendering. Results: A total of 60 RCTs involving 3845 T2DM patients were included in the analysis. The results showed that the probiotics (Bifidobacterium, Lactobacillus, Lactococcus, Propionibacterium, etc.) were more effective in reducing HOMA-IR than fish oil (Surca = 0.935). Bifidobacterium demonstrated the highest efficacy in reducing HbA1c levels (Surca = 0.963). Regarding lipid metabolism, fish oil was superior to probiotics in lowering TG and TC levels (Surca values of 0.978 and 0.902, respectively). Furthermore, fish oil outperformed probiotics in reducing TNF-α (Surca = 0.839) and leptin (Surca = 0.712), and increasing adiponectin levels (Surca = 0.742). Node-splitting analysis showed good consistency (P > 0.05 for direct, indirect, and network comparison across various interventions). Conclusions: In T2DM patients, fish oil was more effective than probiotics in regulating lipid metabolism. Probiotics outperformed fish oil in regulating glucose metabolism particularly; specifically, Bifidobacterium showed higher efficacy in reducing blood glucose.
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2518786-7
ISSN	1758-5996
ISSN	1758-5996
DOI	10.1186/s13098-024-01266-3
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Article: Single coil endovascular embolization of very tiny (≤2 mm) intracranial aneurysms: one center's experience.

Li, Yao / Bai, Peng / Li, Jinghui / Xiang, Shouwei / Geng, Xin / Zou, Yanghong / Huang, Wenqiang / Yu, Hualin

Journal of integrative neuroscience

2022 Volume 21, Issue 1, Page(s) 27

Abstract: ... ...

Abstract	Background
MeSH term(s)	Adult ; Embolization, Therapeutic/instrumentation ; Embolization, Therapeutic/methods ; Female ; Follow-Up Studies ; Humans ; Intracranial Aneurysm/therapy ; Male ; Middle Aged ; Outcome and Process Assessment, Health Care ; Retrospective Studies ; Stents
Language	English
Publishing date	2022-01-24
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2136427-8
ISSN	0219-6352
ISSN	0219-6352
DOI	10.31083/j.jin2101027
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Article: PDE4a predicts poor prognosis and promotes metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma.

Peng, Yanghong / Li, Yijun / Tian, Yu / Ao, Guokun

Journal of Cancer

2018 Volume 9, Issue 13, Page(s) 2389–2396

Abstract: Phosphodiesterases (PDEs) was found to be involved in a variety of cancer pathologies by modulating the degradation of levels of cAMP/cGMP. However, the prognostic significance and biological effect of PDE4a in hepatocellular carcinoma (HCC) have not ... ...

Abstract	Phosphodiesterases (PDEs) was found to be involved in a variety of cancer pathologies by modulating the degradation of levels of cAMP/cGMP. However, the prognostic significance and biological effect of PDE4a in hepatocellular carcinoma (HCC) have not been understood completely. In the present study, PDE4a expression was detected in a cohort of HCC and matched adjacent liver tissues (n = 210) by immunohistochemistry staining and Western immunoblotting assay, And
Language	English
Publishing date	2018-06-14
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.24079
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Article ; Online: Silencing of rice PPR gene PPS1 exhibited enhanced sensibility to abiotic stress and remarkable accumulation of ROS.

Xiao, Haijun / Liu, Zhongjie / Zou, Xue / Xu, Yanghong / Peng, Leilei / Hu, Jun / Lin, Honghui

Journal of plant physiology

2021 Volume 258-259, Page(s) 153361

Abstract: Abiotic stresses widely constrain the development and reproduction of plant, especially impaired the yield of crops greatly. Recent researches presented pentatricopeptide repeat (PPR) proteins play crucial role in response to abiotic stress. However, the ...

Abstract	Abiotic stresses widely constrain the development and reproduction of plant, especially impaired the yield of crops greatly. Recent researches presented pentatricopeptide repeat (PPR) proteins play crucial role in response to abiotic stress. However, the underlying mechanism of PPR genes in regulation of abiotic stress is still obscures. In our recent study, we found that the knockout of rice PPS1 causes pleiotropic growth disorders, including growth retardation, dwarf and sterile pollen, and finally leads to impaired C-U RNA editing at five consecutive sites on the mitochondrial nad3. In this study, we further investigate the roles of PPS1 in abiotic stress tolerance, we confirmed that pss1-RNAi line exhibited enhanced sensitivity to salinity and ABA stress at vegetative stage, specifically. While reactive oxygen species (ROS) accumulate significantly only at reproductive stage, which further activated the expression of several ROS-scavenging system related genes. These results implied that PPS1 functioned on ROS signaling network to contribute for the flexibility to abiotic stresses. Our research emphasizes the stress adaptability mediated by the PPR protein, and also provides new insight into the understanding of the interaction between cytoplasm and nucleus and signal transduction involved in RNA editing.
MeSH term(s)	Gene Silencing/physiology ; Oryza/genetics ; Oryza/physiology ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Reactive Oxygen Species/metabolism ; Stress, Physiological/genetics
Chemical Substances	Plant Proteins ; Reactive Oxygen Species
Language	English
Publishing date	2021-01-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	283647-6
ISSN	1618-1328 ; 0176-1617
ISSN (online)	1618-1328
ISSN	0176-1617
DOI	10.1016/j.jplph.2020.153361
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Article: Silencing of rice PPR gene PPS1 exhibited enhanced sensibility to abiotic stress and remarkable accumulation of ROS

Xiao, Haijun / Liu, Zhongjie / Zou, Xue / Xu, Yanghong / Peng, Leilei / Hu, Jun / Lin, Honghui

Journal of plant physiology. 2021 Mar., Apr., v. 258-259

2021

Abstract	Abiotic stresses widely constrain the development and reproduction of plant, especially impaired the yield of crops greatly. Recent researches presented pentatricopeptide repeat (PPR) proteins play crucial role in response to abiotic stress. However, the underlying mechanism of PPR genes in regulation of abiotic stress is still obscures. In our recent study, we found that the knockout of rice PPS1 causes pleiotropic growth disorders, including growth retardation, dwarf and sterile pollen, and finally leads to impaired C–U RNA editing at five consecutive sites on the mitochondrial nad3. In this study, we further investigate the roles of PPS1 in abiotic stress tolerance, we confirmed that pss1-RNAi line exhibited enhanced sensitivity to salinity and ABA stress at vegetative stage, specifically. While reactive oxygen species (ROS) accumulate significantly only at reproductive stage, which further activated the expression of several ROS-scavenging system related genes. These results implied that PPS1 functioned on ROS signaling network to contribute for the flexibility to abiotic stresses. Our research emphasizes the stress adaptability mediated by the PPR protein, and also provides new insight into the understanding of the interaction between cytoplasm and nucleus and signal transduction involved in RNA editing.
Keywords	RNA ; abiotic stress ; genes ; growth retardation ; mitochondria ; pollen ; reactive oxygen species ; reproduction ; rice ; salt tolerance ; signal transduction ; stress tolerance ; vegetative growth
Language	English
Dates of publication	2021-03
Publishing place	Elsevier GmbH
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	283647-6
ISSN	1618-1328 ; 0176-1617
ISSN (online)	1618-1328
ISSN	0176-1617
DOI	10.1016/j.jplph.2020.153361
Database	NAL-Catalogue (AGRICOLA)

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Article: Predictive value of novel inflammatory markers platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio in arterial stiffness in patients with diabetes: A propensity score-matched analysis.

Ning, Peng / Yang, Fan / Kang, Jun / Yang, Jing / Zhang, Jiaxing / Tang, Yi / Ou, Yanghong / Wan, Haiyan / Cao, Hongyi

Frontiers in endocrinology

2022 Volume 13, Page(s) 1039700

Abstract: Background: Increased arterial stiffness is common in patients with diabetes, and inflammation is one of the main causes of increased arterial stiffness. Platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and monocyte-to- ... ...

Abstract	Background: Increased arterial stiffness is common in patients with diabetes, and inflammation is one of the main causes of increased arterial stiffness. Platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and monocyte-to-lymphocyte ratio (MLR) are novel inflammatory markers that are reproducible, widely available, and easy to measure, and are associated with low costs. This study sought to investigate the predictive value of these novel inflammatory markers in patients with diabetes having arterial stiffness. Methods: We retrospectively included inpatients with diabetes mellitus from the Endocrinology Department of the Chengdu Fifth People's Hospital from June 2021 to May 2022 and collected data on their general information, biochemical indicators, and brachial-ankle pulse wave velocity (baPWV). After propensity matching, the risk relationship between PLR, NLR, and MLR and arterial stiffness was assessed in the recruited patients. Results: A total of 882 hospitalized patients with diabetes were included in this study and categorized into the low baPWV (507 cases) or high baPWV group (375 cases) based on the baPWV. After propensity matching, there were 180 patients in all in the high and low baPWV groups. Univariate and multivariate logistic regression analyses revealed that high PLR, NLR, and MLR were independently associated with an increased risk of arterial stiffness in patients with diabetes. In the receiver operating characteristic curve analysis, the NLR area under the curve (AUC) was 0.7194 (sensitivity = 84.4%, specificity = 51.1%) when distinguishing low baPWV and high baPWV in patients with diabetes, which was higher than that for PLR AUC (0.6477) and MLR AUC (0.6479), and the combined diagnosis for AUC. Conclusions: NLR was superior to PLR, and MLR and combined diagnosis have certain predictive values that indicate the increase in arterial stiffness in patients with diabetes. These predictive values can help with the early identification of increased arterial stiffness in patients with diabetes.
MeSH term(s)	Humans ; Neutrophils ; Monocytes ; Retrospective Studies ; Ankle Brachial Index ; Vascular Stiffness ; Propensity Score ; Pulse Wave Analysis ; Lymphocytes ; Diabetes Mellitus/diagnosis
Language	English
Publishing date	2022-12-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.1039700
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Article ; Online: Microwave-promoted solvent-free synthesis of para-quinone methides (p-QMs) derivatives

Zhang-Qin Liu / Peng-Sheng You / Chuan-Hua Wu / Yang-Hong Han

Journal of Saudi Chemical Society, Vol 24, Iss 1, Pp 120-

2020 Volume 126

Abstract: A rapid and efficient methodology for the synthesis of polysubstituted para-quinone methides (p-QMs) from aldehyde and 2,6-di-tert-butylphenol has been achieved in solvent-free and microwave irradiation condition within 33 min. This strategy displays the ...

Abstract	A rapid and efficient methodology for the synthesis of polysubstituted para-quinone methides (p-QMs) from aldehyde and 2,6-di-tert-butylphenol has been achieved in solvent-free and microwave irradiation condition within 33 min. This strategy displays the advantages including high atom economy, good functional group tolerance, and environmentally friendly operation. Keywords: Para-Quinone methides (p-QMs), Green chemistry, Microwave irradiation, Environment friendly synthesis
Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Heterologous vaccination with subunit protein vaccine induces a superior neutralizing capacity against BA.4/5-included SARS-CoV-2 variants than homologous vaccination of mRNA vaccine.

Peng, Dandan / Zhao, Tingmei / Hong, Weiqi / Fu, Minyang / He, Cai / Chen, Li / Ren, Wenyan / Lei, Hong / Yang, Jingyun / Alu, Aqu / Ni, Yanghong / Liu, Jian / Li, Jiong / Wang, Wei / Shen, Guobo / Zhao, Zhiwei / Yang, Li / Yang, Jinliang / Wang, Zhenling /

Tanaka, Yoshimasa / Lu, Guangwen / Song, Xiangrong / Wei, Xiawei

MedComm

2023 Volume 4, Issue 2, Page(s) e238

Abstract: BA.4 and BA.5 (BA.4/5), the subvariants of Omicron, are more transmissible than BA.1 with more robust immune evasion capability because of its unique spike protein mutations. In light of such situation, the vaccination against severe acute respiratory ... ...

Abstract	BA.4 and BA.5 (BA.4/5), the subvariants of Omicron, are more transmissible than BA.1 with more robust immune evasion capability because of its unique spike protein mutations. In light of such situation, the vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is in desperate need of the third booster. It has been reported that heterologous boosters might produce more effective immunity against wild-type SARS-CoV-2 and the variants. Additionally, the third heterologous protein subunit booster should be considered potentially. In the present study, we prepared a Delta full-length spike protein sequence-based mRNA vaccine as the "priming" shot and developed a recombinant trimeric receptor-binding domain (RBD) protein vaccine referred to as RBD-HR/trimer as a third heterologous booster. Compared to the homologous mRNA group, the heterologous group (RBD-HR/trimer vaccine primed with two mRNA vaccines) induced higher neutralizing antibody titers against BA.4/5-included SARS-CoV-2 variants. In addition, heterologous vaccination exhibited stronger cellular immune response and long-lasting memory response than the homologous mRNA vaccine. In conclusion, a third heterologous boosting with RBD-HR/trimer following two-dose mRNA priming vaccination should be a superior strategy than a third homologous mRNA vaccine. The RBD-HR/trimer vaccine becomes an appropriate candidate for a booster immune injection.
Language	English
Publishing date	2023-03-10
Publishing country	China
Document type	Journal Article
ISSN	2688-2663
ISSN (online)	2688-2663
DOI	10.1002/mco2.238
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