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  1. Article ; Online: Immunotherapy, Chemotherapy, or Both: Options for First-Line Therapy for Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma.

    Ho, Alan L

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2022  Volume 41, Issue 4, Page(s) 736–741

    Abstract: The Oncology Grand Rounds series is designed to place original reports published in ... ...

    Abstract The Oncology Grand Rounds series is designed to place original reports published in the
    MeSH term(s) Humans ; Head and Neck Neoplasms/drug therapy ; Immunotherapy/methods ; Neoplasm Recurrence, Local/drug therapy ; Platinum ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Male ; Aged
    Chemical Substances Platinum (49DFR088MY)
    Language English
    Publishing date 2022-10-12
    Publishing country United States
    Document type Case Reports ; Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.01408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
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    Zs.MO 650: Show issues

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  2. Article ; Online: Androgen Receptor Pathway in Salivary Gland Cancer.

    Ho, Alan L

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2021  Volume 39, Issue 36, Page(s) 4069–4072

    MeSH term(s) Humans ; Receptors, Androgen/genetics ; Salivary Gland Neoplasms/genetics ; Tosyl Compounds
    Chemical Substances Receptors, Androgen ; Tosyl Compounds
    Language English
    Publishing date 2021-10-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.21.01983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1847: Show issues Location:
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    Zs.MO 650: Show issues

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  3. Article ; Online: Targeting HRAS in Head and Neck Cancer: Lessons From the Past and Future Promise.

    Desilets, Antoine / Ho, Alan L

    Cancer journal (Sudbury, Mass.)

    2023  Volume 28, Issue 5, Page(s) 363–368

    Abstract: Abstract: HRAS mutations define a unique biologic subset of head and neck squamous cell carcinoma. Oncogenic HRAS is uniquely dependent on posttranslational farnesylation for membrane localization and activation of downstream signaling. Tipifarnib, a ... ...

    Abstract Abstract: HRAS mutations define a unique biologic subset of head and neck squamous cell carcinoma. Oncogenic HRAS is uniquely dependent on posttranslational farnesylation for membrane localization and activation of downstream signaling. Tipifarnib, a farnesyltransferase inhibitor, demonstrated encouraging antitumor activity for HRAS mutant head and neck squamous cell carcinoma and modest activity for HRAS mutant salivary gland cancer. New combination strategies to circumvent intrinsic and acquired resistance to TFIs are being investigated.
    MeSH term(s) Biological Products ; Cell Line, Tumor ; Farnesyltranstransferase ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/genetics ; Humans ; Mutation ; Proto-Oncogene Proteins p21(ras)/genetics ; Squamous Cell Carcinoma of Head and Neck
    Chemical Substances Biological Products ; Farnesyltranstransferase (EC 2.5.1.29) ; HRAS protein, human (EC 3.6.5.2) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2023-08-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2018400-1
    ISSN 1540-336X ; 1528-9117 ; 1081-4442
    ISSN (online) 1540-336X
    ISSN 1528-9117 ; 1081-4442
    DOI 10.1097/PPO.0000000000000616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4470: Show issues Location:
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    Zs.MO 163: Show issues

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  4. Article ; Online: Mediating roles of sleep quality and resilience in the relationships between chronotypes and mental health symptoms.

    Poon, Kean / Ho, Mimi S H / Tai, Alan P L / Leung, Mei-Kei / Chan, Meanne C M / Lau, Way K W

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 5874

    Abstract: Sleep and mental health are intrinsically intertwined, but not every individual with problems sleeping develops a mental health disorder. This study examined the association among chronotypes, resilience, sleep quality and mental health symptoms amongst ... ...

    Abstract Sleep and mental health are intrinsically intertwined, but not every individual with problems sleeping develops a mental health disorder. This study examined the association among chronotypes, resilience, sleep quality and mental health symptoms amongst otherwise healthy individuals. Two hundred adults (M
    MeSH term(s) Adult ; Humans ; Female ; Young Adult ; Male ; Mental Health ; Sleep Quality ; Resilience, Psychological ; Chronotype ; Mental Disorders ; Sleep ; Anxiety/psychology ; Depression/psychology ; Surveys and Questionnaires
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56688-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Assessing Squarates as Amine-Reactive Probes.

    Taylor, Katherine I / Ho, Jordan S / Trial, Hallie O / Carter, Alan W / Kiessling, Laura L

    Journal of the American Chemical Society

    2023  Volume 145, Issue 46, Page(s) 25056–25060

    Abstract: Probes that covalently label protein targets facilitate the identification of ligand-binding sites. Lysine residues are prevalent in the proteome, making them attractive substrates for covalent probes. However, identifying electrophiles that undergo ... ...

    Abstract Probes that covalently label protein targets facilitate the identification of ligand-binding sites. Lysine residues are prevalent in the proteome, making them attractive substrates for covalent probes. However, identifying electrophiles that undergo amine-specific, regioselective reactions with binding site lysine residues is challenging. Squarates can engage in two sequential conjugate addition-elimination reactions with amines. Nitrogen donation reduces the second reaction rate, making the mono squaramide a mild electrophile. We postulated that this mild electrophilicity would demand a longer residence time near the amine, affording higher selectivity for binding site lysines. Therefore, we compared the kinetics of squarate and monosquaramide amine substitution to alternative amine bioconjugation handles. The data revealed that
    MeSH term(s) Amines/chemistry ; Lysine/chemistry ; Binding Sites
    Chemical Substances Amines ; Lysine (K3Z4F929H6)
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.2c05691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  6. Article ; Online: Complete genomes and comparative analyses of Streptomyces phages that influence secondary metabolism and sporulation.

    Kronheim, Sarah / Solomon, Ethan / Ho, Louis / Glossop, Michelle / Davidson, Alan R / Maxwell, Karen L

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 9820

    Abstract: Bacteria in the genus Streptomyces are found ubiquitously in nature and are known for the number and diversity of specialized metabolites they produce, as well as their complex developmental lifecycle. Studies of the viruses that prey on Streptomyces, ... ...

    Abstract Bacteria in the genus Streptomyces are found ubiquitously in nature and are known for the number and diversity of specialized metabolites they produce, as well as their complex developmental lifecycle. Studies of the viruses that prey on Streptomyces, known as phages, have aided the development of tools for genetic manipulation of these bacteria, as well as contributing to a deeper understanding of Streptomyces and their behaviours in the environment. Here, we present the genomic and biological characterization of twelve Streptomyces phages. Genome analyses reveal that these phages are closely related genetically, while experimental approaches show that they have broad overlapping host ranges, infect early in the Streptomyces lifecycle, and induce secondary metabolite production and sporulation in some Streptomyces species. This work expands the group of characterized Streptomyces phages and improves our understanding of Streptomyces phage-host dynamics.
    MeSH term(s) Bacteriophages/genetics ; Streptomyces/genetics ; Secondary Metabolism/genetics ; Genome, Viral ; Genomics ; Phylogeny
    Language English
    Publishing date 2023-06-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-36938-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Therapeutic strategies for systemic therapies of human papillomavirus-related oropharyngeal cancer.

    Hung, Tony K W / Ho, Alan L / Pfister, David G

    Journal of surgical oncology

    2021  Volume 124, Issue 6, Page(s) 952–961

    Abstract: Our understanding of human papillomavirus (HPV)-related oropharyngeal cancer (OPC) and its molecular basis continues to evolve and produce important insights into customized therapeutic strategies. Novel therapeutics exploiting HPV-related targets are ... ...

    Abstract Our understanding of human papillomavirus (HPV)-related oropharyngeal cancer (OPC) and its molecular basis continues to evolve and produce important insights into customized therapeutic strategies. Novel therapeutics exploiting HPV-related targets are being evaluated in the incurable setting, while the favorable prognosis of locoregionally advanced disease has stimulated investigation into de-escalation strategies. There is much opportunity for better personalization of standard therapy according to HPV status. This review discusses both current and investigational therapeutic strategies for HPV-related OPC.
    MeSH term(s) Clinical Trials, Phase III as Topic ; Humans ; Oropharyngeal Neoplasms/pathology ; Oropharyngeal Neoplasms/therapy ; Oropharyngeal Neoplasms/virology ; Papillomaviridae/isolation & purification ; Papillomavirus Infections/pathology ; Papillomavirus Infections/therapy ; Papillomavirus Infections/virology ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2021-09-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 82063-5
    ISSN 1096-9098 ; 0022-4790
    ISSN (online) 1096-9098
    ISSN 0022-4790
    DOI 10.1002/jso.26688
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 706: Show issues Location:
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  8. Article ; Online: Author Correction: High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2.

    Chan, Charles W F / Wang, Bei / Nan, Lang / Huang, Xiner / Mao, Tianjiao / Chu, Hoi Yee / Luo, Cuiting / Chu, Hin / Choi, Gigi C G / Shum, Ho Cheung / Wong, Alan S L

    Nature biomedical engineering

    2024  Volume 8, Issue 3, Page(s) 336

    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Published Erratum
    ISSN 2157-846X
    ISSN (online) 2157-846X
    DOI 10.1038/s41551-024-01177-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Challenges and Opportunities for Developing New Therapeutics for Salivary Gland Cancers.

    Ho, Alan L / Pfister, David G

    Journal of oncology practice

    2018  Volume 14, Issue 2, Page(s) 109–110

    MeSH term(s) Clinical Trials as Topic ; Combined Modality Therapy ; Disease Management ; Humans ; Salivary Gland Neoplasms/diagnosis ; Salivary Gland Neoplasms/etiology ; Salivary Gland Neoplasms/therapy ; Treatment Outcome
    Language English
    Publishing date 2018-02-05
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2236338-5
    ISSN 1935-469X ; 1554-7477
    ISSN (online) 1935-469X
    ISSN 1554-7477
    DOI 10.1200/JOP.18.00039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The evolving landscape of salivary gland tumors.

    Steuer, Conor E / Hanna, Glenn J / Viswanathan, Kartik / Bates, James E / Kaka, Azeem S / Schmitt, Nicole C / Ho, Alan L / Saba, Nabil F

    CA: a cancer journal for clinicians

    2023  Volume 73, Issue 6, Page(s) 597–619

    Abstract: Salivary gland cancers are a rare, histologically diverse group of tumors. They range from indolent to aggressive and can cause significant morbidity and mortality. Surgical resection remains the mainstay of treatment, but radiation and systemic therapy ... ...

    Abstract Salivary gland cancers are a rare, histologically diverse group of tumors. They range from indolent to aggressive and can cause significant morbidity and mortality. Surgical resection remains the mainstay of treatment, but radiation and systemic therapy are also critical parts of the care paradigm. Given the rarity and heterogeneity of these cancers, they are best managed in a multidisciplinary program. In this review, the authors highlight standards of care as well as exciting new research for salivary gland cancers that will strive for better patient outcomes.
    MeSH term(s) Humans ; Salivary Gland Neoplasms/diagnosis ; Salivary Gland Neoplasms/therapy
    Language English
    Publishing date 2023-07-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603553-x
    ISSN 1542-4863 ; 0007-9235
    ISSN (online) 1542-4863
    ISSN 0007-9235
    DOI 10.3322/caac.21807
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