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  1. Article ; Online: Takotsubo cardiomyopathy triggered by frequent psychogenic nonepileptic seizures: A case report.

    Yomogida, Daichi / Kuwano, Hiroyuki / Miyakoshi, Tatsuya / Mizuta, Shiori / Horikawa, Shinjiro / Koshida, Yoshinao

    Acute medicine & surgery

    2024  Volume 11, Issue 1, Page(s) e941

    Abstract: Background: Coexistence of Takotsubo cardiomyopathy and psychogenic nonepileptic seizures has rarely been reported. Herein, we report a case of Takotsubo cardiomyopathy triggered by psychogenic nonepileptic seizures.: Case presentation: A 50-year-old ...

    Abstract Background: Coexistence of Takotsubo cardiomyopathy and psychogenic nonepileptic seizures has rarely been reported. Herein, we report a case of Takotsubo cardiomyopathy triggered by psychogenic nonepileptic seizures.
    Case presentation: A 50-year-old woman with a 22-year history of dissociative and panic disorders and a 7-year history of seizures increasing in frequency was admitted due to cardiogenic shock. Based on the left ventriculography and electroencephalography findings, she was diagnosed with Takotsubo cardiomyopathy and psychogenic nonepileptic seizures. Seizures were controlled using antipsychotic agents, resulting in improved cardiac function, and she was discharged. However, she died of cardiopulmonary arrest 9 days after discharge.
    Conclusion: Since controlling psychogenic epileptic seizures is difficult, Takotsubo cardiomyopathy triggered by psychogenic nonepileptic seizures may have poor prognosis, requiring careful management and close monitoring.
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2751184-4
    ISSN 2052-8817 ; 2052-8817
    ISSN (online) 2052-8817
    ISSN 2052-8817
    DOI 10.1002/ams2.941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Successful treatment of hemochromatosis with renal tubular dysgenesis in a preterm infant.

    Koura, Uta / Horikawa, Shinjiro / Okabe, Mako / Kawasaki, Yukako / Makimoto, Masami / Mizuta, Koichi / Yoshida, Taketoshi

    Clinical case reports

    2015  Volume 3, Issue 8, Page(s) 690–693

    Abstract: We report the first surviving case of neonatal hemochromatosis with renal tubular dysgenesis. Renal failure was treated with peritoneal dialysis. Although hepatic failure from neonatal hemochromatosis was progressive, repeated exchange transfusions ... ...

    Abstract We report the first surviving case of neonatal hemochromatosis with renal tubular dysgenesis. Renal failure was treated with peritoneal dialysis. Although hepatic failure from neonatal hemochromatosis was progressive, repeated exchange transfusions improved jaundice and coagulopathy. The patient gained weight and received a liver transplantation from her father.
    Language English
    Publishing date 2015-06-20
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dysregulation of Amphiregulin stimulates the pathogenesis of cystic lymphangioma.

    Yoshida, Naofumi / Yamamoto, Seiji / Hamashima, Takeru / Okuno, Noriko / Okita, Naruho / Horikawa, Shinjiro / Hayashi, Masao / Dang, Thanh Chung / Nguyen, Quang Linh / Nishiyama, Koichi / Makino, Teruhiko / Ishii, Yoko / Tomihara, Kei / Shimizu, Tadamichi / Shibuya, Masabumi / Noguchi, Makoto / Sasahara, Masakiyo

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 19

    Abstract: Along with blood vessels, lymphatic vessels play an important role in the circulation of body fluid and recruitment of immune cells. Postnatal lymphangiogenesis commonly occurs from preexisting lymphatic vessels by sprouting, which is induced by ... ...

    Abstract Along with blood vessels, lymphatic vessels play an important role in the circulation of body fluid and recruitment of immune cells. Postnatal lymphangiogenesis commonly occurs from preexisting lymphatic vessels by sprouting, which is induced by lymphangiogenic factors such as vascular endothelial growth factor C (VEGF-C). However, the key signals and cell types that stimulate pathological lymphangiogenesis, such as human cystic lymphangioma, are less well known. Here, we found that mouse dermal fibroblasts that infiltrate to sponges subcutaneously implanted express VEGF-D and sushi, Von Willebrand factor type A, EGF, and pentraxin domain containing 1 (SVEP1) in response to PDGFRβ signal. In vitro,
    MeSH term(s) Amphiregulin/genetics ; Amphiregulin/metabolism ; Amphiregulin/pharmacology ; Animals ; Cell Proliferation/drug effects ; Endothelial Cells/metabolism ; Female ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Humans ; Lymphangiogenesis/drug effects ; Lymphangiogenesis/physiology ; Lymphangioma, Cystic/genetics ; Lymphangioma, Cystic/metabolism ; Lymphangioma, Cystic/pathology ; Lymphatic Vessels/metabolism ; Male ; Mice ; Mice, Knockout ; Receptor, Platelet-Derived Growth Factor beta/genetics ; Receptor, Platelet-Derived Growth Factor beta/metabolism ; Vascular Endothelial Growth Factor C/metabolism ; Vascular Endothelial Growth Factor D
    Chemical Substances AREG protein, human ; Amphiregulin ; Areg protein, mouse ; Vascular Endothelial Growth Factor C ; Vascular Endothelial Growth Factor D ; Vegfd protein, mouse ; Receptor, Platelet-Derived Growth Factor beta (EC 2.7.10.1)
    Language English
    Publishing date 2021-05-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2019580118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: PDGFRα plays a crucial role in connective tissue remodeling.

    Horikawa, Shinjiro / Ishii, Yoko / Hamashima, Takeru / Yamamoto, Seiji / Mori, Hisashi / Fujimori, Toshihiko / Shen, Jie / Inoue, Ran / Nishizono, Hirofumi / Itoh, Hiroshi / Majima, Masataka / Abraham, David / Miyawaki, Toshio / Sasahara, Masakiyo

    Scientific reports

    2015  Volume 5, Page(s) 17948

    Abstract: Platelet derived growth factor (PDGF) plays a pivotal role in the remodeling of connective tissues. Emerging data indicate the distinctive role of PDGF receptor-α (PDGFRα) in this process. In the present study, the Pdgfra gene was systemically ... ...

    Abstract Platelet derived growth factor (PDGF) plays a pivotal role in the remodeling of connective tissues. Emerging data indicate the distinctive role of PDGF receptor-α (PDGFRα) in this process. In the present study, the Pdgfra gene was systemically inactivated in adult mouse (α-KO mouse), and the role of PDGFRα was examined in the subcutaneously implanted sponge matrices. PDGFRα expressed in the fibroblasts of Pdgfra-preserving control mice (Flox mice), was significantly reduced in the sponges in α-KO mice. Neovascularized areas were largely suppressed in the α-KO mice than in the Flox mice, whereas the other parameters related to the blood vessels and endothelial cells were similar. The deposition of collagen and fibronectin and the expression of collagen 1a1 and 3a1 genes were significantly reduced in α-KO mice. There was a significantly decrease in the number and dividing fibroblasts in the α-KO mice, and those of macrophages were similar between the two genotypes. Hepatocyte growth factor (Hgf) gene expression was suppressed in Pdgfra-inactivated fibroblasts and connective tissue. The findings implicate the role of PDGFRα-dependent ECM and HGF production in fibroblasts that promotes the remodeling of connective tissue and suggest that PDGFRα may be a relevant target to regulate connective tissue remodeling.
    MeSH term(s) Animals ; Blood Vessels/drug effects ; Blood Vessels/metabolism ; Cell Count ; Collagen/metabolism ; Connective Tissue/drug effects ; Connective Tissue/metabolism ; Extracellular Matrix/drug effects ; Extracellular Matrix/metabolism ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Fibronectins/metabolism ; Fluorescent Antibody Technique ; Hepatocyte Growth Factor/metabolism ; Implants, Experimental ; Mice, Inbred C57BL ; Mice, Knockout ; Neovascularization, Physiologic/drug effects ; Receptor, Platelet-Derived Growth Factor alpha/metabolism ; Skin/cytology ; Tamoxifen/pharmacology
    Chemical Substances Fibronectins ; Tamoxifen (094ZI81Y45) ; Hepatocyte Growth Factor (67256-21-7) ; Collagen (9007-34-5) ; Receptor, Platelet-Derived Growth Factor alpha (EC 2.7.10.1)
    Language English
    Publishing date 2015-12-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep17948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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