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  1. Article ; Online: The future of HIV testing in eastern and southern Africa: Broader scope, targeted services.

    Grimsrud, Anna / Wilkinson, Lynne / Ehrenkranz, Peter / Behel, Stephanie / Chidarikire, Thato / Chisenga, Tina / Golin, Rachel / Johnson, Cheryl Case / Milanga, Maureen / Onyekwena, Obinna / Sundaram, Maaya / Wong, Vincent / Baggaley, Rachel

    PLoS medicine

    2023  Volume 20, Issue 3, Page(s) e1004182

    Abstract: In this Policy Forum, Anna Grimsrud and colleagues discuss the future of HIV testing in eastern and southern Africa, using insights gleaned from a 2021 expert consultation. ...

    Abstract In this Policy Forum, Anna Grimsrud and colleagues discuss the future of HIV testing in eastern and southern Africa, using insights gleaned from a 2021 expert consultation.
    MeSH term(s) Humans ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; Africa, Southern/epidemiology ; HIV Testing ; Africa, Eastern/epidemiology
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2185925-5
    ISSN 1549-1676 ; 1549-1277
    ISSN (online) 1549-1676
    ISSN 1549-1277
    DOI 10.1371/journal.pmed.1004182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The future of HIV testing in eastern and southern Africa

    Anna Grimsrud / Lynne Wilkinson / Peter Ehrenkranz / Stephanie Behel / Thato Chidarikire / Tina Chisenga / Rachel Golin / Cheryl Case Johnson / Maureen Milanga / Obinna Onyekwena / Maaya Sundaram / Vincent Wong / Rachel Baggaley

    PLoS Medicine, Vol 20, Iss 3, p e

    Broader scope, targeted services.

    2023  Volume 1004182

    Abstract: In this Policy Forum, Anna Grimsrud and colleagues discuss the future of HIV testing in eastern and southern Africa, using insights gleaned from a 2021 expert consultation. ...

    Abstract In this Policy Forum, Anna Grimsrud and colleagues discuss the future of HIV testing in eastern and southern Africa, using insights gleaned from a 2021 expert consultation.
    Keywords Medicine ; R
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The promise of paediatric dolutegravir.

    Golin, Rachel / Samuel, Jeffrey M / Phelps, B Ryan / Persaud, Udita / Malati, Christine Y / Siberry, George K

    Journal of the International AIDS Society

    2020  Volume 24, Issue 1, Page(s) e25660

    MeSH term(s) Child ; HIV Infections/drug therapy ; HIV Integrase Inhibitors/economics ; HIV Integrase Inhibitors/therapeutic use ; Heterocyclic Compounds, 3-Ring/economics ; Heterocyclic Compounds, 3-Ring/therapeutic use ; Humans ; Oxazines/economics ; Oxazines/therapeutic use ; Piperazines/economics ; Piperazines/therapeutic use ; Pyridones/economics ; Pyridones/therapeutic use
    Chemical Substances HIV Integrase Inhibitors ; Heterocyclic Compounds, 3-Ring ; Oxazines ; Piperazines ; Pyridones ; dolutegravir (DKO1W9H7M1)
    Language English
    Publishing date 2020-11-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2467110-1
    ISSN 1758-2652 ; 1758-2652
    ISSN (online) 1758-2652
    ISSN 1758-2652
    DOI 10.1002/jia2.25660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Children and their families are entitled to the benefits of differentiated ART delivery.

    Wilkinson, Lynne / Siberry, George K / Golin, Rachel / Phelps, Benjamin R / Wolf, Hilary T / Modi, Surbhi / Grimsrud, Anna

    Journal of the International AIDS Society

    2020  Volume 23, Issue 4, Page(s) e25482

    Language English
    Publishing date 2020-04-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2467110-1
    ISSN 1758-2652 ; 1758-2652
    ISSN (online) 1758-2652
    ISSN 1758-2652
    DOI 10.1002/jia2.25482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Development and Pilot-Testing of a Cognitive Behavioral Coping Skills Group Intervention for Patients with Chronic Hepatitis C.

    Evon, Donna M / Golin, Carol E / Ruffin, Rachel / Fried, Michael W

    Contemporary clinical trials communications

    2017  Volume 6, Page(s) 85–96

    Abstract: Psychosocial interventions for patients with chronic hepatitis C viral (HCV) infection are needed to attenuate the impact of extrahepatic symptoms, comorbid conditions, and treatment side effects on HCV health outcomes. We adapted empirically-supported ... ...

    Abstract Psychosocial interventions for patients with chronic hepatitis C viral (HCV) infection are needed to attenuate the impact of extrahepatic symptoms, comorbid conditions, and treatment side effects on HCV health outcomes. We adapted empirically-supported interventions for similar patient populations to develop a Cognitive Behavioral Coping Skills group intervention for HCV patients (CBCS-HCV) undergoing treatment. The objectives of this paper are to describe the research activities associated with CBCS-HCV development and pilot testing, including: (1) formative work leading to intervention development; (2) preliminary study protocol; and (3) pilot feasibility testing of the intervention and study design. Formative work included a literature review, qualitative interviews, and adaption, development, and review of study materials. A preliminary study protocol is described. We evaluate the feasibility of conducting a randomized controlled trial (RCT) of the CBCS-HCV with 12 study participants in Wave 1 testing to examine: (a) feasibility of intervention delivery; (b) patient acceptability; (c) recruitment, enrollment, retention; (d) feasibility of conducting a RCT; (d) therapist protocol fidelity; and (e) feasibility of data collection. Numerous lessons were learned. We found very high rates of data collection, participant attendance, engagement, retention and acceptability, and therapist protocol fidelity. We conclude that many aspects of the CBCS-HCV intervention and study protocol were highly feasible. The greatest challenge during this Wave 1 pilot study was efficiency of participant enrollment due to changes in standard of care treatment. These findings informed two additional waves of pilot testing to examine effect sizes and potential improvements in clinical outcomes, with results forthcoming.
    Language English
    Publishing date 2017-04-02
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2451-8654
    ISSN (online) 2451-8654
    DOI 10.1016/j.conctc.2017.03.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Families matter: differentiated service delivery for HIV.

    Srivastava, Meena / Amzel, Anouk / Golin, Rachel / Grimsrud, Anna / Sullivan, David / Wilkinson, Lynne / Phelps, B Ryan

    The lancet. HIV

    2019  Volume 6, Issue 10, Page(s) e646–e648

    MeSH term(s) Anti-HIV Agents/therapeutic use ; Child ; Child, Preschool ; Delivery of Health Care ; Family ; Female ; HIV Infections/drug therapy ; HIV Infections/prevention & control ; Humans ; Infant ; Male
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2019-08-12
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2352-3018
    ISSN (online) 2352-3018
    DOI 10.1016/S2352-3018(19)30235-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: PEPFAR's response to the convergence of the HIV and COVID-19 pandemics in Sub-Saharan Africa.

    Golin, Rachel / Godfrey, Catherine / Firth, Jacqueline / Lee, Lana / Minior, Thomas / Phelps, B Ryan / Raizes, Elliot G / Ake, Julie A / Siberry, George K

    Journal of the International AIDS Society

    2020  Volume 23, Issue 8, Page(s) e25587

    Abstract: Introduction: The COVID-19 pandemic reached the African continent in less than three months from when the first cases were reported from mainland China. As COVID-19 preparedness and response plans were rapidly instituted across sub-Saharan Africa, many ... ...

    Abstract Introduction: The COVID-19 pandemic reached the African continent in less than three months from when the first cases were reported from mainland China. As COVID-19 preparedness and response plans were rapidly instituted across sub-Saharan Africa, many governments and donor organizations braced themselves for the unknown impact the COVID-19 pandemic would have in under-resourced settings with high burdens of PLHIV. The potential negative impact of COVID-19 in these countries is uncertain, but is estimated to contribute both directly and indirectly to the morbidity and mortality of PLHIV, requiring countries to leverage existing HIV care systems to propel COVID-19 responses, while safeguarding PLHIV and HIV programme gains. In anticipation of COVID-19-related disruptions, PEPFAR promptly established guidance to rapidly adapt HIV programmes to maintain essential HIV services while protecting recipients of care and staff from COVID-19. This commentary reviews PEPFAR's COVID-19 technical guidance and provides country-specific examples of programme adaptions in sub-Saharan Africa.
    Discussion: The COVID-19 pandemic may pose significant risks to the continuity of HIV services, especially in countries with high HIV prevalence and weak and over-burdened health systems. Although there is currently limited understanding of how COVID-19 affects PLHIV, it is imperative that public health systems and academic centres monitor the impact of COVID-19 on PLHIV. The general principles of the HIV programme adaptation guidance from PEPFAR prioritize protecting the gains in the HIV response while minimizing in-person home and facility visits and other direct contact when COVID-19 control measures are in effect. PEPFAR-supported clinical, laboratory, supply chain, community and data reporting systems can play an important role in mitigating the impact of COVID-19 in sub-Saharan Africa.
    Conclusions: As community transmission of COVID-19 continues and the number of country cases rise, fragile health systems may be strained. Utilizing the adaptive, data-driven programme approaches in facilities and communities established and supported by PEPFAR provides the opportunity to strengthen the COVID-19 response while protecting the immense gains spanning HIV prevention, testing and treatment reached thus far.
    MeSH term(s) Acquired Immunodeficiency Syndrome/complications ; Acquired Immunodeficiency Syndrome/drug therapy ; Acquired Immunodeficiency Syndrome/epidemiology ; Acquired Immunodeficiency Syndrome/mortality ; Africa South of the Sahara/epidemiology ; Betacoronavirus ; COVID-19 ; China ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Cost of Illness ; Delivery of Health Care/economics ; Delivery of Health Care/standards ; Delivery of Health Care/statistics & numerical data ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV Infections/mortality ; Humans ; International Cooperation ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Prevalence ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2467110-1
    ISSN 1758-2652 ; 1758-2652
    ISSN (online) 1758-2652
    ISSN 1758-2652
    DOI 10.1002/jia2.25587
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  8. Article: Novel patient-reported outcomes (PROs) used in a pilot and feasibility study of a Cognitive Behavioral Coping Skills (CBCS) group intervention for patients with chronic hepatitis C.

    Evon, Donna M / Golin, Carol E / Ruffin, Rachel / Ayres, Shauna / Fried, Michael W

    Pilot and feasibility studies

    2018  Volume 4, Page(s) 92

    Abstract: Background: Patients with chronic hepatitis C virus (HCV) experience reduced quality of life, HCV-associated symptoms, comorbid conditions, and treatment side effects. The Cognitive Behavioral Coping Skills group intervention for HCV (CBCS-HCV) was ... ...

    Abstract Background: Patients with chronic hepatitis C virus (HCV) experience reduced quality of life, HCV-associated symptoms, comorbid conditions, and treatment side effects. The Cognitive Behavioral Coping Skills group intervention for HCV (CBCS-HCV) was developed using the Stage Model of Behavioral Therapies Research. Intervention development and initial feasibility testing in wave 1 participants were previously reported. The primary objective of this subsequent pilot with wave 2-3 participants was to investigate the effect sizes and clinical improvements in patient-reported outcomes (PROs) and trial and intervention feasibility.
    Methods: A pilot feasibility two-arm randomized controlled trial using block randomization to assign patients to CBCS-HCV or standard of care was conducted. Participants attended nine group sessions: four before HCV treatment and five during treatment. PRO data were collected at five time points: before the CBCS intervention (T1), immediately before HCV treatment (T2), during HCV treatment (T3, T4), and 1 month post-intervention/post-HCV treatment (T5). PROs included quality of life, perceived stress, HCV symptoms, and medication adherence. Cohen's
    Results: Several WGCs and BGDs (ES > .35) suggest that the CBCS-HCV may promote improvements in PROs: psychological stress, depression, anger, anxiety, sleep disturbance, and fatigue. The intervention did not appear to impact social functioning, pain, or medication adherence. Cognitive behavioral skills and group therapy dynamics, but not HCV treatment self-efficacy, may mediate improvements in PROs. Most aspects of the study trial, including intervention implementation, were feasible. Patient acceptance and retention were exceptional. The greatest feasibility challenge was due to patients needing to initiate treatment as soon as medications were obtained, but often before a full block could be created in wave 3. Challenges with PRO data collection were identified that will be resolved in future studies.
    Conclusions: The CBCS-HCV intervention warrants future investigation in an efficacy trial to evaluate improvements in selected PROs. The next step is to pilot test the CBCS-HCV delivered via telehealth to an expanded pool of patients to reduce patient barriers, hone technical logistics, and improve intervention reach and effectiveness.
    Trial registration: NCT03057236 Retrospectively registered.
    Language English
    Publishing date 2018-06-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2809935-7
    ISSN 2055-5784
    ISSN 2055-5784
    DOI 10.1186/s40814-018-0285-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pursuing use of optimal formulations for paediatric HIV epidemic control - a look at the use of LPV/r oral pellets and oral granules.

    Malati, Christine Y / Golin, Rachel / O'Brien, Lisa / Sugandhi, Nandita / Srivastava, Meena / Larson, Chris / Phelps, Benjamin R

    Journal of the International AIDS Society

    2019  Volume 22, Issue 4, Page(s) e25267

    Abstract: Introduction: Despite a significant reduction in mother-to-child transmission of HIV, an estimated 180,000 children were infected with HIV in 2017, and only 52% of children under 15 years of age living with HIV (CLHIV) are on life-saving antiretroviral ... ...

    Abstract Introduction: Despite a significant reduction in mother-to-child transmission of HIV, an estimated 180,000 children were infected with HIV in 2017, and only 52% of children under 15 years of age living with HIV (CLHIV) are on life-saving antiretroviral therapy (ART). Without effective treatment, half of CLHIV die before the age of two years and only one in five survives to five years of age.
    Discussion: Over the past four years, the United States Food and Drug Administration tentatively approved new formulations of lopinavir/ritonavir (LPV/r) in the form of oral pellets and oral granules. However, the slow uptake of the aforementioned formulations in the low- and middle-income countries with the highest paediatric HIV burden is largely due to three challenges: limited manufacturing capacity; current unit cost of the pellets and granules; and slow uptake of these new formulations by policy makers and health care workers.
    Conclusions: Solutions to overcome these barriers include ensuring availability of an adequate supply of LPV/r oral pellets and oral granules, considering all programmatic and clinical factors when selecting paediatric ART formulations, and leveraging current resources to decrease paediatric HIV morbidity and mortality.
    MeSH term(s) Administration, Oral ; Adolescent ; Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/chemistry ; Anti-HIV Agents/economics ; Child ; Child, Preschool ; Drug Combinations ; Drug Compounding/economics ; Epidemics ; Female ; HIV Infections/drug therapy ; HIV Infections/economics ; HIV Infections/epidemiology ; Humans ; Infectious Disease Transmission, Vertical ; Lopinavir/administration & dosage ; Lopinavir/chemistry ; Lopinavir/economics ; Male ; Pediatrics ; Ritonavir/administration & dosage ; Ritonavir/chemistry ; Ritonavir/economics
    Chemical Substances Anti-HIV Agents ; Drug Combinations ; Lopinavir (2494G1JF75) ; Ritonavir (O3J8G9O825)
    Language English
    Publishing date 2019-04-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2467110-1
    ISSN 1758-2652 ; 1758-2652
    ISSN (online) 1758-2652
    ISSN 1758-2652
    DOI 10.1002/jia2.25267
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  10. Article ; Online: PEPFAR’s response to the convergence of the HIV and COVID‐19 pandemics in Sub‐Saharan Africa

    Golin, Rachel / Godfrey, Catherine / Firth, Jacqueline / Lee, Lana / Minior, Thomas / Phelps, B Ryan / Raizes, Elliot G / Ake, Julie A / Siberry, George K

    Journal of the International AIDS Society

    2020  Volume 23, Issue 8

    Keywords Public Health, Environmental and Occupational Health ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2467110-1
    ISSN 1758-2652
    ISSN 1758-2652
    DOI 10.1002/jia2.25587
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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