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Article ; Online: The use of the Capability-Opportunity- Motivation Behavior (COM-B) model to identify barriers to medication adherence and the application of mobile health technology in adults with coronary heart disease: A qualitative study.

Park, Linda G / Ng, Fion / Handley, Margaret A

PEC innovation

2023 Volume 3, Page(s) 100209

Abstract: Objective: Among patients with coronary heart disease, we sought to address the research questions of: 1) What is the acceptability of applying a technology-enabled approach to support medication adherence?; and 2) What are barriers to medication ... ...

Abstract	Objective: Among patients with coronary heart disease, we sought to address the research questions of: 1) What is the acceptability of applying a technology-enabled approach to support medication adherence?; and 2) What are barriers to medication adherence using the Capability-Opportunity-Motivation Behavior (COM-B) model as a guiding framework? Methods: Applying qualitative research methods, we employed a series of 3 focus groups per individual (total 9 sessions). Coded data from thematic analysis were mapped to the COM-B model components for meaningful associations. Results: Fourteen participants were recruited (median age 69.5 ± 11, 50% female). Barriers to medication adherence were organized along these COM-B domains: psychological capability (forgetfulness, distractions, fear of side effects), physical opportunity (inaccessible medications, inability to renew prescriptions), reflective (burdening family members), and automatic motivation (medication fatigue, health decline). Conclusions: Tailored text messaging and mobile phone apps were perceived as helpful tools for medication adherence. The COM-B model was useful to provide a comprehensive, theory-driven evaluation of patients' beliefs and motivations on whether to engage in medication adherence. Innovation: To date, text messaging and mobile applications have not been widely implemented in the clinical setting and provide a major opportunity to innovate on approaches to address medication adherence.
Language	English
Publishing date	2023-09-07
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-6282
ISSN (online)	2772-6282
DOI	10.1016/j.pecinn.2023.100209
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The use of the Capability-Opportunity- Motivation Behavior (COM-B) model to identify barriers to medication adherence and the application of mobile health technology in adults with coronary heart disease

Linda G. Park / Fion Ng / Margaret A. Handley

PEC Innovation, Vol 3, Iss , Pp 100209- (2023)

A qualitative study

2023

Abstract	Objective: Among patients with coronary heart disease, we sought to address the research questions of: 1) What is the acceptability of applying a technology-enabled approach to support medication adherence?; and 2) What are barriers to medication adherence using the Capability-Opportunity-Motivation Behavior (COM-B) model as a guiding framework? Methods: Applying qualitative research methods, we employed a series of 3 focus groups per individual (total 9 sessions). Coded data from thematic analysis were mapped to the COM-B model components for meaningful associations. Results: Fourteen participants were recruited (median age 69.5 ± 11, 50% female). Barriers to medication adherence were organized along these COM-B domains: psychological capability (forgetfulness, distractions, fear of side effects), physical opportunity (inaccessible medications, inability to renew prescriptions), reflective (burdening family members), and automatic motivation (medication fatigue, health decline). Conclusions: Tailored text messaging and mobile phone apps were perceived as helpful tools for medication adherence. The COM-B model was useful to provide a comprehensive, theory-driven evaluation of patients' beliefs and motivations on whether to engage in medication adherence. Innovation: To date, text messaging and mobile applications have not been widely implemented in the clinical setting and provide a major opportunity to innovate on approaches to address medication adherence.
Keywords	Medication adherence ; Mobile health ; Text messaging ; Mobile applications ; Focus groups ; Qualitative research ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Implementation of Video Blood Pressure Visits in the Veterans Health Administration.

Carrico, Margaret / Frosch, Cortney / Craig, Kathleen / Carter, Maia / Falk, Jami / Guerrero, Sandra / Huang, Lisa / Kossoudji, Andrea / Michelson, Trevor R / Miller, Pamela / Park, Catherine / Solt, Traci / Wakefield, Bonnie J

Telemedicine journal and e-health : the official journal of the American Telemedicine Association

2023 Volume 30, Issue 4, Page(s) 1006–1012

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Humans ; Blood Pressure ; Veterans Health ; Hypertension/drug therapy ; Patient-Centered Care ; COVID-19/epidemiology ; Veterans
Language	English
Publishing date	2023-11-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2035659-6
ISSN	1556-3669 ; 1530-5627
ISSN (online)	1556-3669
ISSN	1530-5627
DOI	10.1089/tmj.2023.0269
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Article ; Online: CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing.

Lugano, Doreen I / Barrett, Lindsey N / Chaput, Dale / Park, Margaret A / Westerheide, Sandy D

RNA biology

2023 Volume 21, Issue 1, Page(s) 1–11

Abstract: The Cell Division Cycle and Apoptosis Regulator (CCAR) protein family members have recently emerged as regulators of alternative splicing and transcription, as well as having other key physiological functions. For example, mammalian CCAR2/DBC1 forms a ... ...

Abstract	The Cell Division Cycle and Apoptosis Regulator (CCAR) protein family members have recently emerged as regulators of alternative splicing and transcription, as well as having other key physiological functions. For example, mammalian CCAR2/DBC1 forms a complex with the zinc factor protein ZNF326 to integrate alternative splicing with RNA polymerase II transcriptional elongation in AT-rich regions of the DNA. Additionally,
MeSH term(s)	Animals ; Alternative Splicing ; Base Sequence ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Ribonucleoproteins/genetics ; Ribonucleoproteins/metabolism ; RNA Splicing ; Splicing Factor U2AF/genetics ; Splicing Factor U2AF/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism
Chemical Substances	Caenorhabditis elegans Proteins ; Ribonucleoproteins ; Splicing Factor U2AF ; ccar-1 protein, C elegans ; Membrane Proteins ; UAF-1 protein, C elegans
Language	English
Publishing date	2023-12-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2159587-2
ISSN	1555-8584 ; 1555-8584
ISSN (online)	1555-8584
ISSN	1555-8584
DOI	10.1080/15476286.2023.2289707
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Article ; Online: Developmental change in predictive motor abilities.

Park, Se-Woong / Cardinaux, Annie / Crozier, Dena / Russo, Marta / Kjelgaard, Margaret / Sinha, Pawan / Sternad, Dagmar

iScience

2023 Volume 26, Issue 2, Page(s) 106038

Abstract: Prediction is critical for successful interactions with a dynamic environment. To test the development of predictive processes over the life span, we designed a suite of interceptive tasks implemented as interactive video games. Four tasks involving ... ...

Abstract	Prediction is critical for successful interactions with a dynamic environment. To test the development of predictive processes over the life span, we designed a suite of interceptive tasks implemented as interactive video games. Four tasks involving interactions with a flying ball with titrated challenge quantified spatiotemporal aspects of prediction. For comparison, reaction time was assessed in a matching task. The experiments were conducted in a museum, where over 400 visitors across all ages participated, and in a laboratory with a focused age group. Results consistently showed that predictive ability improved with age to reach adult level by age 12. In contrast, reaction time continued to decrease into late adolescence. Inter-task correlations revealed that the tasks tested different aspects of predictive processes. This developmental progression complements recent findings on cerebellar and cortical maturation. Additionally, these results can serve as normative data to study predictive processes in individuals with neurodevelopmental conditions.
Language	English
Publishing date	2023-01-25
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.106038
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Article ; Online: An Outlook on Harnessing Technological Innovative Competence in Sustainably Transforming African Agriculture.

Asem-Hiablie, Senorpe / Uyeh, Daniel Dooyum / Adelaja, Adesoji / Gebremedhin, Kifle / Srivastava, Ajit / Ileleji, Klein / Gitau, Margaret / Ha, Yushin / Park, Tusan

Global challenges (Hoboken, NJ)

2023 Volume 7, Issue 9, Page(s) 2300033

Abstract: Agricultural value chains worldwide provide essential support to livelihoods, ecosystem services, and the growing bioeconomy. The coronavirus disease 2019 (COVID-19) pandemic slowed down or reversed decades of agricultural growth and exposed the ... ...

Abstract	Agricultural value chains worldwide provide essential support to livelihoods, ecosystem services, and the growing bioeconomy. The coronavirus disease 2019 (COVID-19) pandemic slowed down or reversed decades of agricultural growth and exposed the vulnerabilities of farmers and the food insecure in Africa, thus reiterating the need to build resilience, agility, and adaptability for a sustainable agriculture. Existing social, political, environmental, and economic challenges demonstrate that a path to faster sustainable growth is increased productivity through improved input quality, of which technical inputs are a part. This work presents a perspective calling for African innovative competence in technological and methodological applications and solutions as part of the most critical area of a holistic organization for social progress. It finds that while performances of previous agricultural transformation efforts offer insights for future directions, novel pathways fitting to the diversity of situations and contexts on the continent are needed. These may include vertical agriculture in land-constrained regions to grow high-value products, ocean or sea farming in coastal regions, development of multiple-harvesting crops, and self-replicating plants. Developing standards that integrate current scientific methodologies and technologies with indigenous knowledge for agricultural growth and disaster management will bring the complementary benefits of both worlds into optimal development.
Language	English
Publishing date	2023-08-23
Publishing country	Germany
Document type	Journal Article
ISSN	2056-6646
ISSN (online)	2056-6646
DOI	10.1002/gch2.202300033
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Article ; Online: Associations between mothers' emotion regulation and real-time experiences of negative emotion: The moderating role of caregiving context.

Park, Ye Rang / Kerr, Margaret L / Smiley, Patricia A / Borelli, Jessica L

Infant mental health journal

2022 Volume 43, Issue 5, Page(s) 769–782

Abstract: Parents' emotion regulation and emotional experiences have important consequences for family well-being and child outcomes. Little is known about whether traitlike emotion regulation abilities predict statelike experiences of real-time negative emotion. ... ...

Abstract	Parents' emotion regulation and emotional experiences have important consequences for family well-being and child outcomes. Little is known about whether traitlike emotion regulation abilities predict statelike experiences of real-time negative emotion. Using ecological momentary assessment (EMA), this study examines associations between mothers' self-reported emotion regulation abilities and their real-time experiences of negative emotion, as well as the moderating role of caregiving context among 145 mothers (41% Hispanic; 31% earned below $40,000) of young children (mean age = 20.9 months) across a 10-day period. Results indicated that on average, mothers who report high levels of traitlike rumination and difficulties in emotion regulation also report more statelike negative emotion. Further, the presence of children weakened the associations between mothers' traitlike reports of emotion dysregulation and statelike EMA negative emotion reports. The findings demonstrate the importance of parents' emotion regulation for supporting family well-being, especially when parents are separated from their children; the findings may have implications for developing family interventions.
MeSH term(s)	Child ; Child, Preschool ; Emotional Regulation ; Emotions/physiology ; Female ; Humans ; Infant ; Mother-Child Relations/psychology ; Mothers/psychology ; Parenting/psychology ; Parents
Language	English
Publishing date	2022-08-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	225602-2
ISSN	1097-0355 ; 0163-9641
ISSN (online)	1097-0355
ISSN	0163-9641
DOI	10.1002/imhj.22009
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Article ; Online: The Effects of Outdoor versus Indoor Exercise on Psychological Health, Physical Health, and Physical Activity Behaviour: A Systematic Review of Longitudinal Trials.

Noseworthy, Matt / Peddie, Luke / Buckler, E Jean / Park, Faith / Pham, Margaret / Pratt, Spencer / Singh, Arpreet / Puterman, Eli / Liu-Ambrose, Teresa

International journal of environmental research and public health

2023 Volume 20, Issue 3

Abstract: A growing body of research is exploring the potential added health benefits of exercise when performed outdoors in nature versus indoors. This systematic review aimed to compare the effects of exercise in outdoor environments versus indoor environments ... ...

Abstract	A growing body of research is exploring the potential added health benefits of exercise when performed outdoors in nature versus indoors. This systematic review aimed to compare the effects of exercise in outdoor environments versus indoor environments on psychological health, physical health, and physical activity behaviour. We searched nine databases from inception to March 2021 for English language, peer-reviewed articles: MEDLINE, Embase, PubMed, Scopus, Web of Science, CINAHL, SportsDiscus, GreenFile, and CENTRAL. We included randomized and non-randomized trials that compared multiple bouts of exercise in outdoor versus indoor environments, and that assessed at least one outcome related to physical health, psychological health, or physical activity behaviour. Due to minimal outcome overlap and a paucity of studies, we performed a narrative synthesis. We identified 10 eligible trials, including 7 randomized controlled trials, and a total of 343 participants. Participant demographics, exercise protocols, and outcomes varied widely. In the 10 eligible studies, a total of 99 comparisons were made between outdoor and indoor exercise; all 25 statistically significant comparisons favoured outdoor exercise. Interpretation of findings was hindered by an overall high risk of bias, unclear reporting, and high outcome heterogeneity. There is limited evidence for added health or behaviour benefits of outdoor exercise versus indoor exercise. Rigorous randomized controlled trials are needed with larger samples and clear reporting.
MeSH term(s)	Humans ; Exercise ; Motor Activity ; Mental Health
Language	English
Publishing date	2023-01-17
Publishing country	Switzerland
Document type	Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20031669
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Article ; Online: Anatomical Study of Domain Rescue of Palatal Length in Patients With a Wide Cleft Palate: Buccal Flap Reconstruction in Primary Palatoplasty.

Morrison, Kerry A / Park, Jenn / Rochlin, Danielle / Lico, Margaret / Flores, Roberto L

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2022 Volume 61, Issue 1, Page(s) 103–109

Abstract: Background: This study characterizes the potential loss of velar length in patients with a wide cleft and rescue of this loss of domain by local flap reconstruction, providing anatomic evidence in support of primary lengthening of the soft palate during ...

Abstract	Background: This study characterizes the potential loss of velar length in patients with a wide cleft and rescue of this loss of domain by local flap reconstruction, providing anatomic evidence in support of primary lengthening of the soft palate during palatoplasty. Methods: A retrospective review was conducted of all patients with a cleft palate at least 10mm in width, who underwent primary palatoplasty with a buccal flap prior to 18 months of age over a 2-year period. All patients underwent primary palatoplasty with horizontal transection of the nasal mucosa, which was performed after nasal mucosa repair, but prior to muscular reconstruction. The resulting palatal lengthening was measured and the mucosal defect was reconstructed with a buccal flap. Results: Of the 22 patients included, 3 (13.6%) had a history of Pierre Robin sequence, and 5 (22.7%) had an associated syndrome. No patients had a Veau I cleft, 7 (31.8%) had a Veau II, 12 (54.5%) had a Veau III, and 3 had (13.6%) a Veau IV cleft. All patients had a right buccal flap during primary palatoplasty. The mean cleft width at the posterior nasal spine was 10.6 ± 2.82mm, and mean lengthening of the velum after horizontal transection of the nasal mucosa closure was 10.5 ± 2.23mm. There were 2 (9.1%) fistulas, 1 (4.5%) wound dehiscence, 1 (4.5%) 30-day readmission, and no bleeding complications. Conclusions: Patients with a wide cleft palate have a potential loss of 1cm velar length. The buccal flap can rescue the loss of domain in palatal length, and potentially improve palatal excursion.
MeSH term(s)	Humans ; Infant ; Cleft Palate/surgery ; Cleft Palate/complications ; Plastic Surgery Procedures ; Surgical Flaps ; Palate, Soft/surgery ; Fistula/surgery ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2022-08-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1069409-2
ISSN	1545-1569 ; 0009-8701 ; 1055-6656
ISSN (online)	1545-1569
ISSN	0009-8701 ; 1055-6656
DOI	10.1177/10556656221117930
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Article: Blood Cholesterol and Triglycerides Associate with Right Ventricular Function in Pulmonary Hypertension.

Fakhry, Battoul / Peterson, Laura / Comhair, Suzy A A / Sharp, Jacqueline / Park, Margaret M / Tang, W H Wilson / Neumann, Donald R / DiFilippo, Frank P / Farha, Samar / Erzurum, Serpil C / Mulya, Anny

medRxiv : the preprint server for health sciences

2024

Abstract: Background: Blood lipids are dysregulated in pulmonary hypertension (PH). Lower high-density lipoproteins cholesterol (HDL-C) and low-density lipoproteins cholesterol (LDL-C) are associated with disease severity and death in PH. Right ventricle (RV) ... ...

Abstract	Background: Blood lipids are dysregulated in pulmonary hypertension (PH). Lower high-density lipoproteins cholesterol (HDL-C) and low-density lipoproteins cholesterol (LDL-C) are associated with disease severity and death in PH. Right ventricle (RV) dysfunction and failure are the major determinants of morbidity and mortality in PH. This study aims to test the hypothesis that dyslipidemia is associated with RV dysfunction in PH. Methods: We enrolled healthy control subjects (n=12) and individuals with PH (n=30) (age: 18-65 years old). Clinical characteristics, echocardiogram, 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography (PET) scan, blood lipids, including total cholesterol (TC), triglycerides (TG), lipoproteins (LDL-C and HDL-C), and N-terminal pro-B type Natriuretic Peptide (NT-proBNP) were determined. Results: Individuals with PH had lower HDL-C [PH, 41±12; control, 56±16 mg/dL, Conclusion: These findings confirm dyslipidemia is associated with worse right ventricular function in PH.
Language	English
Publishing date	2024-01-22
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.20.24301498
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