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Article ; Online: Unusual T

Romero-Olmedo, Addi Josua / Schulz, Axel Ronald / Das Gupta, Dennis / Staudenraus, Daniel / Hirseland, Heike / Camara, Bärbel / Ferrara, Sebastian / Schulze-Koops, Hendrik / Rummel, Mathias / Mei, Henrik E / Lohoff, Michael / Keller, Christian

Journal of medical virology

2024 Volume 96, Issue 1, Page(s) e29367

MeSH term(s)	Humans ; Receptors, Chemokine ; COVID-19 ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; Chemokines ; Immunologic Memory
Chemical Substances	Receptors, Chemokine ; Chemokines
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Letter
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29367
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: First Measurement of the |t| Dependence of Incoherent J/ψ Photonuclear Production.

Acharya, S / Adamová, D / Adler, A / Aglieri Rinella, G / Agnello, M / Agrawal, N / Ahammed, Z / Ahmad, S / Ahn, S U / Ahuja, I / Akindinov, A / Al-Turany, M / Aleksandrov, D / Alessandro, B / Alfanda, H M / Alfaro Molina, R / Ali, B / Alici, A / Alizadehvandchali, N /

Alkin, A / Alme, J / Alocco, G / Alt, T / Altamura, A R / Altsybeev, I / Alvarado, J R / Anaam, M N / Andrei, C / Andronic, A / Anguelov, V / Antinori, F / Antonioli, P / Apadula, N / Aphecetche, L / Appelshäuser, H / Arata, C / Arcelli, S / Aresti, M / Arnaldi, R / Arneiro, J G M C A / Arsene, I C / Arslandok, M / Augustinus, A / Averbeck, R / Azmi, M D / Baba, H / Badalà, A / Bae, J / Baek, Y W / Bai, X / Bailhache, R / Bailung, Y / Balbino, A / Baldisseri, A / Balis, B / Banerjee, D / Banoo, Z / Barbera, R / Barile, F / Barioglio, L / Barlou, M / Barnaföldi, G G / Barnby, L S / Barret, V / Barreto, L / Bartels, C / Barth, K / Bartsch, E / Bastid, N / Basu, S / Batigne, G / Battistini, D / Batyunya, B / Bauri, D / Bazo Alba, J L / Bearden, I G / Beattie, C / Becht, P / Behera, D / Belikov, I / Bell Hechavarria, A D C / Bellini, F / Bellwied, R / Belokurova, S / Bencedi, G / Beole, S / Bercuci, A / Berdnikov, Y / Berdnikova, A / Bergmann, L / Besoiu, M G / Betev, L / Bhaduri, P P / Bhasin, A / Bhat, M A / Bhattacharjee, B / Bianchi, L / Bianchi, N / Bielčík, J / Bielčíková, J / Biernat, J / Bigot, A P / Bilandzic, A / Biro, G / Biswas, S / Bize, N / Blair, J T / Blau, D / Blidaru, M B / Bluhme, N / Blume, C / Boca, G / Bock, F / Bodova, T / Bogdanov, A / Boi, S / Bok, J / Boldizsár, L / Bombara, M / Bond, P M / Bonomi, G / Borel, H / Borissov, A / Borquez Carcamo, A G / Bossi, H / Botta, E / Bouziani, Y E M / Bratrud, L / Braun-Munzinger, P / Bregant, M / Broz, M / Bruno, G E / Buckland, M D / Budnikov, D / Buesching, H / Bufalino, S / Buhler, P / Burmasov, N / Buthelezi, Z / Bylinkin, A / Bysiak, S A / Cai, M / Caines, H / Caliva, A / Calvo Villar, E / Camacho, J M M / Camerini, P / Canedo, F D M / Cantway, S L / Carabas, M / Carballo, A A / Carnesecchi, F / Caron, R / Carvalho, L A D / Castillo Castellanos, J / Catalano, F / Ceballos Sanchez, C / Chakaberia, I / Chakraborty, P / Chandra, S / Chapeland, S / Chartier, M / Chattopadhyay, S / Cheng, T / Cheshkov, C / Cheynis, B / Chibante Barroso, V / Chinellato, D D / Chizzali, E S / Cho, J / Cho, S / Chochula, P / Christakoglou, P / Christensen, C H / Christiansen, P / Chujo, T / Ciacco, M / Cicalo, C / Cindolo, F / Ciupek, M R / Clai, G / Colamaria, F / Colburn, J S / Colella, D / Colocci, M / Concas, M / Conesa Balbastre, G / Conesa Del Valle, Z / Contin, G / Contreras, J G / Coquet, M L / Cortese, P / Cosentino, M R / Costa, F / Costanza, S / Cot, C / Crkovská, J / Crochet, P / Cruz-Torres, R / Cui, P / Dainese, A / Danisch, M C / Danu, A / Das, P / Das, S / Dash, A R / Dash, S / De Caro, A / de Cataldo, G / de Cuveland, J / De Falco, A / De Gruttola, D / De Marco, N / De Martin, C / De Pasquale, S / Deb, R / Deb, S / Del Grande, R / Dello Stritto, L / Deng, W / Dhankher, P / Di Bari, D / Di Mauro, A / Diab, B / Diaz, R A / Dietel, T / Ding, Y / Divià, R / Dixit, D U / Djuvsland, Ø / Dmitrieva, U / Dobrin, A / Dönigus, B / Dubinski, J M / Dubla, A / Dudi, S / Dupieux, P / Durkac, M / Dzalaiova, N / Eder, T M / Ehlers, R J / Eisenhut, F / Ejima, R / Elia, D / Erazmus, B / Ercolessi, F / Erhardt, F / Ersdal, M R / Espagnon, B / Eulisse, G / Evans, D / Evdokimov, S / Fabbietti, L / Faggin, M / Faivre, J / Fan, F / Fan, W / Fantoni, A / Fasel, M / Fecchio, P / Feliciello, A / Feofilov, G / Fernández Téllez, A / Ferrandi, L / Ferrer, M B / Ferrero, A / Ferrero, C / Ferretti, A / Feuillard, V J G / Filova, V / Finogeev, D / Fionda, F M / Flor, F / Flores, A N / Foertsch, S / Fokin, I / Fokin, S / Fragiacomo, E / Frajna, E / Fuchs, U / Funicello, N / Furget, C / Furs, A / Fusayasu, T / Gaardhøje, J J / Gagliardi, M / Gago, A M / Gahlaut, T / Galvan, C D / Gangadharan, D R / Ganoti, P / Garabatos, C / Garcia, A T / García Chávez, T / Garcia-Solis, E / Gargiulo, C / Garner, K / Gasik, P / Gautam, A / Gay Ducati, M B / Germain, M / Ghimouz, A / Ghosh, C / Giacalone, M / Giubellino, P / Giubilato, P / Glaenzer, A M C / Glässel, P / Glimos, E / Goh, D J Q / Gonzalez, V / Gorgon, M / Goswami, K / Gotovac, S / Grabski, V / Graczykowski, L K / Grecka, E / Grelli, A / Grigoras, C / Grigoriev, V / Grigoryan, S / Grosa, F / Grosse-Oetringhaus, J F / Grosso, R / Grund, D / Guardiano, G G / Guernane, R / Guilbaud, M / Gulbrandsen, K / Gündem, T / Gunji, T / Guo, W / Gupta, A / Gupta, R / Gwizdziel, K / Gyulai, L / Habib, M K / Hadjidakis, C / Haider, F U / Hamagaki, H / Hamdi, A / Hamid, M / Han, Y / Hanley, B G / Hannigan, R / Hansen, J / Haque, M R / Harris, J W / Harton, A / Hassan, H / Hatzifotiadou, D / Hauer, P / Havener, L B / Heckel, S T / Hellbär, E / Helstrup, H / Hemmer, M / Herman, T / Herrera Corral, G / Herrmann, F / Herrmann, S / Hetland, K F / Heybeck, B / Hillemanns, H / Hippolyte, B / Hoffmann, F W / Hofman, B / Hohlweger, B / Hong, G H / Horst, M / Horzyk, A / Hou, Y / Hristov, P / Hughes, C / Huhn, P / Huhta, L M / Humanic, T J / Hutson, A / Hutter, D / Ilkaev, R / Ilyas, H / Inaba, M / Innocenti, G M / Ippolitov, M / Isakov, A / Isidori, T / Islam, M S / Ivanov, M / Ivanov, V / Iversen, K E / Jablonski, M / Jacak, B / Jacazio, N / Jacobs, P M / Jadlovska, S / Jadlovsky, J / Jaelani, S / Jahnke, C / Jakubowska, M J / Janik, M A / Janson, T / Jercic, M / Ji, S / Jia, S / Jimenez, A A P / Jonas, F / Jones, D M / Jowett, J M / Jung, J / Jung, M / Junique, A / Jusko, A / Kabus, M J / Kaewjai, J / Kalinak, P / Kalteyer, A S / Kalweit, A / Kaplin, V / Karasu Uysal, A / Karatovic, D / Karavichev, O / Karavicheva, T / Karczmarczyk, P / Karpechev, E / Kebschull, U / Keidel, R / Keijdener, D L D / Keil, M / Ketzer, B / Khade, S S / Khan, A M / Khan, S / Khanzadeev, A / Kharlov, Y / Khatun, A / Khuntia, A / Kidson, M B / Kileng, B / Kim, B / Kim, C / Kim, D J / Kim, E J / Kim, J / Kim, J S / Kim, M / Kim, S / Kim, T / Kimura, K / Kirsch, S / Kisel, I / Kiselev, S / Kisiel, A / Kitowski, J P / Klay, J L / Klein, J / Klein, S / Klein-Bösing, C / Kleiner, M / Klemenz, T / Kluge, A / Knospe, A G / Kobdaj, C / Kollegger, T / Kondratyev, A / Kondratyeva, N / Kondratyuk, E / Konig, J / Konigstorfer, S A / Konopka, P J / Kornakov, G / Korwieser, M / Koryciak, S D / Kotliarov, A / Kovalenko, V / Kowalski, M / Kozhuharov, V / Králik, I / Kravčáková, A / Krcal, L / Krivda, M / Krizek, F / Krizkova Gajdosova, K / Kroesen, M / Krüger, M / Krupova, D M / Kryshen, E / Kučera, V / Kuhn, C / Kuijer, P G / Kumaoka, T / Kumar, D / Kumar, L / Kumar, N / Kumar, S / Kundu, S / Kurashvili, P / Kurepin, A / Kurepin, A B / Kuryakin, A / Kushpil, S / Kweon, M J / Kwon, Y / La Pointe, S L / La Rocca, P / Lakrathok, A / Lamanna, M / Landou, A R / Langoy, R / Larionov, P / Laudi, E / Lautner, L / Lavicka, R / Lea, R / Lee, H / Legrand, I / Legras, G / Lehrbach, J / Lelek, T M / Lemmon, R C / León Monzón, I / Lesch, M M / Lesser, E D / Lévai, P / Li, X / Li, X L / Lien, J / Lietava, R / Likmeta, I / Lim, B / Lim, S H / Lindenstruth, V / Lindner, A / Lippmann, C / Liu, A / Liu, D H / Liu, J / Liveraro, G S S / Lofnes, I M / Loizides, C / Lokos, S / Lomker, J / Loncar, P / Lopez, J A / Lopez, X / López Torres, E / Lu, P / Luhder, J R / Lunardon, M / Luparello, G / Ma, Y G / Mager, M / Maire, A / Majerz, E M / Makariev, M V / Malaev, M / Malfattore, G / Malik, N M / Malik, Q W / Malik, S K / Malinina, L / Mallick, D / Mallick, N / Mandaglio, G / Mandal, S K / Manko, V / Manso, F / Manzari, V / Mao, Y / Marcjan, R W / Margagliotti, G V / Margotti, A / Marín, A / Markert, C / Martinengo, P / Martínez, M I / Martínez García, G / Martins, M P P / Masciocchi, S / Masera, M / Masoni, A / Massacrier, L / Mastroserio, A / Matonoha, O / Mattiazzo, S / Matuoka, P F T / Matyja, A / Mayer, C / Mazuecos, A L / Mazzaschi, F / Mazzilli, M / Mdhluli, J E / Mechler, A F / Melikyan, Y / Menchaca-Rocha, A / Meninno, E / Menon, A S / Meres, M / Mhlanga, S / Miake, Y / Micheletti, L / Migliorin, L C / Mihaylov, D L / Mikhaylov, K / Mishra, A N / Miśkowiec, D / Modak, A / Mohanty, A P / Mohanty, B / Mohisin Khan, M / Molander, M A / Monira, S / Moravcova, Z / Mordasini, C / Moreira De Godoy, D A / Morozov, I / Morsch, A / Mrnjavac, T / Muccifora, V / Muhuri, S / Mulligan, J D / Mulliri, A / Munhoz, M G / Munzer, R H / Murakami, H / Murray, S / Musa, L / Musinsky, J / Myrcha, J W / Naik, B / Nambrath, A I / Nandi, B K / Nania, R / Nappi, E / Nassirpour, A F / Nath, A / Nattrass, C / Naydenov, M N / Neagu, A / Negru, A / Nellen, L / Nepeivoda, R / Nese, S / Neskovic, G / Nielsen, B S / Nielsen, E G / Nikolaev, S / Nikulin, S / Nikulin, V / Noferini, F / Noh, S / Nomokonov, P / Norman, J / Novitzky, N / Nowakowski, P / Nyanin, A / Nystrand, J / Ogino, M / Oh, S / Ohlson, A / Okorokov, V A / Oleniacz, J / Oliveira Da Silva, A C / Oliver, M H / Onnerstad, A / Oppedisano, C / Ortiz Velasquez, A / Otwinowski, J / Oya, M / Oyama, K / Pachmayer, Y / Padhan, S / Pagano, D / Paić, G / Paisano-Guzmán, S / Palasciano, A / Panebianco, S / Park, H / Park, J / Parkkila, J E / Patley, Y / Patra, R N / Paul, B / Pei, H / Peitzmann, T / Peng, X / Pennisi, M / Peresunko, D / Perez, G M / Pestov, Y / Petrov, V / Petrovici, M / Pezzi, R P / Piano, S / Pikna, M / Pillot, P / Pinazza, O / Pinsky, L / Pinto, C / Pisano, S / Płoskoń, M / Planinic, M / Pliquett, F / Poghosyan, M G / Polichtchouk, B / Politano, S / Poljak, N / Pop, A / Porteboeuf-Houssais, S / Pozdniakov, V / Pozos, I Y / Pradhan, K K / Prasad, S K / Prasad, S / Preghenella, R / Prino, F / Pruneau, C A / Pshenichnov, I / Puccio, M / Pucillo, S / Pugelova, Z / Qiu, S / Quaglia, L / Quishpe, R E / Ragoni, S / Rakotozafindrabe, A / Ramello, L / Rami, F / Rancien, T A / Rasa, M / Räsänen, S S / Rath, R / Rauch, M P / Ravasenga, I / Read, K F / Reckziegel, C / Redelbach, A R / Redlich, K / Reetz, C A / Regules-Medel, H D / Rehman, A / Reidt, F / Reme-Ness, H A / Rescakova, Z / Reygers, K / Riabov, A / Riabov, V / Ricci, R / Richter, M / Riedel, A A / Riegler, W / Ristea, C / Rodriguez, M V / Rodríguez Cahuantzi, M / Rodríguez Ramírez, S A / Røed, K / Rogalev, R / Rogochaya, E / Rogoschinski, T S / Rohr, D / Röhrich, D / Rojas, P F / Rojas Torres, S / Rokita, P S / Romanenko, G / Ronchetti, F / Rosano, A / Rosas, E D / Roslon, K / Rossi, A / Roy, A / Roy, S / Rubini, N / Ruggiano, D / Rui, R / Russek, P G / Russo, R / Rustamov, A / Ryabinkin, E / Ryabov, Y / Rybicki, A / Rytkonen, H / Ryu, J / Rzesa, W / Saarimaki, O A M / Sadek, R / Sadhu, S / Sadovsky, S / Saetre, J / Šafařík, K / Saha, P / Saha, S K / Saha, S / Sahoo, B / Sahoo, R / Sahoo, S / Sahu, D / Sahu, P K / Saini, J / Sajdakova, K / Sakai, S / Salvan, M P / Sambyal, S / Sanna, I / Saramela, T B / Sarkar, D / Sarkar, N / Sarma, P / Sarritzu, V / Sarti, V M / Sas, M H P / Schambach, J / Scheid, H S / Schiaua, C / Schicker, R / Schmah, A / Schmidt, C / Schmidt, H R / Schmidt, M O / Schmidt, M / Schmidt, N V / Schmier, A R / Schotter, R / Schröter, A / Schukraft, J / Schweda, K / Scioli, G / Scomparin, E / Seger, J E / Sekiguchi, Y / Sekihata, D / Selina, M / Selyuzhenkov, I / Senyukov, S / Seo, J J / Serebryakov, D / Šerkšnytė, L / Sevcenco, A / Shaba, T J / Shabetai, A / Shahoyan, R / Shangaraev, A / Sharma, A / Sharma, B / Sharma, D / Sharma, H / Sharma, M / Sharma, S / Sharma, U / Shatat, A / Sheibani, O / Shigaki, K / Shimomura, M / Shin, J / Shirinkin, S / Shou, Q / Sibiriak, Y / Siddhanta, S / Siemiarczuk, T / Silva, T F / Silvermyr, D / Simantathammakul, T / Simeonov, R / Singh, B / Singh, K / Singh, R / Singh, S / Singh, V K / Singhal, V / Sinha, T / Sitar, B / Sitta, M / Skaali, T B / Skorodumovs, G / Slupecki, M / Smirnov, N / Snellings, R J M / Solheim, E H / Song, J / Songmoolnak, A / Sonnabend, C / Soramel, F / Soto-Hernandez, A B / Spijkers, R / Sputowska, I / Staa, J / Stachel, J / Stan, I / Steffanic, P J / Stiefelmaier, S F / Stocco, D / Storehaug, I / Stratmann, P / Strazzi, S / Stylianidis, C P / Suaide, A A P / Suire, C / Sukhanov, M / Suljic, M / Sultanov, R / Sumberia, V / Sumowidagdo, S / Swain, S / Szarka, I / Szymkowski, M / Taghavi, S F / Taillepied, G / Takahashi, J / Tambave, G J / Tang, S / Tang, Z / Tapia Takaki, J D / Tapus, N / Tarasovicova, L A / Tarzila, M G / Tassielli, G F / Tauro, A / Tejeda Muñoz, G / Telesca, A / Terlizzi, L / Terrevoli, C / Thakur, S / Thomas, D / Tikhonov, A / Timmins, A R / Tkacik, M / Tkacik, T / Toia, A / Tokumoto, R / Tomohiro, K / Topilskaya, N / Toppi, M / Tork, T / Torres, V V / Torres Ramos, A G / Trifiró, A / Triolo, A S / Tripathy, S / Tripathy, T / Trogolo, S / Trubnikov, V / Trzaska, W H / Trzcinski, T P / Tumkin, A / Turrisi, R / Tveter, T S / Ullaland, K / Ulukutlu, B / Uras, A / Urioni, M / Usai, G L / Vala, M / Valle, N / van Doremalen, L V R / van Leeuwen, M / van Veen, C A / van Weelden, R J G / Vande Vyvre, P / Varga, D / Varga, Z / Vasileiou, M / Vasiliev, A / Vázquez Doce, O / Vazquez Rueda, O / Vechernin, V / Vercellin, E / Vergara Limón, S / Verma, R / Vermunt, L / Vértesi, R / Verweij, M / Vickovic, L / Vilakazi, Z / Villalobos Baillie, O / Villani, A / Vino, G / Vinogradov, A / Virgili, T / Virta, M M O / Vislavicius, V / Vodopyanov, A / Volkel, B / Völkl, M A / Voloshin, K / Voloshin, S A / Volpe, G / von Haller, B / Vorobyev, I / Vozniuk, N / Vrláková, J / Wan, J / Wang, C / Wang, D / Wang, Y / Wegrzynek, A / Weiglhofer, F T / Wenzel, S C / Wessels, J P / Wiechula, J / Wikne, J / Wilk, G / Wilkinson, J / Willems, G A / Windelband, B / Winn, M / Wright, J R / Wu, W / Wu, Y / Xu, R / Yadav, A / Yadav, A K / Yalcin, S / Yamaguchi, Y / Yang, S / Yano, S / Yin, Z / Yoo, I-K / Yoon, J H / Yu, H / Yuan, S / Yuncu, A / Zaccolo, V / Zampolli, C / Zanone, F / Zardoshti, N / Zarochentsev, A / Závada, P / Zaviyalov, N / Zhalov, M / Zhang, B / Zhang, C / Zhang, L / Zhang, S / Zhang, X / Zhang, Y / Zhang, Z / Zhao, M / Zherebchevskii, V / Zhi, Y / Zhou, D / Zhou, Y / Zhu, J / Zhu, Y / Zugravel, S C / Zurlo, N

Physical review letters

2024 Volume 132, Issue 16, Page(s) 162302

Abstract: ... mesons as a function of the Mandelstam |t| variable is presented. The measurement was carried out ... x range (0.3-1.4)×10^{-3}. Cross sections are given in five |t| intervals in the range 0.04<|t|<1 ... of the gluon density in the colliding hadron predict a |t| dependence of the cross section much steeper ...

Abstract	The first measurement of the cross section for incoherent photonuclear production of J/ψ vector mesons as a function of the Mandelstam \|t\| variable is presented. The measurement was carried out with the ALICE detector at midrapidity, \|y\|<0.8, using ultraperipheral collisions of Pb nuclei at a center-of-mass energy per nucleon pair of sqrt[s_{NN}]=5.02 TeV. This rapidity interval corresponds to a Bjorken-x range (0.3-1.4)×10^{-3}. Cross sections are given in five \|t\| intervals in the range 0.04<\|t\|<1 GeV^{2} and compared to the predictions by different models. Models that ignore quantum fluctuations of the gluon density in the colliding hadron predict a \|t\| dependence of the cross section much steeper than in data. The inclusion of such fluctuations in the same models provides a better description of the data.
Language	English
Publishing date	2024-05-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.132.162302
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Article ; Online: NK/T-cell lymphoma masquerading as penile chancre.

Ahuja, Rhea / Manandhar, Keepa / Jain, Ayush / Narwal, Anubhav / Mallick, Saumyaranjan / Gupta, Somesh

International journal of dermatology

2024

Language	English
Publishing date	2024-04-22
Publishing country	England
Document type	Letter
ZDB-ID	412254-9
ISSN	1365-4632 ; 0011-9059 ; 1461-1244
ISSN (online)	1365-4632
ISSN	0011-9059 ; 1461-1244
DOI	10.1111/ijd.17206
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Article ; Online: Antigen recognition reinforces regulatory T cell mediated Leishmania major persistence.

Zayats, Romaniya / Mou, Zhirong / Yazdanpanah, Atta / Gupta, Gaurav / Lopez, Paul / Nayar, Deesha / Koh, Wan H / Uzonna, Jude E / Murooka, Thomas T

Nature communications

2023 Volume 14, Issue 1, Page(s) 8449

Abstract: Cutaneous Leishmania major infection elicits a rapid T cell response that is insufficient to clear ... residually infected cells, possibly due to the accumulation of regulatory T cells in healed skin. Here ...

Abstract	Cutaneous Leishmania major infection elicits a rapid T cell response that is insufficient to clear residually infected cells, possibly due to the accumulation of regulatory T cells in healed skin. Here, we used Leishmania-specific TCR transgenic mice as a sensitive tool to characterize parasite-specific effector and immunosuppressive responses in vivo using two-photon microscopy. We show that Leishmania-specific Tregs displayed higher suppressive activity compared to polyclonal Tregs, that was mediated through IL-10 and not through disrupting cell-cell contacts or antigen presentation. In vivo expansion of endogenous Leishmania-specific Tregs resulted in disease reactivation that was also IL-10 dependent. Interestingly, lack of Treg expansion that recognized the immunodominant Leishmania peptide PEPCK was sufficient to restore robust effector Th1 responses and resulted in parasite control exclusively in male hosts. Our data suggest a stochastic model of Leishmania major persistence in skin, where cellular factors that control parasite numbers are counterbalanced by Leishmania-specific Tregs that facilitate parasite persistence.
MeSH term(s)	Mice ; Animals ; Male ; T-Lymphocytes, Regulatory ; Interleukin-10/genetics ; Leishmania major/genetics ; Leishmaniasis, Cutaneous ; Mice, Transgenic
Chemical Substances	Interleukin-10 (130068-27-8)
Language	English
Publishing date	2023-12-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-44297-6
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Article ; Online: A Faster Prostate MRI: Comparing a Novel Denoised, Single-Average T

Kelleher, Colm B / Macdonald, Jacob / Jaffe, Tracy A / Allen, Brian C / Kalisz, Kevin R / Kauffman, Travis H / Smith, Jordan D / Maurer, Kimberly R / Thomas, Sarah P / Coleman, Aaron D / Zaki, Islam H / Kannengiesser, Stephan / Lafata, Kyle / Gupta, Rajan T / Bashir, Mustafa R

Journal of magnetic resonance imaging : JMRI

2023 Volume 58, Issue 2, Page(s) 620–629

Abstract: Background: The T: Purpose/hypothesis: To determine whether a denoised, single-average T ... Field strength/sequence: A 3 T; T: Assessment: Nine readers randomly assessed complete exams ... including T: Statistical tests: Generalized linear mixed effects models for differences in lesion ...

Abstract	Background: The T Purpose/hypothesis: To determine whether a denoised, single-average T Study type: Retrospective. Population: A total of 45 males (age range 60-75 years) who underwent clinically indicated prostate MRI examinations, 21 of whom had pathologically proven prostate cancer. Field strength/sequence: A 3 T; T Assessment: Nine readers randomly assessed complete exams including T Statistical tests: Generalized linear mixed effects models for differences in lesion detection, image quality features, and overall preference between T Results: There was no significant difference between sequences regarding identification of lesions with PI-RADS ≥3 (P = 0.10) or PI-RADS score (P = 0.77). Reader agreement was excellent for lesion identification (ICC = 0.84). There was no significant overall preference between the two sequences regarding image quality (P = 0.07, 95% CI: [-0.23, 0.01]). Reader agreement was good regarding sequence preference (ICC = 0.62). Data conclusion: Use of single-average, denoised T Evidence level: 3. Technical efficacy: Stage 3.
MeSH term(s)	Male ; Humans ; Middle Aged ; Aged ; Magnetic Resonance Imaging/methods ; Prostate/diagnostic imaging ; Prostate/pathology ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Retrospective Studies ; Pelvis/pathology
Language	English
Publishing date	2023-01-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.28577
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Article: GZMK+CD8+ T cells Target a Specific Acinar Cell Type in Sjögren's Disease.

Warner, Blake / Pranzatelli, Thomas / Perez, Paola / Ku, Anson / Matuck, Bruno Fernandes / Huynh, Khoa / Sakai, Shunsuke / Abed, Mehdi / Jang, Shyh-Ing / Yamada, Eiko / Dominick, Kalie / Ahmed, Zara / Oliver, Amanda / Wasikowski, Rachael / Easter, Quinn / Magone, M Teresa / Baer, Alan / Pelayo, Eileen / Khavandgar, Zohreh /

Research square

2023

Abstract: ... in SjD. Notably, GZMK+CD8 T cells, enriched in SjD, exhibited a cytotoxic phenotype and were physically ...

Abstract	Sjögren's Disease (SjD) is a systemic autoimmune disease without a clear etiology or effective therapy. Utilizing unbiased single-cell and spatial transcriptomics to analyze human minor salivary glands in health and disease we developed a comprehensive understanding of the cellular landscape of healthy salivary glands and how that landscape changes in SjD patients. We identified novel seromucous acinar cell types and identified a population of PRR4+CST3+WFDC2- seromucous acinar cells that are particularly targeted in SjD. Notably, GZMK+CD8 T cells, enriched in SjD, exhibited a cytotoxic phenotype and were physically associated with immune-engaged epithelial cells in disease. These findings shed light on the immune response's impact on transitioning acinar cells with high levels of secretion and explain the loss of this specific cell population in SjD. This study explores the complex interplay of varied cell types in the salivary glands and their role in the pathology of Sjögren's Disease.
Language	English
Publishing date	2023-12-19
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-3601404/v1
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Article ; Online: “I can’t do it”

Tyler Shelby / Cailin Arechiga / Amanda J. Gupta / Rachel Hennein / Christopher Schenck / Brian Weeks / Maritza Bond / Linda Niccolai / J. Lucian Davis / Lauretta E. Grau

BMC Public Health, Vol 22, Iss 1, Pp 1-

A qualitative study exploring case and contact experiences with COVID-19 contact tracing

2022 Volume 11

Abstract: Abstract Background Low engagement in contact tracing for COVID-19 dramatically reduces its impact, but little is known about how experiences, environments and characteristics of cases and contacts influence engagement. Methods We recruited a convenience ...

Abstract	Abstract Background Low engagement in contact tracing for COVID-19 dramatically reduces its impact, but little is known about how experiences, environments and characteristics of cases and contacts influence engagement. Methods We recruited a convenience sample of COVID-19 cases and contacts from the New Haven Health Department’s contact tracing program for interviews about their contact tracing experiences. We analyzed transcripts thematically, organized themes using the Capability, Opportunity, Motivation, Behavior (COM-B) model, and identified candidate interventions using the linked Behavior Change Wheel Framework. Results We interviewed 21 cases and 12 contacts. Many felt physically or psychologically incapable of contact tracing participation due to symptoms or uncertainty about protocols. Environmental factors and social contacts also influenced engagement. Finally, physical symptoms, emotions and low trust in and expectations of public health authorities influenced motivation to participate. Conclusion To improve contact tracing uptake, programs should respond to clients’ physical and emotional needs; increase clarity of public communications; address structural and social factors that shape behaviors and opportunities; and establish and maintain trust. We identify multiple potential interventions that may help achieve these goals.
Keywords	Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: It takes T to tango: immunotherapy in MM.

Gupta, Vikas A / Dhodapkar, Madhav V

Blood

2022 Volume 139, Issue 9, Page(s) 1259–1260

MeSH term(s)	Immunologic Factors ; Immunotherapy
Chemical Substances	Immunologic Factors
Language	English
Publishing date	2022-03-03
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2021013816
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Article ; Online: Diagnostic utility of LMO2 immunohistochemistry in distinguishing T-lymphoblastic leukemia/lymphoma from thymoma.

Bansal, Divya / Pasricha, Sunil / Gupta, Gurudutt / Sharma, Anila / Durga, Garima / Kamboj, Meenakshi / Mehta, Anurag

Indian journal of pathology & microbiology

2024 Volume 67, Issue 1, Page(s) 141–144

Abstract: Distinguishing T-lymphoblastic leukemia/lymphoma (T-ALL/T-LBL) from thymomas (especially B1 or B2 ... expressed in neoplastic lymphoblasts of T-ALL/T-LBL and is absent in thymocytes of normal thymuses or ... showed expression of LMO2 in the neoplastic cells. LMO2 is a reliable marker of transformed T-cell ...

Abstract	Distinguishing T-lymphoblastic leukemia/lymphoma (T-ALL/T-LBL) from thymomas (especially B1 or B2 type) can be challenging particularly in limited trucut biopsy material where appreciating architecture is difficult or the background epithelial component does not provide tangible evidence for definite diagnosis. As a pathologist, it is important to accurately diagnose these neoplasms because they have entirely distinct management protocols. Recent studies have reported that LIM Domain Only 2 (LMO2) is expressed in neoplastic lymphoblasts of T-ALL/T-LBL and is absent in thymocytes of normal thymuses or thymomas. An observational study was done to test the sensitivity and specificity of LMO2 in differentiating neoplastic lymphoblasts from thymocytes of thymomas/normal thymuses. Our study showed that LMO2 had sensitivity of 70% and specificity of 100% in diagnosing LBL. None of the thymomas (B1 or B2 type) showed expression of LMO2 in the neoplastic cells. LMO2 is a reliable marker of transformed T-cell precursors and should be routinely included in immunohistochemical panel when evaluating thymic/mediastinal neoplasms.
MeSH term(s)	Humans ; Thymoma/diagnosis ; Thymoma/pathology ; Immunohistochemistry ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Thymus Neoplasms/diagnosis ; Thymus Neoplasms/pathology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Lymphoma, T-Cell ; Proto-Oncogene Proteins ; Adaptor Proteins, Signal Transducing ; LIM Domain Proteins/metabolism
Chemical Substances	LMO2 protein, human ; Proto-Oncogene Proteins ; Adaptor Proteins, Signal Transducing ; LIM Domain Proteins
Language	English
Publishing date	2024-02-15
Publishing country	India
Document type	Observational Study ; Journal Article
ZDB-ID	197621-7
ISSN	0974-5130 ; 0377-4929
ISSN (online)	0974-5130
ISSN	0377-4929
DOI	10.4103/ijpm.ijpm_111_23
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Article ; Online: Joint radial trajectory correction for accelerated T

Bano, Wajiha / Holmes, Will / Goodburn, Rosie / Golbabaee, Mohammad / Gupta, Amit / Withey, Sam / Tree, Alison / Oelfke, Uwe / Wetscherek, Andreas

Medical physics

2023 Volume 50, Issue 11, Page(s) 7027–7038

Abstract: Background: T: Purpose: The purpose of this work is to demonstrate the feasibility ... of the accelerated T: Materials and methods: The proposed method was validated in a numerical phantom, where two T ... Results: Numerical simulations demonstrated that, for all noise levels, T: Conclusion: Using ...

Abstract	Background: T Purpose: The purpose of this work is to demonstrate the feasibility of the accelerated T Materials and methods: The proposed method was validated in a numerical phantom, where two T Results: Numerical simulations demonstrated that, for all noise levels, T Conclusion: Using the proposed approach, a retrospective data-driven gradient delay correction can be performed, which is particularly relevant for hybrid devices, where full information on the machine configuration is not available for image reconstruction. T
MeSH term(s)	Male ; Humans ; Retrospective Studies ; Magnetic Resonance Imaging ; Image Processing, Computer-Assisted/methods ; Phantoms, Imaging ; Head and Neck Neoplasms/diagnostic imaging ; Head and Neck Neoplasms/radiotherapy ; Particle Accelerators
Language	English
Publishing date	2023-05-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	188780-4
ISSN	2473-4209 ; 0094-2405
ISSN (online)	2473-4209
ISSN	0094-2405
DOI	10.1002/mp.16479
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