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Article ; Online: Sir Richard Doll, M.D., F.R.S. (1912-2005).

Gross, Nicholas

American journal of respiratory and critical care medicine

2012 Volume 186, Issue 11, Page(s) ix

MeSH term(s)	History, 20th Century ; Humans ; Lung Neoplasms/history ; Lung Neoplasms/prevention & control ; Physician's Role ; Pulmonary Medicine/history ; United Kingdom
Language	English
Publishing date	2012-12-01
Publishing country	United States
Document type	Biography ; Historical Article ; Portraits
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.201211-1982ED
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Article: In memoriam Christian Crone, M.D., Ph.D. (1926-1990).

Gjedde, A / Gross, P M / Hansen, A J

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

1993 Volume 13, Issue 1, Page(s) 3–4

MeSH term(s)	Capillaries ; History, 20th Century ; Microcirculation ; Physiology/history
Language	English
Publishing date	1993-01
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article
ZDB-ID	604628-9
ISSN	1559-7016 ; 0271-678X
ISSN (online)	1559-7016
ISSN	0271-678X
DOI	10.1038/jcbfm.1993.3
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Book: Autobiography of Samuel D. Gross, M.D

Gross, Samuel D

with sketches of his contemporaries

(Medicine & society in America)

1972

Title variant	Samuel D. Gross, an autobiography
Author's details	edited by his sons
Series title	Medicine & society in America
MeSH term(s)	Physicians
Language	English
Dates of publication	1972-1887
Size	2 v. :, ill., port.
Edition	Reprint ed.
Publisher	Arno Press : New York Times
Publishing place	New York
Document type	Book
Note	Originally published: Philadelphia : G. Barrie Publisher, 1887. ; Spine title: Samuel D. Gross, an autobiography. ; Includes index.
ISBN	9780405039539 ; 0405039530 ; 9780405039805 ; 0405039808 ; 9780405039812 ; 0405039816
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Determination of procoagulant activity in human normal immunoglobulin preparations for therapeutic use by FXIa chromogenic assay: Evaluation of test kit sensitivity, reference standard performance and product formulation effects on the FXIa assay.

Behr-Gross, M-E / Le Tallec, D / Sinitskaya, N / Milne, C / Etscheid, M

Pharmeuropa bio & scientific notes

2024 Volume 2024, Page(s) 27–75

Abstract: In 2010, the reporting of thrombotic adverse events for one subcutaneous and certain intravenous immunoglobulins (IGs) raised some concerns. In Europe, regulatory bodies rapidly revised compendial specifications for therapeutic IGs to ensure they do not ... ...

Abstract	In 2010, the reporting of thrombotic adverse events for one subcutaneous and certain intravenous immunoglobulins (IGs) raised some concerns. In Europe, regulatory bodies rapidly revised compendial specifications for therapeutic IGs to ensure they do not exhibit thrombogenic (procoagulant) activity (PCA). At the global level, a working group (GWG) was launched with the aim of assessing PCA measurement methods and limits, considering results obtained by human IG manufacturers during in-process controls. The GWG created three dedicated subgroups to investigate the FXIa chromogenic assay, the non-activated partial thromboplastin time (NAPTT) test and the thrombin generation assay (TGA). The European Directorate for the Quality of Medicines & HealthCare (EDQM) was responsible for co-ordinating the subgroup in charge of evaluating the FXIa chromogenic assay in a study that assessed the sensitivity and robustness of two commercial chromogenic FXIa test kits. The impact of IG product formulation on FXIa recovery and the suitability of PCA-containing IG products as potential reference standards/controls were also assessed. IG materials representative of marketed products were provided to four laboratories for a study that was carried out in two steps: 1) two chromogenic FXIa test kit manufacturers assessed the performance and determined optimal test conditions by their respective methods, 2) two OMCLs studied both kits using an optimised study design. Regarding sensitivity, the study results identified suitable dose-response intervals and limits with both chromogenic FXIa test kits. This allowed the establishment of dilution ranges for optimal detection of FXIa/PCA in 5 % and 10 % IG products in the range of 1-6 mIU/mL. However, careful optimisation of the sample dilutions was required (notably to avoid potential matrix effects) and the choice of the mode of data acquisition (kinetic or end-point method) contributed to sensitivity in routine use. Importantly, the composition of IG products was of minor concern for FXIa determination with both test kits. Potential reference materials evaluated in the study behaved as expected and could be useful should a separate reference standard to the FXIa WHO IS be deemed necessary in future.
MeSH term(s)	Humans ; Immunoglobulin G ; Immunoglobulins, Intravenous ; Thrombin ; Blood Coagulation Tests ; Reference Standards
Chemical Substances	Immunoglobulin G ; Immunoglobulins, Intravenous ; Thrombin (EC 3.4.21.5)
Language	English
Publishing date	2024-03-27
Publishing country	France
Document type	Journal Article
ZDB-ID	2613598-X
ISSN	2075-2504 ; 2075-2504
ISSN (online)	2075-2504
ISSN	2075-2504
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Telemedicine in nursing homes: Insights on the social acceptance and ethical acceptability of telemedical consultations.

Offermann, Julia / Ziefle, Martina / Sira, Nataliya / Groß, Dominik / Wilhelmy, Saskia

Digital health

2023 Volume 9, Page(s) 20552076231213444

Abstract: Introduction: The increasing number of older adults in need of care, the resulting rise in demand for care services and the shortage of nursing staff are major challenges for society. In these situations, the use of telemedicine seems promising - ... ...

Abstract	Introduction: The increasing number of older adults in need of care, the resulting rise in demand for care services and the shortage of nursing staff are major challenges for society. In these situations, the use of telemedicine seems promising - especially in nursing homes when the focus is on rapid support in acute medical cases. However, in addition to the medical and technical potential, the acceptability and usability of the use of telemedical consultations are crucial for a sustainable implementation and acceptance. Our research aims at a holistic identification of socially and ethically relevant parameters for the evaluation of telemedical consultations in nursing homes. Methods: Presentation of the empirical approach of an interdisciplinary cooperation that combines social and ethical research perspectives during an entire research project. Qualitative analysis of social and ethical aspects based on an interview study with care personnel (N = 14) who have experiences with telemedical consultations in nursing homes, as an example of this interdisciplinary collaboration and to show first insights. Results: The results of the interview study show a slightly positive evaluation of the use of telemedical consultations in nursing homes. Six main categories were identified to capture and differentiate ethically and socially relevant perceived benefits and barriers (contact with physicians, general, personnel-related, residents-related, technical, and organizational aspects). Conclusion: The study results allow initial recommendations for the implementation of telemedicine consultations in nursing homes considering socially and ethically relevant aspects. These recommendations can be used to inform medical and technical experts in the field of telemedicine. In addition, the presentation of the interdisciplinary collaboration shows that the close integration of social and ethical aspects in research enables a holistic dimension of the use of telemedicine.
Language	English
Publishing date	2023-11-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2819396-9
ISSN	2055-2076
ISSN	2055-2076
DOI	10.1177/20552076231213444
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Article ; Online: Vom Nationalsozialisten zum Hitler-Erklärer: Die autobiografischen Umdeutungen des Psychiaters Johann Recktenwald (1882–1964).

Groß, Dominik / Schmidt, Mathias / Engels, Pascal / Kaiser, Stephanie

Fortschritte der Neurologie-Psychiatrie

2022 Volume 92, Issue 4, Page(s) 121–127

Abstract: Aim of the study: The focus of this article is the psychiatrist Johann Recktenwald (1882-1964) who has so far received little attention: acquitted of the charge of "crimes against humanity", he went public in post-war Germany with a neuropsychiatric ... ...

Title translation	From Nazi to Hitler Analyst: The Autobiographical Reinterpretations of the Psychiatrist Johann Recktenwald (1882-1964).
Abstract	Aim of the study: The focus of this article is the psychiatrist Johann Recktenwald (1882-1964) who has so far received little attention: acquitted of the charge of "crimes against humanity", he went public in post-war Germany with a neuropsychiatric treatise on Hitler. But is this appearance as a Hitler-critical psychiatrist consistent with the available historical sources? What was Recktenwald's relationship with the Nazi regime, and how did he behave in the "Third Reich" towards the patients entrusted to his care? Methods: The paper is largely based on documents from various archives, some of which have been evaluated for the first time, and on court records. The latter are supplemented and compared with the writings of Recktenwald and the available secondary literature. Results: During the "Third Reich", Recktenwald served the Nazi regime in many ways, was jointly responsible for numerous patient murders and thus moved into the role of a Nazi perpetrator. After his acquittal in post-war Germany, he endeavored to construct a personal distance to National Socialism by critically examining Hitler's psychopathology, which at the same time served his own exculpation. Conclusion: Recktenwald is a particularly impressive example of the efforts of Nazi perpetrators to retrospectively rewrite their own role in the "Third Reich" - and at the same time a reflection of a post-war society that was willing to accept such biographical reinterpretations in order to avoid coming to terms with the Nazi past.
MeSH term(s)	Male ; Humans ; National Socialism ; Psychiatrists ; Retrospective Studies ; Germany
Language	German
Publishing date	2022-11-29
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	625328-3
ISSN	1439-3522 ; 0720-4299
ISSN (online)	1439-3522
ISSN	0720-4299
DOI	10.1055/a-1930-3133
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Article ; Online: Author response: The two lives of neurologist Helmut J. Bauer (1914-2008): Renowned MS specialist and National Socialist.

Schmidt, Mathias / Groß, Dominik

Neurology

2020 Volume 94, Issue 22, Page(s) 1002–1003

MeSH term(s)	Humans ; National Socialism ; Neurologists ; Neurology ; Specialization
Language	English
Publishing date	2020-05-30
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000009540
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Article ; Online: Author response: The two lives of neurologist Helmut J. Bauer (1914-2008): Renowned MS specialist and National Socialist.

Schmidt, Mathias / Groß, Dominik

Neurology

2020 Volume 94, Issue 22, Page(s) 1001

MeSH term(s)	Humans ; National Socialism ; Neurologists ; Neurology ; Specialization
Language	English
Publishing date	2020-05-30
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000009538
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Article ; Online: Chore or desire? Students' response to online lessons in scientific integrity.

Sira, N / Decker, M / Kordtomeikel, F / Winkens, A / Leicht-Scholten, C / Groß, D

Accountability in research

2022 , Page(s) 1–18

Abstract: One of the main responsibilities of universities for their students, researchers, and society is to teach scientific integrity. Over the years, many universities-including RWTH Aachen University-have developed modules to impart the rules of good ... ...

Abstract	One of the main responsibilities of universities for their students, researchers, and society is to teach scientific integrity. Over the years, many universities-including RWTH Aachen University-have developed modules to impart the rules of good scientific practice. The current case study outlines the "Scientific Integrity" online course of RWTH Aachen University that has been offered to all master's students starting in October 2020; it explains to what extent the topic of scientific integrity meets genuine interest among students. Based on the online questionnaires that students were asked to fill out before starting the course (Q1) and after completing the course (Q2), it was verified that the implemented course achieved a satisfactory, but expandable acceptance. 57% of study participants initially (Q1) strongly affirmed to be interested in the topic; said percentage increased to 65.3% at the end of the course (Q2). While at the time of Q1 most students admitted that they would not take the course if it were voluntary, the majority of study participants came to the opposite conclusion after the course (Q2). The results suggest that the assessment of the relevance of the course may be dependent on familiarity with its contents.
Language	English
Publishing date	2022-11-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2069334-5
ISSN	1545-5815 ; 0898-9621
ISSN (online)	1545-5815
ISSN	0898-9621
DOI	10.1080/08989621.2022.2145956
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Article: The Yin and Yang of the oxytocin and stress systems: opposites, yet interdependent and intertwined determinants of lifelong health trajectories.

Uvnäs-Moberg, Kerstin / Gross, Mechthild M / Calleja-Agius, Jean / Turner, Jonathan D

Frontiers in endocrinology

2024 Volume 15, Page(s) 1272270

Abstract: During parturition and the immediate post-partum period there are two opposite, yet interdependent and intertwined systems that are highly active and play a role in determining lifelong health and behaviour in both the mother and her infant: the stress ... ...

Abstract	During parturition and the immediate post-partum period there are two opposite, yet interdependent and intertwined systems that are highly active and play a role in determining lifelong health and behaviour in both the mother and her infant: the stress and the anti-stress (oxytocin) system. Before attempting to understand how the environment around birth determines long-term health trajectories, it is essential to understand how these two systems operate and how they interact. Here, we discuss together the hormonal and neuronal arms of both the hypothalamic-pituitary-adrenal (HPA) axis and the oxytocinergic systems and how they interact. Although the HPA axis and glucocorticoid stress axis are well studied, the role of oxytocin as an extremely powerful anti-stress hormone deserves more attention. It is clear that these anti-stress effects depend on oxytocinergic nerves emanating from the supraoptic nucleus (SON) and paraventricular nucleus (PVN), and project to multiple sites at which the stress system is regulated. These, include projections to corticotropin releasing hormone (CRH) neurons within the PVN, to the anterior pituitary, to areas involved in sympathetic and parasympathetic nervous control, to NA neurons in the locus coeruleus (LC), and to CRH neurons in the amygdala. In the context of the interaction between the HPA axis and the oxytocin system birth is a particularly interesting period as, for both the mother and the infant, both systems are very strongly activated within the same narrow time window. Data suggest that the HPA axis and the oxytocin system appear to interact in this early-life period, with effects lasting many years. If mother-child skin-to-skin contact occurs almost immediately postpartum, the effects of the anti-stress (oxytocin) system become more prominent, moderating lifelong health trajectories. There is clear evidence that HPA axis activity during this time is dependent on the balance between the HPA axis and the oxytocin system, the latter being reinforced by specific somatosensory inputs, and this has long-term consequences for stress reactivity.
MeSH term(s)	Oxytocin/metabolism ; Humans ; Hypothalamo-Hypophyseal System/metabolism ; Hypothalamo-Hypophyseal System/physiology ; Pituitary-Adrenal System/metabolism ; Pituitary-Adrenal System/physiology ; Female ; Animals ; Stress, Psychological/metabolism ; Stress, Physiological/physiology ; Pregnancy ; Yin-Yang
Chemical Substances	Oxytocin (50-56-6)
Language	English
Publishing date	2024-04-16
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2024.1272270
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