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  1. Article ; Online: Neurobiology of Aging: New Insights From Across the Research Spectrum.

    Villeda, Saul / Brown-Borg, Holly / Anderson, Rozalyn

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2023  Volume 78, Issue 6, Page(s) 869–871

    MeSH term(s) Neurobiology
    Language English
    Publishing date 2023-05-30
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/glad110
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  2. Article ; Online: Caloric restriction has a new player.

    Rhoads, Timothy W / Anderson, Rozalyn M

    Science (New York, N.Y.)

    2022  Volume 375, Issue 6581, Page(s) 620–621

    Abstract: Reverse translation of a human caloric restriction trial finds an immunometabolic regulator. ...

    Abstract Reverse translation of a human caloric restriction trial finds an immunometabolic regulator.
    MeSH term(s) Caloric Restriction ; Humans
    Language English
    Publishing date 2022-02-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abn6576
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  3. Article ; Online: Taking the long view on metabolism.

    Rhoads, Timothy W / Anderson, Rozalyn M

    Science (New York, N.Y.)

    2021  Volume 373, Issue 6556, Page(s) 738–739

    Language English
    Publishing date 2021-08-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abl4537
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  4. Article ; Online: Strength in diversity: Intra-cellular metabolite sharing enhances longevity.

    Lamming, Dudley W / Anderson, Rozalyn M

    Cell

    2022  Volume 186, Issue 1, Page(s) 8–9

    Abstract: Much of our foundational knowledge of cellular biology comes from studies in budding yeast, often described as a simple unicellular eukaryotic model. In this issue of Cell, Correia-Melo et al. describe an unappreciated feature of yeast biology involving ... ...

    Abstract Much of our foundational knowledge of cellular biology comes from studies in budding yeast, often described as a simple unicellular eukaryotic model. In this issue of Cell, Correia-Melo et al. describe an unappreciated feature of yeast biology involving intra-cellular metabolite exchange, where cells adapt and respond as part of a community, and go on to show that sharing of resources linked to methionine metabolism enhances longevity of cooperating cells.
    MeSH term(s) Longevity ; Saccharomyces cerevisiae/metabolism ; Eukaryotic Cells ; Cytoplasm ; Saccharomycetales
    Language English
    Publishing date 2022-12-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.12.012
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    Zs.A 1167: Show issues Location:
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  5. Article ; Online: Nutrition, longevity and disease: From molecular mechanisms to interventions.

    Longo, Valter D / Anderson, Rozalyn M

    Cell

    2022  Volume 185, Issue 9, Page(s) 1455–1470

    Abstract: Diet as a whole, encompassing food composition, calorie intake, and the length and frequency of fasting periods, affects the time span in which health and functional capacity are maintained. Here, we analyze aging and nutrition studies in simple ... ...

    Abstract Diet as a whole, encompassing food composition, calorie intake, and the length and frequency of fasting periods, affects the time span in which health and functional capacity are maintained. Here, we analyze aging and nutrition studies in simple organisms, rodents, monkeys, and humans to link longevity to conserved growth and metabolic pathways and outline their role in aging and age-related disease. We focus on feasible nutritional strategies shown to delay aging and/or prevent diseases through epidemiological, model organism, clinical, and centenarian studies and underline the need to avoid malnourishment and frailty. These findings are integrated to define a longevity diet based on a multi-pillar approach adjusted for age and health status to optimize lifespan and healthspan in humans.
    MeSH term(s) Caloric Restriction ; Diet ; Longevity ; Nutritional Status
    Language English
    Publishing date 2022-04-28
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.04.002
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  6. Article ; Online: Optimal data acquisition in tomography.

    Javidan, Mahshad / Esfandi, Hadi / Anderson, Rozalyn / Pashaie, Ramin

    Journal of the Optical Society of America. A, Optics, image science, and vision

    2023  Volume 40, Issue 12, Page(s) 2259–2276

    Abstract: In tomography, three-dimensional images of a medium are reconstructed from a set of two-dimensional projections. Each projection is the result of a measurement made by the scanner via radiating some form of energy and collecting the scattered field after ...

    Abstract In tomography, three-dimensional images of a medium are reconstructed from a set of two-dimensional projections. Each projection is the result of a measurement made by the scanner via radiating some form of energy and collecting the scattered field after interacting with the medium. The information content of these measurements is not equal, and one projection can be more informative than others. By choosing the most informative measurement at every step of scanning, an optimal tomography system can maximize the speed of data acquisition and temporal resolution of acquired images, reducing the operation cost and exposure to possible harmful radiations. The aim of this paper is to introduce mathematical algorithms that can be used to design measurements with optimal information content when imaging static or dynamically evolving objects.
    Language English
    Publishing date 2023-11-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 283633-6
    ISSN 1520-8532 ; 1084-7529 ; 0740-3232
    ISSN (online) 1520-8532
    ISSN 1084-7529 ; 0740-3232
    DOI 10.1364/JOSAA.506113
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    Zs.B 2689: Show issues Location:
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  7. Article ; Online: Alpha-Ketoglutarate, the Metabolite that Regulates Aging in Mice.

    Rhoads, Timothy W / Anderson, Rozalyn M

    Cell metabolism

    2020  Volume 32, Issue 3, Page(s) 323–325

    Abstract: In this issue of Cell Metabolism, Asadi Shahmirzadi et al. (2020) demonstrate that late-onset dietary supplementation with calcium alpha-ketoglutarate results in increased survival, compressed morbidity, and reduced frailty in mice. The study provides ... ...

    Abstract In this issue of Cell Metabolism, Asadi Shahmirzadi et al. (2020) demonstrate that late-onset dietary supplementation with calcium alpha-ketoglutarate results in increased survival, compressed morbidity, and reduced frailty in mice. The study provides further evidence for critical links between metabolism, inflammation, and aging.
    MeSH term(s) Aging ; Animals ; Inflammation ; Ketoglutaric Acids ; Longevity ; Mice ; Morbidity
    Chemical Substances Ketoglutaric Acids
    Language English
    Publishing date 2020-09-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2020.08.009
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    Zs.A 6169: Show issues Location:
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  8. Article ; Online: Can we make drug discovery targeting fundamental mechanisms of aging a reality?

    Le Couteur, David G / Anderson, Rozalyn M / de Cabo, Rafael

    Expert opinion on drug discovery

    2021  Volume 17, Issue 2, Page(s) 97–100

    MeSH term(s) Aging ; Drug Discovery ; Humans
    Language English
    Publishing date 2021-10-22
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2259618-5
    ISSN 1746-045X ; 1746-0441
    ISSN (online) 1746-045X
    ISSN 1746-0441
    DOI 10.1080/17460441.2022.1993818
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  9. Article: Nutrition, longevity and disease: From molecular mechanisms to interventions

    Longo, Valter D. / Anderson, Rozalyn M.

    Cell. 2022 Apr. 28, v. 185, no. 9

    2022  

    Abstract: Diet as a whole, encompassing food composition, calorie intake, and the length and frequency of fasting periods, affects the time span in which health and functional capacity are maintained. Here, we analyze aging and nutrition studies in simple ... ...

    Abstract Diet as a whole, encompassing food composition, calorie intake, and the length and frequency of fasting periods, affects the time span in which health and functional capacity are maintained. Here, we analyze aging and nutrition studies in simple organisms, rodents, monkeys, and humans to link longevity to conserved growth and metabolic pathways and outline their role in aging and age-related disease. We focus on feasible nutritional strategies shown to delay aging and/or prevent diseases through epidemiological, model organism, clinical, and centenarian studies and underline the need to avoid malnourishment and frailty. These findings are integrated to define a longevity diet based on a multi-pillar approach adjusted for age and health status to optimize lifespan and healthspan in humans.
    Keywords diet ; energy intake ; food composition ; health status ; longevity ; malnutrition
    Language English
    Dates of publication 2022-0428
    Size p. 1455-1470.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.04.002
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  10. Article: Reversal of neuronal tau pathology, metabolic dysfunction, and electrophysiological defects via adiponectin pathway-dependent AMPK activation.

    McGregor, Eric R / Lasky, Danny J / Rippentrop, Olivia J / Clark, Josef P / Wright, Samantha L G / Jones, Mathew V / Anderson, Rozalyn M

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Changes in brain mitochondrial metabolism are coincident with functional decline; however, direct links between the two have not been established. Here, we show that mitochondrial targeting via the adiponectin receptor activator AdipoRon (AR) clears ... ...

    Abstract Changes in brain mitochondrial metabolism are coincident with functional decline; however, direct links between the two have not been established. Here, we show that mitochondrial targeting via the adiponectin receptor activator AdipoRon (AR) clears neurofibrillary tangles (NFTs) and rescues neuronal tauopathy-associated defects. AR reduced levels of phospho-tau and lowered NFT burden by a mechanism involving the energy-sensing kinase AMPK and the growth-sensing kinase GSK3b. The transcriptional response to AR included broad metabolic and functional pathways. Induction of lysosomal pathways involved activation of LC3 and p62, and restoration of neuronal outgrowth required the stress-responsive kinase JNK. Negative consequences of NFTs on mitochondrial activity, ATP production, and lipid stores were corrected. Defects in electrophysiological measures (e.g., resting potential, resistance, spiking profiles) were also corrected. These findings reveal a network linking mitochondrial function, cellular maintenance processes, and electrical aspects of neuronal function that can be targeted via adiponectin receptor activation.
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.07.579204
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