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Article ; Online: Strategic Masking to Protect Patients from All Respiratory Viral Infections.

Klompas, Michael / Baker, Meghan A / Rhee, Chanu / Baden, Lindsey R

2023 Volume 389, Issue 1, Page(s) 4–6

MeSH term(s)	Humans ; Respiratory Tract Infections/prevention & control ; Virus Diseases/prevention & control ; Masks
Language	English
Publishing date	2023-06-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMp2306223
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Article ; Online: Co-production and adaptation of a prison-based problem-solving workbook to support the mental health of patients housed within a medium- and low-secure forensic service.

Perry, Amanda E / Baker, Heather / Aboaja, Anne / Wilson, Lindsey / Morris, Sarah

Health expectations : an international journal of public participation in health care and health policy

2024 Volume 27, Issue 2, Page(s) e13997

Abstract: Introduction: Problem-solving skills (PSS) help to provide a systematic approach to dealing with and managing complex problems. The overall aim of this study was to assess the acceptability and feasibility of developing and adapting a prison-based PSS ... ...

Abstract	Introduction: Problem-solving skills (PSS) help to provide a systematic approach to dealing with and managing complex problems. The overall aim of this study was to assess the acceptability and feasibility of developing and adapting a prison-based PSS workbook for adults within a medium- and low-secure hospital. Method: We used the Medical Research Council framework in our participatory mixed methods study incorporating an adapted survey (to identify what types of problems people experience in secure hospitals), a series of three interactive workshops (to co-produce two case study examples for a workbook) and we gathered feedback from patients and hospital staff on the acceptability and feasibility of the workbook. Data from the survey were used to inform the case study examples, and the feedback from patients and hospital staff was descriptively summarised and the results consolidated. Results: In total, 82 (51%) patients took part in the survey; 22 patients and 49 hospital staff provided feedback on the workbook. The survey results indicated that patients regularly experience problems while in the hospital. Patients reported problems relating to restrictions of freedom and boredom. The workshops produced two case studies for the workbooks, with mainly positive patient and staff feedback. More work is required to improve the visual representation of the characters in the case studies, the amount and content of the language and the mechanism of the intervention delivery. Conclusion: The adaptation process proved acceptable and feasible to both patients and staff. The co-production methodology for the workbook and feedback from patients and staff was an effective way of iteratively refining the materials to ensure that they were both meaningful and acceptable to staff and patients. Subsequent work is required to develop the workbook and evaluate the feasibility of the intervention delivery, recruitment rates, uptake and adherence to the PSS using a randomised controlled trial. Patient or public contribution: At each stage of the project consultation with patients and/or hospital staff was involved.
MeSH term(s)	Adult ; Humans ; Prisons ; Mental Health ; Problem Solving ; Patients ; Surveys and Questionnaires
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2119434-8
ISSN	1369-7625 ; 1369-6513
ISSN (online)	1369-7625
ISSN	1369-6513
DOI	10.1111/hex.13997
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Article ; Online: Profiles of body image concerns and their associations with disordered eating behaviors.

Baker, Sarah / Maïano, Christophe / Houle, Simon A / Nadon, Lindsey / Aimé, Annie / Morin, Alexandre J S

Appetite

2023 Volume 191, Page(s) 107082

Abstract: Although body image concerns (BIC) are recognized as a core driver in the development of disordered eating behaviors, the combined role of various types of BIC remains underexamined. This study relied on latent profile analysis to identify the main ... ...

Abstract	Although body image concerns (BIC) are recognized as a core driver in the development of disordered eating behaviors, the combined role of various types of BIC remains underexamined. This study relied on latent profile analysis to identify the main configurations of self-reported BIC (i.e., body checking and avoidance, perceived physical appearance, and fear of negative appearance evaluation) observed in a sample of 419 French-Canadian individuals (M
Language	English
Publishing date	2023-10-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1461347-5
ISSN	1095-8304 ; 0195-6663
ISSN (online)	1095-8304
ISSN	0195-6663
DOI	10.1016/j.appet.2023.107082
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Article ; Online: Nanopore adaptive sampling for targeted mitochondrial genome sequencing and bloodmeal identification in hematophagous insects.

Kipp, Evan J / Lindsey, Laramie L / Milstein, Marissa S / Blanco, Cristina M / Baker, Julia P / Faulk, Christopher / Oliver, Jonathan D / Larsen, Peter A

Parasites & vectors

2023 Volume 16, Issue 1, Page(s) 68

Abstract: Background: Blood-feeding insects are important vectors for an array of zoonotic pathogens. While previous efforts toward generating molecular resources have largely focused on major vectors of global medical and veterinary importance, molecular data ... ...

Abstract	Background: Blood-feeding insects are important vectors for an array of zoonotic pathogens. While previous efforts toward generating molecular resources have largely focused on major vectors of global medical and veterinary importance, molecular data across a large number of hematophagous insect taxa remain limited. Advancements in long-read sequencing technologies and associated bioinformatic pipelines provide new opportunities for targeted sequencing of insect mitochondrial (mt) genomes. For engorged hematophagous insects, such technologies can be leveraged for both insect mitogenome genome assembly and identification of vertebrate blood-meal sources. Methods: We used nanopore adaptive sampling (NAS) to sequence genomic DNA from four species of field-collected, blood-engorged mosquitoes (Aedes and Culex spp.) and one deer fly (Chrysops sp.). NAS was used for bioinformatical enrichment of mtDNA reads of hematophagous insects and potential vertebrate blood-meal hosts using publically available mt genomes as references. We also performed an experimental control to compare results of traditional non-NAS nanopore sequencing to the mt genome enrichment by the NAS method. Results: Complete mitogenomes were assembled and annotated for all five species sequenced with NAS: Aedes trivittatus, Aedes vexans, Culex restuans, Culex territans and the deer fly, Chrysops niger. In comparison to data generated during our non-NAS control experiment, NAS yielded a substantially higher proportion of reference-mapped mtDNA reads, greatly streamlining downstream mitogenome assembly and annotation. The NAS-assembled mitogenomes ranged in length from 15,582 to 16,045 bp, contained between 78.1% and 79.0% A + T content and shared the anticipated arrangement of 13 protein-coding genes, two ribosomal RNAs, and 22 transfer RNAs. Maximum likelihood phylogenies were generated to further characterize each insect species. Additionally, vertebrate blood-meal analysis was successful in three samples sequenced, with mtDNA-based phylogenetic analyses revealing that blood-meal sources for Chrysops niger, Culex restuans and Aedes trivittatus were human, house sparrow (Passer domesticus) and eastern cottontail rabbit (Sylvilagus floridanus), respectively. Conclusions: Our findings show that NAS has dual utility to simultaneously molecularly identify hematophagous insects and their blood-meal hosts. Moreover, our data indicate NAS can facilitate a wide array of mitogenomic systematic studies through novel 'phylogenetic capture' methods. We conclude that the NAS approach has great potential for broadly improving genomic resources used to identify blood-feeding insects, answer phylogenetic questions and elucidate complex pathways for the transmission of vector-borne pathogens.
MeSH term(s)	Rabbits ; Animals ; Humans ; Genome, Mitochondrial ; Nanopores ; Phylogeny ; Mosquito Vectors ; Deer ; Culex/genetics ; Aedes/genetics ; Vertebrates ; DNA, Mitochondrial/genetics
Chemical Substances	DNA, Mitochondrial
Language	English
Publishing date	2023-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2409480-8
ISSN	1756-3305 ; 1756-3305
ISSN (online)	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-023-05679-3
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Article ; Online: Within arm's reach: The role of proximity in speech generating device use of ambulatory children with autism.

Baker, Alison / Bean, Allison / Cargill, Lindsey Paden / Lyle, Samantha

International journal of speech-language pathology

2021 Volume 24, Issue 1, Page(s) 88–96

Abstract: Purpose: ...

Abstract	Purpose:
MeSH term(s)	Arm ; Autism Spectrum Disorder/complications ; Autistic Disorder ; Child ; Communication Aids for Disabled ; Humans ; Speech
Language	English
Publishing date	2021-08-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2402483-1
ISSN	1754-9515 ; 1754-9507
ISSN (online)	1754-9515
ISSN	1754-9507
DOI	10.1080/17549507.2021.1961861
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Article: Bone Cements Used in Vertebral Augmentation: A State-of-the-art Narrative Review.

Williams, Tyree D / Adler, Talia / Smokoff, Lindsey / Kaur, Anmoldeep / Rodriguez, Benjamin / Prakash, Kavita Jyoti / Redzematovic, Edib / Baker, Turner S / Rapoport, Benjamin I / Yoon, Edward S / Beall, Douglas P / Dordick, Jonathan S / De Leacy, Reade A

Journal of pain research

2024 Volume 17, Page(s) 1029–1040

Abstract: Vertebral compression fractures (VCFs) are common in osteoporotic patients, with a frequency projected to increase alongside a growing geriatric population. VCFs often result in debilitating back pain and decreased mobility. Cement augmentation, a ... ...

Abstract	Vertebral compression fractures (VCFs) are common in osteoporotic patients, with a frequency projected to increase alongside a growing geriatric population. VCFs often result in debilitating back pain and decreased mobility. Cement augmentation, a minimally invasive surgical technique, is widely used to stabilize fractures and restore vertebral height. Acrylic-based cements and calcium phosphate cements are currently the two primary fill materials utilized for these procedures. Despite their effectiveness, acrylic bone cements and calcium phosphate cements have been associated with various intraoperative and postoperative incidents impacting VCF treatment. Over the past decade, discoveries in the field of biomedical engineering and material science have shown advancements toward addressing these limitations. This narrative review aims to assess the potential pitfalls and barriers of the various types of bone cements.
Language	English
Publishing date	2024-03-13
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2495284-9
ISSN	1178-7090
ISSN	1178-7090
DOI	10.2147/JPR.S437827
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Article ; Online: Generation and Culture of Tumor and Metastatic Organoids from Murine Models of Pancreatic Ductal Adenocarcinoma.

Baker, Lindsey A / Tuveson, David A

Methods in molecular biology (Clifton, N.J.)

2018 Volume 1882, Page(s) 117–133

Abstract: Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy that is refractory to all current therapies. Research into the mechanisms driving this cancer is the key to developing better diagnostic and treatment options which are urgently needed in the ... ...

Abstract	Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy that is refractory to all current therapies. Research into the mechanisms driving this cancer is the key to developing better diagnostic and treatment options which are urgently needed in the clinic. Genetically engineered mouse models of PDA have been valuable research tools, enabling studies of all stages of PDA progression. However, these models are difficult and time-consuming to breed, and engineering further mutations into these models requires additional time. Recently, organoid cultures of PDA have emerged as alternative models for this disease. Organoids can be rapidly generated from mouse models of PDA and enable genetic and biochemical perturbation of all stages of PDA progression. Here, we describe the generation and propagation of organoid models from PDA tumors and metastases harvested from genetically engineered mouse models.
MeSH term(s)	Animals ; Carcinoma, Pancreatic Ductal/pathology ; Cryopreservation/instrumentation ; Cryopreservation/methods ; Disease Models, Animal ; Humans ; Mice ; Organoids/pathology ; Pancreatic Neoplasms/pathology ; Primary Cell Culture/instrumentation ; Primary Cell Culture/methods ; Tumor Cells, Cultured
Language	English
Publishing date	2018-10-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-8879-2_10
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Article ; Online: Desirability of Outcome Ranking and Response Adjusted for Antibiotic Risk (DOOR/RADAR) Post Hoc Analysis Supports Equipoise for Antibiotic Initiation Strategies in Intensive Care Unit-Acquired Pneumonia.

Guidry, Christopher A / Chollet-Hinton, Lynn / Baker, Jordan / O'Dell, Jacob C / Beyene, Robel T / Watson, Christopher M / Sawyer, Robert G / Simpson, Steven Q / Atchison, Leanne / Derickson, Michael / Cooper, Lindsey C / Pennington, G Patton / VandenBerg, Sheri / Halimeh, Bachar N

Surgical infections

2024 Volume 25, Issue 3, Page(s) 221–224

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Anti-Bacterial Agents/therapeutic use ; Pneumonia, Ventilator-Associated/drug therapy ; Pilot Projects ; Intensive Care Units
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1440120-4
ISSN	1557-8674 ; 1096-2964
ISSN (online)	1557-8674
ISSN	1096-2964
DOI	10.1089/sur.2023.367
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Zs.A 5617: Show issues

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Article ; Online: Home enteral nutrition: A descriptive study.

Mundi, Manpreet S / Mohamed Elfadil, Osman / Olson, Danelle A / Pattinson, Adele K / Epp, Lisa M / Miller, Lisa D / Seegmiller, Sara L / Schneckloth, Jill M / Baker, Margaret R / Abdelmagid, Marwa G / Patel, Ankitaben / Wescott, Bethaney A / Elder, Lindsey S / Hagenbrock, Martha C / Sefried, Lindsey E / Hurt, Ryan T

JPEN. Journal of parenteral and enteral nutrition

2023 Volume 47, Issue 4, Page(s) 550–562

Abstract: Background: With data demonstrating benefit, the prevalence of home enteral nutrition (HEN) has increased significantly over the last few decades. Despite this increase, there remains a paucity of data regarding real-world use of HEN including clinical ... ...

Abstract	Background: With data demonstrating benefit, the prevalence of home enteral nutrition (HEN) has increased significantly over the last few decades. Despite this increase, there remains a paucity of data regarding real-world use of HEN including clinical outcomes and complications. Methods: Descriptive analysis of prospectively maintained database of our specialized HEN program was undertaken. Patients who received care in our program with HEN initiation date between January 1, 2018, and December 31, 2020, were included in the analysis. Data regarding demographic information, anthropometrics, enteral nutrition (EN) regimen, electrolytes, and nutrition therapy history were included and tracked until July 31, 2021. Results: During the study period, 1600 patients initiated HEN treatment under our care. Majority of the study population needed EN therapy due to malignancy and its complications, including malignant dysphagia or mechanical obstruction (60.6%) followed by neurodegenerative diseases (7.5%). By the end of the study period, a majority of the patients (82%) stopped HEN treatment. Of these, 44.2% achieved EN goals and/or oral autonomy. Patients continued HEN treatment for a median of 100 (interquartile range, 32-301) days. Overall, 53.2% of patients experienced/reported at least one HEN-related complication that was clinically managed by the HEN team. Complications included tube-related, enteral feeding intolerance (EFI), and electrolyte shifts. Conclusion: In our study population, HEN was most utilized to manage malignancy-related complications, including dysphagia. Unfortunately, complications, including EFI and tube-related complications, remained quite prevalent. Further evaluation regarding risk factors for complications and preventive mechanisms, such as increased education, is indicated.
MeSH term(s)	Humans ; Infant, Newborn ; Enteral Nutrition/adverse effects ; Deglutition Disorders/etiology ; Deglutition Disorders/therapy ; Home Care Services ; Neoplasms/complications ; Neoplasms/therapy
Language	English
Publishing date	2023-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	800861-9
ISSN	1941-2444 ; 0148-6071
ISSN (online)	1941-2444
ISSN	0148-6071
DOI	10.1002/jpen.2498
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Zs.A 1524: Show issues

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Article ; Online: Generation and Culture of Human Pancreatic Ductal Adenocarcinoma Organoids from Resected Tumor Specimens.

Baker, Lindsey A / Tiriac, Hervé / Tuveson, David A

Methods in molecular biology (Clifton, N.J.)

2018 Volume 1882, Page(s) 97–115

Abstract: The recent development of human organoids as patient-specific models of pancreatic ductal adenocarcinoma (PDA) has helped set the stage for a new era of personalized medicine. Organoids can be generated from a resected PDA tumor in as little as 2-4 weeks, ...

Abstract	The recent development of human organoids as patient-specific models of pancreatic ductal adenocarcinoma (PDA) has helped set the stage for a new era of personalized medicine. Organoids can be generated from a resected PDA tumor in as little as 2-4 weeks, and are amenable to therapeutic screening as well as genetic and biochemical perturbation. Moreover, because these models promote the propagation of the neoplastic PDA cells at the expense of the stromal cells, transcriptome and genome-wide sequencing of organoids offers an unprecedented view of the genetic and expression changes occurring in the neoplastic cells of individual tumors. Here, we describe methods to generate PDA organoid cultures from resected human tumor specimens. We also describe how to propagate, cryopreserve, and thaw human PDA organoid cultures.
MeSH term(s)	Carcinoma, Pancreatic Ductal/pathology ; Carcinoma, Pancreatic Ductal/surgery ; Cell Culture Techniques/instrumentation ; Cell Culture Techniques/methods ; Cryopreservation/instrumentation ; Cryopreservation/methods ; Humans ; Organoids/pathology ; Pancreas/pathology ; Pancreas/surgery ; Pancreatectomy ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Tumor Cells, Cultured
Language	English
Publishing date	2018-10-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-8879-2_9
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