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Article: A Study of Substrate Variability and the Distribution of Opuntia cespitosa (Cactaceae) from Southern Ohio to Central Alabama, USA

Drezner, Taly Dawn

Journal of the Arizona-Nevada Academy of Science. 2020 Oct. 9, v. 49, no. 1

2020

Abstract: ... were sampled for %O.M. (organic matter), %sand, %silt, %clay, pH, and kg/ha of P, K, Ca, Mg, and Zn ...

Abstract	Opuntia cespitosa (Cactaceae, previously known under the synonym O. humifusa) is found over eastern North America, yet its populations are very sparse and small despite effective vegetative reproduction. Their edaphic preferences are poorly known, and may limit the distribution and success of the species. Soils were sampled for %O.M. (organic matter), %sand, %silt, %clay, pH, and kg/ha of P, K, Ca, Mg, and Zn in 33 populations over a wide area of eastern North America. Tissue testing was carried out in three populations. Opuntia cespitosa occurs over a wide variety of nutrient conditions and soil textures, including both acidic and alkaline soils, though soil nutrients were generally poor and thin. Populations of the species occurred on soils with very high levels of calcium that could be toxic for other plants, exceeding 20,000 kg/ha in some areas. Plants in these areas also had high Ca tissue levels, also common in desert cacti. Kruskal-Wallis and Spearman′s correlation results suggest that population size was not related to the soil attributes tested, but does indicate that areas mowed by large mowers have larger populations. This may be the result of local vegetative spread of fragments by mowers.
Keywords	asexual reproduction ; calcium ; organic matter ; pH ; population size ; toxicity ; Alabama ; Ohio
Language	English
Dates of publication	2020-1009
Size	p. 22-28.
Publishing place	Arizona-Nevada Academy of Science
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2237858-3
ISSN	1533-6085 ; 0193-8509
ISSN (online)	1533-6085
ISSN	0193-8509
DOI	10.2181/036.049.0103
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Exercise recommendations in athletes with coronary artery calcification.

Lechner, Katharina / Halle, Martin / Scherr, Johannes / Drezner, Jonathan A

European journal of preventive cardiology

2019 Volume 27, Issue 8, Page(s) 882–884

MeSH term(s)	Athletes ; Cardiovascular Agents/therapeutic use ; Computed Tomography Angiography ; Coronary Angiography ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/mortality ; Coronary Artery Disease/physiopathology ; Coronary Artery Disease/therapy ; Death, Sudden, Cardiac/prevention & control ; Exercise ; Humans ; Predictive Value of Tests ; Prognosis ; Protective Factors ; Risk Assessment ; Risk Factors ; Risk Reduction Behavior ; Vascular Calcification/diagnostic imaging ; Vascular Calcification/mortality ; Vascular Calcification/physiopathology ; Vascular Calcification/therapy
Chemical Substances	Cardiovascular Agents
Language	English
Publishing date	2019-10-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2626011-6
ISSN	2047-4881 ; 2047-4873
ISSN (online)	2047-4881
ISSN	2047-4873
DOI	10.1177/2047487319881700
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Zs.A 4686: Show issues

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Article ; Online: HIV Prevention Services for Hispanic/Latino Persons in THRIVE, 2015-2020.

Bonacci, Robert A / Tanner, Mary R / Zhu, Weiming / Hayes, Tameka / Dominguez, Kenneth L / Iqbal, Kashif / Wiener, Jeffrey / Drezner, Kate / Jennings, Jacky M / Tsoi, Benjamin / Wendell, Debbie / Hoover, Karen W

American journal of preventive medicine

2023 Volume 65, Issue 2, Page(s) 213–220

Abstract: Introduction: Hispanic/Latino men who have sex with men (MSM) and transgender women (TGW) are disproportionately affected by HIV in the U.S. This study evaluated HIV prevention services and outcomes among Hispanic/Latino MSM and TGW in the Targeted ... ...

Abstract	Introduction: Hispanic/Latino men who have sex with men (MSM) and transgender women (TGW) are disproportionately affected by HIV in the U.S. This study evaluated HIV prevention services and outcomes among Hispanic/Latino MSM and TGW in the Targeted Highly Effective Interventions to Reduce the HIV Epidemic (THRIVE) demonstration project and consider lessons learned. Methods: The authors described the THRIVE demonstration project services provided to Hispanic/Latino MSM and TGW in 7 U.S. jurisdictions from 2015 to 2020. HIV prevention service outcomes were compared between 1 site with (2,147 total participants) and 6 sites without (1,129 total participants) Hispanic/Latino-oriented pre-exposure prophylaxis clinical services, and Poisson regression was used to estimate the adjusted RR between sites and pre-exposure prophylaxis outcomes. Analyses were conducted from 2021 to 2022. Results: The THRIVE demonstration project served 2,898 and 378 Hispanic/Latino MSM and TGW, respectively, with 2,519 MSM (87%) and 320 TGW (85%) receiving ≥1 HIV screening test. Among 2,002 MSM and 178 TGW eligible for pre-exposure prophylaxis, 1,011 (50%) MSM and 98 (55%) TGW received pre-exposure prophylaxis prescriptions, respectively. MSM and TGW were each 2.0 times more likely to be linked to pre-exposure prophylaxis (95% CI=1.4, 2.9 and 95% CI=1.2, 3.6, respectively) and 1.6 and 2.1 times more likely to be prescribed pre-exposure prophylaxis (95% CI=1.1, 2.2 and 95% CI=1.1, 4.1), respectively, at the site providing Hispanic/Latino-oriented pre-exposure prophylaxis clinical services than at other sites and adjusted for age group. Conclusions: The THRIVE demonstration project delivered comprehensive HIV prevention services to Hispanic/Latino MSM and TGW. Hispanic/Latino-oriented clinical settings may improve HIV prevention service delivery to persons in Hispanic/Latino communities.
MeSH term(s)	Female ; Humans ; Male ; Hispanic or Latino ; HIV Infections/epidemiology ; HIV Infections/ethnology ; HIV Infections/prevention & control ; Homosexuality, Male ; Sexual and Gender Minorities ; Transgender Persons ; Pre-Exposure Prophylaxis ; Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/therapeutic use
Chemical Substances	Anti-HIV Agents
Language	English
Publishing date	2023-03-03
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	632646-8
ISSN	1873-2607 ; 0749-3797
ISSN (online)	1873-2607
ISSN	0749-3797
DOI	10.1016/j.amepre.2023.01.042
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Zs.A 2096: Show issues

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Article ; Online: US Food and Drug Administration Approval Summary: Nivolumab Plus Platinum-Doublet Chemotherapy for the Neoadjuvant Treatment of Patients With Resectable Non-Small-Cell Lung Cancer.

Akinboro, Oladimeji / Drezner, Nicole / Amatya, Anup / Runyan, Jin / Fourie-Zirkelbach, Jeanne / Zhao, Miao / Bi, Youwei / Korsah, Kwadwo / Mixter, Bronwyn / Tang, Shenghui / Larkins, Erin / Pazdur, Richard / Beaver, Julia A / Singh, Harpreet

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2023 Volume 41, Issue 17, Page(s) 3249–3259

Abstract: Purpose: On March 4, 2022, the US Food and Drug Administration (FDA) approved nivolumab plus platinum-doublet chemotherapy for the neoadjuvant treatment of patients with resectable non-small-cell lung cancer (NSCLC). We discuss the FDA's review of the ... ...

Abstract	Purpose: On March 4, 2022, the US Food and Drug Administration (FDA) approved nivolumab plus platinum-doublet chemotherapy for the neoadjuvant treatment of patients with resectable non-small-cell lung cancer (NSCLC). We discuss the FDA's review of the key data and regulatory considerations supporting this approval. Patients and methods: The approval was based on the results of CheckMate 816, an international, multiregional, active-controlled trial that randomly assigned 358 patients with resectable NSCLC, stage IB (≥4 cm) to IIIA (N2) per the American Joint Committee on Cancer seventh staging edition to receive either nivolumab plus platinum-doublet or platinum-doublet chemotherapy alone for three cycles before planned surgical resection. The major efficacy end point that supported this approval was event-free survival (EFS). Results: At the first planned interim analysis (IA), the hazard ratio (HR) for EFS was 0.63 (95% CI, 0.45 to 0.87; Conclusion: This approval, the first for any regimen for the neoadjuvant treatment of NSCLC in the United States, was supported by a statistically significant and clinically meaningful improvement in EFS with no evidence of detriment in OS or negative impact on patients' receipt and timing of surgery or surgical outcomes.
MeSH term(s)	Humans ; United States ; Carcinoma, Non-Small-Cell Lung ; Nivolumab/therapeutic use ; Platinum/therapeutic use ; Lung Neoplasms ; Neoadjuvant Therapy ; United States Food and Drug Administration ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Ipilimumab/therapeutic use
Chemical Substances	Nivolumab (31YO63LBSN) ; Platinum (49DFR088MY) ; Ipilimumab
Language	English
Publishing date	2023-05-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.22.02509
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 650: Show issues

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Article ; Online: Sudden Death Associated With Sickle Cell Trait Before and After Mandatory Screening.

Buchanan, Benjamin K / Siebert, David M / Zigman Suchsland, Monica L / Drezner, Jonathan A / Asif, Irfan M / O'Connor, Francis G / Harmon, Kimberly G

Sports health

2020 Volume 12, Issue 3, Page(s) 241–245

Abstract: Background: Sickle cell trait (SCT) has been associated with an increased risk of sudden death in athletes during strenuous exercise. In August 2010, the National Collegiate Athletic Association (NCAA) began requiring athletes to be screened for SCT, ... ...

Abstract	Background: Sickle cell trait (SCT) has been associated with an increased risk of sudden death in athletes during strenuous exercise. In August 2010, the National Collegiate Athletic Association (NCAA) began requiring athletes to be screened for SCT, provide proof of SCT status, or sign a waiver and launched an educational campaign for athletes, coaches, and medical staff. The impact of this program is unknown. The purpose of this study was to determine the incidence of death associated with sickle cell trait (daSCT) in NCAA athletes before and after legislation. Hypothesis: NCAA SCT legislation will decrease the incidence of daSCT. Study design: Observational study. Level of evidence: Level 2. Methods: A database of NCAA athlete deaths from 2000 to 2019 was reviewed for daSCT. A total of 8,309,050 athlete-years (AY) were included. Incidence of death was calculated before and after legislation. Results: The incidence of daSCT in Division I (DI) football athletes before legislation (n = 9) was 1:28,145 AY and after legislation (n = 1) was 1:250,468 AY (relative risk [RR], 0.112; 95% CI, 0.003-0.811; Conclusion: The incidence of daSCT in DI football athletes has decreased significantly since legislation was enacted. Cases of daSCT outside of football are rare. It is unclear whether the decrease is related to screening for SCT, education, or both. Clinical relevance: This is the first evidence that NCAA SCT legislation may save lives.
MeSH term(s)	Adolescent ; Death, Sudden/epidemiology ; Death, Sudden/prevention & control ; Humans ; Incidence ; Male ; Mandatory Testing/legislation & jurisprudence ; Sickle Cell Trait/complications ; Sickle Cell Trait/diagnosis ; Sports/legislation & jurisprudence ; United States/epidemiology ; Young Adult
Language	English
Publishing date	2020-04-09
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	2508802-6
ISSN	1941-0921 ; 1941-7381
ISSN (online)	1941-0921
ISSN	1941-7381
DOI	10.1177/1941738120915690
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Zs.A 6996: Show issues

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Article ; Online: Sudden Death and Catastrophic Injury Reporting: A Call to Action for Athletic Trainers.

Dompier, Thomas P / Kucera, Kristen L / Drezner, Jonathan A / Casa, Douglas J / Register-Mihalik, Johna K / Guskiewicz, Kevin M

Journal of athletic training

2019 Volume 54, Issue 2, Page(s) 122–123

Language	English
Publishing date	2019-01-22
Publishing country	United States
Document type	Editorial
ZDB-ID	2070051-9
ISSN	1938-162X ; 1062-6050
ISSN (online)	1938-162X
ISSN	1062-6050
DOI	10.4085/1062-6050-77-18
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Article: Tumor-induced osteomalacia.

Drezner, M K

Reviews in endocrine & metabolic disorders

2001 Volume 2, Issue 2, Page(s) 175–186

MeSH term(s)	Animals ; Humans ; Neoplasms/complications ; Neoplasms/metabolism ; Osteomalacia/diagnosis ; Osteomalacia/etiology ; Osteomalacia/metabolism ; Osteomalacia/physiopathology ; Osteomalacia/therapy
Language	English
Publishing date	2001-10-29
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2185718-0
ISSN	1389-9155
ISSN	1389-9155
DOI	10.1023/a:1010006811394
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Zs.A 6069: Show issues

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Article: Multiple Fungal Metabolites Including Mycotoxins in Naturally Infected and

Spanic, Valentina / Katanic, Zorana / Sulyok, Michael / Krska, Rudolf / Puskas, Katalin / Vida, Gyula / Drezner, Georg / Šarkanj, Bojan

Microorganisms

2020 Volume 8, Issue 4

Abstract: In this study, the occurrence of multiple fungal metabolites including mycotoxins was determined in four different winter wheat varieties in a field experiment in Croatia. One group was naturally infected, while the second group was inoculated with ... ...

Abstract	In this study, the occurrence of multiple fungal metabolites including mycotoxins was determined in four different winter wheat varieties in a field experiment in Croatia. One group was naturally infected, while the second group was inoculated with a
Language	English
Publishing date	2020-04-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms8040578
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Article ; Online: Electrocardiogram interpretation in college athletes: Local institution versus sports cardiology center interpretation.

Petek, Bradley J / Drezner, Jonathan A / Prutkin, Jordan M / Owens, David S / Tran, Tomio / Harmon, Kimberly G

Journal of electrocardiology

2020 Volume 62, Page(s) 49–56

Abstract: ... interpretation agreement and substantial interobserver reliability (k = 0.611, p < .001) between local and SCC-SC ...

Abstract	Background: Electrocardiogram (ECG) screening in athletes enhances the detection of conditions associated with sudden cardiac death (SCD), but concerns remain for false positive results when conducted outside of specialized centers. This study compared ECG interpretation in college athletes between local physicians and a sports cardiology center (SCC). Methods: Screening ECGs in athletes from eight Pacific-12 Conference institutions performed between 2010 and 2016 were included. Local interpretation was compared to SCC interpretation using both the Seattle Criteria (SCC-SC) and the International Criteria (SCC-IC). Results: A total of 2445 athlete ECGs (mean age 18.5 years; 57.1% male; 63.2% Caucasian and 15.3% African American) were reviewed. The proportion of ECGs classified as abnormal was similar between local and SCC-SC interpretation (3.5% vs. 3.4%, respectively; p = .94), but was lower by SCC-IC interpretation (1.5%, p < .001). ECG abnormalities interpreted as normal by local physicians but as abnormal by SCC-SC (n = 33) and SCC-IC (n = 16) standards included: pathological Q waves (n = 15 SCC-SC; n = 3 SCC-IC), T-wave inversions (n = 8 both), and ST-depressions (n = 3 both). There was a 97.5% ECG interpretation agreement and substantial interobserver reliability (k = 0.611, p < .001) between local and SCC-SC interpretation in athletes screened starting one year after publication of the Seattle Criteria (n = 1388). Both local and SCC physicians correctly identified six abnormal ECGs associated with conditions at risk of SCD. Conclusions: ECG interpretation by local physicians at college universities had similar accuracy compared to a specialized SCC with a low overall abnormal rate, similar sensitivity, and substantial interobserver reliability. Uniform application of current ECG interpretation standards is recommended to further improve accuracy.
MeSH term(s)	Adolescent ; Athletes ; Cardiology ; Death, Sudden, Cardiac ; Electrocardiography ; Female ; Humans ; Male ; Mass Screening ; Reproducibility of Results
Language	English
Publishing date	2020-08-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	410286-1
ISSN	1532-8430 ; 0022-0736
ISSN (online)	1532-8430
ISSN	0022-0736
DOI	10.1016/j.jelectrocard.2020.08.002
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Zs.A 701: Show issues

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Article: PHEX gene and hypophosphatemia.

Drezner, M K

Kidney international

2000 Volume 57, Issue 1, Page(s) 9–18

Abstract: PHEX gene and hypophosphatemia. X-linked hypophosphatemia (XLH) and tumor-induced osteomalacia (TIO) are diseases that have in common abnormal proximal renal tubular function resulting in increased renal clearance of inorganic phosphorus and ... ...

Abstract	PHEX gene and hypophosphatemia. X-linked hypophosphatemia (XLH) and tumor-induced osteomalacia (TIO) are diseases that have in common abnormal proximal renal tubular function resulting in increased renal clearance of inorganic phosphorus and hypophosphatemia. The recent discovery of the PHEX gene has provided new insights to these disorders. In this regard, identification of the PHEX gene product as a membrane-bound endopeptidase suggests that the pathophysiologic cascade underlying XLH likely involves inactivation mutations of the gene causing a failure to clear an active hormone, phosphatonin, from the circulation. The presence of this hormone through unknown mechanisms decreases the sodium-dependent phosphate cotransporter in the kidney, resulting in impaired phosphate transport. In contrast, TIO likely evolves secondary to tumor overproduction of the putative phosphatonin, which exerts physiologic function despite efforts to counteract the resultant hypophosphatemia with overproduction of PHEX transcripts that are insufficient to accommodate the enhanced substrate load. These potential pathophysiologic mechanisms for XLH and TIO provide valuable inroads to understanding phosphate homeostasis, as well as vitamin D metabolism, bone mineralization, and calcium metabolism.
MeSH term(s)	Humans ; Hypophosphatemia/genetics ; PHEX Phosphate Regulating Neutral Endopeptidase ; Phenotype ; Proteins/genetics
Chemical Substances	Proteins ; PHEX Phosphate Regulating Neutral Endopeptidase (EC 3.4.24.-) ; PHEX protein, human (EC 3.4.24.-)
Language	English
Publishing date	2000-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1046/j.1523-1755.2000.00807.x
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