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  1. Article ; Online: PI3K/AKT signaling pathway: a possible target for adjuvant therapy in COVID-19.

    Khezri, Mohammad Rafi

    Human cell

    2021  Volume 34, Issue 2, Page(s) 700–701

    MeSH term(s) Antiviral Agents/therapeutic use ; Azithromycin/pharmacology ; Azithromycin/therapeutic use ; COVID-19/drug therapy ; COVID-19/metabolism ; Chemotherapy, Adjuvant ; Humans ; Inflammation Mediators/metabolism ; Interleukin-6/metabolism ; NF-kappa B/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; Transcription Factor AP-1/metabolism ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Antiviral Agents ; Inflammation Mediators ; Interleukin-6 ; NF-kappa B ; Transcription Factor AP-1 ; Tumor Necrosis Factor-alpha ; Azithromycin (83905-01-5) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2021-01-11
    Publishing country Japan
    Document type Letter
    ZDB-ID 1149134-6
    ISSN 1749-0774 ; 0914-7470
    ISSN (online) 1749-0774
    ISSN 0914-7470
    DOI 10.1007/s13577-021-00484-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3676: Show issues Location:
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  2. Article ; Online: Gut microbiota and circadian rhythm in Alzheimer's disease pathophysiology: a review and hypothesis on their association.

    Khezri, Mohammad Rafi / Ghasemnejad-Berenji, Morteza

    npj aging

    2023  Volume 9, Issue 1, Page(s) 9

    Abstract: Alzheimer's disease (AD) is the most common neurodegenerative disease and the leading cause of dementia worldwide. Different pathologic changes have been introduced to be involved in its progression. Although amyloid-β (Aβ) deposition and tau ... ...

    Abstract Alzheimer's disease (AD) is the most common neurodegenerative disease and the leading cause of dementia worldwide. Different pathologic changes have been introduced to be involved in its progression. Although amyloid-β (Aβ) deposition and tau hyperphosphorylation and aggregation are mainly considered the main characterizations of AD, several other processes are involved. In recent years, several other changes, including alterations in gut microbiota proportion and circadian rhythms, have been noticed due to their role in AD progression. However, the exact mechanism indicating the association between circadian rhythms and gut microbiota abundance has not been investigated yet. This paper aims to review the role of gut microbiota and circadian rhythm in AD pathophysiology and introduces a hypothesis to explain their association.
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2731-6068
    ISSN (online) 2731-6068
    DOI 10.1038/s41514-023-00104-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Probable Mechanism of Hair Loss in Patients With COVID-19.

    Khezri, Mohammad Rafi / Ghasemnejad-Berenji, Morteza

    The American Journal of dermatopathology

    2022  Volume 44, Issue 7, Page(s) 539–541

    MeSH term(s) Alopecia ; COVID-19 ; Humans
    Language English
    Publishing date 2022-02-15
    Publishing country United States
    Document type Letter
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000002145
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  4. Article ; Online: The PI3K/AKT Signaling Pathway and Caspase-3 in Alzheimer's Disease: Which One Is the Beginner?

    Khezri, Mohammad Rafi / Ghasemnejad-Berenji, Morteza / Moloodsouri, Donya

    Journal of Alzheimer's disease : JAD

    2023  Volume 92, Issue 2, Page(s) 391–393

    Abstract: One of the main players in apoptosis during Alzheimer's disease progression are different members of caspase family of proteases. The most well-known member of this family is caspase-3, in which alterations of its levels have been detected in samples ... ...

    Abstract One of the main players in apoptosis during Alzheimer's disease progression are different members of caspase family of proteases. The most well-known member of this family is caspase-3, in which alterations of its levels have been detected in samples from Alzheimer's disease patients. There are numerous intracellular factors involved in regulation of cellular apoptosis through regulation of caspase-3 activity, the most important of which is the PI3K/AKT signaling pathway. This commentary tries to highlight the probable relations between PI3K/AKT signaling pathway and caspase-3 in Alzheimer's disease.
    MeSH term(s) Humans ; Alzheimer Disease/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Caspase 3/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Signal Transduction ; Apoptosis/physiology
    Chemical Substances Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Caspase 3 (EC 3.4.22.-) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
    Language English
    Publishing date 2023-02-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-221157
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    Zs.A 6084: Show issues Location:
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  5. Article ; Online: Bmal1 and Gut-lung axis in SARS-CoV-2 infection: New insight into the effects of melatonin on COVID-19 patients?

    Khezri, Mohammad Rafi / Varzandeh, Reza / Ghasemnejad-Berenji, Morteza

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 164, Page(s) 114291

    Abstract: Coronavirus disease 2019 (COVID-19), is known as one of the most known challenge worldwide. Numerous studies have tried to introduce different mechanisms involved in the pathophysiology of COVID-19 and efforts in this field are also ongoing. The presence ...

    Abstract Coronavirus disease 2019 (COVID-19), is known as one of the most known challenge worldwide. Numerous studies have tried to introduce different mechanisms involved in the pathophysiology of COVID-19 and efforts in this field are also ongoing. The presence of SARS-CoV-2 RNA in feces of COVID-19 patients along with a variety of gastrointestinal symptoms may show a significant association between gut microbiota and SARS-CoV-2 infection. However, the exact mechanism indicating how SARS-CoV-2 and gut flora influence each other remains unknown. This paper aims to introduce a possible molecular mechanism based on recent findings on the association between circadian rhythm and gut flora in COVID-19 patients to express a new insight into the probable mechanism of melatonin in protection against SARS-CoV-2 infection.
    MeSH term(s) Humans ; COVID-19 ; Gastrointestinal Tract ; Lung ; Melatonin/metabolism ; Melatonin/pharmacology ; Melatonin/therapeutic use ; RNA, Viral ; SARS-CoV-2
    Chemical Substances Melatonin (JL5DK93RCL) ; RNA, Viral ; BMAL1 protein, human
    Language English
    Publishing date 2023-01-23
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.114291
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  6. Article ; Online: Role of Bmal1 and Gut Microbiota in Alzheimer's Disease and Parkinson's Disease Pathophysiology: The Probable Effect of Melatonin on Their Association.

    Khezri, Mohammad Rafi / Esmaeili, Ayda / Ghasemnejad-Berenji, Morteza

    ACS chemical neuroscience

    2023  Volume 14, Issue 21, Page(s) 3883–3893

    Abstract: In recent years, the role of new factors in the pathophysiology of neurodegenerative diseases has been investigated. Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases worldwide. Although pathological ... ...

    Abstract In recent years, the role of new factors in the pathophysiology of neurodegenerative diseases has been investigated. Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases worldwide. Although pathological changes such as the accumulation of aggregated proteins in the brain and inflammatory responses are known as the main factors involved in the development of these diseases, new studies show the role of gut microbiota and circadian rhythm in the occurrence of these changes. However, the association between circadian rhythm and gut microbiota in AD and PD has not yet been investigated. Recent results propose that alterations in circadian rhythm regulators, mainly Bmal1, may regulate the abundance of gut microbiota. This correlation has been linked to the regulation of the expression of immune-related genes and Bmal-1 mediated oscillation of IgA and hydrogen peroxide production. These data seem to provide new insight into the molecular mechanism of melatonin inhibiting the progression of AD and PD. Therefore, this manuscript aims to review the role of the gut microbiota and circadian rhythm in health and AD and PD and also presents a hypothesis on the effect of melatonin on their communication.
    MeSH term(s) Humans ; Alzheimer Disease/drug therapy ; Parkinson Disease/drug therapy ; Gastrointestinal Microbiome/physiology ; Melatonin/metabolism ; Neurodegenerative Diseases
    Chemical Substances Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.3c00418
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  7. Article ; Online: Therapeutic potential of ADAM10 modulation in Alzheimer's disease: a review of the current evidence.

    Khezri, Mohammad Rafi / Mohebalizadeh, Mehdi / Ghasemnejad-Berenji, Morteza

    Cell communication and signaling : CCS

    2023  Volume 21, Issue 1, Page(s) 60

    Abstract: Alzheimer's disease (AD), the most common neurodegenerative disease worldwide, is caused by loss of neurons and synapses in central nervous system. Several causes for neuronal death in AD have been introduced, the most important of which are ... ...

    Abstract Alzheimer's disease (AD), the most common neurodegenerative disease worldwide, is caused by loss of neurons and synapses in central nervous system. Several causes for neuronal death in AD have been introduced, the most important of which are extracellular amyloid β (Aβ) accumulation and aggregated tau proteins. Increasing evidence suggest that targeting the process of Aβ production to reduce its deposition can serve as a therapeutic option for AD management. In this regard, therapeutic interventions shown that a disintegrin and metalloproteinase domain-containing protein (ADAM) 10, involved in non-amyloidogenic pathway of amyloid precursor protein processing, is known to be a suitable candidate. Therefore, this review aims to examine the molecular properties of ADAM10, its role in AD, and introduce it as a therapeutic target to reduce the progression of the disease. Video abstract.
    MeSH term(s) Humans ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Neurodegenerative Diseases ; Amyloid beta-Protein Precursor/metabolism ; ADAM10 Protein ; Amyloid Precursor Protein Secretases/metabolism ; Membrane Proteins/metabolism
    Chemical Substances Amyloid beta-Peptides ; Amyloid beta-Protein Precursor ; ADAM10 Protein (EC 3.4.24.81) ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; ADAM10 protein, human (EC 3.4.24.81) ; Membrane Proteins
    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Video-Audio Media ; Journal Article ; Review
    ZDB-ID 2126315-2
    ISSN 1478-811X ; 1478-811X
    ISSN (online) 1478-811X
    ISSN 1478-811X
    DOI 10.1186/s12964-023-01072-w
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  8. Article ; Online: The pharmacological effects of Berberine and its therapeutic potential in different diseases: Role of the phosphatidylinositol 3-kinase/AKT signaling pathway.

    Khezri, Mohammad Rafi / Mohammadipanah, Somayeh / Ghasemnejad-Berenji, Morteza

    Phytotherapy research : PTR

    2023  Volume 38, Issue 1, Page(s) 349–367

    Abstract: The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway plays a central role in cell growth and survival and is disturbed in various pathologies. The PI3K is a kinase that generates phosphatidylinositol-3,4,5-trisphosphate (PI (3-5) P3), as a ... ...

    Abstract The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway plays a central role in cell growth and survival and is disturbed in various pathologies. The PI3K is a kinase that generates phosphatidylinositol-3,4,5-trisphosphate (PI (3-5) P3), as a second messenger responsible for the translocation of AKT to the plasma membrane and its activation. However, due to the crucial role of the PI3K/AKT pathway in regulation of cell survival processes, it has been introduced as a main therapeutic target for natural compounds during the progression of different pathologies. Berberine, a plant-derived isoquinone alkaloid, is known because of its anti-inflammatory, antioxidant, antidiabetic, and antitumor properties. The effect of this natural compound on cell survival processes has been shown to be mediated by modulation of the intracellular pathways. However, the effects of this natural compound on the PI3K/AKT pathway in various pathologies have not been reviewed so far. Therefore, this paper aims to review the PI3K/AKT-mediated effects of Berberine in different types of cancer, diabetes, cardiovascular, and central nervous system diseases.
    MeSH term(s) Phosphatidylinositol 3-Kinase/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Berberine/pharmacology ; Berberine/therapeutic use ; Phosphatidylinositol 3-Kinases/metabolism ; Signal Transduction
    Chemical Substances Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Berberine (0I8Y3P32UF) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
    Language English
    Publishing date 2023-11-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.8040
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    Zs.B 3092: Show issues Location:
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  9. Article ; Online: The interplay between the PI3K/AKT pathway and circadian clock in physiologic and cancer-related pathologic conditions.

    Khezri, Mohammad Rafi / Hsueh, Hsiang-Yin / Mohammadipanah, Somayeh / Khalili Fard, Javad / Ghasemnejad-Berenji, Morteza

    Cell proliferation

    2024  , Page(s) e13608

    Abstract: The circadian clock is responsible for the regulation of different cellular processes, and its disturbance has been linked to the development of different diseases, such as cancer. The main molecular mechanism for this issue has been linked to the ... ...

    Abstract The circadian clock is responsible for the regulation of different cellular processes, and its disturbance has been linked to the development of different diseases, such as cancer. The main molecular mechanism for this issue has been linked to the crosstalk between core clock regulators and intracellular pathways responsible for cell survival. The PI3K/AKT signalling pathway is one of the most known intracellular pathways in the case of cancer initiation and progression. This pathway regulates different aspects of cell survival including proliferation, apoptosis, metabolism, and response to environmental stimuli. Accumulating evidence indicates that there is a link between the PI3K/AKT pathway activity and circadian rhythm in physiologic and cancer-related pathogenesis. Different classes of PI3Ks and AKT isoforms are involved in regulating circadian clock components in a transcriptional and functional manner. Reversely, core clock components induce a rhythmic fashion in PI3K and AKT activity in physiologic and pathogenic conditions. The aim of this review is to re-examine the interplay between this pathway and circadian clock components in normal condition and cancer pathogenesis, which provides a better understanding of how circadian rhythms may be involved in cancer progression.
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1064202-x
    ISSN 1365-2184 ; 0008-8730 ; 0960-7722
    ISSN (online) 1365-2184
    ISSN 0008-8730 ; 0960-7722
    DOI 10.1111/cpr.13608
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    Zs.A 532: Show issues Location:
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  10. Article ; Online: Therapeutic potential of loureirin A against SARS-CoV-2 infection.

    Khezri, Mohammad Rafi / Moloodsouri, Donya / Hodaei, Darya / Ghasemnejad-Berenji, Morteza

    Phytotherapy research : PTR

    2022  Volume 36, Issue 8, Page(s) 3011–3012

    MeSH term(s) COVID-19/drug therapy ; Chalcones ; Humans ; Resins, Plant ; SARS-CoV-2
    Chemical Substances Chalcones ; Resins, Plant ; loureirin A
    Language English
    Publishing date 2022-03-31
    Publishing country England
    Document type Letter
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.7453
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