LIVIVO - Search results -

Search results

Result 1 - 10 of total 19

Search options

Article ; Online: The implication of the SUMOylation pathway in breast cancer pathogenesis and treatment.

Rabellino, Andrea / Khanna, Kum Kum

Critical reviews in biochemistry and molecular biology

2020 Volume 55, Issue 1, Page(s) 54–70

Abstract: Breast cancer is the most commonly diagnosed malignancy in woman worldwide, and is the second most common cause of death in developed countries. The transformation of a normal cell into a malignant derivate requires the acquisition of diverse genomic and ...

Abstract	Breast cancer is the most commonly diagnosed malignancy in woman worldwide, and is the second most common cause of death in developed countries. The transformation of a normal cell into a malignant derivate requires the acquisition of diverse genomic and proteomic changes, including enzymatic post-translational modifications (PTMs) on key proteins encompassing critical cell signaling events. PTMs occur on proteins after translation, and regulate several aspects of proteins activity, including their localization, activation and turnover. Deregulation of PTMs can potentially lead to tumorigenesis, and several de-regulated PTM pathways contribute to abnormal cell proliferation during breast tumorigenesis. SUMOylation is a PTM that plays a pivotal role in numerous aspects of cell physiology, including cell cycle regulation, protein trafficking and turnover, and DNA damage repair. Consistently with this, the deregulation of the SUMO pathway is observed in different human pathologies, including breast cancer. In this review we will describe the role of SUMOylation in breast tumorigenesis and its implication for breast cancer therapy.
MeSH term(s)	Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Cell Proliferation/genetics ; DNA Damage ; DNA, Neoplasm/genetics ; DNA, Neoplasm/metabolism ; Female ; Humans ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Protein Transport ; Sumoylation
Chemical Substances	DNA, Neoplasm ; Neoplasm Proteins
Language	English
Publishing date	2020-03-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Video-Audio Media
ZDB-ID	1000977-2
ISSN	1549-7798 ; 1381-3455 ; 1040-9238
ISSN (online)	1549-7798
ISSN	1381-3455 ; 1040-9238
DOI	10.1080/10409238.2020.1738332
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1024: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article: RAD51 paralogs promote genomic integrity and chemoresistance in cancer by facilitating homologous recombination.

Harris, Janelle Louise / Rabellino, Andrea / Khanna, Kum Kum

Annals of translational medicine

2019 Volume 6, Issue Suppl 2, Page(s) S122

Language	English
Publishing date	2019-01-22
Publishing country	China
Document type	Editorial ; Comment
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm.2018.12.30
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Roles of Ubiquitination and SUMOylation in the Regulation of Angiogenesis.

Rabellino, Andrea / Andreani, Cristina / Scaglioni, Pier Paolo

Current issues in molecular biology

2019 Volume 35, Page(s) 109–126

Abstract: The generation of new blood vessels from the existing vasculature is a dynamic and complex mechanism known as angiogenesis. Angiogenesis occurs during the entire lifespan of vertebrates and participates in many physiological processes. Furthermore, ... ...

Abstract	The generation of new blood vessels from the existing vasculature is a dynamic and complex mechanism known as angiogenesis. Angiogenesis occurs during the entire lifespan of vertebrates and participates in many physiological processes. Furthermore, angiogenesis is also actively involved in many human diseases and disorders, including cancer, obesity and infections. Several inter-connected molecular pathways regulate angiogenesis, and post-translational modifications, such as phosphorylation, ubiquitination and SUMOylation, tightly regulate these mechanisms and play a key role in the control of the process. Here, we describe in detail the roles of ubiquitination and SUMOylation in the regulation of angiogenesis.
MeSH term(s)	Animals ; Endothelial Cells/enzymology ; Endothelial Cells/metabolism ; Humans ; Neovascularization, Pathologic/enzymology ; Neovascularization, Pathologic/metabolism ; Neovascularization, Physiologic/genetics ; Neovascularization, Physiologic/physiology ; Phosphorylation ; Protein Processing, Post-Translational/genetics ; Protein Processing, Post-Translational/physiology ; Receptors, Notch/genetics ; Receptors, Notch/metabolism ; Receptors, Vascular Endothelial Growth Factor/genetics ; Receptors, Vascular Endothelial Growth Factor/metabolism ; Signal Transduction/genetics ; Signal Transduction/physiology ; Sumoylation ; Ubiquitination
Chemical Substances	Receptors, Notch ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1)
Language	English
Publishing date	2019-08-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.21775/cimb.035.109
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5122: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: The Role of PIAS SUMO E3-Ligases in Cancer.

Rabellino, Andrea / Andreani, Cristina / Scaglioni, Pier Paolo

Cancer research

2017 Volume 77, Issue 7, Page(s) 1542–1547

Abstract: SUMOylation modifies the interactome, localization, activity, and lifespan of its target proteins. This process regulates several cellular machineries, including transcription, DNA damage repair, cell-cycle progression, and apoptosis. Accordingly, ... ...

Abstract	SUMOylation modifies the interactome, localization, activity, and lifespan of its target proteins. This process regulates several cellular machineries, including transcription, DNA damage repair, cell-cycle progression, and apoptosis. Accordingly, SUMOylation is critical in maintaining cellular homeostasis, and its deregulation leads to the corruption of a plethora of cellular processes that contribute to disease states. Among the proteins involved in SUMOylation, the protein inhibitor of activated STAT (PIAS) E3-ligases were initially described as transcriptional coregulators. Recent findings also indicate that they have a role in regulating protein stability and signaling transduction pathways. PIAS proteins interact with up to 60 cellular partners affecting several cellular processes, most notably immune regulation and DNA repair, but also cellular proliferation and survival. Here, we summarize the current knowledge about their role in tumorigenesis and cancer-related processes.
MeSH term(s)	Animals ; Cell Movement ; Epithelial-Mesenchymal Transition ; Humans ; Neoplasms/etiology ; Neoplasms/pathology ; Phosphatidylinositol 3-Kinases/physiology ; Protein Inhibitors of Activated STAT/physiology ; Proto-Oncogene Proteins c-myc/physiology ; Sumoylation ; Tumor Suppressor Protein p53/physiology ; Ubiquitin-Protein Ligases/physiology
Chemical Substances	MYC protein, human ; Protein Inhibitors of Activated STAT ; Proto-Oncogene Proteins c-myc ; Tumor Suppressor Protein p53 ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
Language	English
Publishing date	2017-04-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-16-2958
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.135/5: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: PML Degradation: Multiple Ways to Eliminate PML.

Rabellino, Andrea / Scaglioni, Pier Paolo

Frontiers in oncology

2013 Volume 3, Page(s) 60

Abstract: The promyelocytic leukemia tumor suppressor gene (PML) critically regulates several cellular functions that oppose tumorigenesis such as oncogene-induced senescence, apoptosis, the response to DNA damage and to viral infections. PML deficiency occurs ... ...

Abstract	The promyelocytic leukemia tumor suppressor gene (PML) critically regulates several cellular functions that oppose tumorigenesis such as oncogene-induced senescence, apoptosis, the response to DNA damage and to viral infections. PML deficiency occurs commonly in a broad spectrum of human cancers through mechanisms that involve its aberrant ubiquitination and degradation. Furthermore, several viruses encode viral proteins that promote viral replication through degradation of PML. These observations suggest that restoration of PML should lead to potent antitumor effects or antiviral responses. In this review we will summarize the mechanisms involved in PML degradation with the intent to highlight novel therapeutic strategies to trigger PML restoration.
Language	English
Publishing date	2013-03-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2013.00060
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Author Correction: Direct stimulation of ERBB2 highlights a novel cytostatic signaling pathway driven by the receptor Thr

Gaviraghi, Marco / Rabellino, Andrea / Andolfo, Annapaola / Brand, Matthias / Brombin, Chiara / Bagnato, Paola / De Feudis, Giuseppina / Raimondi, Andrea / Locatelli, Alberta / Tosoni, Daniela / Mazza, Davide / Gianni, Luca / Tonon, Giovanni / Yarden, Yosef / Tacchetti, Carlo / Daniele, Tiziana

Scientific reports

2021 Volume 11, Issue 1, Page(s) 18202

Language	English
Publishing date	2021-09-08
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-97699-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Mapping alexithymia: Level of emotional awareness differentiates emotion-specific somatosensory maps.

Lloyd, Chantelle S / Stafford, Erin / McKinnon, Margaret C / Rabellino, Daniela / D'Andrea, Wendy / Densmore, Maria / Thome, Janine / Neufeld, Richard W J / Lanius, Ruth A

Child abuse & neglect

2021 Volume 113, Page(s) 104919

Abstract: Background: Emotions have been associated with culturally universal and distinct bodily sensation "maps". Despite this knowledge, to date few studies have explored emotion-specific topography along clinically relevant dimensions, such as alexithymia.: ...

Abstract	Background: Emotions have been associated with culturally universal and distinct bodily sensation "maps". Despite this knowledge, to date few studies have explored emotion-specific topography along clinically relevant dimensions, such as alexithymia. Objective: We aimed to investigate emotion-specific topographies among individuals exposed to childhood maltreatment or neglect with absent (n = 51) or with probable (n = 46) alexithymia in adulthood, as defined by scores on the Toronto Alexithymia Scale (TAS-20). Participants and setting: Ninety eight adult participants with exposure to childhood maltreatment or neglect were recruited to complete an online survey. Methods: Using the well-validated emBODY tool (Nummenmaa et al., 2014), participants reported on their somatic experience of 17 emotions. Results: Random effects analyses revealed topographically distinct bodily sensation t-maps that differentiated participants who endorsed probable alexithymia from those who did not (p-FDR < .05). Consistent with our a priori hypothesis, the probable alexithymia group reported a muted, diffuse and undifferentiated pattern of emotion-specific bodily sensation, whereas the non-alexithymia group reported a more distinct and localized pattern. Conclusions: These results suggest that difficulty identifying and labeling emotions, as observed in alexithymia, may arise, in part, from an altered perception of somatic activation. It is well-established that childhood maltreatment predicts the development of alexithymia symptoms. The preliminary findings presented here expand our working understanding of the physical markers of childhood trauma, which may be used in practice to aid detection and to monitor treatment outcomes.
MeSH term(s)	Adult ; Humans ; Affective Symptoms ; Emotions ; Surveys and Questionnaires
Language	English
Publishing date	2021-01-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	799143-5
ISSN	1873-7757 ; 0145-2134
ISSN (online)	1873-7757
ISSN	0145-2134
DOI	10.1016/j.chiabu.2020.104919
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1437: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Author Correction

Marco Gaviraghi / Andrea Rabellino / Annapaola Andolfo / Matthias Brand / Chiara Brombin / Paola Bagnato / Giuseppina De Feudis / Andrea Raimondi / Alberta Locatelli / Daniela Tosoni / Davide Mazza / Luca Gianni / Giovanni Tonon / Yosef Yarden / Carlo Tacchetti / Tiziana Daniele

Scientific Reports, Vol 11, Iss 1, Pp 1-

Direct stimulation of ERBB2 highlights a novel cytostatic signaling pathway driven by the receptor Thr701 phosphorylation

2021 Volume 1

Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Direct stimulation of ERBB2 highlights a novel cytostatic signaling pathway driven by the receptor Thr

Scientific reports

2020 Volume 10, Issue 1, Page(s) 16906

Abstract: ERBB2 is a ligand-less tyrosine kinase receptor expressed at very low levels in normal tissues; when overexpressed, it is involved in malignant transformation and tumorigenesis in several carcinomas. In cancer cells, ERBB2 represents the preferred ... ...

Abstract	ERBB2 is a ligand-less tyrosine kinase receptor expressed at very low levels in normal tissues; when overexpressed, it is involved in malignant transformation and tumorigenesis in several carcinomas. In cancer cells, ERBB2 represents the preferred partner of other members of the ERBB receptor family, leading to stronger oncogenic signals, by promoting both ERK and AKT activation. The identification of the specific signaling downstream of ERBB2 has been impaired by the lack of a ligand and of an efficient way to selectively activate the receptor. In this paper, we found that antibodies (Abs) targeting different epitopes on the ERBB2 extracellular domain foster the activation of ERBB2 homodimers, and surprisingly induce a unique cytostatic signaling cascade promoting an ERK-dependent ERBB2 Thr
MeSH term(s)	Cell Line, Tumor ; Cell Proliferation/physiology ; Cell Transformation, Neoplastic/metabolism ; Cytostatic Agents/metabolism ; Dimerization ; Extracellular Signal-Regulated MAP Kinases ; Humans ; Phosphorylation/physiology ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor Protein-Tyrosine Kinases/metabolism ; Receptor, ErbB-2/immunology ; Signal Transduction/physiology
Chemical Substances	Cytostatic Agents ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24)
Language	English
Publishing date	2020-10-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-73835-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Nullifying the CDKN2AB locus promotes mutant K-ras lung tumorigenesis.

Schuster, Katja / Venkateswaran, Niranjan / Rabellino, Andrea / Girard, Luc / Peña-Llopis, Samuel / Scaglioni, Pier Paolo

Molecular cancer research : MCR

2014 Volume 12, Issue 6, Page(s) 912–923

Abstract: Unlabelled: Lung cancer commonly displays a number of recurrent genetic abnormalities, and about 30% of lung adenocarcinomas carry activating mutations in the Kras gene, often concomitantly with inactivation of tumor suppressor genes p16(INK4A) and p14( ... ...

Abstract	Unlabelled: Lung cancer commonly displays a number of recurrent genetic abnormalities, and about 30% of lung adenocarcinomas carry activating mutations in the Kras gene, often concomitantly with inactivation of tumor suppressor genes p16(INK4A) and p14(ARF) of the CDKN2AB locus. However, little is known regarding the function of p15INK4B translated from the same locus. To determine the frequency of CDKN2AB loss in human mutant KRAS lung cancer, The Cancer Genome Atlas (TCGA) database was interrogated. Two-hit inactivation of CDKN2A and CDKN2B occurs frequently in patients with mutant KRAS lung adenocarcinoma. Moreover, p15INK4B loss occurs in the presence of biallelic inactivation of p16(INK4A) and p14(ARF), suggesting that p15INK4B loss confers a selective advantage to mutant KRAS lung cancers that are p16(INK4A) and p14(ARF) deficient. To determine the significance of CDKN2AB loss in vivo, genetically engineered lung cancer mouse models that express mutant Kras in the respiratory epithelium were utilized. Importantly, complete loss of CDKN2AB strikingly accelerated mutant Kras-driven lung tumorigenesis, leading to loss of differentiation, increased metastatic disease, and decreased overall survival. Primary mutant Kras lung epithelial cells lacking Cdkn2ab had increased clonogenic potential. Furthermore, comparative analysis of mutant Kras;Cdkn2a null with Kras;Cdkn2ab null mice and experiments with mutant KRAS;CDKN2AB-deficient human lung cancer cells indicated that p15INK4B is a critical tumor suppressor. Thus, the loss of CDKN2AB is of biologic significance in mutant KRAS lung tumorigenesis by fostering cellular proliferation, cancer cell differentiation, and metastatic behavior. Implications: These findings indicate that mutant Kras;Cdkn2ab null mice provide a platform for accurately modeling aggressive lung adenocarcinoma and testing therapeutic modalities.
MeSH term(s)	Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Adenocarcinoma of Lung ; Animals ; Carcinogenesis/genetics ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Cyclin-Dependent Kinase Inhibitor p15/genetics ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Disease Models, Animal ; Genes, ras ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Mice ; Mice, Transgenic ; Microarray Analysis ; Plasmids
Chemical Substances	Cyclin-Dependent Kinase Inhibitor p15 ; Cyclin-Dependent Kinase Inhibitor p16
Language	English
Publishing date	2014-03-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2098788-2
ISSN	1557-3125 ; 1541-7786
ISSN (online)	1557-3125
ISSN	1541-7786
DOI	10.1158/1541-7786.MCR-13-0620-T
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5744: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito