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Article ; Online: Characterization of Microplastics Released Based on Polyester Fabric Construction during Washing and Drying

Sola Choi / Miyeon Kwon / Myung-Ja Park / Juhea Kim

Polymers, Vol 13, Iss 4277, p

2021 Volume 4277

Abstract: With the increasing production of synthetic materials, more microplastic fibers are being generated while washing clothes. Consequently, these particles are increasingly detected in the aquatic environment. Synthetic fibers produced via washing have a ... ...

Abstract	With the increasing production of synthetic materials, more microplastic fibers are being generated while washing clothes. Consequently, these particles are increasingly detected in the aquatic environment. Synthetic fibers produced via washing have a relatively high contribution to microplastic pollution. Hence, recent research on reducing the release of microplastic fibers is attracting considerable attention. In this study, fabric-specific analysis was performed by strictly controlling various factors, and each washing and drying process was improved by focusing on the mechanical factors affecting microplastic release. Furthermore, the mass of the collected microplastic fibers and their length distribution were measured. Fabric construction, including chemical composition and yarn type, impacted the microplastics released during washing and drying. Differences in the mechanical factors during washing helped to identify the physical factors affecting microplastic release. These results on the release of microplastics may provide a basis for developing a filter system that can minimize the unintended environmental consequences.
Keywords	microplastics ; microplastic fibers ; polyester fabric ; fabric construction ; laundry ; Organic chemistry ; QD241-441
Subject code	660
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Analysis of Microplastics Released from Plain Woven Classified by Yarn Types during Washing and Drying

Sola Choi / Miyeon Kwon / Myung-Ja Park / Juhea Kim

Polymers, Vol 13, Iss 2988, p

2021 Volume 2988

Abstract: Microplastics reach the aquatic environment through wastewater. Larger debris is removed in sewage treatment plants, but filters are not explicitly designed to retain sewage sludge’s microplastic or terrestrial soils. Therefore, the effective ... ...

Abstract	Microplastics reach the aquatic environment through wastewater. Larger debris is removed in sewage treatment plants, but filters are not explicitly designed to retain sewage sludge’s microplastic or terrestrial soils. Therefore, the effective quantification of filtration system to mitigate microplastics is needed. To mitigate microplastics, various devices have been designed, and the removal efficiency of devices was compared. However, this study focused on identifying different fabrics that shed fewer microplastics. Therefore, in this study, fabric-specific analyses of microplastics of three different fabrics during washing and drying processes were studied. Also, the change in the generation of microplastics for each washing process of standard washing was investigated. The amount of microplastics released according to the washing process was analyzed, and the collected microplastics’ weight, length, and diameter were measured and recorded. According to the different types of yarn, the amount of microplastic fibers produced during washing and drying varied. As the washing processes proceed, the amount of microplastics gradually decreased. The minimum length (>40 µm) of micro-plastics generated were in plain-woven fabric. These results will be helpful to mitigate microplastics in the production of textiles and in selecting built-in filters, and focusing on the strict control of other parameters will be useful for the development of textile-based filters, such as washing bags.
Keywords	microplastics ; microplastic fiber ; washing textile ; drying textile ; polyester yarn types ; Organic chemistry ; QD241-441
Subject code	660
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Characterization of Microplastics Released Based on Polyester Fabric Construction during Washing and Drying.

Choi, Sola / Kwon, Miyeon / Park, Myung-Ja / Kim, Juhea

Polymers

2021 Volume 13, Issue 24

Abstract	With the increasing production of synthetic materials, more microplastic fibers are being generated while washing clothes. Consequently, these particles are increasingly detected in the aquatic environment. Synthetic fibers produced via washing have a relatively high contribution to microplastic pollution. Hence, recent research on reducing the release of microplastic fibers is attracting considerable attention. In this study, fabric-specific analysis was performed by strictly controlling various factors, and each washing and drying process was improved by focusing on the mechanical factors affecting microplastic release. Furthermore, the mass of the collected microplastic fibers and their length distribution were measured. Fabric construction, including chemical composition and yarn type, impacted the microplastics released during washing and drying. Differences in the mechanical factors during washing helped to identify the physical factors affecting microplastic release. These results on the release of microplastics may provide a basis for developing a filter system that can minimize the unintended environmental consequences.
Language	English
Publishing date	2021-12-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym13244277
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Analysis of Microplastics Released from Plain Woven Classified by Yarn Types during Washing and Drying.

Choi, Sola / Kwon, Miyeon / Park, Myung-Ja / Kim, Juhea

Polymers

2021 Volume 13, Issue 17

Abstract: Microplastics reach the aquatic environment through wastewater. Larger debris is removed in sewage treatment plants, but filters are not explicitly designed to retain sewage sludge's microplastic or terrestrial soils. Therefore, the effective ... ...

Abstract	Microplastics reach the aquatic environment through wastewater. Larger debris is removed in sewage treatment plants, but filters are not explicitly designed to retain sewage sludge's microplastic or terrestrial soils. Therefore, the effective quantification of filtration system to mitigate microplastics is needed. To mitigate microplastics, various devices have been designed, and the removal efficiency of devices was compared. However, this study focused on identifying different fabrics that shed fewer microplastics. Therefore, in this study, fabric-specific analyses of microplastics of three different fabrics during washing and drying processes were studied. Also, the change in the generation of microplastics for each washing process of standard washing was investigated. The amount of microplastics released according to the washing process was analyzed, and the collected microplastics' weight, length, and diameter were measured and recorded. According to the different types of yarn, the amount of microplastic fibers produced during washing and drying varied. As the washing processes proceed, the amount of microplastics gradually decreased. The minimum length (>40 µm) of micro-plastics generated were in plain-woven fabric. These results will be helpful to mitigate microplastics in the production of textiles and in selecting built-in filters, and focusing on the strict control of other parameters will be useful for the development of textile-based filters, such as washing bags.
Language	English
Publishing date	2021-09-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym13172988
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Article ; Online: Pathologic properties of SOD3 variant R213G in the cardiovascular system through the altered neutrophils function.

Myung-Ja Kwon / Kyo-Young Lee / Won-Gug Ham / Lee-Jung Tak / Gaurav Agrahari / Tae-Yoon Kim

PLoS ONE, Vol 15, Iss 1, p e

2020 Volume 0227449

Abstract: The SOD3 variant, SOD3R213G, results from substitution of arginine to glycine at amino acid 213 (R213G) in its heparin binding domain (HBD) and is a common genetic variant, reported to be associated with ischemic heart disease. However, little is ... ...

Abstract	The SOD3 variant, SOD3R213G, results from substitution of arginine to glycine at amino acid 213 (R213G) in its heparin binding domain (HBD) and is a common genetic variant, reported to be associated with ischemic heart disease. However, little is understood about the role of SOD3R213G in innate immune function, and how it leads to dysfunction of the cardiovascular system. We observed pathologic changes in SOD3R213G transgenic (Tg) mice, including cystic medial degeneration of the aorta, heart inflammation, and increased circulating and organ infiltrating neutrophils. Interestingly, SOD3R213G altered the profile of SOD3 interacting proteins in neutrophils in response to G-CSF. Unexpectedly, we found that G-CSF mediated tyrosine phosphatase, SH-PTP1 was down-regulated in the neutrophils of SOD3R213G overexpressing mice. These effects were recovered by reconstitution with Wt SOD3 expressing bone marrow cells. Overall, our study reveals that SOD3R213G plays a crucial role in the function of the cardiovascular system by controlling innate immune response and signaling. These results suggest that reconstitution with SOD3 expressing bone marrow cells may be a therapeutic strategy to treat SOD3R213G mediated diseases.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pathologic properties of SOD3 variant R213G in the cardiovascular system through the altered neutrophils function.

Kwon, Myung-Ja / Lee, Kyo-Young / Ham, Won-Gug / Tak, Lee-Jung / Agrahari, Gaurav / Kim, Tae-Yoon

PloS one

2020 Volume 15, Issue 1, Page(s) e0227449

Abstract	The SOD3 variant, SOD3R213G, results from substitution of arginine to glycine at amino acid 213 (R213G) in its heparin binding domain (HBD) and is a common genetic variant, reported to be associated with ischemic heart disease. However, little is understood about the role of SOD3R213G in innate immune function, and how it leads to dysfunction of the cardiovascular system. We observed pathologic changes in SOD3R213G transgenic (Tg) mice, including cystic medial degeneration of the aorta, heart inflammation, and increased circulating and organ infiltrating neutrophils. Interestingly, SOD3R213G altered the profile of SOD3 interacting proteins in neutrophils in response to G-CSF. Unexpectedly, we found that G-CSF mediated tyrosine phosphatase, SH-PTP1 was down-regulated in the neutrophils of SOD3R213G overexpressing mice. These effects were recovered by reconstitution with Wt SOD3 expressing bone marrow cells. Overall, our study reveals that SOD3R213G plays a crucial role in the function of the cardiovascular system by controlling innate immune response and signaling. These results suggest that reconstitution with SOD3 expressing bone marrow cells may be a therapeutic strategy to treat SOD3R213G mediated diseases.
MeSH term(s)	Animals ; Aorta/metabolism ; Aorta/pathology ; Bone Marrow Cells/cytology ; Bone Marrow Cells/metabolism ; Cell Proliferation ; Disease Models, Animal ; Down-Regulation ; Granulocyte Colony-Stimulating Factor/metabolism ; Heart Diseases/immunology ; Heart Diseases/metabolism ; Heart Diseases/pathology ; Immunity, Innate ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Mutagenesis, Site-Directed ; Myocardium/metabolism ; Myocardium/pathology ; Neutrophil Infiltration/physiology ; Neutrophils/cytology ; Neutrophils/metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 6/metabolism ; Receptors, CCR2/metabolism ; Signal Transduction ; Superoxide Dismutase/genetics ; Superoxide Dismutase/metabolism
Chemical Substances	Ccr2 protein, mouse ; Receptors, CCR2 ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Superoxide Dismutase (EC 1.15.1.1) ; Protein Tyrosine Phosphatase, Non-Receptor Type 6 (EC 3.1.3.48)
Language	English
Publishing date	2020-01-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0227449
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: SOD3 Variant, R213G, Altered SOD3 Function, Leading to ROS-Mediated Inflammation and Damage in Multiple Organs of Premature Aging Mice.

Kwon, Myung-Ja / Lee, Kyo-Young / Lee, Han-Woong / Kim, Jung-Ho / Kim, Tae-Yoon

Antioxidants & redox signaling

2015 Volume 23, Issue 12, Page(s) 985–999

Abstract: Aims: Among the isoforms of superoxide dismutase, SOD3 is uniquely associated with the extracellular matrix (ECM) by virtue of its heparin-binding domain (HBD). Substitution of arginine by glycine at amino acid 213 (R213G) of its HBD was first ... ...

Abstract	Aims: Among the isoforms of superoxide dismutase, SOD3 is uniquely associated with the extracellular matrix (ECM) by virtue of its heparin-binding domain (HBD). Substitution of arginine by glycine at amino acid 213 (R213G) of its HBD was first identified in patients with heart failure, followed by many studies that focused on the role of this variant (SOD3(R213G)) in ischemic heart disease and cardiovascular disease. However, the biological significance of this mutation in a physiological context is largely unknown. Results: As a first step, we generated SOD3(R213G) transgenic mice, in which the variant gene was driven by the β-actin promoter allowing expression in all tissues. Unexpectedly, we found that SOD3(R213G) transgenic mice exhibited premature aging, including hair graying, abnormal gait, and a shortened life span. Specifically, the aged mice showed systemic inflammation and organ degeneration. In addition, aged SOD3(R213G) mice are susceptible to neutrophil-mediated inflammation. Among other functions, the neutrophils of SOD3(R213G) mice produce high amounts of reactive oxygen species, which would normally be controlled by SOD3 in ECM. Innovation: These findings showed for the first time that arginine 213 in the HBD of SOD3 is critical for maintaining proper organ function through moderating the normal innate immune response, which would otherwise lead to chronic inflammation and degenerative diseases in aged mice. Conclusion: Therefore, patients with this variant may be treated with SOD3 as a therapeutic strategy to prevent or cure these diseases.
MeSH term(s)	Aging, Premature/metabolism ; Aging, Premature/pathology ; Animal Structures/metabolism ; Animals ; Arginine/metabolism ; Cell Line, Tumor ; Glycine/metabolism ; Humans ; Inflammation/metabolism ; Melanocytes/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Mutation ; Neutrophils/metabolism ; Neutrophils/pathology ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Reactive Oxygen Species/metabolism ; Superoxide Dismutase/genetics ; Superoxide Dismutase/metabolism
Chemical Substances	Protein Isoforms ; Reactive Oxygen Species ; Arginine (94ZLA3W45F) ; SOD3 protein, human (EC 1.15.1.1) ; Sod3 protein, mouse (EC 1.15.1.1) ; Superoxide Dismutase (EC 1.15.1.1) ; Glycine (TE7660XO1C)
Language	English
Publishing date	2015-10-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1483836-9
ISSN	1557-7716 ; 1523-0864
ISSN (online)	1557-7716
ISSN	1523-0864
DOI	10.1089/ars.2014.6035
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Zs.A 5488: Show issues

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Article ; Online: Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis.

Bang, In Hyuk / Kwon, Oh Kwang / Hao, Lihua / Park, Dami / Chung, Myung-Ja / Oh, Byung-Chul / Lee, Sangkyu / Bae, Eun Ju / Park, Byung-Hyun

Experimental & molecular medicine

2019 Volume 51, Issue 9, Page(s) 1–11

Abstract: The active spliced form of X-box-binding protein 1 (XBP1s) is a key modulator of ER stress, but the functional role of its post-translational modification remains unclear. Here, we demonstrate that XBP1s is a deacetylation target of Sirt6 and that its ... ...

Abstract	The active spliced form of X-box-binding protein 1 (XBP1s) is a key modulator of ER stress, but the functional role of its post-translational modification remains unclear. Here, we demonstrate that XBP1s is a deacetylation target of Sirt6 and that its deacetylation protects against ER stress-induced hepatic steatosis. Specifically, the abundance of acetylated XBP1s and concordant hepatic steatosis were increased in hepatocyte-specific Sirt6 knockout and obese mice but were decreased by genetic overexpression and pharmacological activation of Sirt6. Mechanistically, we identified that Sirt6 deacetylated a transactivation domain of XBP1s at Lys257 and Lys297 and promoted XBP1s protein degradation through the ubiquitin-proteasome system. Overexpression of XBP1s, but not its deacetylation mutant 2KR (K257/297R), in mice increased lipid accumulation in the liver. Importantly, in liver tissues obtained from patients with nonalcoholic fatty liver disease (NAFLD), the extent of XBP1s acetylation correlated positively with the NAFLD activity score but negatively with the Sirt6 level. Collectively, we present direct evidence supporting the importance of XBP1 acetylation in ER stress-induced hepatic steatosis.
MeSH term(s)	Acetylation ; Animals ; Endoplasmic Reticulum Stress/genetics ; Fatty Liver/genetics ; Fatty Liver/pathology ; Gene Expression Regulation/genetics ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Humans ; Lipid Metabolism/genetics ; Liver/metabolism ; Liver/pathology ; Male ; Mice ; Mice, Knockout/genetics ; Mice, Obese ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/pathology ; Protein Processing, Post-Translational/genetics ; Proteolysis ; Sirtuins/genetics ; X-Box Binding Protein 1/genetics
Chemical Substances	X-Box Binding Protein 1 ; XBP1 protein, human ; SIRT6 protein, human (EC 3.5.1.-) ; Sirtuins (EC 3.5.1.-)
Language	English
Publishing date	2019-09-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1328915-9
ISSN	2092-6413 ; 1226-3613 ; 0378-8512
ISSN (online)	2092-6413
ISSN	1226-3613 ; 0378-8512
DOI	10.1038/s12276-019-0309-0
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Zs.A 4775: Show issues

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Article ; Online: Mediatory roles of leukotriene B

Kwon, Sun-Young / Ro, MyungJa / Kim, Jae-Hong

Scientific reports

2019 Volume 9, Issue 1, Page(s) 5936

Abstract: Sepsis, a systemic inflammatory response syndrome caused by infection, is the most common disease in patients treated in intensive care units. Endotoxic shock, the most critical form of sepsis, is caused by gram-negative bacterial infection. However, the ...

Abstract	Sepsis, a systemic inflammatory response syndrome caused by infection, is the most common disease in patients treated in intensive care units. Endotoxic shock, the most critical form of sepsis, is caused by gram-negative bacterial infection. However, the detailed mechanism of endotoxic shock remains unclear. In the present study, we observed that the production of leukotriene B
MeSH term(s)	Animals ; Disease Models, Animal ; Endotoxemia/chemically induced ; Endotoxemia/metabolism ; Endotoxemia/pathology ; Gene Expression Regulation ; Inflammation/chemically induced ; Inflammation/metabolism ; Inflammation/pathology ; Leukotriene B4/metabolism ; Lipopolysaccharides/toxicity ; Male ; Mice ; Mice, Inbred C57BL ; Receptors, Leukotriene B4/metabolism ; Shock, Septic/chemically induced ; Shock, Septic/metabolism ; Shock, Septic/pathology ; Signal Transduction
Chemical Substances	Lipopolysaccharides ; Receptors, Leukotriene B4 ; Leukotriene B4 (1HGW4DR56D)
Language	English
Publishing date	2019-04-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-42410-8
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Article ; Online: Leukotriene B

Ro, MyungJa / Kwon, Sun-Young / Kim, Jae-Hong

Allergy

2019 Volume 74, Issue 9, Page(s) 1797–1799

MeSH term(s)	Asthma/diagnosis ; Asthma/etiology ; Asthma/metabolism ; Biomarkers ; Disease Susceptibility ; Humans ; Interleukin-17/biosynthesis ; Neutrophils/immunology ; Neutrophils/metabolism ; Receptors, Leukotriene B4/metabolism
Chemical Substances	Biomarkers ; IL17A protein, human ; Interleukin-17 ; Receptors, Leukotriene B4
Language	English
Publishing date	2019-04-04
Publishing country	Denmark
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.13789
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