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Article ; Online: Spaceflight Promoted Myocardial Differentiation of Induced Pluripotent Stem Cells: Results from Tianzhou-1 Space Mission.

Li, Hong / Zhu, Huimin / Zhang, Fengzhi / Dong, Xiaohui / Hao, Tong / Jiang, Xiaoxia / Zheng, Weibo / Zhang, Tao / Chen, Xi / Wang, Peizhe / Na, Jie / Wang, Changyong / Zhou, Jin

Stem cells and development

2019 Volume 28, Issue 6, Page(s) 357–360

Abstract: ... on the physiological function of mammalian cells. In this study, we took opportunity of the Tianzhou-1 (TZ-1) mission ...

Abstract	During space travel, exposure to microgravity may have profound influence on the physiological function of mammalian cells. In this study, we took opportunity of the Tianzhou-1 (TZ-1) mission to investigate how spaceflight may affect cardiac differentiation of mouse induced pluripotent stem cells (iPSCs). A bioreactor was engineered to perform cell culturing and the time-lapse imaging experiments on-orbit. Transgenic iPSC lines with either Oct4 or α-myosin heavy chain (αMHC) promoter driving green fluorescent protein (GFP) expression were used to study cardiomyocyte (CM) differentiation in real microgravity. The differentiation status was monitored by GFP fluorescence intensity. Interestingly, compared with cells cultured in identical environment at ground gravity, embryoid bodies (EBs) derived from Oct4 reporter iPSC downregulated GFP significantly quicker in space. Meanwhile, EBs derived from αMHC reporter iPSC activated GFP strongly 4 days after launch (P < 0.05) and lasted for 10 days afterward, indicating robust CM formation. This is the first real-time imaging study of iPSC myocardial differentiation in space. Under our experimental condition, real microgravity enhanced the CM differentiation process of iPSCs. Our study provided rare information about iPSC cardiac differentiation in space. In the future, similar automated stem cell experiments may help to realize personalized cardiac tissue biomanufacturing and drug test during space travel.
MeSH term(s)	Animals ; Cell Differentiation ; Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/metabolism ; Mice ; Myocardium/cytology ; Myocardium/metabolism ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/metabolism ; Space Flight ; Weightlessness
Language	English
Publishing date	2019-02-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2142214-X
ISSN	1557-8534 ; 1547-3287
ISSN (online)	1557-8534
ISSN	1547-3287
DOI	10.1089/scd.2018.0240
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Article ; Online: 3D Embedded Printing of Complex Biological Structures with Supporting Bath of Pluronic F-127.

Hu, Tianzhou / Cai, Zhengwei / Yin, Ruixue / Zhang, Wenjun / Bao, Chunyan / Zhu, Linyong / Zhang, Honbo

Polymers

2023 Volume 15, Issue 17

Abstract: Biofabrication is crucial in contemporary tissue engineering. The primary challenge in biofabrication lies in achieving simultaneous replication of both external organ geometries and internal structures. Particularly for organs with high oxygen demand, ... ...

Abstract	Biofabrication is crucial in contemporary tissue engineering. The primary challenge in biofabrication lies in achieving simultaneous replication of both external organ geometries and internal structures. Particularly for organs with high oxygen demand, the incorporation of a vascular network, which is usually intricate, is crucial to enhance tissue viability, which is still a difficulty in current biofabrication technology. In this study, we address this problem by introducing an innovative three-dimensional (3D) printing strategy using a thermo-reversible supporting bath which can be easily removed by decreasing the temperature. This technology is capable of printing hydrated materials with diverse crosslinked mechanisms, encompassing gelatin, hyaluronate, Pluronic F-127, and alginate. Furthermore, the technology can replicate the external geometry of native tissues and organs from computed tomography data. The work also demonstrates the capability to print lines around 10 μm with a nozzle with a diameter of 60 μm due to the extra force exerted by the supporting bath, by which the line size was largely reduced, and this technique can be used to fabricate intricate capillary networks.
Language	English
Publishing date	2023-08-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym15173493
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Article ; Online: Independent and interactive effects of ozone and thermal inversion exposure on the risk of gestational diabetes mellitus in Wuhan, China.

Zhao, Gaichan / Zhang, Faxue / Zhong, Yuanyuan / Zhang, Yan / Zhang, Xupeng / Zhu, Shijie / Zhang, Xiaowei / Li, Tianzhou / Zhu, Wei / Li, Dejia

Environmental science and pollution research international

2023 Volume 30, Issue 39, Page(s) 91315–91323

Abstract: The adverse effects of exposure to thermal inversion (TI) and ozone ( ... ...

Abstract	The adverse effects of exposure to thermal inversion (TI) and ozone (O
MeSH term(s)	Child ; Pregnancy ; Female ; Humans ; Diabetes, Gestational/epidemiology ; Ozone/analysis ; Particulate Matter/analysis ; Pregnancy Trimester, First ; China/epidemiology ; Air Pollution/analysis ; Maternal Exposure ; Air Pollutants/analysis
Chemical Substances	Ozone (66H7ZZK23N) ; Particulate Matter ; Air Pollutants
Language	English
Publishing date	2023-07-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-28855-5
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Article ; Online: Rational design of formamidine tin-based perovskite solar cell with 30% potential efficiency

Liang, Kaiwen / Huang, Like / Wang, Tianzhou / Wang, Chaofeng / Guo, Yi / Yue, Yunliang / Liu, Xiaohui / Zhang, Jing / Hu, Ziyang / Zhu, Yuejin

Physical chemistry chemical physics : PCCP

2023 Volume 25, Issue 13, Page(s) 9413–9427

Abstract: As a promising photovoltaic technology, halide perovskite solar cells (PSCs) have recently attracted wide attention. This work presents a systematic simulation of low bandgap formamidinium tin iodide ( ... ...

Abstract	As a promising photovoltaic technology, halide perovskite solar cells (PSCs) have recently attracted wide attention. This work presents a systematic simulation of low bandgap formamidinium tin iodide (FASnI
Language	English
Publishing date	2023-03-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d2cp05226a
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Article ; Online: Joint Exposure to Ambient Air Pollutants Might Elevate the Risk of Small for Gestational Age (SGA) Infants in Wuhan: Evidence From a Cross-Sectional Study.

Zhang, Faxue / Zhang, Xupeng / Zhong, Yuanyuan / Zhu, Shijie / Zhao, Gaichan / Zhang, Xiaowei / Li, Tianzhou / Zhang, Yan / Zhu, Wei

International journal of public health

2023 Volume 67, Page(s) 1605391

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Pregnancy ; Child ; Infant ; Female ; Humans ; Aged ; Adult ; Air Pollutants/adverse effects ; Air Pollutants/analysis ; Cross-Sectional Studies ; Environmental Pollutants ; Gestational Age ; Maternal Exposure/adverse effects ; Air Pollution/adverse effects ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; China/epidemiology ; Nitrogen Dioxide
Chemical Substances	Air Pollutants ; Environmental Pollutants ; Particulate Matter ; Nitrogen Dioxide (S7G510RUBH)
Language	English
Publishing date	2023-01-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2274130-6
ISSN	1661-8564 ; 1661-8556
ISSN (online)	1661-8564
ISSN	1661-8556
DOI	10.3389/ijph.2022.1605391
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Article: Structural Evolution and Transitions of Mechanisms in Creep Deformation of Nanocrystalline FeCrAl Alloys.

Yao, Huan / Ye, Tianzhou / Wang, Pengfei / Wu, Junmei / Zhang, Jing / Chen, Ping

Nanomaterials (Basel, Switzerland)

2023 Volume 13, Issue 4

Abstract: FeCrAl alloys have been suggested as one of the most promising fuel cladding materials for the development of accident tolerance fuel. Creep is one of the important mechanical properties of the FeCrAl alloys used as fuel claddings under high temperature ... ...

Abstract	FeCrAl alloys have been suggested as one of the most promising fuel cladding materials for the development of accident tolerance fuel. Creep is one of the important mechanical properties of the FeCrAl alloys used as fuel claddings under high temperature conditions. This work aims to elucidate the deformation feature and underlying mechanism during the creep process of nanocrystalline FeCrAl alloys using atomistic simulations. The creep curves at different conditions are simulated for FeCrAl alloys with grain sizes (GS) of 5.6-40 nm, and the dependence of creep on temperature, stress and GS are analyzed. The transitions of the mechanisms are analyzed by stress and GS exponents firstly, and further checked not only from microstructural evidence, but also from a vital comparison of activation energies for creep and diffusion. Under low stress conditions, grain boundary (GB) diffusion contributes more to the overall creep deformation than lattice diffusion does for the alloy with small GSs. However, for the alloy with larger GSs, lattice diffusion controls creep. Additionally, a high temperature helps the transition of diffusional creep from the GB to the dominant lattice. Under medium- and high-stress conditions, GB slip and dislocation motion begin to control the creep mechanism. The amount of GB slip increases with the temperature, or decreases with GS. GS and temperature also have an impact on the dislocation behavior. The higher the temperature or the smaller the GS is, the smaller the stress at which the dislocation motion begins to affect creep.
Language	English
Publishing date	2023-02-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano13040631
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Article ; Online: Functional and clinical characteristics of focal adhesion kinases in cancer progression

Zhaoyu Zhang / Jinlong Li / Simin Jiao / Guangda Han / Jiaming Zhu / Tianzhou Liu

Frontiers in Cell and Developmental Biology, Vol

2022 Volume 10

Abstract: Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and an adaptor protein that primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in response to stress. Increasing evidence has shown that at the pathological ... ...

Abstract	Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and an adaptor protein that primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in response to stress. Increasing evidence has shown that at the pathological level, FAK is highly expressed in multiple tumors in several systems (including lung, liver, gastric, and colorectal cancers) and correlates with tumor aggressiveness and patient prognosis. At the molecular level, FAK promotes tumor progression mainly by altering survival signals, invasive capacity, epithelial-mesenchymal transition, the tumor microenvironment, the Warburg effect, and stemness of tumor cells. Many effective drugs have been developed based on the comprehensive role of FAK in tumor cells. In addition, its potential as a tumor marker cannot be ignored. Here, we discuss the pathological and pre-clinical evidence of the role of FAK in cancer development; we hope that these findings will assist in FAK-based clinical studies.
Keywords	FAK ; cancer progression ; clinical significance ; molecular mechanisms ; prognosis ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Association between traffic-related air pollution and osteoporotic fracture hospitalizations in inland and coastal areas: evidences from the central areas of two cities in Shandong Province, China.

Zhang, Xupeng / Yu, Shengwen / Zhang, Faxue / Zhu, Shijie / Zhao, Gaichan / Zhang, Xiaowei / Li, Tianzhou / Yu, Bo / Zhu, Wei / Li, Dejia

Archives of osteoporosis

2023 Volume 18, Issue 1, Page(s) 96

Abstract: Our result showed that short-term exposure to traffic-related air pollutants (TRAPs) might increase the risk of hospitalizations for osteoporotic fractures. It was suggested that government should formulate emission reduction policies to protect the ... ...

Abstract	Our result showed that short-term exposure to traffic-related air pollutants (TRAPs) might increase the risk of hospitalizations for osteoporotic fractures. It was suggested that government should formulate emission reduction policies to protect the health of citizens. Introduction: As the main source of urban air pollution in China, exhaust emissions of motor vehicles have been linked to adverse health outcomes, but evidence of the relationship between short-term exposure to TRAPs and osteoporotic fractures is still relatively rare. Methods: In this study, a total of 5044 inpatients from an inland city (Jinan) and a coastal city (Qingdao), two cities with developed transportation in Shandong Province, were included. A generalized additive model (GAM) was used to investigate the association between TRAPs and hospitalizations for osteoporotic fractures. The stratified analyses were performed by gender and age. Results: Positive associations between TRAPs and osteoporotic fracture hospitalizations were observed. We found that short-term exposure to TRAPs was associated with increased numbers of hospitalizations for osteoporotic fractures. PM Conclusion: This study implied that short-term exposure to TRAPs pollution was associated with an increased risk of hospitalizations for osteoporotic fractures. Female patients and patients aged 65 + years appeared to be more vulnerable to TRAPs, suggesting that poor air quality is a modifiable risk factor for osteoporotic fractures.
MeSH term(s)	Humans ; Female ; Osteoporotic Fractures/epidemiology ; Cities/epidemiology ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Nitrogen Dioxide/analysis ; Air Pollution/adverse effects ; Air Pollution/analysis ; Hospitalization ; China/epidemiology ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis
Chemical Substances	Particulate Matter ; Nitrogen Dioxide (S7G510RUBH)
Language	English
Publishing date	2023-07-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2253231-6
ISSN	1862-3514 ; 1862-3522
ISSN (online)	1862-3514
ISSN	1862-3522
DOI	10.1007/s11657-023-01308-9
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Article ; Online: Ambient particulate matter, a novel factor hindering life spans of HIV/AIDS patients: Evidence from a ten-year cohort study in Hubei, China.

Zhang, Faxue / Zhu, Shijie / Tang, Hen / Zhao, Dingyuan / Zhang, Xupeng / Zhao, Gaichan / Zhang, Xiaowei / Li, Tianzhou / Ruan, Lianguo / Zhu, Wei

The Science of the total environment

2023 Volume 875, Page(s) 162589

Abstract: Background: The life spans of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients have been extended in the era of antiretroviral therapy. However, few studies have considered the influence of the environment on the life ... ...

Abstract	Background: The life spans of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients have been extended in the era of antiretroviral therapy. However, few studies have considered the influence of the environment on the life expectancy of people living with HIV/AIDS. Several studies have investigated mortality and air pollution associations, but the evidence for associations between long-term exposure to particulate matter (PM) and mortality among HIV/AIDS patients remains extremely sparse. Methods: We conceived a dynamic cohort study by enrolling people with HIV/AIDS from 103 counties in Hubei province, China from 2010 to 2019, with 23,809 persons and 78,457.2 person-years of follow-up. The county-level annual concentrations of PM Results: Per 1 μg/m Conclusions: This study added to the existing evidence that long-term exposure to ambient PM adversely affects the life spans of HIV/AIDS patients. Hence, public health departments should take proactive measures to prevent further life loss and promote survival among those living with HIV/AIDS.
MeSH term(s)	Humans ; Middle Aged ; Aged ; Particulate Matter/analysis ; Air Pollutants/analysis ; Acquired Immunodeficiency Syndrome/epidemiology ; Acquired Immunodeficiency Syndrome/chemically induced ; Cohort Studies ; Longevity ; HIV ; Environmental Exposure/adverse effects ; Air Pollution/analysis ; China/epidemiology
Chemical Substances	Particulate Matter ; Air Pollutants
Language	English
Publishing date	2023-03-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.162589
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Article: Functional and clinical characteristics of focal adhesion kinases in cancer progression.

Zhang, Zhaoyu / Li, Jinlong / Jiao, Simin / Han, Guangda / Zhu, Jiaming / Liu, Tianzhou

Frontiers in cell and developmental biology

2022 Volume 10, Page(s) 1040311

Abstract	Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and an adaptor protein that primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in response to stress. Increasing evidence has shown that at the pathological level, FAK is highly expressed in multiple tumors in several systems (including lung, liver, gastric, and colorectal cancers) and correlates with tumor aggressiveness and patient prognosis. At the molecular level, FAK promotes tumor progression mainly by altering survival signals, invasive capacity, epithelial-mesenchymal transition, the tumor microenvironment, the Warburg effect, and stemness of tumor cells. Many effective drugs have been developed based on the comprehensive role of FAK in tumor cells. In addition, its potential as a tumor marker cannot be ignored. Here, we discuss the pathological and pre-clinical evidence of the role of FAK in cancer development; we hope that these findings will assist in FAK-based clinical studies.
Language	English
Publishing date	2022-11-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2022.1040311
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