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  1. Article ; Online: POM-1 inhibits P2 receptors and exhibits anti-inflammatory effects in macrophages.

    Pimenta-Dos-Reis, Gabriela / Torres, Eduardo José Lopes / Quintana, Paula Gabriela / Vidal, Lincon Onorio / Dos Santos, Bárbara Andréa Fortes / Lin, Chuan-Sheng / Heise, Norton / Persechini, Pedro Muanis / Schachter, Julieta

    Purinergic signalling

    2017  Volume 13, Issue 4, Page(s) 611–627

    Abstract: Extracellular nucleotides can modulate the immunological response by activating purinergic receptors (P2Rs) on the cell surface of macrophages, dendritic, and other immune cells. In particular, the activation of P2X7R can induce release of cytokines and ... ...

    Abstract Extracellular nucleotides can modulate the immunological response by activating purinergic receptors (P2Rs) on the cell surface of macrophages, dendritic, and other immune cells. In particular, the activation of P2X7R can induce release of cytokines and cell death as well as the uptake of large molecules through the cell membrane by a mechanism still poorly understood. Polyoxotungstate-1 (POM-1) has been proposed as a potent inhibitor of ecto-nucleotidases, enzymes that hydrolyze extracellular nucleotides, regulating the activity of P2Rs. However, the potential impact of POM-1 on P2Rs has not been evaluated. Here, we used fluorescent dye uptake, cytoplasmic free Ca
    MeSH term(s) Adenosine Triphosphatases/metabolism ; Animals ; Macrophages/drug effects ; Macrophages/metabolism ; Mice ; Purinergic P2X Receptor Antagonists/pharmacology ; Receptors, Purinergic P2X7/metabolism ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Tungsten Compounds/pharmacology
    Chemical Substances Purinergic P2X Receptor Antagonists ; Receptors, Purinergic P2X7 ; Tungsten Compounds ; Adenosine Triphosphatases (EC 3.6.1.-) ; ectoATPase (EC 3.6.1.-)
    Language English
    Publishing date 2017-10-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2172143-9
    ISSN 1573-9546 ; 1573-9538
    ISSN (online) 1573-9546
    ISSN 1573-9538
    DOI 10.1007/s11302-017-9588-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Detection of Leptospira in a forest fragmentation area in eastern Amazon: A unique health approach.

    de Souza Rocha, Katarine / da Rocha Albuquerque, Mírian / da Silva Brito, Jacqueline / Pimenta, Gabriela Castanheira / Dos Reis, Thalita Amaral / Xavier, Diego Arruda / Guimarães de Moraes, Carla Cristina

    Comparative immunology, microbiology and infectious diseases

    2022  Volume 82, Page(s) 101757

    Abstract: The objective of this study was to detect the presence of anti-Leptospira spp. in samples of humans and domestic animals of forest fragmentation areas in the Brazilian Amazon. A total of 208 samples from dogs, cats, and humans were collected during two ... ...

    Abstract The objective of this study was to detect the presence of anti-Leptospira spp. in samples of humans and domestic animals of forest fragmentation areas in the Brazilian Amazon. A total of 208 samples from dogs, cats, and humans were collected during two expeditions within the same fragment. Detection of anti-Leptospira spp. antibodies was performed by the Microscopic Agglutination Test (MAT) using live antigens from 19 Leptospira spp. serogroups and DNA detection of Leptospira 16S rRNA gene was done using Polymerase Chain Reaction. After the analysis, we observed 24.03% (50/208) of reactive serum samples, where the most prevalent serogroups circulating in the human and animal population were Canicola, Djasiman, Cynopteri, and Serjoe. Leptospira DNA was detected only in the samples of 13 dogs, which demonstrated 100% identity with L. interrogans DNA deposited in the GenBank. We concluded that there is a circulation of Leptospira spp. in the studied fragment.
    Language English
    Publishing date 2022-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 436522-7
    ISSN 1878-1667 ; 0147-9571
    ISSN (online) 1878-1667
    ISSN 0147-9571
    DOI 10.1016/j.cimid.2022.101757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1443: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Detection of Leptospira in a forest fragmentation area in eastern Amazon: A unique health approach

    de Souza Rocha, Katarine / da Rocha Albuquerque, Mírian / da Silva Brito, Jacqueline / Pimenta, Gabriela Castanheira / dos Reis, Thalita Amaral / Xavier, Diego Arruda / Guimarães de Moraes, Carla Cristina

    Comparative immunology, microbiology, and infectious diseases. 2022 Mar., v. 82

    2022  

    Abstract: The objective of this study was to detect the presence of anti-Leptospira spp. in samples of humans and domestic animals of forest fragmentation areas in the Brazilian Amazon. A total of 208 samples from dogs, cats, and humans were collected during two ... ...

    Abstract The objective of this study was to detect the presence of anti-Leptospira spp. in samples of humans and domestic animals of forest fragmentation areas in the Brazilian Amazon. A total of 208 samples from dogs, cats, and humans were collected during two expeditions within the same fragment. Detection of anti-Leptospira spp. antibodies was performed by the Microscopic Agglutination Test (MAT) using live antigens from 19 Leptospira spp. serogroups and DNA detection of Leptospira 16S rRNA gene was done using Polymerase Chain Reaction. After the analysis, we observed 24.03% (50/208) of reactive serum samples, where the most prevalent serogroups circulating in the human and animal population were Canicola, Djasiman, Cynopteri, and Serjoe. Leptospira DNA was detected only in the samples of 13 dogs, which demonstrated 100% identity with L. interrogans DNA deposited in the GenBank. We concluded that there is a circulation of Leptospira spp. in the studied fragment.
    Keywords agglutination tests ; blood serum ; genes ; habitat fragmentation ; humans ; microbiology ; polymerase chain reaction ; serotypes ; Amazonia
    Language English
    Dates of publication 2022-03
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 436522-7
    ISSN 1878-1667 ; 0147-9571
    ISSN (online) 1878-1667
    ISSN 0147-9571
    DOI 10.1016/j.cimid.2022.101757
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1443: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Accessing the Variability of Multicopy Genes in Complex Genomes using Unassembled Next-Generation Sequencing Reads: The Case of Trypanosoma cruzi Multigene Families.

    Reis-Cunha, João Luís / Coqueiro-Dos-Santos, Anderson / Pimenta-Carvalho, Samuel Alexandre / Marques, Larissa Pinheiro / Rodrigues-Luiz, Gabriela F / Baptista, Rodrigo P / Almeida, Laila Viana de / Honorato, Nathan Ravi Medeiros / Lobo, Francisco Pereira / Fraga, Vanessa Gomes / Galvão, Lucia Maria da Cunha / Bueno, Lilian Lacerda / Fujiwara, Ricardo Toshio / Cardoso, Mariana Santos / Cerqueira, Gustavo Coutinho / Bartholomeu, Daniella C

    mBio

    2022  Volume 13, Issue 6, Page(s) e0231922

    Abstract: Repetitive elements cause assembly fragmentation in complex eukaryotic genomes, limiting the study of their variability. The genome of Trypanosoma cruzi, the parasite that causes Chagas disease, has a high repetitive content, including multigene families. ...

    Abstract Repetitive elements cause assembly fragmentation in complex eukaryotic genomes, limiting the study of their variability. The genome of Trypanosoma cruzi, the parasite that causes Chagas disease, has a high repetitive content, including multigene families. Although many T. cruzi multigene families encode surface proteins that play pivotal roles in host-parasite interactions, their variability is currently underestimated, as their high repetitive content results in collapsed gene variants. To estimate sequence variability and copy number variation of multigene families, we developed a read-based approach that is independent of gene-specific read mapping and
    MeSH term(s) Humans ; Animals ; Mice ; Trypanosoma cruzi/genetics ; DNA Copy Number Variations ; Genome, Protozoan ; Mannose-Binding Protein-Associated Serine Proteases/genetics ; Multigene Family ; Chagas Disease/parasitology ; High-Throughput Nucleotide Sequencing/methods ; Mammals/genetics
    Chemical Substances Mannose-Binding Protein-Associated Serine Proteases (EC 3.4.21.-)
    Language English
    Publishing date 2022-10-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02319-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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