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  1. Article ; Online: Systems Pharmacology Strategy for the Investigation of Action Mechanisms of Qin Herb Libanotis Buchtormensis (

    Feng, Rundong / Wang, Lifang / Chai, Hu / Jiao, Jie / Zhang, Peng / Zheng, Xu / Liu, Haijing / Zhang, Wenjuan / Wu, Suli

    Endocrine, metabolic & immune disorders drug targets

    2023  Volume 24, Issue 1, Page(s) 142–152

    Abstract: Introduction: Qin medicines are medicinal plants growing in habitat around the peak of Qinling ... one of the popular Qin herbs, which has been widely used for the treatment of various diseases ...

    Abstract Introduction: Qin medicines are medicinal plants growing in habitat around the peak of Qinling Mountain. Their unique curative effects on bone metabolic diseases and pain diseases have been favoured by the local people in clinical trials for thousands of years. Libanotis buchtormensis (Fisch.) DC. (LBD), is one of the popular Qin herbs, which has been widely used for the treatment of various diseases, such as osteoporosis, rheumatic, and cardiovascular diseases. However, due to the multiple compounds in LBD, the underlying molecular mechanisms of LBD remain unclear.
    Objective: This study aimed to systemically investigate the underlying mechanisms of LBD against bone diseases.
    Methods: In this study, a systems pharmacology platform included the potential active compound screening, target fishing, and network pharmacological analysis was employed to decipher the action mechanisms of LBD.
    Results: As a result, 12 potential active compounds and 108 targets were obtained. Furthermore, compound-target network and target-pathway network analysis showed that multi-components interacted with multi-targets and multi-pathways, i.e., MARK signalling pathway, mTORC1 signalling pathway, etc., involved in the regulation of the immune system and circulatory system. These results suggested the mechanisms of the therapeutic effects of LBD on various diseases through most compounds targeted by multiple targets.
    Conclusion: In conclusion, we successfully predicted the LBD bioactive compounds and potential targets, implying that LBD could be applied as a novel therapeutic herb in osteoporosis, rheumatic, and cardiovascular diseases. This work provides insight into the therapeutic mechanisms of LBD for treating various diseases.
    MeSH term(s) Humans ; Drugs, Chinese Herbal/pharmacology ; Medicine, Chinese Traditional/methods ; Network Pharmacology ; Cardiovascular Diseases/drug therapy ; Osteoporosis/drug therapy ; Molecular Docking Simulation
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2023-07-19
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2228325-0
    ISSN 2212-3873 ; 1871-5303
    ISSN (online) 2212-3873
    ISSN 1871-5303
    DOI 10.2174/1871530323666230720143415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5824: Show issues Location:
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  2. Article: [Clinical characteristics analysis of 22 062 patients of foot and ankle deformity from QIN Sihe Orthopaedic Surgery Database between May 25, 1978 and December 31, 2020].

    Qin, Sihe / Guo, Baofeng / Zheng, Xuejian / Shi, Lei / Zhao, Jun / Wang, Yilan

    Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

    2023  Volume 37, Issue 1, Page(s) 74–80

    Abstract: Objective: Based on the clinical data of patients with foot and ankle deformities in the QIN Sihe ... were searched in the QIN Sihe Orthopedic Surgery Database. The gender, age at operation, regional ...

    Abstract Objective: Based on the clinical data of patients with foot and ankle deformities in the QIN Sihe Orthopaedic Surgery Database, to analyze the characteristics and treatment strategies of foot and ankle deformities, and provide a basis for clinical decision-making.
    Methods: A total of 22 062 patients with foot and ankle deformities who received orthopedic surgery between May 25, 1978 and December 31, 2020 were searched in the QIN Sihe Orthopedic Surgery Database. The gender, age at operation, regional distribution, etiology, type of deformity, operation method, postoperative fixation method, and other information were collected.
    Results: Among the 22 062 patients, there were 13 046 males (59.13%) and 9 016 females (40.87%); the age at operation ranged from 1 to 77 years, with a median of 17 years, and 20 026 cases (90.77%) were aged 5 to 40 years. The patients came from 32 provinces, municipalities, and autonomous regions across the China and 5 countries including India and the United States,
    Conclusion: Male patients with foot and ankle deformities account for a large proportion, and the population distribution is mainly adolescents, with a wide distribution of regions, causes and diseases, and talipes equinovarus and varus foot are the main types of deformities. Foot and ankle deformities are often combined with deformities of other parts of the lower limb, which requires a holistic treatment concept. The application of foot soft tissue and bone surgery combined with Ilizarov external fixator and combined external fixators provides a guarantee for the correction of complex foot and ankle deformities.
    MeSH term(s) Female ; Adolescent ; Humans ; Male ; Ankle/surgery ; Orthopedics ; Ilizarov Technique ; Lower Extremity/surgery ; Arthrodesis/methods ; Clubfoot/epidemiology ; Clubfoot/etiology ; Clubfoot/surgery ; Treatment Outcome
    Language Chinese
    Publishing date 2023-01-27
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1420212-8
    ISSN 1002-1892
    ISSN 1002-1892
    DOI 10.7507/1002-1892.202209065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Correction to: Huang Qin decoction increases SLC6A4 expression and blocks the NFκB-mediated NLRP3/Caspase1/GSDMD pathway to disrupt colitisassociated carcinogenesis.

    Tao, Yili / Wang, Lai / Ye, Xiaofeng / Qian, Xin / Pan, Danye / Dong, Xiaoyu / Jiang, Qian / Hu, Po

    Functional & integrative genomics

    2024  Volume 24, Issue 3, Page(s) 80

    Language English
    Publishing date 2024-04-25
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2014670-X
    ISSN 1438-7948 ; 1438-793X
    ISSN (online) 1438-7948
    ISSN 1438-793X
    DOI 10.1007/s10142-024-01343-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Huang Qin decoction increases SLC6A4 expression and blocks the NFκB-mediated NLRP3/Caspase1/GSDMD pathway to disrupt colitis-associated carcinogenesis.

    Tao, Yili / Wang, Lai / Ye, Xiaofeng / Qian, Xin / Pan, Danye / Dong, Xiaoyu / Jiang, Qian / Hu, Po

    Functional & integrative genomics

    2024  Volume 24, Issue 2, Page(s) 55

    Abstract: Huang Qin decoction (HQD) is a traditional Chinese medicine formula for treating colitis ...

    Abstract Huang Qin decoction (HQD) is a traditional Chinese medicine formula for treating colitis, but the effects and molecular mechanism of action of HQD in colitis-associated carcinogenesis (CAC) are still unclear. Therefore, we aimed to determine the beneficial effects of HQD on CAC in mice and to reveal the underlying mechanism involved. AOM/DSS was used to induce CAC in mice, and the effects of HQD on tumorigenesis in mice were examined (with mesalazine serving as a positive control). Mesalazine or HQD treatment alleviated body weight loss and decreased the disease activity index in mice induced by AOM/DSS. Mesalazine or HQD treatment also suppressed the shortening of colon tissue length, the number of tumors, and the infiltration of inflammatory cells. The genes targeted by HQD were predicted and verified, followed by knockout experiments. Elevated SLC6A4 and inhibited serotonin production and inflammation were observed in HQD-treated mice. HQD inhibited the NFκB and NLRP3/caspase1/GSDMD pathways. The therapeutic effect of HQD was diminished in SLC6A4-deficient AOM/DSS mice. Additionally, the downregulation of SLC6A4 mitigated the inhibitory effect of HQD-containing serum on MODE-K cell pyroptosis. Our findings suggest that SLC6A4 is a pivotal regulator of HQD-alleviated CAC via its modulation of the NLRP3/caspase1/GSDMD pathway.
    MeSH term(s) Mice ; Animals ; Scutellaria baicalensis ; Mesalamine ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Colitis/chemically induced ; Colitis/complications ; Colitis/drug therapy ; Carcinogenesis/metabolism ; Mice, Inbred C57BL
    Chemical Substances Mesalamine (4Q81I59GXC) ; NLR Family, Pyrin Domain-Containing 3 Protein
    Language English
    Publishing date 2024-03-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2014670-X
    ISSN 1438-7948 ; 1438-793X
    ISSN (online) 1438-7948
    ISSN 1438-793X
    DOI 10.1007/s10142-024-01334-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A four-component combination derived from Huang-Qin Decoction significantly enhances anticancer activity of irinotecan.

    Xu, Dou-Dou / Hou, Xiao-Ying / Wang, Ou / Wang, Di / Li, Dan-Ting / Qin, Si-Yuan / Lv, Bo / Dai, Xiao-Min / Zhang, Zun-Jian / Wan, Jian-Bo / Xu, Feng-Guo

    Chinese journal of natural medicines

    2021  Volume 19, Issue 5, Page(s) 364–375

    Abstract: Huang-Qin Decoction (HQD) is a classic prescription for diarrhea in Chinese medicine treatment ...

    Abstract Huang-Qin Decoction (HQD) is a classic prescription for diarrhea in Chinese medicine treatment. Recent studies have demonstrated that HQD and its modified formulation PHY906 could ameliorate irinotecan (CPT-11) induced gastrointestinal (GI) toxicity and enhance its anticancer therapeutic efficacy. Nevertheless, which constituents in HQD are effective is still unclear so far. The study aims to screen out the key bioactive components combination from HQD that could enhance the anticancer effect of CPT-11. First, the potential bioactive constituents were obtained through system pharmacology strategy. Then the bioactivity of each constituent was investigated synthetically from the aspects of NCM460 cell migration, TNF-α release of THP-1-derived macrophage and MTT assay in HCT116 cell. The contribution of each constituent in HQD was evaluated using the bioactive index E
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Apoptosis ; Cell Proliferation ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; HCT116 Cells ; Humans ; Irinotecan/pharmacology ; Scutellaria baicalensis/chemistry ; Xenograft Model Antitumor Assays
    Chemical Substances Antineoplastic Agents ; Drugs, Chinese Herbal ; Irinotecan (7673326042)
    Language English
    Publishing date 2021-04-30
    Publishing country China
    Document type Journal Article
    ZDB-ID 2192577-X
    ISSN 1875-5364 ; 2095-6975 ; 1672-3651
    ISSN (online) 1875-5364
    ISSN 2095-6975 ; 1672-3651
    DOI 10.1016/S1875-5364(21)60034-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Community characteristics of macroinvertebrates and ecosystem health assessment in Qin River, a main tributary of the Yellow River in China.

    Li, Yanli / Li, Xue / Liu, Qingwei / Xu, Zongxue / Wang, Mingshi

    Environmental science and pollution research international

    2023  Volume 30, Issue 19, Page(s) 56410–56424

    Abstract: To know well the ecosystem health status of Qin River, a main tributary of the Yellow River and ... the largest river in Jincheng region, macroinvertebrates from 49 sampling sites in the Qin River and ... poor" and "poor" sites were mainly located in the middle reach of the Qin River and upper-middle reach ...

    Abstract To know well the ecosystem health status of Qin River, a main tributary of the Yellow River and the largest river in Jincheng region, macroinvertebrates from 49 sampling sites in the Qin River and its largest tributary, the Dan River, were investigated, and community characteristics were analyzed in the autumn of 2020; a Benthic index of Biotic Integrity (B-IBI) was established based on four metrics by a series of steps. The results showed that a total of 38 species of macroinvertebrates were collected and identified, belonging to 6 orders and 19 families, consisting of 17 Insecta species, 13 Gastropoda species, and 4 Oligochaeta species. Four species in Insecta belonged to EPT (E, Ephemeroptera; P, Plecoptera; T, Trichoptera); 10 species in Insecta belonged to Chironomidae and Tipulidae families. All species in Gastropoda belonged to Basematophora order, and, especially, Bellamya aeruginosa is highly tolerant to nutrients. All species in Oligochaetes belonged to Tubificidae family, which indicates eutrophication and low-dissolved oxygen. The dominant species in the study were Ephemera orientalis, Chironomus riparius Meigen, and Limnodrilus claparedianus. The final B-IBI scores varied from 0.75 to 3.75, with 5 sites in "excellent," 10 sites in "good," 10 sites in "normal" status, 12 sites in "poor" status, 12 sites in "very poor." "Very poor" and "poor" sites were mainly located in the middle reach of the Qin River and upper-middle reach of the Dan River in Jincheng region. B-IBI strongly differentiated the reference sites and impaired sites, suggesting the suitability of the B-IBI in the Qin River basin. Significantly negative correlations between NH
    MeSH term(s) Humans ; Animals ; Ecosystem ; Invertebrates ; Rivers ; Environmental Monitoring/methods ; Insecta ; Gastropoda ; China ; Chironomidae ; Oligochaeta ; Ephemeroptera
    Language English
    Publishing date 2023-03-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-26314-9
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  7. Article ; Online: Network pharmacological analysis to reveal the mechanism governing the effect of Qin Xi Tong on osteoarthritis and rheumatoid arthritis.

    Lv, Yanyan / Zhang, Jie / Li, Chao / Wang, Li / Lei, Lei / Huang, Xiaoqiang

    Clinical rheumatology

    2023  Volume 42, Issue 8, Page(s) 2209–2222

    Abstract: Introduction: Qin Xi Tong (QXT), produced by water extracts of Caulis Sinomenii, is clinically ...

    Abstract Introduction: Qin Xi Tong (QXT), produced by water extracts of Caulis Sinomenii, is clinically effective in the therapy of rheumatoid arthritis (RA). It is also a complementary agent for osteoarthritis (OA). This study aimed to screen the candidate targets and identify the potential mechanisms of QXT against RA and OA.
    Method: The active ingredients contained in QXT were queried from the TCMSP database. Their predicted targets were obtained through web-based databases, including TCMSP, BATMAN-TCM, CTD, and PharmMapper. The OA and RA targets were collected from the Genecards database and the GSE55235 dataset. Based on the DAVID database, GO and KEGG enrichment analyses of disease-drug common targets predicted potential signaling pathways for QXT. In addition, core targets were identified by mapping component-target-disease interaction networks with Cytoscape 3.9.1 and STRING. The Swissdock and Pymol tools further validate the predicted results.
    Results: A total of 161 genes were put forward as potential targets for treating RA and OA. These genes might be involved in joint inflammation, including the IL-17 signaling pathway, MAPK signaling pathway, and TNF signaling pathway. They also regulated the progression of joint injuries, such as apoptosis, Th17 cell differentiation, and osteoclast differentiation. In addition, we identified 12 core targets of QXT. Molecular docking results showed that QXT has a high affinity with these core targets.
    Conclusions: This study reveals the mechanism governing the effect of QXT on RA and OA, predicts the direct target, and provides new ideas for clinical treatment. Key Points • Our study reveals the underlying mechanism of QXT in the treatment of RA and OA. • Further research into the effects of compounds in QXT alone would be of interest.
    MeSH term(s) Humans ; Molecular Docking Simulation ; Osteoarthritis/drug therapy ; Arthritis, Rheumatoid/drug therapy ; Apoptosis ; Cell Differentiation ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Medicine, Chinese Traditional
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2023-05-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-023-06625-5
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    Zs.A 1740: Show issues Location:
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  8. Article: [Analysis on the characteristics of 837 patients with post-traumatic lower limb deformities from QIN Sihe Orthopaedic Surgery Database between May 25, 1978 and December 31, 2020].

    Qin, Sihe / Guo, Baofeng / Zheng, Xuejian / Shi, Lei / Wang, Yilan / Zhao, Jun

    Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

    2022  Volume 36, Issue 8, Page(s) 1011–1014

    Abstract: ... lower limb deformity based on QIN Sihe Orthopaedic Surgery Database.: Methods: A clinical data of 837 ... December 31, 2020 in QIN Sihe Orthopaedic Surgery Database were analyzed retrospectively. The information ...

    Abstract Objective: To summarize and analyze the characteristics and treatment strategies of post-traumatic lower limb deformity based on QIN Sihe Orthopaedic Surgery Database.
    Methods: A clinical data of 837 patients with post-traumatic lower limb deformities treated by orthopaedic surgery between May 25, 1978 and December 31, 2020 in QIN Sihe Orthopaedic Surgery Database were analyzed retrospectively. The information of the patient's gender, age at the time of surgery, region of origin, cause of trauma, deformity side, orthopedic surgery related information (operation time, location, type, and fixation method after operation) were summarized and analyzed.
    Results: All patients came from 32 provinces, municipalities, autonomous regions, and Taiwan in China. Among them, 551 cases (65.83%) were male and 286 cases (34.17%) were female. The age of the patients at the time of surgery was 3-84 years old, with an average of 27.6 years old, and the most patients were 16-45 years old (559 cases, 66.78%). The main cause of trauma was traffic accident injury (639 cases, 76.34%). The deformity mainly involved unilateral limbs, including 394 cases (47.07%) on the left side and 376 cases (44.92%) on the right side. The most patients were admitted between 2008 and 2017, accounting for 53.05% (444/837). All patients were operated on one or more sites (1 048 sites), among which ankle and toe surgery were the most, accounting for 48.38% (507/1 048). The patients received 1204 surgeries including tendon lengthening and soft tissue contracture release,
    Conclusion: Post-traumatic lower extremity deformity patients have a large proportion of males, with a wide geographical distribution, involving various parts of the lower extremities, and most commonly in the foot and ankle. Orthopedic surgery combined with bone external fixation (Ilizarov technique) is the main methods for correction and functional reconstruction of post-traumatic lower limb deformity.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; External Fixators ; Female ; Humans ; Ilizarov Technique ; Lower Extremity/surgery ; Male ; Middle Aged ; Orthopedics ; Retrospective Studies ; Treatment Outcome ; Young Adult
    Language Chinese
    Publishing date 2022-08-02
    Publishing country China
    Document type Journal Article
    ZDB-ID 1420212-8
    ISSN 1002-1892
    ISSN 1002-1892
    DOI 10.7507/1002-1892.202204098
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Network pharmacology analysis reveals neuroprotective effects of the Qin-Zhi-Zhu-Dan Formula in Alzheimer's disease.

    Xu, Wenxiu / Ren, Beida / Zhang, Zehan / Chen, Congai / Xu, Tian / Liu, Shuling / Ma, Chongyang / Wang, Xueqian / Wang, Qingguo / Cheng, Fafeng

    Frontiers in neuroscience

    2022  Volume 16, Page(s) 943400

    Abstract: ... neurodegenerative diseases. The Qin-Zhi-Zhu-Dan Formula (QZZD) is derived from a widely used Chinese patent drug-Qing-Kai ...

    Abstract There is yet no effective drug for Alzheimer's disease (AD) which is one of the world's most common neurodegenerative diseases. The Qin-Zhi-Zhu-Dan Formula (QZZD) is derived from a widely used Chinese patent drug-Qing-Kai-Ling Injection. It consists of
    Language English
    Publishing date 2022-10-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2022.943400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Toxicological safety evaluation of Qin-Zhi-Zhu-Dan formula in rats during the treatment and recovery periods.

    Xu, Wenxiu / Chen, Dan / Zhang, Zehan / Liu, Shuling / Chen, Congai / Sun, Chunyan / Ni, Wenchao / Kang, Xiangdong / Shang, Guojiao / Wang, Xueqian / Cheng, Fafeng / Wang, Qingguo

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 987997

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.987997
    Database MEDical Literature Analysis and Retrieval System OnLINE

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