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Article ; Online: New insights into mechanisms regulating pulmonary adventitial fibroblast proliferation.

Sutliff, Roy L

2016 Volume 219, Issue 1, Page(s) 17–19

MeSH term(s)	Adventitia ; Cell Proliferation ; Cells, Cultured ; Fibroblasts ; Lung ; Pulmonary Artery
Language	English
Publishing date	2016-08-16
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	2218636-0
ISSN	1748-1716 ; 1748-1708
ISSN (online)	1748-1716
ISSN	1748-1708
DOI	10.1111/apha.12753
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Article ; Online: Macrophage Signaling Pathways in Pulmonary Nontuberculous Mycobacteria Infections.

Prasla, Zohra / Sutliff, Roy L / Sadikot, Ruxana T

American journal of respiratory cell and molecular biology

2020 Volume 63, Issue 2, Page(s) 144–151

Abstract: The incidence and prevalence of nontuberculous mycobacteria (NTM) lung disease is rising worldwide and accounts for most clinical cases of NTM disease. NTM infections occur in both immunocompetent and immunocompromised hosts. Macrophages are the primary ... ...

Abstract	The incidence and prevalence of nontuberculous mycobacteria (NTM) lung disease is rising worldwide and accounts for most clinical cases of NTM disease. NTM infections occur in both immunocompetent and immunocompromised hosts. Macrophages are the primary host cells that initiate an immune response to NTM. Defining the molecular events that govern the control of infection within macrophages is fundamental to understanding the pathogenesis of NTM disease. Here, we review key macrophage host signaling pathways that contribute to the host immune response to pulmonary NTM infections. In this review, we focus primarily on NTM that are known to cause lung disease, including
MeSH term(s)	Animals ; Humans ; Lung Diseases/metabolism ; Lung Diseases/microbiology ; Macrophages/metabolism ; Mycobacterium Infections, Nontuberculous/metabolism ; Mycobacterium Infections, Nontuberculous/microbiology ; Nontuberculous Mycobacteria/pathogenicity ; Signal Transduction/physiology
Language	English
Publishing date	2020-03-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	1025960-0
ISSN	1535-4989 ; 1044-1549
ISSN (online)	1535-4989
ISSN	1044-1549
DOI	10.1165/rcmb.2019-0241TR
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Zs.A 2851: Show issues

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Article ; Online: Comparison of arterial storage conditions for delayed arterial ring testing.

McLaughlin, Dylan K / Hoffmann, Carson / Sasaki, Maiko / Li, Feifei / Ma, Jing / Cui, Xiangqin / Sutliff, Roy L / Brewster, Luke P

JVS-vascular science

2023 Volume 4, Page(s) 100122

Abstract: ... tested were: Opti-MEM (37°C or 4°C), Krebs-HEPES with 1.8 mmol/L or 2.5 mmol/L calcium (4°C), or ...

Abstract	Objective: Arterial ring testing is the gold standard for measuring arterial function. Increased arterial tone through arterial contraction and impaired endothelial relaxation (endothelial dysfunction) are key metrics of impaired arterial health in peripheral arterial disease (PAD). To allow for comparative testing of arteries during standard laboratory hours, storage buffers and conditions have been used to extend the functional life of arteries. Various storage conditions have been compared, but there has not been a robust comparison or validation in human arteries. The objective of this work is to optimize storage of arterial segments for endothelial cell (EC) testing in a murine model and to test EC function in human PAD arteries. We hypothesized that certain storage conditions would be superior to others. Methods: Healthy murine aortas were harvested from 10- to 14-week-old C57/Bl6J male and female mice and compared under different storage protocols (24 hours) to immediate arterial testing. The storage conditions tested were: Opti-MEM (37°C or 4°C), Krebs-HEPES with 1.8 mmol/L or 2.5 mmol/L calcium (4°C), or Wisconsin (WI) solution at 4°C. Vascular function was evaluated by isometric force testing. Endothelium-dependent and -independent relaxation were measured after precontraction with addition of methacholine or sodium nitroprusside, respectively. Arterial contraction was stimulated with potassium chloride or phenylephrine. Analysis of variance was used to determine significance compared with immediate testing with Results: We found that 4°C WI and 37°C Opti-MEM best preserved endothelium-dependent relaxation and performed similarly to immediately testing aortas (termed fresh for freshly tested) ( Conclusions: In healthy murine aortas, arterial storage for 24 hours in 4°C WI or 37°C Opti-MEM both preserved endothelium-dependent relaxation and maximum force of contraction. In human PAD arteries stored in 4° WI, flow conditions before arterial harvest, but not arterial calcification, led to differences in arterial relaxation in human PAD arteries. Arterial contractility was more robust (11/28 arteries) compared with arterial relaxation (7/28 arteries), but was not significantly different under flow or calcification parameters. This work defines ideal storage conditions for arterial ring testing and identifies that EC dysfunction from disturbed flow may persist in delayed ex vivo arterial testing.
Language	English
Publishing date	2023-07-20
Publishing country	United States
Document type	Journal Article
ISSN	2666-3503
ISSN (online)	2666-3503
DOI	10.1016/j.jvssci.2023.100122
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Article ; Online: Redox Biology of Peroxisome Proliferator-Activated Receptor-γ in Pulmonary Hypertension.

Tseng, Victor / Sutliff, Roy L / Hart, C Michael

Antioxidants & redox signaling

2019 Volume 31, Issue 12, Page(s) 874–897

Abstract: Significance: ...

Abstract	Significance:
MeSH term(s)	Animals ; Down-Regulation ; Gene Expression Regulation ; Humans ; Hypertension, Pulmonary/genetics ; Hypertension, Pulmonary/metabolism ; MicroRNAs/genetics ; Nitric Oxide/metabolism ; Oxidation-Reduction ; PPAR gamma/metabolism ; Protein Processing, Post-Translational ; Signal Transduction ; Transcription Factors/metabolism
Chemical Substances	MicroRNAs ; PPAR gamma ; PPARG protein, human ; Transcription Factors ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2019-02-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	1483836-9
ISSN	1557-7716 ; 1523-0864
ISSN (online)	1557-7716
ISSN	1523-0864
DOI	10.1089/ars.2018.7695
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Article: MicroRNA-155 Modulates Macrophages' Response to Non-Tuberculous Mycobacteria through COX-2/PGE2 Signaling.

Yuan, Zhihong / Prasla, Zohra / Lee, Frances Eun-Hyung / Bedi, Brahmchetna / Sutliff, Roy L / Sadikot, Ruxana T

Pathogens (Basel, Switzerland)

2021 Volume 10, Issue 8

Abstract: Non-tuberculous mycobacteria (NTM) have been recognized as a causative agent of various human diseases, including severe infections in immunocompromised patients, such as people living with HIV. The most common species identified is ... ...

Abstract	Non-tuberculous mycobacteria (NTM) have been recognized as a causative agent of various human diseases, including severe infections in immunocompromised patients, such as people living with HIV. The most common species identified is the
Language	English
Publishing date	2021-07-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens10080920
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Article: Summer research programs.

Sutliff, Roy L

The Physiologist

2011 Volume 54, Issue 6, Page(s) 261–262

Abstract: A summer research experience is an excellent opportunity for undergraduate students to gain valuable research experience. With a little bit of planning, students can become familiar with the research area in which they are interested and begin to make ... ...

Abstract	A summer research experience is an excellent opportunity for undergraduate students to gain valuable research experience. With a little bit of planning, students can become familiar with the research area in which they are interested and begin to make connections with experts in the field. Time spent discussing goals for the project can yield peer-reviewed abstracts and publications. As a result, an application to graduate school can be greatly improved by a summer research experience, and students can have more options to consider as they embark on graduate training.
MeSH term(s)	Biomedical Research ; Education, Graduate/organization & administration ; Humans ; Internship, Nonmedical/organization & administration ; Mentors ; Physiology/education ; United States
Language	English
Publishing date	2011-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	208883-6
ISSN	1522-1202 ; 0031-9376
ISSN (online)	1522-1202
ISSN	0031-9376
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Article ; Online: Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis.

Cho, Kyu-Won / Andrade, Mark / Bae, Seongho / Kim, Sangsung / Eyun Kim, Jin / Jang, Er Yearn / Lee, Sangho / Husain, Ahsan / Sutliff, Roy L / Calvert, John W / Park, Changwon / Yoon, Young-Sup

Circulation

2023 Volume 147, Issue 24, Page(s) 1823–1842

Abstract: Background: Shortly after birth, cardiomyocytes exit the cell cycle and cease proliferation. At present, the regulatory mechanisms for this loss of proliferative capacity are poorly understood. CBX7 (chromobox 7), a polycomb group (PcG) protein, ... ...

Abstract	Background: Shortly after birth, cardiomyocytes exit the cell cycle and cease proliferation. At present, the regulatory mechanisms for this loss of proliferative capacity are poorly understood. CBX7 (chromobox 7), a polycomb group (PcG) protein, regulates the cell cycle, but its role in cardiomyocyte proliferation is unknown. Methods: We profiled CBX7 expression in the mouse hearts through quantitative real-time polymerase chain reaction, Western blotting, and immunohistochemistry. We overexpressed CBX7 in neonatal mouse cardiomyocytes through adenoviral transduction. We knocked down CBX7 by using constitutive and inducible conditional knockout mice ( Results: We explored Conclusions: Our results demonstrate that CBX7 directs the cell cycle exit of cardiomyocytes during the postnatal period by regulating its downstream targets TARDBP and RBM38. This is the first study to demonstrate the role of CBX7 in regulation of cardiomyocyte proliferation, and CBX7 could be an important target for cardiac regeneration.
MeSH term(s)	Animals ; Mice ; Animals, Newborn ; Cell Proliferation ; DNA-Binding Proteins/metabolism ; Mice, Knockout ; Myocytes, Cardiac/metabolism ; Polycomb-Group Proteins/metabolism
Chemical Substances	Cbx7 protein, mouse ; DNA-Binding Proteins ; Polycomb-Group Proteins ; Rbm38 protein, mouse ; Tardbp protein, mouse
Language	English
Publishing date	2023-05-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.122.061131
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Article ; Online: Probing the Intracellular Delivery of Nanoparticles into Hard-to-Transfect Cells.

Yang, Xuan / Wen, Xiaowei / Dai, Jie / Chen, Yanming / Ding, Wanchuan / Wang, Jun / Gu, Xiang / Zhang, Xuejin / Chen, Jin / Sutliff, Roy L / Emory, Steven R / Ruan, Gang

ACS nano

2022 Volume 16, Issue 6, Page(s) 8751–8765

Abstract: Hard-to-transfect cells are cells that are known to present special difficulties in intracellular delivery of exogenous entities. However, the special transport behaviors underlying the special delivery problem in these cells have so far not been ... ...

Abstract	Hard-to-transfect cells are cells that are known to present special difficulties in intracellular delivery of exogenous entities. However, the special transport behaviors underlying the special delivery problem in these cells have so far not been examined carefully. Here, we combine single-particle motion analysis, cell biology studies, and mathematical modeling to investigate nanoparticle transport in bone marrow-derived mesenchymal stem cells (BMSCs), a technologically important type of hard-to-transfect cells. Tat peptide-conjugated quantum dots (QDs-Tat) were used as the model nanoparticles. Two different yet complementary single-particle methods, namely, pair-correlation function and single-particle tracking, were conducted on the same cell samples and on the same viewing stage of a confocal microscope. Our results reveal significant differences in each individual step of transport of QDs-Tat in BMSCs
MeSH term(s)	Humans ; HeLa Cells ; Nanoparticles ; Quantum Dots ; Peptides ; Biological Transport
Chemical Substances	Peptides
Language	English
Publishing date	2022-05-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.1c07648
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Article ; Online: HIV-1, reactive oxygen species, and vascular complications.

Porter, Kristi M / Sutliff, Roy L

Free radical biology & medicine

2012 Volume 53, Issue 1, Page(s) 143–159

Abstract: Over 1 million people in the United States and 33 million individuals worldwide suffer from HIV/AIDS. Since its discovery, HIV/AIDS has been associated with an increased susceptibility to opportunistic infection due to immune dysfunction. Highly active ... ...

Abstract	Over 1 million people in the United States and 33 million individuals worldwide suffer from HIV/AIDS. Since its discovery, HIV/AIDS has been associated with an increased susceptibility to opportunistic infection due to immune dysfunction. Highly active antiretroviral therapies restore immune function and, as a result, people infected with HIV-1 are living longer. This improved survival of HIV-1 patients has revealed a previously unrecognized risk of developing vascular complications, such as atherosclerosis and pulmonary hypertension. The mechanisms underlying these HIV-associated vascular disorders are poorly understood. However, HIV-induced elevations in reactive oxygen species (ROS), including superoxide and hydrogen peroxide, may contribute to vascular disease development and progression by altering cell function and redox-sensitive signaling pathways. In this review, we summarize the clinical and experimental evidence demonstrating HIV- and HIV antiretroviral therapy-induced alterations in reactive oxygen species and how these effects are likely to contribute to vascular dysfunction and disease.
MeSH term(s)	HIV Infections/complications ; HIV Infections/physiopathology ; HIV-1/pathogenicity ; Humans ; Reactive Oxygen Species/metabolism ; Vascular Diseases/etiology
Chemical Substances	Reactive Oxygen Species
Language	English
Publishing date	2012-04-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2012.03.019
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Article ; Online: MicroRNA-155 Modulates Macrophages’ Response to Non-Tuberculous Mycobacteria through COX-2/PGE2 Signaling

Zhihong Yuan / Zohra Prasla / Frances Eun-Hyung Lee / Brahmchetna Bedi / Roy L. Sutliff / Ruxana T. Sadikot

Pathogens, Vol 10, Iss 920, p

2021 Volume 920

Abstract	Non-tuberculous mycobacteria (NTM) have been recognized as a causative agent of various human diseases, including severe infections in immunocompromised patients, such as people living with HIV. The most common species identified is the Mycobacterium avium -intracellulare complex (MAI/MAC), accounting for a majority of infections. Despite abundant information detailing the clinical significance of NTM, little is known about host–pathogen interactions in NTM infection. MicroRNAs (miRs) serve as important post-transcriptional regulators of gene expression. Using a microarray profile, we found that the expression of miR-155 and cyclo-oxygenase 2 (COX-2) is significantly increased in bone-marrow-derived macrophages from mice and human monocyte-derived macrophages from healthy volunteers that are infected with NTM. Antagomir against miR-155 effectively suppressed expression of COX-2 and reduced Prostaglandin E 2 (PGE2) secretion, suggesting that COX-2/PGE2 expression is dependent on miR-155. Mechanistically, we found that inhibition of NF-κB activity significantly reduced miR-155/COX-2 expression in infected macrophages. Most importantly, blockade of COX-2, E-prostanoid receptors (EP2 and EP4) enhanced killing of MAI in macrophages. These findings provide novel mechanistic insights into the role of miR-155/COX-2/PGE2 signalling and suggest that induction of these pathways enhances survival of mycobacteria in macrophages. Defining host–pathogen interactions can lead to novel immunomodulatory therapies for NTM infections which are difficult to treat.
Keywords	non-tuberculous mycobacteria ; Mycobacterium avium ; COX-2 ; PGE2 ; miR-155 ; Medicine ; R
Subject code	616
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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