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Article ; Online: Evaluation of reading level of online patient education materials discussing dermatologic care for patients undergoing dialysis.

Gallo Marin, Benjamin / Mulligan, Kathleen M / Robinson-Bostom, Leslie

JAAD international

2022 Volume 8, Page(s) 58–59

Language	English
Publishing date	2022-06-11
Publishing country	United States
Document type	Journal Article
ISSN	2666-3287
ISSN (online)	2666-3287
DOI	10.1016/j.jdin.2022.05.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Transforming Aging Services: Area Agencies on Aging and the COVID-19 Response.

Gallo, Haley B / Wilber, Kathleen H

The Gerontologist

2020 Volume 61, Issue 2, Page(s) 152–158

Abstract: For over four decades, Area Agencies on Aging (AAAs) have served as focal points to help older adults remain in their homes and communities. AAAs partner with other organizations to administer services authorized under the Older Americans Act (OAA). AAAs ...

Abstract	For over four decades, Area Agencies on Aging (AAAs) have served as focal points to help older adults remain in their homes and communities. AAAs partner with other organizations to administer services authorized under the Older Americans Act (OAA). AAAs represent loosely coupled systems; they are responsive to guidelines established by the OAA while maintaining flexibility to leverage limited resources, establish partnerships, and create innovative programs to meet community needs. As stay-at-home orders and concern for safety have kept many older adults homebound during the coronavirus disease 2019 (COVID-19) pandemic, an important question is how the Aging Network, including the over 600 AAAs, has responded to these rapidly changing needs. Although time and more systematic assessments are required, available information suggests that the loosely coupled network of AAAs has been a key, adaptable resource. This article begins with a description of the Aging Network and its history before turning to how the community-specific, collaborative, and evolving nature of AAAs places them at a unique position to respond to the challenges that arise with COVID-19. It concludes with how AAAs can continue to adapt to meet the needs of older adults and the people who care for them.
MeSH term(s)	Aged ; Aging ; COVID-19 ; Humans ; Pandemics ; SARS-CoV-2 ; United States
Language	English
Publishing date	2020-12-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	216760-8
ISSN	1758-5341 ; 0016-9013
ISSN (online)	1758-5341
ISSN	0016-9013
DOI	10.1093/geront/gnaa213
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Article ; Online: Withdrawn 2.0-update on withdrawn drugs with pharmacovigilance data.

Gallo, Kathleen / Goede, Andrean / Eckert, Oliver-Andreas / Gohlke, Bjoern-Oliver / Preissner, Robert

Nucleic acids research

2023 Volume 52, Issue D1, Page(s) D1503–D1507

Abstract: One challenge in the development of novel drugs is their interaction with potential off-targets, which can cause unintended side-effects, that can lead to the subsequent withdrawal of approved drugs. At the same time, these off-targets may also present a ...

Abstract	One challenge in the development of novel drugs is their interaction with potential off-targets, which can cause unintended side-effects, that can lead to the subsequent withdrawal of approved drugs. At the same time, these off-targets may also present a chance for the repositioning of withdrawn drugs for new indications, which are potentially rare or more severe than the original indication and where certain adverse reactions may be avoidable or tolerable. To enable further insights into this topic, we updated our database Withdrawn by adding pharmacovigilance data from the FDA Adverse Event Reporting System (FAERS), as well as mechanism of action and human disease pathway prediction features for drugs that are or were temporarily withdrawn or discontinued in at least one country. As withdrawal data are still spread over dozens of national websites, we are continuously updating our lists of discontinued or withdrawn drugs and related (off-)targets. Furthermore, new systematic entry points for browsing the data, such as an ATC tree, were added, increasing the accessibility of the database in a user-friendly way. Withdrawn 2.0 is publicly available without the need for registration or login at https://bioinformatics.charite.de/withdrawn_3/index.php.
MeSH term(s)	Humans ; Drug-Related Side Effects and Adverse Reactions ; Pharmacovigilance ; Safety-Based Drug Withdrawals ; Databases, Pharmaceutical/standards
Language	English
Publishing date	2023-12-20
Publishing country	England
Document type	Journal Article
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkad1017
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Article ; Online: The Multi-Faceted Consequences of NRF2 Activation throughout Carcinogenesis.

Occhiuto, Christopher J / Moerland, Jessica A / Leal, Ana S / Gallo, Kathleen A / Liby, Karen T

Molecules and cells

2023 Volume 46, Issue 3, Page(s) 176–186

Abstract: The oxidative balance of a cell is maintained by the Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2-related factor 2 (NRF2) pathway. This cytoprotective pathway detoxifies reactive oxygen species and xenobiotics. The role of the ... ...

Abstract	The oxidative balance of a cell is maintained by the Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2-related factor 2 (NRF2) pathway. This cytoprotective pathway detoxifies reactive oxygen species and xenobiotics. The role of the KEAP1/NRF2 pathway as pro-tumorigenic or anti-tumorigenic throughout stages of carcinogenesis (including initiation, promotion, progression, and metastasis) is complex. This mini review focuses on key studies describing how the KEAP1/NRF2 pathway affects cancer at different phases. The data compiled suggest that the roles of KEAP1/NRF2 in cancer are highly dependent on context; specifically, the model used (carcinogen-induced vs genetic), the tumor type, and the stage of cancer. Moreover, emerging data suggests that KEAP1/NRF2 is also important for regulating the tumor microenvironment and how its effects are amplified either by epigenetics or in response to co-occurring mutations. Further elucidation of the complexity of this pathway is needed in order to develop novel pharmacological tools and drugs to improve patient outcomes.
MeSH term(s)	Humans ; Carcinogenesis/genetics ; Kelch-Like ECH-Associated Protein 1/genetics ; Kelch-Like ECH-Associated Protein 1/metabolism ; Neoplasms/genetics ; Neoplasms/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Signal Transduction ; Tumor Microenvironment
Chemical Substances	Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; NFE2L2 protein, human
Language	English
Publishing date	2023-03-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1148964-9
ISSN	0219-1032 ; 1016-8478
ISSN (online)	0219-1032
ISSN	1016-8478
DOI	10.14348/molcells.2023.2191
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Article ; Online: SuperPred 3.0: drug classification and target prediction-a machine learning approach.

Gallo, Kathleen / Goede, Andrean / Preissner, Robert / Gohlke, Bjoern-Oliver

Nucleic acids research

2022 Volume 50, Issue W1, Page(s) W726–W731

Abstract: Since the last published update in 2014, the SuperPred webserver has been continuously developed to offer state-of-the-art models for drug classification according to ATC classes and target prediction. For the first time, a thoroughly filtered ATC ... ...

Abstract	Since the last published update in 2014, the SuperPred webserver has been continuously developed to offer state-of-the-art models for drug classification according to ATC classes and target prediction. For the first time, a thoroughly filtered ATC dataset, that is suitable for accurate predictions, is provided along with detailed information on the achieved predictions. This aims to overcome the challenges in comparing different published prediction methods, since performance can vary greatly depending on the training dataset used. Additionally, both ATC and target prediction have been reworked and are now based on machine learning models instead of overall structural similarity, stressing the importance of functional groups for the mechanism of action of small molecule substances. Additionally, the dataset for the target prediction has been extensively filtered and is no longer only based on confirmed binders but also includes non-binding substances to reduce false positives. Using these methods, accuracy for the ATC prediction could be increased by almost 5% to 80.5% compared to the previous version, and additionally the scoring function now offers values which are easily assessable at first glance. SuperPred 3.0 is publicly available without the need for registration at: https://prediction.charite.de/index.php.
MeSH term(s)	Machine Learning ; Pharmaceutical Preparations/chemistry ; Databases, Chemical
Chemical Substances	Pharmaceutical Preparations
Language	English
Publishing date	2022-05-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkac297
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Article ; Online: It's Time We Looked Under the Hood: An In-Depth Examination of Five Public California Area Agencies on Aging.

Gallo, Haley B / Marnfeldt, Kelly Ann / Navarro, Adria E / Wilber, Kathleen H

The Gerontologist

2022 Volume 62, Issue 10, Page(s) 1420–1430

Abstract: Background and objectives: As the older adult population grows, it is important to understand the effectiveness of service delivery systems that support aging in place. Studying service delivery processes and organizational structures of Area Agencies ... ...

Abstract	Background and objectives: As the older adult population grows, it is important to understand the effectiveness of service delivery systems that support aging in place. Studying service delivery processes and organizational structures of Area Agencies on Aging (AAAs) is essential for future efforts to understand service delivery outcomes and innovations. Research design and methods: We conducted site visits with 5 government-run California AAAs. We used a template and constant comparative analysis to analyze transcripts from site visits and focus groups with key informants. Results: AAA representatives discussed how their organizational structure was related to (a) which services and programs they provided; (b) administrative cost savings and access to funding sources; (c) inter- and intra-agency coordination; and (d) visibility among clients and community partners. Discussion and implications: These findings can be used to guide decisions surrounding how changes in AAA structure may affect funding, coordination, service delivery, and visibility, among other factors. Consolidating the AAA with other departments and programs facilitates coordination and shared administrative costs, yet consolidation may reduce standalone AAAs' visibility and ability to innovate. AAA structure should be tailored to fit community resources, local government organization, and the needs of older residents.
MeSH term(s)	Aged ; Humans ; Aging ; California ; Environment ; Independent Living
Language	English
Publishing date	2022-08-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	216760-8
ISSN	1758-5341 ; 0016-9013
ISSN (online)	1758-5341
ISSN	0016-9013
DOI	10.1093/geront/gnac124
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Inequity concerns surrounding research years and the dermatology residency match.

Zheng, David X / Gallo Marin, Benjamin / Mulligan, Kathleen M / Nambudiri, Vinod E

International journal of dermatology

2022 Volume 61, Issue 7, Page(s) e247–e248

MeSH term(s)	Dermatology/education ; Humans ; Internship and Residency ; United States
Language	English
Publishing date	2022-03-29
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	412254-9
ISSN	1365-4632 ; 0011-9059 ; 1461-1244
ISSN (online)	1365-4632
ISSN	0011-9059 ; 1461-1244
DOI	10.1111/ijd.16179
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The current state of fellowship leadership in dermatology: trends in workforce demographics and scholarly productivity.

Ahmad, Areebah S / Mulligan, Kathleen M / Zheng, David X / O'Connell, Katie A / Gallo Marin, Benjamin / Koshelev, Misha V

Clinical and experimental dermatology

2023 Volume 48, Issue 5, Page(s) 538–540

MeSH term(s)	Humans ; United States ; Fellowships and Scholarships ; Leadership ; Dermatology ; Workforce ; Demography
Language	English
Publishing date	2023-01-12
Publishing country	England
Document type	Letter
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1093/ced/llad011
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Article ; Online: SuperNatural 3.0-a database of natural products and natural product-based derivatives.

Gallo, Kathleen / Kemmler, Emanuel / Goede, Andrean / Becker, Finnja / Dunkel, Mathias / Preissner, Robert / Banerjee, Priyanka

Nucleic acids research

2022 Volume 51, Issue D1, Page(s) D654–D659

Abstract: Natural products (NPs) are single chemical compounds, substances or mixtures produced by a living organism - found in nature. Evolutionarily, NPs have been used as healing agents since thousands of years and still today continue to be the most important ... ...

Abstract	Natural products (NPs) are single chemical compounds, substances or mixtures produced by a living organism - found in nature. Evolutionarily, NPs have been used as healing agents since thousands of years and still today continue to be the most important source of new potential therapeutic preparations. Natural products have played a key role in modern drug discovery for several diseases. Furthermore, following consumers' increasing demand for natural food ingredients, many efforts have been made to discover natural low-calorie sweeteners in recent years. SuperNatural 3.0 is a freely available database of natural products and derivatives. The updated version contains 449 058 natural compounds along with their structural and physicochemical information. Additionally, information on pathways, mechanism of action, toxicity, vendor information if available, drug-like chemical space prediction for several diseases as antiviral, antibacterial, antimalarial, anticancer, and target specific cells like the central nervous system (CNS) are also provided for the natural compounds. The updated version of the database also provides a valuable pool of natural compounds in which potential highly sweet compounds are expected to be found. The possible taste profile of the natural compounds was predicted using our published VirtualTaste models. The SuperNatural 3.0 database is freely available via http://bioinf-applied.charite.de/supernatural_3, without any login or registration.
MeSH term(s)	Biological Products/chemistry ; Databases, Factual ; Drug Discovery ; Taste ; Anti-Bacterial Agents
Chemical Substances	Biological Products ; Anti-Bacterial Agents
Language	English
Publishing date	2022-11-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkac1008
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Article: BRAF Inhibitor Resistance Confers Increased Sensitivity to Mitotic Inhibitors.

Misek, Sean A / Foda, Bardees M / Dexheimer, Thomas S / Akram, Maisah / Conrad, Susan E / Schmidt, Jens C / Neubig, Richard R / Gallo, Kathleen A

Frontiers in oncology

2022 Volume 12, Page(s) 766794

Abstract: Single agent and combination therapy with ... ...

Abstract	Single agent and combination therapy with BRAF
Language	English
Publishing date	2022-04-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.766794
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