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Article ; Online: Effect of High-Intensity Interval Exercise versus Continuous Low-Intensity Aerobic Exercise with Blood Flow Restriction on Psychophysiological Responses: A Randomized Crossover Study.

de Queiros, Victor S / Rolnick, Nicholas / Sabag, Angelo / Wilde, Phelipe / Peçanha, Thiago / Aniceto, Rodrigo Ramalho / Rocha, Roberto Felipe Câmara / Delgado, Douglas Z / de Araújo Tinôco Cabral, Breno Guilherme / Dantas, Paulo Moreira Silva

Journal of sports science & medicine

2024 Volume 23, Issue 1, Page(s) 114–125

Abstract: This study compared the effect of continuous low-intensity aerobic exercise with blood flow restriction (LI-AE-BFR) versus high-intensity interval exercise (HIIE), matching total external mechanical work between conditions, on perceptual (exertion, pain, ...

Abstract	This study compared the effect of continuous low-intensity aerobic exercise with blood flow restriction (LI-AE-BFR) versus high-intensity interval exercise (HIIE), matching total external mechanical work between conditions, on perceptual (exertion, pain, affective and pleasure) and physiological responses (heart rate [HR], blood lactate [BL] and muscle fatigue). Ten healthy untrained men (25.6 ± 3.78 years old; 75.02 ± 12.02 kg; 172.2 ± 6.76 cm; 24.95 ± 3.16 kg/m²) completed three visits to the laboratory. In visit 1, anthropometry, blood pressure and peak running velocity on the treadmill were measured. In visits 2 and 3, participants were randomly assigned to HIIE or LI-AE-BFR, both in treadmill. HIIE consisted of 10 one-minute stimuli at 80% of peak running velocity interspersed with one-minute of passive recovery. LI-AE-BFR consisted of 20-minutes of continuous walking at 40% of peak running velocity with bilateral cuffs inflated to 50% of arterial occlusion pressure. BL and maximum isometric voluntary contraction (MIVC - fatigue measure) were measured pre- and immediately post-exercise. HR, rating of perceived exertion (RPE), and rating of perceived pain (RPP) were recorded after each stimulus in HIIE and every two minutes in LI-AE-BFR. Affective response to the session, pleasure, and future intention to exercise (FIE) were assessed 10 minutes after the intervention ended. Increases in BL concentrations were greater in HIIE (p = 0.028;
MeSH term(s)	Adult ; Humans ; Male ; Young Adult ; Cross-Over Studies ; Exercise/physiology ; Heart Rate/physiology ; Hemodynamics ; Physical Exertion/physiology
Language	English
Publishing date	2024-03-01
Publishing country	Turkey
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial
ZDB-ID	2075564-8
ISSN	1303-2968 ; 1303-2968
ISSN (online)	1303-2968
ISSN	1303-2968
DOI	10.52082/jssm.2024.114
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Article ; Online: Evaluation of stiffness loss of reinforced concrete beams using the diffuse ultrasound method.

Tinoco, Isaque Vargas / Pinto, Roberto Caldas de Andrade

Ultrasonics

2021 Volume 117, Page(s) 106540

Abstract: Flexural cracks are common in reinforced concrete (RC) beams. At service loads, the tensile stresses induced by the bending moments cause beam sections to crack, leading to loss of stiffness and a consequent increase in beam deflections. Serviceability ... ...

Abstract	Flexural cracks are common in reinforced concrete (RC) beams. At service loads, the tensile stresses induced by the bending moments cause beam sections to crack, leading to loss of stiffness and a consequent increase in beam deflections. Serviceability limit states in RC beam design include maximum deflection and maximum crack widths. Cracks affect the propagation of ultrasound by disrupting its travel path, which leads to a strongly scattering of the ultrasonic waves. As a result, there is a delay in the arrival of the ultrasonic energy flux, which can be observed by the increasing formation of coda waves. This resultant incoherent wavefield can be approximated by the diffuse ultrasound method. The diffuse ultrasound method can better describe the cracking effects over a larger region of the RC element compared to the ultrasonic pulse velocity, the most used ultrasound parameter in concrete applications. Changes in the diffuse ultrasound parameters (diffusivity, dissipation and ATME) can be related to the extent of cracking in a RC element. The objective of this research was to apply the diffuse ultrasound method to evaluate the stiffness loss due to flexural cracking of RC beams. Beams with different longitudinal flexural reinforcement ratios were cast and submitted to a bending test. The deflection at mid-span, and thus beam stiffness, was monitored during the test. Ultrasound transducers were installed in the central region of the beams with ultrasound readings performed during the tests in order to acquire the waveforms at various loading stages. For each waveform, the diffuse ultrasound parameters were recovered using a time-frequency analysis. The behavior of the diffuse parameters with increasing progressive damage caused by flexural cracking was analyzed and correlated to the stiffness loss of the beams. As a result, it was observed that diffusivity and ATME were the most sensitive parameters to identify the onset of cracking and also were seen to be related to beam stiffness variation at early cracking stage. When correlated with stiffness loss values up to 70%, diffusivity and ATME presented high mean correlation coefficients, allowing to conclude that it is possible to estimate the stiffness loss through the diffuse ultrasound parameters in the interval following the beginning of the cracking process.
Language	English
Publishing date	2021-07-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	200839-7
ISSN	1874-9968 ; 0041-624X
ISSN (online)	1874-9968
ISSN	0041-624X
DOI	10.1016/j.ultras.2021.106540
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Article ; Online: Cell-Intrinsic CD38 Expression Sustains Exhausted CD8

DeRogatis, Julia M / Neubert, Emily N / Viramontes, Karla M / Henriquez, Monique L / Nicholas, Dequina A / Tinoco, Roberto

Journal of virology

2023 Volume 97, Issue 4, Page(s) e0022523

Abstract: Acute and chronic viral infections result in the differentiation of effector and exhausted T cells with functional and phenotypic differences that dictate whether the infection is cleared or progresses to chronicity. High CD38 expression has been ... ...

Abstract	Acute and chronic viral infections result in the differentiation of effector and exhausted T cells with functional and phenotypic differences that dictate whether the infection is cleared or progresses to chronicity. High CD38 expression has been observed on CD8
MeSH term(s)	CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/virology ; Cell Differentiation/genetics ; Lymphocytic Choriomeningitis/metabolism ; Lymphocytic choriomeningitis virus/genetics ; Persistent Infection ; Animals ; Mice ; Cell Survival/genetics ; Up-Regulation ; Cell Proliferation/genetics
Chemical Substances	Cd38 protein, mouse (EC 3.2.2.5)
Language	English
Publishing date	2023-04-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.00225-23
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Article ; Online: PD-1 Immune Checkpoint Blockade and PSGL-1 Inhibition Synergize to Reinvigorate Exhausted T Cells.

Viramontes, Karla M / Neubert, Emily N / DeRogatis, Julia M / Tinoco, Roberto

Frontiers in immunology

2022 Volume 13, Page(s) 869768

Abstract: Chronic viral infections where the antigen persists long-term, induces an exhaustion phenotype in responding T cells. It is now evident that immune checkpoints on T cells including PD-1, CTLA-4, and PSGL-1 ( ...

Abstract	Chronic viral infections where the antigen persists long-term, induces an exhaustion phenotype in responding T cells. It is now evident that immune checkpoints on T cells including PD-1, CTLA-4, and PSGL-1 (
MeSH term(s)	CD8-Positive T-Lymphocytes/immunology ; Hepatitis A Virus Cellular Receptor 2/immunology ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Lymphocytic Choriomeningitis/drug therapy ; Lymphocytic Choriomeningitis/immunology ; Lymphocytic choriomeningitis virus/immunology ; Membrane Glycoproteins/antagonists & inhibitors ; Membrane Glycoproteins/immunology ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/immunology
Chemical Substances	Hepatitis A Virus Cellular Receptor 2 ; Immune Checkpoint Inhibitors ; Membrane Glycoproteins ; P-selectin ligand protein ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor
Language	English
Publishing date	2022-06-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.869768
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Article ; Online: Targeting the PSGL-1 pathway for immune modulation.

Tinoco, Roberto / Bradley, Linda M

Immunotherapy

2017 Volume 9, Issue 10, Page(s) 785–788

MeSH term(s)	Animals ; Biomarkers ; Cell Differentiation ; Cell Movement ; Humans ; Immunomodulation/immunology ; Immunotherapy ; Leukocytes/immunology ; Leukocytes/physiology ; Membrane Glycoproteins/immunology ; Membrane Glycoproteins/metabolism ; Signal Transduction/immunology
Chemical Substances	Biomarkers ; Membrane Glycoproteins ; P-selectin ligand protein
Language	English
Publishing date	2017-09-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1750-7448
ISSN (online)	1750-7448
DOI	10.2217/imt-2017-0078
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Article: Type 2 diabetes epidemic in Mexico. Burden of disease 1990-2021 analysis and implications for public policies.

Montoya, Alejandra / Gallardo-Rincón, Hector / Silva-Tinoco, Rubén / García-Cerde, Rodrigo / Razo, Christian / Ong, Liane / Stafford, Lauryn / Lenox, Hailey / Tapia-Conyer, Roberto

Gaceta medica de Mexico

2024 Volume 159, Issue 6, Page(s) 474–486

Abstract: Background: Mexico faces a challenge due to the burden imposed by type 2 diabetes (T2D).: Objective: To analyze T2D epidemiology and burden in Mexico from 1990 to 2021, at the national and state levels.: Material and methods: Estimates from the ... ...

Title translation	Epidemia de diabetes tipo 2 en México. Análisis de la carga de la enfermedad 1990-2021 e implicaciones en la política pública.
Abstract	Background: Mexico faces a challenge due to the burden imposed by type 2 diabetes (T2D). Objective: To analyze T2D epidemiology and burden in Mexico from 1990 to 2021, at the national and state levels. Material and methods: Estimates from the Global Burden of Disease 2021 study were used to evaluate the prevalence, incidence, mortality, fatal and non-fatal burden. Metabolic, environmental and behavioral factors were considered. Comparative analyses were carried out by gender, age and state of the country. Results: The prevalence of T2D increased by 25%. The incidence increased in those younger than 45 years, with a mortality decrease being found among women. The rate of disability-adjusted life years (DALY) showed an increase in all states, from 45.2% in Nuevo León to 237.6% in Tabasco. In 2021, T2D caused the loss of 3.1 million DALYs, which accounted for 6.6% of total burden in Mexico, out of which 64% was due to premature deaths. Diabetic neuropathy affected 47%, and there were 270,000 cases of visual impairment; 66.3% of the burden was attributed to obesity. Conclusions: Comprehensive policies are urgently needed in order to reduce the burden of T2D in Mexico, through standardized guidelines, evidence-based strategies and technological resources that improve medical care accessibility and efficiency.
MeSH term(s)	Humans ; Female ; Mexico/epidemiology ; Diabetes Mellitus, Type 2/epidemiology ; Public Policy ; Epidemics ; Cost of Illness ; Global Health
Language	English
Publishing date	2024-02-23
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	425456-9
ISSN	0016-3813
ISSN	0016-3813
DOI	10.24875/GMM.M24000835
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Article ; Online: Outcomes of Pleural Space Infections in Patients With Indwelling Pleural Catheters for Active Malignancies.

Chang, Christopher H / Ost, David E / Jimenez, Carlos A / Saltijeral, Sahara N / Eapen, Georgie A / Casal, Roberto F / Sabath, Bruce F / Lin, Julie / Cerrillos, Eben / Nevarez Tinoco, Tamara / Grosu, Horiana B

Journal of bronchology & interventional pulmonology

2024 Volume 31, Issue 2, Page(s) 155–159

Abstract: Background: Pleural infections related to indwelling pleural catheters (IPCs) are an uncommon clinical problem. However, management decisions can be complex for patients with active malignancies due to their comorbidities and limited life expectancies. ... ...

Abstract	Background: Pleural infections related to indwelling pleural catheters (IPCs) are an uncommon clinical problem. However, management decisions can be complex for patients with active malignancies due to their comorbidities and limited life expectancies. There are limited studies on the management of IPC-related infections, including whether to remove the IPC or use intrapleural fibrinolytics. Methods: We conducted a retrospective cohort study of patients with active malignancies and IPC-related empyemas at our institution between January 1, 2005 and May 31, 2021. The primary outcome was to evaluate clinical outcomes in patients with malignant pleural effusions and IPC-related empyemas treated with intrapleural tissue plasminogen activator (tPA) and deoxyribonuclease (DNase) compared with those treated with tPA alone or no intrapleural fibrinolytic therapy. The secondary outcome evaluated was the incidence of bleeding complications. Results: We identified 69 patients with a malignant pleural effusion and an IPC-related empyema. Twenty patients received tPA/DNase, 9 received tPA alone, and 40 were managed without fibrinolytics. Those treated with fibrinolytics were more likely to have their IPCs removed as part of the initial management strategy ( P =0.004). The rate of surgical intervention and mortality attributable to the empyema were not significantly different between treatment groups. There were no bleeding events in any group. Conclusion: In patients with IPC-related empyemas, we did not find significant differences in the rates of surgical intervention, empyema-related mortality, or bleeding complications in those treated with intrapleural tPA/DNase, tPA alone, or no fibrinolytics. More patients who received intrapleural fibrinolytics had their IPCs removed, which may have been due to selection bias.
MeSH term(s)	Humans ; Tissue Plasminogen Activator/therapeutic use ; Fibrinolytic Agents/therapeutic use ; Empyema, Pleural/drug therapy ; Retrospective Studies ; Pleural Effusion, Malignant/drug therapy ; Pleural Effusion, Malignant/complications ; Catheters, Indwelling/adverse effects ; Deoxyribonucleases ; Pleural Effusion/therapy
Chemical Substances	Tissue Plasminogen Activator (EC 3.4.21.68) ; Fibrinolytic Agents ; Deoxyribonucleases (EC 3.1.-)
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2478320-1
ISSN	1948-8270 ; 1944-6586
ISSN (online)	1948-8270
ISSN	1944-6586
DOI	10.1097/LBR.0000000000000956
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Article ; Online: Water Resources Management in Mexico, Chile and Brazil

Clara Tinoco / Natalia Julio / Bruno Meirelles / Raúl Pineda / Ricardo Figueroa / Roberto Urrutia / Óscar Parra

Sustainability, Vol 14, Iss 5814, p

Comparative Analysis of Their Progress on SDG 6.5.1 and the Role of Governance

2022 Volume 5814

Abstract: Integrated Water Resources Management (IWRM) is globally regarded as a suitable alternative to adapt to the effects of Climate Change. Chile, México, and Brazil are developing countries that are highly vulnerable to climate change and have different ... ...

Abstract	Integrated Water Resources Management (IWRM) is globally regarded as a suitable alternative to adapt to the effects of Climate Change. Chile, México, and Brazil are developing countries that are highly vulnerable to climate change and have different water management models, thus presenting the strengths and challenges for IWRM compliance. Our analysis aims to compare advances in terms of the achievement of SDG 6.5.1 in these countries, in relation to the degree of implementation of IWRM and their correlation to the OECD principles on Water Governance. We used IWRM Data Portal, UNEP-DHI, including 33 indicators, and we used the proposal of Bertule et al., (2018) to analyze the relationship among IWRM and governance. Our findings indicate that the Chilean model has low social involvement in water management due to a market-based water governance system with weak state regulation and lack of legal instruments to implement watershed management programs. In Mexico and Brazil, there is greater citizen involvement in watershed organizations, and ecosystems and aquifers have been incorporated to aid with water management. These three countries show a low performance of gender indicators, deficient financing, and information in terms of decision-making, and a lack of effective mechanisms for social participation, which are key aspects of governance.
Keywords	water security ; watershed management ; SDG6 ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	710
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: PSGL-1 Immune Checkpoint Inhibition for CD4

DeRogatis, Julia M / Viramontes, Karla M / Neubert, Emily N / Tinoco, Roberto

Frontiers in immunology

2021 Volume 12, Page(s) 636238

Abstract: Immune checkpoint inhibition targeting T cells has shown tremendous promise in the treatment of many cancer types and are now standard therapies for patients. While standard therapies have focused on PD-1 and CTLA-4 blockade, additional immune ... ...

Abstract	Immune checkpoint inhibition targeting T cells has shown tremendous promise in the treatment of many cancer types and are now standard therapies for patients. While standard therapies have focused on PD-1 and CTLA-4 blockade, additional immune checkpoints have shown promise in promoting anti-tumor immunity. PSGL-1, primarily known for its role in cellular migration, has also been shown to function as a negative regulator of CD4
MeSH term(s)	Animals ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Immune Checkpoint Inhibitors/therapeutic use ; Lymphocytes, Tumor-Infiltrating/drug effects ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Membrane Glycoproteins/antagonists & inhibitors ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/immunology ; Membrane Glycoproteins/metabolism ; Mice, Knockout ; Molecular Targeted Therapy ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/metabolism ; Phenotype ; Signal Transduction ; Tumor Microenvironment ; Mice
Chemical Substances	Immune Checkpoint Inhibitors ; Membrane Glycoproteins ; P-selectin ligand protein
Language	English
Publishing date	2021-02-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.636238
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Article ; Online: HMGB2 regulates the differentiation and stemness of exhausted CD8

Neubert, Emily N / DeRogatis, Julia M / Lewis, Sloan A / Viramontes, Karla M / Ortega, Pedro / Henriquez, Monique L / Buisson, Rémi / Messaoudi, Ilhem / Tinoco, Roberto

Nature communications

2023 Volume 14, Issue 1, Page(s) 5631

Abstract: Chronic infections and cancers evade the host immune system through mechanisms that induce T cell exhaustion. The heterogeneity within the exhausted ... ...

Abstract	Chronic infections and cancers evade the host immune system through mechanisms that induce T cell exhaustion. The heterogeneity within the exhausted CD8
MeSH term(s)	Humans ; CD8-Positive T-Lymphocytes ; HMGB2 Protein/genetics ; Persistent Infection ; Cell Differentiation ; Virus Diseases ; Neoplasms
Chemical Substances	HMGB2 Protein
Language	English
Publishing date	2023-09-13
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-41352-0
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