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  1. Article: Structural pharmacology of PTH and PTHrP.

    Suva, Larry J / Friedman, Peter A

    Vitamins and hormones

    2022  Volume 120, Page(s) 1–21

    Abstract: Parathyroid hormone (PTH) and PTH-related peptide (PTHrP) regulate extracellular phosphate and calcium homeostasis as well as bone remodeling. PTH is a classic endocrine peptide hormone whose synthesis and negative feedback by multiple factors control ... ...

    Abstract Parathyroid hormone (PTH) and PTH-related peptide (PTHrP) regulate extracellular phosphate and calcium homeostasis as well as bone remodeling. PTH is a classic endocrine peptide hormone whose synthesis and negative feedback by multiple factors control release from the parathyroid glands. PTHrP is ubiquitously expressed (pre- and postnatally) and acts in an autocrine/paracrine manner. This review considers the structural pharmacology and actions of PTH and PTHrP, biological consequences of inherited mutations, engineered analogs that illuminate similarities and differences in physiologic actions, and targeted therapeutic opportunities.
    MeSH term(s) Humans ; Parathyroid Hormone/genetics ; Parathyroid Hormone/pharmacology ; Parathyroid Hormone-Related Protein/pharmacology
    Chemical Substances Parathyroid Hormone ; Parathyroid Hormone-Related Protein
    Language English
    Publishing date 2022-04-22
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 201161-x
    ISSN 2162-2620 ; 0083-6729
    ISSN (online) 2162-2620
    ISSN 0083-6729
    DOI 10.1016/bs.vh.2022.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Link between the Gut and Bone: Bone Health Impacted by Changes in Gut Microbiota.

    Suva, Larry J

    The American journal of pathology

    2018  Volume 189, Issue 2, Page(s) 229–230

    Abstract: This commentary highlights the article by Hathaway-Schrader et al that studies the impact of antibiotic-disruption of the gut microbiota on long-term bone development. ...

    Abstract This commentary highlights the article by Hathaway-Schrader et al that studies the impact of antibiotic-disruption of the gut microbiota on long-term bone development.
    MeSH term(s) Anti-Bacterial Agents ; Bone Density ; Bone Development ; Bone and Bones ; Gastrointestinal Microbiome
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2018-11-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2018.11.004
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  3. Article: PTH and PTHrP Actions on Bone.

    Suva, Larry J / Friedman, Peter A

    Handbook of experimental pharmacology

    2020  Volume 262, Page(s) 27–45

    Abstract: Parathyroid hormone (PTH), PTH-related peptide (PTHrP), PTHR, and their cognate G protein-coupled receptor play defining roles in the regulation of extracellular calcium and phosphate metabolism and in controlling skeletal growth and repair. Acting ... ...

    Abstract Parathyroid hormone (PTH), PTH-related peptide (PTHrP), PTHR, and their cognate G protein-coupled receptor play defining roles in the regulation of extracellular calcium and phosphate metabolism and in controlling skeletal growth and repair. Acting through complex signaling mechanisms that in many instances proceed in a tissue-specific manner, precise control of these processes is achieved. A variety of direct and indirect disease processes, along with genetic anomalies, can cause these schemes to become dysfunctional. Here, we review the basic components of this regulatory network and present both the well-established elements and emerging findings and concepts with the overall objective to provide a framework for understanding the elementary aspects of how PTH and PTHrP behave and as a call to encourage further investigation that will yield more comprehensive understanding of the physiological and pathological steps at play, with a goal toward novel therapeutic interventions.
    MeSH term(s) Bone and Bones ; Calcium/chemistry ; Calcium/metabolism ; Parathyroid Hormone ; Parathyroid Hormone-Related Protein ; Signal Transduction
    Chemical Substances Parathyroid Hormone ; Parathyroid Hormone-Related Protein ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-05-28
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2020_362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  4. Article ; Online: PTH Regulation of FGF23 Fragments: A Tail in Two Acts

    Suva, Larry J / Friedman, Peter A

    Endocrinology

    2017  Volume 158, Issue 5, Page(s) 1106–1108

    Language English
    Publishing date 2017--29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/en.2017-00185
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  5. Article ; Online: Predictive estimation of ovine hip joint centers: A regression approach.

    Henry, Aaron / Benner, Carson / Easwaran, Anish / Veerapalli, Likhitha / Gaddy, Dana / Suva, Larry J / Robbins, Andrew B

    Journal of biomechanics

    2023  Volume 161, Page(s) 111861

    Abstract: Estimation of the hip joint center in ovine biomechanical analysis is often overlooked or estimated using a marker on the greater trochanter which can result in large errors that propagate through subsequent analyses. The purpose of this study was to ... ...

    Abstract Estimation of the hip joint center in ovine biomechanical analysis is often overlooked or estimated using a marker on the greater trochanter which can result in large errors that propagate through subsequent analyses. The purpose of this study was to develop a novel method of estimating the hip joint centers in sheep to facilitate more accurate analysis of ovine biomechanics. CT scans from 16 sheep of varying ages, weight, sex, and phenotypes were acquired and the data was used to calculate the known hip joint center by sphere fitting the femoral head. Anatomical measurements and additional subject information were used to create a variety of regression models to estimate the hip joint centers in absence of CT data. The best regression equation created utilized markers placed on the tuber coxae and tuber ischii of the pelvis and resulted in a mean 3D Euclidean distance error of 6.43 ± 2.22 mm (mean ± standard deviation) between the known and estimated hip joint center. The regression models produced allow for more detailed, accurate and robust analysis of sheep biomechanics.
    MeSH term(s) Animals ; Sheep ; Hip Joint/diagnostic imaging ; Femur Head ; Femur ; Pelvis ; Ilium ; Biomechanical Phenomena
    Language English
    Publishing date 2023-11-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218076-5
    ISSN 1873-2380 ; 0021-9290
    ISSN (online) 1873-2380
    ISSN 0021-9290
    DOI 10.1016/j.jbiomech.2023.111861
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  6. Article ; Online: Imaging the vasculature by microCT; ain't no bones about it.

    Suva, Larry J

    Bone

    2012  Volume 50, Issue 1, Page(s) 400

    MeSH term(s) Animals ; Blood Vessels/ultrastructure ; Female ; Humans ; Male ; Tibia/blood supply
    Language English
    Publishing date 2012-01
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 632515-4
    ISSN 1873-2763 ; 8756-3282
    ISSN (online) 1873-2763
    ISSN 8756-3282
    DOI 10.1016/j.bone.2011.08.034
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    Zs.A 1571: Show issues Location:
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    Zs.MO 332: Show issues

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  7. Article ; Online: Characterization of TNSALP expression, localization, and activity in ovine utero-placental tissues†.

    Stenhouse, Claire / Halloran, Katherine M / Newton, Makenzie G / Moses, Robyn M / Sah, Nirvay / Suva, Larry J / Gaddy, Dana / Bazer, Fuller W

    Biology of reproduction

    2023  Volume 109, Issue 6, Page(s) 954–964

    Abstract: Tissue-nonspecific alkaline phosphatase (TNSALP; encoded by ALPL gene) has a critical role in the regulation of phosphate homeostasis postnatally. However, the utero-placental expression of TNSALP and the role in phosphate transport in pregnancy is ... ...

    Abstract Tissue-nonspecific alkaline phosphatase (TNSALP; encoded by ALPL gene) has a critical role in the regulation of phosphate homeostasis postnatally. However, the utero-placental expression of TNSALP and the role in phosphate transport in pregnancy is poorly understood. Estrous cycles of ewes were synchronized, and ewes were euthanized and hysterectomized on Days 1, 9, or 14 of the estrous cycle or bred to fertile rams and euthanized and hysterectomized on Days 9, 12, 17, 30, 50, 70, 90, 110, or 125 of pregnancy. The expression of ALPL mRNA, immunolocalization of TNSALP protein, and quantification and localization of TNSALP enzymatic activity was performed on ovine endometria and placentomes. Day of the estrous cycle did not alter ALPL mRNA expression or enzymatic activity of TNSALP. TNSALP protein localized to uterine epithelial and stromal cells, blood vessels, myometrium, caruncular, and cotyledonary stroma. TNSALP activity was localized to uterine epithelia, blood vessels, caruncular stroma (from Day 70 of gestation), and the apical surface of chorionic epithelia (from Day 50 of gestation). TNSALP protein and activity localized to the apical surface of uterine epithelia during the estrous cycle and in early pregnancy. Endometrial TNSALP enzymatic activity was downregulated on Days 17 and 30 of gestation (P < 0.05). Expression of ALPL mRNA decreased in late gestation in endometria and placentomes (P < 0.05). TNSALP activity peaked in placentomes on Days 70 and 90 of gestation. Collectively, these results suggest a potential role of TNSALP in the regulation of phosphate transport and homeostasis at the maternal-conceptus interface in ruminants.
    MeSH term(s) Pregnancy ; Sheep ; Animals ; Female ; Male ; Placenta/metabolism ; Alkaline Phosphatase/metabolism ; Uterus/metabolism ; Endometrium/metabolism ; Sheep, Domestic/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Phosphates/metabolism
    Chemical Substances Alkaline Phosphatase (EC 3.1.3.1) ; RNA, Messenger ; Phosphates
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1118-6
    ISSN 1529-7268 ; 0006-3363
    ISSN (online) 1529-7268
    ISSN 0006-3363
    DOI 10.1093/biolre/ioad113
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    Zs.A 551: Show issues Location:
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  8. Article ; Online: Back to the Future: Evaluation of the Role of Glutamate in Bone Cells.

    Suva, Larry J / Gaddy, Dana

    Calcified tissue international

    2016  Volume 99, Issue 2, Page(s) 112–113

    Language English
    Publishing date 2016
    Publishing country United States
    Document type Editorial
    ZDB-ID 304266-2
    ISSN 1432-0827 ; 0944-0747 ; 0008-0594 ; 0171-967X
    ISSN (online) 1432-0827
    ISSN 0944-0747 ; 0008-0594 ; 0171-967X
    DOI 10.1007/s00223-016-0135-5
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    Zs.A 317: Show issues Location:
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  9. Article ; Online: Hallmarks of Bone Metastasis.

    Johnson, Rachelle W / Suva, Larry J

    Calcified tissue international

    2017  Volume 102, Issue 2, Page(s) 141–151

    Abstract: Breast cancer bone metastasis develops as the result of a series of complex interactions between tumor cells, bone marrow cells, and resident bone cells. The net effect of these interactions are the disruption of normal bone homeostasis, often with ... ...

    Abstract Breast cancer bone metastasis develops as the result of a series of complex interactions between tumor cells, bone marrow cells, and resident bone cells. The net effect of these interactions are the disruption of normal bone homeostasis, often with significantly increased osteoclast and osteoblast activity, which has provided a rational target for controlling tumor progression, with little or no emphasis on tumor eradication. Indeed, the clinical course of metastatic breast cancer is relatively long, with patients likely to experience sequential skeletal-related events (SREs), often over lengthy periods of time, even up to decades. These SREs include bone pain, fractures, and spinal cord compression, all of which may profoundly impair a patient's quality-of-life. Our understanding of the contributions of the host bone and bone marrow cells to the control of tumor progression has grown over the years, yet the focus of virtually all available treatments remains on the control of resident bone cells, primarily osteoclasts. In this perspective, our focus is to move away from the current emphasis on the control of bone cells and focus our attention on the hallmarks of bone metastatic tumor cells and how these differ from primary tumor cells and normal host cells. In our opinion, there remains a largely unmet medical need to develop and utilize therapies that impede metastatic tumor cells while sparing normal host bone and bone marrow cells. This perspective examines the impact of metastatic tumor cells on the bone microenvironment and proposes potential new directions for uncovering the important mechanisms driving metastatic progression in bone based on the hallmarks of bone metastasis.
    MeSH term(s) Animals ; Bone Marrow Cells/physiology ; Bone Neoplasms/metabolism ; Bone Neoplasms/pathology ; Bone Neoplasms/physiopathology ; Bone Neoplasms/secondary ; Bone and Bones/pathology ; Bone and Bones/physiopathology ; Breast Neoplasms/pathology ; Female ; Humans ; Mice ; Osteoblasts/physiology ; Osteoclasts/physiology ; Osteolysis/drug therapy
    Language English
    Publishing date 2017-11-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 304266-2
    ISSN 1432-0827 ; 0944-0747 ; 0008-0594 ; 0171-967X
    ISSN (online) 1432-0827
    ISSN 0944-0747 ; 0008-0594 ; 0171-967X
    DOI 10.1007/s00223-017-0362-4
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  10. Article ; Online: Adjuvant bisphosphonates in breast cancer: the ABCSG-12 study.

    Suva, Larry J

    Current osteoporosis reports

    2010  Volume 8, Issue 2, Page(s) 57–59

    Language English
    Publishing date 2010-04-28
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2186581-4
    ISSN 1544-2241 ; 1544-1873
    ISSN (online) 1544-2241
    ISSN 1544-1873
    DOI 10.1007/s11914-010-0012-5
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